Barth, Jonas

[["dc.bibliographiccitation.firstpage","4511"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","The EMBO Journal"],["dc.bibliographiccitation.lastpage","4523"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Kucherenko, Mariya M."],["dc.contributor.author","Barth, Jonas"],["dc.contributor.author","Fiala, Andre"],["dc.contributor.author","Shcherbata, Halyna R."],["dc.date.accessioned","2018-11-07T09:02:20Z"],["dc.date.available","2018-11-07T09:02:20Z"],["dc.date.issued","2012"],["dc.description.abstract","Mammalian neuronal stem cells produce multiple neuron types in the course of an individual's development. Similarly, neuronal progenitors in the Drosophila brain generate different types of closely related neurons that are born at specific time points during development. We found that in the post-embryonic Drosophila brain, steroid hormones act as temporal cues that specify the cell fate of mushroom body (MB) neuroblast progeny. Chronological regulation of neurogenesis is subsequently mediated by the microRNA (miRNA) let-7, absence of which causes learning impairment due to morphological MB defects. The miRNA let-7 is required to regulate the timing of alpha'/beta' to alpha/beta neuronal identity transition by targeting the transcription factor Abrupt. At a cellular level, the ecdysone-let-7-Ab signalling pathway controls the expression levels of the cell adhesion molecule Fasciclin II in developing neurons that ultimately influences their differentiation. Our data propose a novel role for miRNAs as transducers between chronologically regulated developmental signalling and physical cell adhesion. The EMBO Journal (2012) 31, 4511-4523. doi:10.1038/emboj.2012.298; Published online 16 November 2012"],["dc.description.sponsorship","Max Planck Society; German Research Council [SPP 1392 (FI 821/2-1)]"],["dc.identifier.doi","10.1038/emboj.2012.298"],["dc.identifier.isi","000312446700005"],["dc.identifier.pmid","23160410"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24658"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0261-4189"],["dc.title","Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1819"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","1837"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Barth, Jonas"],["dc.contributor.author","Dipt, Shubham"],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Hermann, Moritz"],["dc.contributor.author","Riemensperger, Thomas"],["dc.contributor.author","Fiala, Andre"],["dc.date.accessioned","2018-11-07T09:44:54Z"],["dc.date.available","2018-11-07T09:44:54Z"],["dc.date.issued","2014"],["dc.description.abstract","Training can improve the ability to discriminate between similar, confusable stimuli, including odors. One possibility of enhancing behaviorally expressed discrimination (i.e., sensory acuity) relies on differential associative learning, during which animals are forced to detect the differences between similar stimuli. Drosophila represents a key model organism for analyzing neuronal mechanisms underlying both odor processing and olfactory learning. However, the ability of flies to enhance fine discrimination between similar odors through differential associative learning has not been analyzed in detail. We performed associative conditioning experiments using chemically similar odorants that we show to evoke overlapping neuronal activity in the fly's antennal lobes and highly correlated activity in mushroom body lobes. We compared the animals' performance in discriminating between these odors after subjecting them to one of two types of training: either absolute conditioning, in which only one odor is reinforced, or differential conditioning, in which one odor is reinforced and a second odor is explicitly not reinforced. First, we show that differential conditioning decreases behavioral generalization of similar odorants in a choice situation. Second, we demonstrate that this learned enhancement in olfactory acuity relies on both conditioned excitation and conditioned inhibition. Third, inhibitory local interneurons in the antennal lobes are shown to be required for behavioral fine discrimination between the two similar odors. Fourth, differential, but not absolute, training causes decorrelation of odor representations in the mushroom body. In conclusion, differential training with similar odors ultimately induces a behaviorally expressed contrast enhancement between the two similar stimuli that facilitates fine discrimination."],["dc.identifier.doi","10.1523/JNEUROSCI.2598-13.2014"],["dc.identifier.isi","000331455000024"],["dc.identifier.pmid","24478363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34499"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Neuroscience"],["dc.relation.issn","0270-6474"],["dc.title","Differential Associative Training Enhances Olfactory Acuity in Drosophila melanogaster"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","147"],["dc.bibliographiccitation.journal","Frontiers