Nolte-Kaitschick, Jessica

[["dc.bibliographiccitation.firstpage","1199"],["dc.bibliographiccitation.issue","7088"],["dc.bibliographiccitation.journal","Nature"],["dc.bibliographiccitation.lastpage","1203"],["dc.bibliographiccitation.volume","440"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Nayernia, Karim"],["dc.contributor.author","Maier, Lars S."],["dc.contributor.author","Wagner, Stefan"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Lee, Jae Ho"],["dc.contributor.author","Nolte, Jessica"],["dc.contributor.author","Wolf, F"],["dc.contributor.author","Li, M. Y."],["dc.contributor.author","Engel, Wolfgang"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2017-09-07T11:53:07Z"],["dc.date.available","2017-09-07T11:53:07Z"],["dc.date.issued","2006"],["dc.description.abstract","Embryonic germ cells as well as germline stem cells from neonatal mouse testis are pluripotent and have differentiation potential similar to embryonic stem cells(1,2), suggesting that the germline lineage may retain the ability to generate pluripotent cells. However, until now there has been no evidence for the pluripotency and plasticity of adult spermatogonial stem cells (SSCs), which are responsible for maintaining spermatogenesis throughout life in the male(3). Here we show the isolation of SSCs from adult mouse testis using genetic selection, with a success rate of 27%. These isolated SSCs respond to culture conditions and acquire embryonic stem cell properties. We name these cells multipotent adult germline stem cells (maGSCs). They are able to spontaneously differentiate into derivatives of the three embryonic germ layers in vitro and generate teratomas in immunodeficient mice. When injected into an early blastocyst, SSCs contribute to the development of various organs and show germline transmission. Thus, the capacity to form multipotent cells persists in adult mouse testis. Establishment of human maGSCs from testicular biopsies may allow individual cell-based therapy without the ethical and immunological problems associated with human embryonic stem cells. Furthermore, these cells may provide new opportunities to study genetic diseases in various cell lineages."],["dc.identifier.doi","10.1038/nature04697"],["dc.identifier.gro","3143702"],["dc.identifier.isi","000237080000047"],["dc.identifier.pmid","16565704"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1245"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0028-0836"],["dc.title","Pluripotency of spermatogonial stem cells from adult mouse testis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","125"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Developmental Cell"],["dc.bibliographiccitation.lastpage","132"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Nayernia, Karim"],["dc.contributor.author","Nolte, Jessica"],["dc.contributor.author","Michelmann, Hans Wilhelm"],["dc.contributor.author","Lee, Jae Ho"],["dc.contributor.author","Rathsack, Kristina"],["dc.contributor.author","Drusenheimer, Nadja"],["dc.contributor.author","Dev, Arvind"],["dc.contributor.author","Wulf, Gerald"],["dc.contributor.author","Ehrmann, Ingrid E."],["dc.contributor.author","Elliott, David J."],["dc.contributor.author","Okpanyi, Vera"],["dc.contributor.author","Zechner, Ulrich"],["dc.contributor.author","Haaf, Thomas"],["dc.contributor.author","Meinhardt, Andreas"],["dc.contributor.author","Engel, Wolfgang"],["dc.date.accessioned","2018-11-07T09:35:07Z"],["dc.date.available","2018-11-07T09:35:07Z"],["dc.date.issued","2006"],["dc.description.abstract","Male gametes originate from a small population of spermatogonial stem cells (SSCs). These cells are believed to divide infinitely and to support spermatogenesis throughout life in the male. Here, we developed a strategy for the establishment of SSC lines from embryonic stem (ES) cells. These cells are able to undergo meiosis, are able to generate haploid male gametes in vitro, and are functional, as shown by fertilization after intracytoplasmic injection into mouse oocytes. Resulting two-cell embryos were transferred into oviducts, and live mice were born. Six of seven animals developed to adult mice. This is a clear indication that male gametes derived in vitro from ES cells by this strategy are able to induce normal fertilization and development. Our approach provides an accessible in vitro model system for studies of mammalian gametogenesis, as well as for the development of new strategies for the generation of transgenic mice and treatment of infertility."],["dc.identifier.doi","10.1016/j.devcel.2006.05.010"],["dc.identifier.isi","000239128300015"],["dc.identifier.pmid","16824959"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32324"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","1534-5807"],["dc.title","In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","184"],["dc.bibliographiccitation.issue","4-5"],["dc.bibliographiccitation.journal","Differentiation"],["dc.bibliographiccitation.lastpage","194"],["dc.bibliographiccitation.volume","80"],["dc.contributor.author","Nolte, Jessica"],["dc.contributor.author","Michelmann, Hans Wilhelm"],["dc.contributor.author","Wolf, Marieke"],["dc.contributor.author","Wulf, Gerald"],["dc.contributor.author","Nayernia, Karim"],["dc.contributor.author","Meinhardt, Andreas"],["dc.contributor.author","Zechner, Ulrich"],["dc.contributor.author","Engel, Wolfgang"],["dc.date.accessioned","2018-11-07T08:37:27Z"],["dc.date.available","2018-11-07T08:37:27Z"],["dc.date.issued","2010"],["dc.description.abstract","Spermatogonial stem cells (SSCs) provide the basis for spermatogenesis throughout adult life by undergoing self-renewal and differentiation into sperm. SSC-derived cell lines called multipotent adult germline