Seitz, Cornelia Sabine

[["dc.bibliographiccitation.firstpage","193"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Allergologia et Immunopathologia"],["dc.bibliographiccitation.lastpage","199"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Seitz, Cornelia S."],["dc.contributor.author","Broecker, Eva-B."],["dc.contributor.author","Trautmann, Axel"],["dc.date.accessioned","2018-11-07T08:54:31Z"],["dc.date.available","2018-11-07T08:54:31Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Macrolides are useful in a wide range of bacterial infections including upper and lower respiratory tract, skin, and sexually transmitted diseases and are used in Helicobacter pylori eradication regimen. Skin symptoms occurring during drug therapy are mostly attributed to the antibiotic, causing considerable limitations of future therapeutic options. The aim of this retrospective analysis was to demonstrate results of diagnostic testing in cases of clinically suspected immediate and delayed macrolide hypersensitivity. Methods: A total of 125 patients with a history of immediate or delayed hypersensitivity symptoms in temporal relation to treatment with a macrolide antibiotic were studied using standardised skin tests followed by oral challenges. Selected patients with severe symptoms were further evaluated with in vitro tests. Results:. Macrolide hypersensitivity was excluded in 109 patients (87.2%) by tolerated oral challenge tests. During 113 challenges in four patients an exanthema was provoked by the suspected macrolide. Only one patient developed a positive late skin test reaction. Out of the 28 Helicobacter pylori-treated patients, one patient with clarithromycin allergy was identified, whereas in eight cases amoxicillin allergy caused the exanthema. Laboratory tests using the suspected macrolides were constantly negative. Conclusions: History alone leads to an over-estimation of macrolide hypersensitivity. Moreover, skin and in vitro tests seem to be not very useful in identifying hypersensitive patients. Challenge tests appear to be necessary for definitely confirming or ruling out macrolide allergy. (C) 2010 SEICAP. Published by Elsevier Espana, S.L. All rights reserved."],["dc.identifier.doi","10.1016/j.aller.2010.06.008"],["dc.identifier.isi","000293608200002"],["dc.identifier.pmid","21269750"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22689"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Doyma Sl"],["dc.relation.issn","1578-1267"],["dc.relation.issn","0301-0546"],["dc.title","Suspicion of macrolide allergy after treatment of infectious diseases including Helicobacter pylori: Results of allergological testing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1738"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Clinical & Experimental Allergy"],["dc.bibliographiccitation.lastpage","1745"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Seitz, Cornelia S."],["dc.contributor.author","Broecker, Eva-B."],["dc.contributor.author","Trautmann, Axel"],["dc.date.accessioned","2018-11-07T11:22:29Z"],["dc.date.available","2018-11-07T11:22:29Z"],["dc.date.issued","2009"],["dc.description.abstract","P>Background Because of their broad antibacterial activity in the gram-negative and gram-positive spectrum, high oral bioavailability, and good tissue penetration, fluoroquinolone antibiotics are widely used. Besides direct drug-related side-effects, fluoroquinolones may cause hypersensitivity reactions. Objective The aim of this retrospective analysis was to present the results of diagnostic testing in cases of clinically suspected fluoroquinolone-induced immediate or delayed hypersensitivity. Methods We studied 101 patients with a history of immediate or delayed hypersensitivity symptoms in temporal relation to treatment with a fluoroquinolone antibiotic using standardized skin testing, followed by oral challenges. Patients with anaphylaxis symptoms were further evaluated with in vitro tests. Results Fluoroquinolone hypersensitivity was excluded in 71 patients by tolerated oral challenge tests. During positive challenge tests, six patients (three out of these had positive and three had negative skin prick tests) developed anaphylaxis symptoms but the presumed IgE-mediated mechanism could not be confirmed by in vitro tests. Patch testing was constantly negative; however, in two patients a rash was induced by the challenge tests. Conclusion History alone leads clearly to a considerable over-estimation of fluoroquinolone hypersensitivity. Moreover, skin or in vitro tests do not seem to be very useful in identifying hypersensitive patients. Challenge tests appear to be necessary for definitely confirming or ruling out fluoroquinolone hypersensitivity. Cite this as: C. S. Seitz, E. B. Brocker and A. Trautmann, Clinical & Experimental Allergy, 2009 (39) 1738-1745."],["dc.identifier.doi","10.1111/j.1365-2222.2009.03338.x"],["dc.identifier.isi","000271001600016"],["dc.identifier.pmid","19735271"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56003"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2222"],["dc.relation.issn","0954-7894"],["dc.title","Diagnostic