in Neural Circuits"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Dipt, Shubham"],["dc.contributor.author","Barth, Jonas"],["dc.contributor.author","Singh, Priyanka"],["dc.contributor.author","Jauch, Mandy"],["dc.contributor.author","Thum, Andreas S."],["dc.contributor.author","Fiala, Andre"],["dc.contributor.author","Riemensperger, Thomas"],["dc.date.accessioned","2018-11-07T09:19:49Z"],["dc.date.available","2018-11-07T09:19:49Z"],["dc.date.issued","2013"],["dc.description.abstract","The fruit fly Drosophila melanogaster represents a key model organism for analyzing how neuronal circuits regulate behavior. The mushroom body in the central brain is a particularly prominent brain region that has been intensely studied in several insect species and been implicated in a variety of behaviors, e.g., associative learning, locomotor activity, and sleep. Drosophila melanogaster offers the advantage that transgenes can be easily expressed in neuronal subpopulations, e.g., in intrinsic mushroom body neurons (Kenyon cells). A number of transgenes has been described and engineered to visualize the anatomy of neurons, to monitor physiological parameters of neuronal activity, and to manipulate neuronal function artificially. To target the expression of these transgenes selectively to specific neurons several sophisticated bi- or even multipartite transcription systems have been invented. However, the number of transgenes that can be combined in the genome of an individual fly is limited in practice. To facilitate the analysis of the mushroom body we provide a compilation of transgenic fruit flies that express transgenes under direct control of the Kenyon-cell specific promoter, mb247. The transgenes expressed are fluorescence reporters to analyze neuroanatomical aspects of the mushroom body, proteins to restrict ectopic gene expression to mushroom bodies, or fluorescent sensors to monitor physiological parameters of neuronal activity of Kenyon cells. Some of the transgenic animals compiled here have been published already, whereas others are novel and characterized here for the first time. Overall, the collection of transgenic flies expressing sensor and reporter genes in Kenyon cells facilitates combinations with binary transcription systems and might, ultimately, advance the physiological analysis of mushroom body function."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2013"],["dc.identifier.doi","10.3389/fncir.2013.00147"],["dc.identifier.isi","000324807300001"],["dc.identifier.pmid","24065891"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9305"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28729"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Research Foundation"],["dc.relation.issn","1662-5110"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Mushroom body miscellanea: transgenic Drosophila strains expressing anatomical and physiological sensor proteins in Kenyon cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","464"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Cell Reports"],["dc.bibliographiccitation.lastpage","478"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Martelli, Carlotta"],["dc.contributor.author","Pech, Ulrike"],["dc.contributor.author","Kobbenbring, Simon"],["dc.contributor.author","Pauls, Dennis"],["dc.contributor.author","Bahl, Britta"],["dc.contributor.author","Sommer, Mirjam Vanessa"],["dc.contributor.author","Pooryasin, Atefeh"],["dc.contributor.author","Barth, Jonas"],["dc.contributor.author","Arias, Carmina Warth Perez"],["dc.contributor.author","Vassiliou, Chrystalleni"],["dc.contributor.author","Luna, Abud Jose Farca"],["dc.contributor.author","Poppinga, Haiko"],["dc.contributor.author","Richter, Florian Gerhard"],["dc.contributor.author","Wegener, Christian"],["dc.contributor.author","Fiala, André"],["dc.contributor.author","Riemensperger, Thomas"],["dc.date.accessioned","2020-12-10T14:23:00Z"],["dc.date.available","2020-12-10T14:23:00Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.celrep.2017.06.043"],["dc.identifier.issn","2211-1247"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71799"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","SIFamide Translates Hunger Signals into Appetitive and Feeding Behavior in Drosophila"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neurogenetics"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Barth, J."],["dc.contributor.author","Hermann, M."],["dc.contributor.author","Fiala, Andre"],["dc.date.accessioned","2018-11-07T09:02:27Z"],["dc.date.available","2018-11-07T09:02:27Z"],["dc.date.issued","2012"],["dc.identifier.isi","000314975100091"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24683"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.publisher.place","London"],["dc.title","Differential conditioning of similar odors enhances olfactory acuity in Drosophila"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]