stem cells (maGSCs) were recently shown to be pluripotent and to have the same potential as embryonic stem cells (ESCs). In a differentiation protocol using retinoic acid(RA) and based on a double selection strategy, we have shown that ESCs are able to undergo meiosis and produce haploid male germ cells in vitro. Using this differentiation protocol we have now succeeded to generate haploid male germ cells from maGSCs in vitro. maGSCs derived from a Stra8-EGFP transgenic mouse line were differentiated into stable spermatogonial stages and further cultured. These cells were transfected with a post meiotic specific promoter construct Prm1-DsRed to monitor retinoic acid(RA) induced differentiation into haploid male gametes. Our protocol is another approach for the production of pluripotent stem cell derived gametes (PSCDGs) and is an alternative for the investigation of mammalian spermatogenesis, germ line gene modification and epigenetic reprogramming. If reproducible with pluripotent cell lines derived from human SSCs, it could also be used as a therapeutic approach for the treatment of male infertility. (C) 2010 International Society of Differentiation. Published by Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SPP 1356, FOR 1041]"],["dc.identifier.doi","10.1016/j.diff.2010.08.001"],["dc.identifier.isi","000283655200002"],["dc.identifier.pmid","20810205"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18533"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","0301-4681"],["dc.title","PSCDGs of mouse multipotent adult germline stem cells can enter and progress through meiosis to form haploid male germ cells in vitro"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","521"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Molecular Human Reproduction"],["dc.bibliographiccitation.lastpage","529"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Zovoilis, Athanasios"],["dc.contributor.author","Nolte, Jessica"],["dc.contributor.author","Drusenheimer, Nadja"],["dc.contributor.author","Zechner, Ulrich"],["dc.contributor.author","Hada, Hiroki"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Nayernia, Karim"],["dc.contributor.author","Engel, Wolfgang"],["dc.date.accessioned","2017-09-07T11:48:13Z"],["dc.date.available","2017-09-07T11:48:13Z"],["dc.date.issued","2008"],["dc.description.abstract","Spermatogonial stem cells (SSCs) isolated from the adult mouse testis and cultured have been shown to respond to culture conditions and become pluripotent, so called multipotent adult germline stem cells (maGSCs). microRNAs (miRNAs) belonging to the 290 and 302 miRNA clusters have been previously classified as embryonic stem cell (ESC) specific. Here, we show that these miRNAs generally characterize pluripotent cells. They are expressed not only in ESCs but also in maGSCs as well as in the F9 embryonic carcinoma cell (ECC) line. In addition, we tested the time-dependent influence of different factors that promote loss of pluripotency on levels of these miRNAs in all three pluripotent cell types. Despite the differences regarding time and extent of differentiation observed between ESCs and maGSCs, expression profiles of both miRNA families showed similarities between these two cell types, suggesting similar underlying mechanisms in maintenance of pluripotency and differentiation. Our results indicate that the 290-miRNA family is connected with Oct-4 and maintenance of the pluripotent state. In contrast, members of the 302-miRNA family are induced during first stages of in vitro differentiation in all cell types tested. Therefore, detection of miRNAs of miR-302 family in pluripotent cells can be attributed to the proportion of spontaneously differentiating cells in cultures of pluripotent cells. These results are consistent with ESC-like nature of maGSCs and their potential as an alternative source of pluripotent cells from non-embryonic tissues."],["dc.identifier.doi","10.1093/molehr/gan044"],["dc.identifier.gro","3143248"],["dc.identifier.isi","000259585200003"],["dc.identifier.pmid","18697907"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/741"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: German Research Foundation [SPP 1356, EN 84/22-1, ZE 442/4-1]"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1360-9947"],["dc.title","Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","26"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.lastpage","29"],["dc.bibliographiccitation.volume","213"],["dc.contributor.author","Mardanpour, Parisa"],["dc.contributor.author","Guan, Kaomei"],["dc.contributor.author","Nolte, Jessica"],["dc.contributor.author","Lee, Jae Ho"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Engel, Wolfgang"],["dc.contributor.author","Nayernia, Karim"],["dc.date.accessioned","2017-09-07T11:48:16Z"],["dc.date.available","2017-09-07T11:48:16Z"],["dc.date.issued","2008"],["dc.description.abstract","Germline stem cells, which can self-renew and generate gametes, are unique stem cells in that they are solely dedicated to transmit genetic information from generation to generation. The germ cells have a special place in the life cycle because they must be able to retain the ability to recreate the organism, a property known as developmental totipotency. Several lines of evidence have suggested the extensive proliferation activity and pluripotency of prenatal, neonatal and adult germline stem cells. We showed that adult male germline stem cells, spermatogonial stem cells, can be converted into embryonic stem cell-like cells, which can differentiate into the somatic stem cells of three germ layers. Different cell types such as vascular, heart, liver, pancreatic and blood cells could also be obtained from these stem