testing in suspected fluoroquinolone hypersensitivity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","405"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Pediatric Allergy and Immunology"],["dc.bibliographiccitation.lastpage","410"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Seitz, Cornelia S."],["dc.contributor.author","Broecker, Eva-B."],["dc.contributor.author","Trautmann, Axel"],["dc.date.accessioned","2018-11-07T08:55:55Z"],["dc.date.available","2018-11-07T08:55:55Z"],["dc.date.issued","2011"],["dc.description.abstract","P>Background: Diagnosis of drug hypersensitivity is often based on history alone. But such a vague diagnosis may cause limitations of therapeutic options in the future. To confirm or rule out drug hypersensitivity, skin testing, in vitro studies, and challenge tests are necessary. However, the diagnostic value of this complex and time-consuming allergologic work-up, especially in children, remains controversial. Objective: Aim of this retrospective analysis was to compare the results of diagnostic testing in children and adolescents with drug hypersensitivity diagnosed on clinical grounds, i.e., temporal relationship and observation of symptoms alone. Methods: We studied 43 children and adolescents (23 females, 20 males, mean age 13) with a history of immediate or delayed hypersensitivity symptoms in temporal relation to drug treatment using standardized skin testing followed by oral challenges. Patients with suspected penicillin hypersensitivity were further evaluated with in vitro tests. Results: Drug hypersensitivity was excluded in 40 patients by tolerated oral challenge tests with the incriminated drug. In two patients, positive challenge tests confirmed non-steroidal anti-inflammatory drug hypersensitivity. One patient with amoxicillin-associated exanthema developed positive late skin test reactions to aminopenicillins. Conclusion: In childhood and adolescence, allergologic testing in cases of suspected drug hypersensitivity is of importance both to establish a correct diagnosis and to prevent unjustified withholding of a drug or class of drugs."],["dc.identifier.doi","10.1111/j.1399-3038.2011.01134.x"],["dc.identifier.isi","000290171000010"],["dc.identifier.pmid","21309856"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23021"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1399-3038"],["dc.relation.issn","0905-6157"],["dc.title","Diagnosis of drug hypersensitivity in children and adolescents: Discrepancy between physician-based assessment and results of testing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1531"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Clinical & Experimental Allergy"],["dc.bibliographiccitation.lastpage","1538"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Trautmann, Axel"],["dc.contributor.author","Seitz, Cornelia S."],["dc.contributor.author","Stoevesandt, J."],["dc.contributor.author","Kerstan, Andreas"],["dc.date.accessioned","2018-11-07T09:32:11Z"],["dc.date.available","2018-11-07T09:32:11Z"],["dc.date.issued","2014"],["dc.description.abstract","BackgroundThe lymphocyte transformation test (LTT) has been promoted as in-vitro test for diagnosis of drug hypersensitivity. For determination of statistical LTT sensitivity, series of patients with clinically uniform reactions followed by complete drug hypersensitivity work-up are mandatory. Assessment of LTT specificity requires control patients who tolerated exposure to the drug studied. ObjectiveTo prospectively determine the diagnostic value of the LTT in a clinically and diagnostically well-defined series of patients. MethodsPatients with exanthematous skin eruptions after ampicillin (AMP) intake were included in this study. After exclusion or confirmation of delayed-onset allergic AMP hypersensitivity by skin and provocation testing, two independent LTTs were performed: one standard LTT and a modified LTT with additional anti-CD3/anti-CD28 monoclonal antibody stimulation. ResultsBy testing, delayed-onset allergic AMP hypersensitivity was diagnosed in 11 patients and definitely ruled out in 26. The standard LTT reached a diagnostic sensitivity of 54.5% while the modified LTT yielded 72.7%. However, the methodical test modification resulted in a decline of specificity from 92.3% (standard LTT) to 76.9%. Conclusions and Clinical RelevanceIn cases of AMP-associated exanthems, the diagnostic value of the LTT compared with routine allergy testing is limited. When evaluating such exanthems, provocation testing remains the gold standard. Delayed reading of intradermal skin tests remains most useful to avoid positive provocation reactions."],["dc.identifier.doi","10.1111/cea.12437"],["dc.identifier.isi","000345461600011"],["dc.identifier.pmid","25323308"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31692"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2222"],["dc.relation.issn","0954-7894"],["dc.title","Aminopenicillin-associated