Seitz, Cornelia Sabine

[["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","132"],["dc.contributor.author","Lorenz, Verena Natalie"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Seitz, Cornelia S."],["dc.date.accessioned","2018-11-07T09:06:56Z"],["dc.date.available","2018-11-07T09:06:56Z"],["dc.date.issued","2012"],["dc.format.extent","S47"],["dc.identifier.isi","000307814000262"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25671"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","New york"],["dc.relation.conference","42nd Annual Meeting of the European-Society-for-Dermatological-Research (ESDR)"],["dc.relation.eventlocation","Venice, ITALY"],["dc.relation.issn","0022-202X"],["dc.title","Impact of c-Rel on proliferation, migration and adhesion of HaCaT cells"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Priebe, M. K."],["dc.contributor.author","Lorenz, Verena Natalie"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Seitz, Cornelia S."],["dc.date.accessioned","2018-11-07T10:00:07Z"],["dc.date.available","2018-11-07T10:00:07Z"],["dc.date.issued","2015"],["dc.format.extent","E6"],["dc.identifier.isi","000351939000034"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37731"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","42nd Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF)"],["dc.relation.eventlocation","Ulm, GERMANY"],["dc.relation.issn","1600-0625"],["dc.relation.issn","0906-6705"],["dc.title","Differential responses of human melanoma cells to c-Rel down-regulation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","415"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.lastpage","422"],["dc.bibliographiccitation.volume","134"],["dc.contributor.author","Lorenz, Verena Natalie"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Seitz, Cornelia S."],["dc.date.accessioned","2018-11-07T09:44:44Z"],["dc.date.available","2018-11-07T09:44:44Z"],["dc.date.issued","2014"],["dc.description.abstract","The c-Rel protein, a member of the NF-kappa B transcription factor family, exerts unique and distinctive functions in various cell types. Although c-Rel is expressed in human epidermis, its functions in keratinocytes are poorly understood. Our small interfering RNA based approach of c-Rel silencing in HaCaT keratinocytes induced altered cell morphology toward a spindle-shaped appearance. In addition, c-Rel downregulation resulted in increased apoptosis and significantly reduced proliferation towing to G2/M cell cycle delay, concomitant aberrant mitotic spindle formation, and induction of phospho-aurora A(Thr288). The relevance of c-Rel in epithelial carcinogenesis was further supported by detection of c-Rel expression in squamous cell carcinomas of the skin. Our studies indicate that c-Rel is a key regulator of cell fate decisions in keratinocytes such as cell growth and death and may have a role in epidermal carcinogenesis."],["dc.description.sponsorship","Wilhelm-Sander-Stiftung [2008.064.1]"],["dc.identifier.doi","10.1038/jid.2013.315"],["dc.identifier.isi","000329896000020"],["dc.identifier.pmid","23892589"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34460"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1523-1747"],["dc.relation.issn","0022-202X"],["dc.title","c-Rel Downregulation Affects Cell Cycle Progression of Human Keratinocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1090"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.lastpage","1096"],["dc.bibliographiccitation.volume","136"],["dc.contributor.author","Lorenz, Verena Natalie"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Seitz, Cornelia S."],["dc.date.accessioned","2018-11-07T10:13:45Z"],["dc.date.available","2018-11-07T10:13:45Z"],["dc.date.issued","2016"],["dc.description.abstract","To maintain proper skin barrier function, epidermal homeostasis requires a subtly governed balance of proliferating and differentiating keratinocytes. While differentiation takes place in the suprabasal layers, proliferation, including mitosis, is usually restricted to the basal layer. Only recently identified as an important regulator of epidermal homeostasis, c-Rel, an NF-kappa B transcription factor subunit, affects the viability and proliferation of epidermal keratinocytes. In human keratinocytes, decreased expression of c-Rel causes a plethora of dysregulated cellular functions including impaired cell viability, increased apoptosis, and abnormalities during mitosis and cell cycle regulation. On the other hand, c-Rel shows aberrant expression in many epidermal tumors. Here, in the context of its role in different cell types and compared with other NF-kappa B subunits, we discuss the putative function of c-Rel as a regulator of epidermal homeostasis and mitotic progression. In addition, implications for disease pathophysiology with perturbed c-Rel function and abnormal homeostasis, such as epidermal carcinogenesis, will be discussed."],["dc.identifier.doi","10.1016/j.jid.2016.02.003"],["dc.identifier.isi","000376784200009"],["dc.identifier.pmid","27032306"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40495"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1523-1747"],["dc.relation.issn","0022-202X"],["dc.title","c-Rel in Epidermal Homeostasis: A Spotlight on c-Rel in Cell Cycle Regulation"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","523"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Archives of Dermatological Research"],["dc.bibliographiccitation.lastpage","530"],["dc.bibliographiccitation.volume","307"],["dc.contributor.author","Lorenz, Verena Natalie"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Seitz, Cornelia S."],["dc.date.accessioned","2018-11-07T09:54:07Z"],["dc.date.available","2018-11-07T09:54:07Z"],["dc.date.issued","2015"],["dc.description.abstract","The transcription factor NF-kappa B exerts key functions in epidermal homeostasis and carcinogenesis. Its c-Rel subunit is expressed in squamous cell carcinoma, and c-Rel down-regulation results in increased apoptosis, G2/M cell cycle delay with reduced proliferation and aberrant mitotic spindle formation. To further study the impact of c-Rel on essential keratinocyte features such as migration and epithelial morphology, c-Rel was down-regulated in HaCaT keratinocytes by a siRNA approach. This inhibition of c-Rel impaired the keratinocyte-typical clustered growth leading to a more scattered appearance of the cultures. The cells were more spindle-shaped and elongated, albeit without expression changes of markers characteristic for epithelial mesenchymal transition. In addition, wound healing-related migration and adhesion to type I collagen, fibronectin, laminin and vitronectin were significantly impaired. On the sub-cellular level, these functional features were not associated with quantitatively altered adhesion receptor or Rho-GTPase expression, but rather with a significantly reduced length of cell-matrix adhesion complexes and altered appearance of filamentous actin. Thus, our studies support a role for c-Rel in processes crucial for keratinocyte integrity and malignant transformation such as adhesion and migration."],["dc.description.sponsorship","Wilhelm-Sander Stiftung [2008.064.1]"],["dc.identifier.doi","10.1007/s00403-015-1562-2"],["dc.identifier.isi","000358126800007"],["dc.identifier.pmid","25842167"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36471"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-069X"],["dc.relation.issn","0340-3696"],["dc.title","The c-Rel subunit of NF-kappa B is a crucial regulator of phenotype and motility of HaCaT keratinocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]