cells. Understanding how spermatogonial stem cells can give rise to pluripotent stem cells and how somatic stem cells differentiate into germ cells could give significant insight into the regulation of developmental totipotency as well as having important implications for male fertility and regenerative medicine."],["dc.identifier.doi","10.1111/j.1469-7580.2008.00930.x"],["dc.identifier.gro","3143270"],["dc.identifier.isi","000257707900003"],["dc.identifier.pmid","18565110"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/765"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.conference","International Conference on Advances in Stem Cell Biology"],["dc.relation.eventlocation","Durham Univ, Durham, ENGLAND"],["dc.relation.ispartof","Journal of Anatomy"],["dc.relation.issn","0021-8782"],["dc.title","Potency of germ cells and its relevance for regenerative medicine"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","41"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Nayernia, Karim"],["dc.contributor.author","Lee, Jae Ho"],["dc.contributor.author","Engel, Wolfgang"],["dc.contributor.author","Nolte, Jessica"],["dc.contributor.author","Drusenheimer, Nadja"],["dc.contributor.author","Rathsack, Kristina"],["dc.contributor.author","Dev, Arvind"],["dc.contributor.author","Wulf, Gerald"],["dc.contributor.author","Ehrmann, Ingrid E."],["dc.contributor.author","Elliott, David J."],["dc.contributor.author","Zechner, Ulrich"],["dc.contributor.author","Haaf, Thomas"],["dc.contributor.author","Meinhardt, Andreas"],["dc.contributor.author","Michelmann, Hans Wilhelm"],["dc.contributor.author","Hasenfuss, Gerlad"],["dc.contributor.author","Guan, Kaomei"],["dc.date.accessioned","2018-11-07T11:04:31Z"],["dc.date.available","2018-11-07T11:04:31Z"],["dc.date.issued","2007"],["dc.description.abstract","Germline and somatic stem cells are distinct types of stem cells that are dedicated to reproduction and somatic tissue regeneration, respectively. Germline stem cells (GSCs), which can self-renew and generate gametes, are unique stem cells in that they are solely dedicated to transmit genetic information from generation to generation. We developed a strategy for the establishment of germline stem cell lines from embryonic stem cells (ES). These cells are able to undergo meiosis, generate haploid male gametes in vitro and are functional, as shown by fertilization after intra-cytoplasmic injection into mouse oocytes. In other approach, we show that bone marrow stem (BMS) cells are able to trans-differentiate into male germ cells. BMS cell-derived germ cells expressed the known molecular markers of primordial germ cells. The ability to derive male germ cells from ES and BMS cells reveals novel aspects of germ cell development and opens the possibilities for use of these cells in reproductive medicine. Conversely, we showed that adult male germline stem cells, spermatogonial stem cells (SSCs), can be converted into embryonic stem cell like cells which can differentiate into the somatic stem cells of three germ layers. Understanding how SSC can give rise to pluripotent stem cells and how somatic stem cells differentiate into germ cells could give significant insights into the regulation of developmental totipotency as well as having important implications for male fertility and regenerative medicine."],["dc.identifier.isi","000254385400001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51863"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1680-6433"],["dc.title","From stem cells to germ cells and from germ cells to stem cells"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","654"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Laboratory Investigation"],["dc.bibliographiccitation.lastpage","663"],["dc.bibliographiccitation.volume","86"],["dc.contributor.author","Nayernia, Karim"],["dc.contributor.author","Lee, Jae Ho"],["dc.contributor.author","Drusenheimer, Nadja"],["dc.contributor.author","Nolte, Jessica"],["dc.contributor.author","Wulf, Gerald"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Gromoll, Joerg"],["dc.contributor.author","Engel, Wolfgang"],["dc.date.accessioned","2018-11-07T09:37:44Z"],["dc.date.available","2018-11-07T09:37:44Z"],["dc.date.issued","2006"],["dc.description.abstract","Recent studies have demonstrated that somatic stem cells have a more flexible potential than expected, whether put into tissue or cultured under different conditions. Bone marrow (BM)-derived stem cells can transdifferentiate into multilineage cells, such as muscle of mesoderm, lung and liver of endoderm, and brain and skin of ectoderm origin. Here we show that BM stem cells are able to transdifferentiate into male germ cells. For derivation of male germ cells from adult BM stem (BMS) cells, we used the Stra8-enhanced green fluoresence protein (EGFP) transgenic mouse line expressing EGFP specifically in male germ cells. BMS cell-derived germ cells expressed the known molecular markers of primordial germ cells, such as fragilis, stella, Rnf17, Mvh and Oct4; as well as molecular markers of spermatogonial stem cells and spermatogonia including Rbm, c-Kit, Tex18, Stra8, Piwil2, Dazl, Hsp90 alpha, beta 1- and alpha 6-integrins. Our ability to derive male germ cells from BMS cells reveals novel aspects of germ cell development and opens the possibilities for use of these cells in reproductive medicine."],["dc.identifier.doi","10.1038/labinvest.3700429"],["dc.identifier.isi","000238312000004"],["dc.identifier.pmid","16652109"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32902"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0023-6837"],["dc.title","Derivation of male germ cells from bone marrow stem cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]