exanthem: lymphocyte transformation testing revisited"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","125"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical & Experimental Allergy"],["dc.bibliographiccitation.lastpage","132"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Trautmann, Axel"],["dc.contributor.author","Seidl, C."],["dc.contributor.author","Stoevesandt, J."],["dc.contributor.author","Seitz, Cornelia S."],["dc.date.accessioned","2018-11-07T10:21:23Z"],["dc.date.available","2018-11-07T10:21:23Z"],["dc.date.issued","2016"],["dc.description.abstract","Background Immunoglobulin E-mediated allergy to drugs and substances used during general anaesthesia as well as non-allergic drug hypersensitivity reactions may account for anaesthesia-induced anaphylaxis. As IgE-mediated anaphylaxis is a potentially life-threatening reaction, identification of the culprit allergen is essential to avoid anaphylaxis recurrence during subsequent general anaesthesia. Objective To study whether preventive recommendations derived from allergy testing after intraoperative anaphylaxis were followed in subsequent general anaesthesia. Methods Results of standardized allergy testing after anaesthesia-induced anaphylaxis and outcome of subsequent general anaesthesia were analysed retrospectively. Results Fifty-three of 107 patients were diagnosed with IgE-mediated allergy to a drug or substance used during general anaesthesia, and 54 patients were test negative. Twenty-eight of 29 allergy patients tolerated subsequent general anaesthesia uneventfully. One patient with cefazolin allergy suffered from anaphylaxis recurrence due to accidental reapplication of cefazolin. Twenty-two of 24 test-negative patients tolerated subsequent general anaesthesia, whereas two patients again developed anaphylaxis despite pre-medication regimens. Conclusion and Clinical Relevance Our results confirm the practical impact of allergy testing in general anaesthesia-induced anaphylaxis. By identification of the allergen, it is possible to avoid allergic anaphylaxis during subsequent anaesthesia. In most cases, recommended pre-medication seems to prevent the recurrence of non-allergic drug hypersensitivity reactions."],["dc.identifier.doi","10.1111/cea.12632"],["dc.identifier.isi","000367924500013"],["dc.identifier.pmid","26767493"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42073"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2222"],["dc.relation.issn","0954-7894"],["dc.title","General anaesthesia-induced anaphylaxis: impact of allergy testing on subsequent anaesthesia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","494"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Investigational Allergology and Clinical Immunology"],["dc.bibliographiccitation.lastpage","495"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Seitz, Cornelia S."],["dc.contributor.author","Trautmann, Axel"],["dc.date.accessioned","2018-11-07T09:01:33Z"],["dc.date.available","2018-11-07T09:01:33Z"],["dc.date.issued","2011"],["dc.identifier.isi","000296171000013"],["dc.identifier.pmid","21995188"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24456"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Esmon Publicidad S A"],["dc.relation.issn","1018-9068"],["dc.title","Cosmetic Facial Peel-Induced Contact Anaphylaxis: Chestnut Allergy Without Latex-Fruit Syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","469"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Immunology and Allergy Clinics of North America"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Trautmann, Axel"],["dc.contributor.author","Seitz, Cornelia S."],["dc.date.accessioned","2018-11-07T08:27:16Z"],["dc.date.available","2018-11-07T08:27:16Z"],["dc.date.issued","2009"],["dc.description.abstract","Itching erythematous or eczematous plaques around injection sites are quite frequent side effects of heparin treatment and clinical symptoms of delayed-type non-IgE-mediated allergic hypersensitivity (DTH) to heparin. For diagnosis, intradermal, patch, and subcutaneous challenge tests with heparins are suitable. In most cases, changing the subcutaneous therapy from unfractionated to low molecular weight heparin or treatment with heparinoids does not provide improvement because of extensive cross-reactivity. Hirudin polypeptides, which exhibit a different chemical structure, are a safe therapeutic alternative for subcutaneous application, however. Importantly, despite DTH to subcutaneously injected heparins, most patients tolerate heparin intravenously. Moreover, in case of therapeutic necessity and DTH to heparins, the simple shift from subcutaneous to intravenous heparin administration without prior testing may be justified."],["dc.identifier.doi","10.1016/j.iac.2009.04.006"],["dc.identifier.isi","000268560300007"],["dc.identifier.pmid","19563992"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16173"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","0889-8561"],["dc.title","Heparin