Seitz, Cornelia Sabine

[["dc.bibliographiccitation.artnumber","19"],["dc.bibliographiccitation.journal","Allergy Asthma and Clinical Immunology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Seitz, Cornelia S."],["dc.contributor.author","Brockow, Knut"],["dc.contributor.author","Hain, Johannes"],["dc.contributor.author","Trautmann, Axel"],["dc.date.accessioned","2018-11-07T09:41:10Z"],["dc.date.available","2018-11-07T09:41:10Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: It is hypothesized that because of higher mast cell numbers and mediator release, mastocytosis predisposes patients for systemic immediate-type hypersensitivity reactions to certain drugs including non-steroidal anti-inflammatory drugs (NSAID). Objective: To clarify whether patients with NSAID hypersensitivity show increased basal serum tryptase levels as sign for underlying mast cell disease. Methods: As part of our allergy work-up, basal serum tryptase levels were determined in all patients with a diagnosis of NSAID hypersensitivity and the severity of the reaction was graded. Patients with confirmed IgE-mediated hymenoptera venom allergy served as a comparison group. Results: Out of 284 patients with NSAID hypersensitivity, 26 were identified with basal serum tryptase > 10.0 ng/mL (9.2%). In contrast, significantly (P = .004) more hymenoptera venom allergic patients had elevated tryptase > 10.0 ng/mL (83 out of 484; 17.1%). Basal tryptase > 20.0 ng/mL was indicative for severe anaphylaxis only in venom allergic subjects (29 patients; 4x grade 2 and 25x grade 3 anaphylaxis), but not in NSAID hypersensitive patients (6 patients; 4x grade 1, 2x grade 2). Conclusions: In contrast to hymenoptera venom allergy, NSAID hypersensitivity do not seem to be associated with elevated basal serum tryptase levels and levels > 20 ng/mL were not related to increased severity of the clinical reaction. This suggests that mastocytosis patients may be treated with NSAID without special precautions."],["dc.description.sponsorship","German Research Foundation (DFG); University of Wurzburg"],["dc.identifier.doi","10.1186/1710-1492-10-19"],["dc.identifier.isi","000335525300001"],["dc.identifier.pmid","24782901"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10105"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33670"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1710-1492"],["dc.relation.issn","1710-1484"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Non-steroidal anti-inflammatory drug hypersensitivity: association with elevated basal serum tryptase?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","268"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Dermatology"],["dc.bibliographiccitation.lastpage","273"],["dc.bibliographiccitation.volume","220"],["dc.contributor.author","Seitz, Cornelia S."],["dc.contributor.author","Berens, Nikolaus"],["dc.contributor.author","Broecker, Eva-B."],["dc.contributor.author","Trautmann, Axel"],["dc.date.accessioned","2018-11-07T08:47:31Z"],["dc.date.available","2018-11-07T08:47:31Z"],["dc.date.issued","2010"],["dc.description.abstract","Background: Rheumatoid arthritis (RA) is a systemic inflammatory disease which may present with extra-articular symptoms, including cutaneous manifestations. Ulcerated rheumatoid nodules, necrotic vasculitic lesions and pyoderma gangrenosum are fairly characteristic and well-recognized causes of skin ulcers in RA. However, most RA patients develop leg ulcers due to other pathophysiological factors posing a diagnostic and therapeutic challenge and leading to considerable morbidity. Methods: A retrospective chart analysis of all patients with RA and leg ulcers hospitalized at our Dermatology Department between January 1998 and March 2008 was performed to evaluate risk factors and identify underlying conditions that predispose RA patients to the development of leg ulcers. Results: A total of 36 patients with RA and leg ulcers were identified. Three patients presented with necrotizing vasculitis and 2 with pyoderma gangrenosum. Chronic venous insufficiency was diagnosed as the underlying cause of leg ulcers in 8 patients, peripheral arterial disease in 4 patients, and combined arterial and venous malfunction in 3 patients. Five patients suffered from pressure ulcers. Interestingly, in 11 patients (31%) other underlying causes besides constricted mobility followed by secondary lymphedema could not be identified, and these ulcers were classified as 'inactivity leg ulcers'. Conclusions: The majority of leg ulcers in patients with RA are due to underlying venous/arterial malfunction while vasculitic or traumatic ulcers are less common. Additionally, we identified a relevant subgroup of patients with 'inactivity ulcers' due to impaired mobility and consecutive lymphedema. Morphology and localization of ulcerations as well as duplex sonography provide the most important clues for accurate diagnosis, ensuring adequate treatment. Copyright (C) 2010 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000284583"],["dc.identifier.isi","000277043800016"],["dc.identifier.pmid","20332595"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9104"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20977"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1018-8665"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Leg Ulceration in Rheumatoid Arthritis - An Underreported Multicausal Complication with Considerable Morbidity: Analysis of Thirty-Six Patients and Review of the Literature"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]