Allergy: Delayed-Type Non-IgE-Mediated Allergic Hypersensitivity to Subcutaneous Heparin Injection"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","821"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Medical Clinics of North America"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","94"],["dc.contributor.author","Trautmann, Axel"],["dc.contributor.author","Seitz, Cornelia S."],["dc.date.accessioned","2018-11-07T08:41:54Z"],["dc.date.available","2018-11-07T08:41:54Z"],["dc.date.issued","2010"],["dc.description.abstract","Inflammatory plaques at injection sites are frequent side effects of heparin treatment and a clinical symptom of delayed-type hypersensitivity (DTH) to heparin. In most cases, changing the subcutaneous therapy from unfractionated to low-molecular-weight heparin or treatment with heparinoids does not provide improvement because of extensive cross-reactivity. Because of their completely different chemical structure, hirudins are a safe alternative for anticoagulation. Despite DTH to subcutaneously injected heparins, patients tolerate heparin intravenously. Therefore, in case of therapeutic necessity and DTH to heparins, the simple shift from subcutaneous to intravenous heparin administration is justified. Skin necrosis is a rare complication of anticoagulation. Heparin-induced skin necrosis is 1 of the symptoms of immune-mediated heparin-induced thrombocytopenia and should result in the immediate cessation of heparin therapy to prevent potentially fatal thrombotic events. This is in contrast to coumarin-induced skin necrosis, where therapy may be continued or restarted at a lower dose."],["dc.identifier.doi","10.1016/j.mcna.2010.03.003"],["dc.identifier.isi","000279959000012"],["dc.identifier.pmid","20609865"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19572"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","0025-7125"],["dc.title","The Complex Clinical Picture of Side Effects to Anticoagulation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","721"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of the American Academy of Dermatology"],["dc.bibliographiccitation.lastpage","728"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Seitz, Cornelia S."],["dc.contributor.author","Rose, Christian"],["dc.contributor.author","Kerstan, Andreas"],["dc.contributor.author","Trautmann, Axel"],["dc.date.accessioned","2018-11-07T09:18:19Z"],["dc.date.available","2018-11-07T09:18:19Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Skin biopsies are commonly performed to confirm drug-induced exanthem (DIE). However, the relevance of histologic examination in discriminating between DIE and non-DIE (NDIE) is controversial. Objective: A retrospective analysis was performed to evaluate the reliability of histologic diagnosis of DIE. Methods: In all, 91 patients with a skin biopsy specimen of an acute exanthem temporally related to a single identifiable drug underwent complete allergy testing. Their biopsy specimens were retrospectively re-evaluated by 2 dermatopathologists blinded to the original reports to test for discrimination between DIE versus NDIE. Results: In 35 patients, non-IgE-mediated drug allergy was confirmed by allergy testing, whereas in 56 patients drug hypersensitivity could be excluded. Sensitivity of pathology reports for diagnosis of DIE reached 62.9% with a positive predictive value of 40.7%. Specificity was 41.1% with a negative predictive value of 69.7%. No significant difference in tissue eosinophilia was detected between DIE and NDIE. Limitations: This was a retrospective study. Conclusions: Dermatopathologic evaluation of skin biopsy specimens is of limited use in differentiating between DIE and NDIE. All efforts should be made to subject these patients to thorough allergy testing for definitely confirming or ruling out drug hypersensitivity."],["dc.identifier.doi","10.1016/j.jaad.2013.06.022"],["dc.identifier.isi","000325752500040"],["dc.identifier.pmid","23932649"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28383"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby-elsevier"],["dc.relation.issn","0190-9622"],["dc.title","Drug-induced exanthems: Correlation of allergy testing with histologic diagnosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","168"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","169"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Seitz, Cornelia S."],["dc.contributor.author","Trautmann, Axel"],["dc.date.accessioned","2021-06-01T10:47:20Z"],["dc.date.available","2021-06-01T10:47:20Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1111/j.1600-0536.2010.01758.x"],["dc.identifier.isi","000280652000008"],["dc.identifier.pmid","20690941"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85562"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0105-1873"],["dc.title","Differential diagnosis of mechanic's hands: think of Jo-1 syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]