Burckhardt, Birgitta-Christina

[["dc.bibliographiccitation.firstpage","286"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Arhiv za Higijenu Rada i Toksikologiju"],["dc.bibliographiccitation.lastpage","303"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Karaica, Dean"],["dc.contributor.author","Breljak, Davorka"],["dc.contributor.author","Lončar, Jovica"],["dc.contributor.author","Lovrić, Mila"],["dc.contributor.author","Micek, Vedran"],["dc.contributor.author","Vrhovac Madunić, Ivana"],["dc.contributor.author","Brzica, Hrvoje"],["dc.contributor.author","Herak-Kramberger, Carol M."],["dc.contributor.author","Dupor, Jana Ivković"],["dc.contributor.author","Ljubojević, Marija"],["dc.contributor.author","Smital, Tvrtko"],["dc.contributor.author","Vogrinc, Željka"],["dc.contributor.author","Burckhardt, Gerhard"],["dc.contributor.author","Burckhardt, Birgitta C."],["dc.contributor.author","Sabolić, Ivan"],["dc.date.accessioned","2020-12-10T18:43:50Z"],["dc.date.available","2020-12-10T18:43:50Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.2478/aiht-2018-69-3157"],["dc.identifier.eissn","0004-1254"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78239"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Sex-independent expression of chloride/formate exchanger Cfex (Slc26a6) in rat pancreas, small intestine, and liver, and male-dominant expression in kidneys"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","F227"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY"],["dc.bibliographiccitation.lastpage","F238"],["dc.bibliographiccitation.volume","311"],["dc.contributor.author","Breljak, Davorka"],["dc.contributor.author","Ljubojevic, Marija"],["dc.contributor.author","Hagos, Yohannes"],["dc.contributor.author","Micek, Vedran"],["dc.contributor.author","Eror, Daniela Balen"],["dc.contributor.author","Madunic, Ivana Vrhovac"],["dc.contributor.author","Brzica, Hrvoje"],["dc.contributor.author","Karaica, Dean"],["dc.contributor.author","Radovic, Nikola"],["dc.contributor.author","Kraus, Ognjen"],["dc.contributor.author","Anzai, Naohiko"],["dc.contributor.author","Koepsell, Hermann"],["dc.contributor.author","Burckhardt, Gerhard"],["dc.contributor.author","Burckhardt, Birgitta-Christina"],["dc.contributor.author","Sabolic, Ivan"],["dc.date.accessioned","2018-11-07T10:11:58Z"],["dc.date.available","2018-11-07T10:11:58Z"],["dc.date.issued","2016"],["dc.description.abstract","The initial step in renal secretion of organic anions (OAs) is mediated by transporters in the basolateral membrane (BLM). Contributors to this process are primary active Na+-K+-ATPase (EC 3.6.3.9), secondary active Na+-dicarboxylate cotransporter 3 (NaDC3/SLC13A3), and tertiary active OA transporters (OATs) OAT1/SLC22A6, OAT2/SLC22A7, and OAT3/SLC22A8. In human kidneys, we analyzed the localization of these transporters by immunochemical methods in tissue cryosections and isolated membranes. The specificity of antibodies was validated with human embryonic kidney-293 cells stably transfected with functional OATs. Na+-K+-ATPase was immunolocalized to the BLM along the entire human nephron. NaDC3-related immunostaining was detected in the BLM of proximal tubules and in the BLM and/or luminal membrane of principal cells in connecting segments and collecting ducts. The thin and thick ascending limbs, macula densa, and distal tubules exhibited no reactivity with the anti-NaDC3 antibody. OAT1-OAT3-related immunostaining in human kidneys was detected only in the BLM of cortical proximal tubules; all three OATs were stained more intensely in S1/S2 segments compared with S3 segment in medullary rays, whereas the S3 segment in the outer stripe remained unstained. Expression of NaDC3, OAT1, OAT2, and OAT3 proteins exhibited considerable interindividual variability in both male and female kidneys, and sex differences in their expression could not be detected. Our experiments provide a side-by-side comparison of basolateral transporters cooperating in renal OA secretion in the human kidney."],["dc.identifier.doi","10.1152/ajprenal.00113.2016"],["dc.identifier.isi","000380826900029"],["dc.identifier.pmid","27053689"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40147"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physiological Soc"],["dc.relation.issn","1522-1466"],["dc.relation.issn","1931-857X"],["dc.title","Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","609"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY"],["dc.bibliographiccitation.lastpage","630"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Brzica, Hrvoje"],["dc.contributor.author","Breljak, Davorka"],["dc.contributor.author","Burckhardt, Birgitta-Christina"],["dc.contributor.author","Burckhardt, Gerhard"],["dc.contributor.author","Sabolic, Ivan"],["dc.date.accessioned","2018-11-07T09:16:48Z"],["dc.date.available","2018-11-07T09:16:48Z"],["dc.date.issued","2013"],["dc.description.abstract","Oxalate urolithiasis (nephrolithiasis) is the most frequent type of kidney stone disease. Epidemiological research has shown that urolithiasis is approximately twice as common in men as in women, but the underlying mechanism of this sex-related prevalence is unclear. Oxalate in the organism partially originate from food (exogenous oxalate) and largely as a metabolic end-product from numerous precursors generated mainly in the liver (endogenous oxalate). Oxalate concentrations in plasma and urine can be modified by various foodstuffs, which can interact in positively or negatively by affecting oxalate absorption, excretion, and/or its metabolic pathways. Oxalate is mostly removed from blood by kidneys and partially via bile and intestinal excretion. In the kidneys, after reaching certain conditions, such as high tubular concentration and damaged integrity of the tubule epithelium, oxalate can precipitate and initiate the formation of stones. Recent studies have indicated the importance of the SoLute Carrier 26 (SLC26) family of membrane transporters for handling oxalate. Two members of this family [Sulfate Anion Transporter 1 (SAT-1; SLC26A1) and Chloride/Formate EXchanger (CFEX; SLC26A6)] may contribute to oxalate transport in the intestine, liver, and kidneys. Malfunction or absence of SAT-1 or CFEX has been associated with hyperoxaluria and urolithiasis. However, numerous questions regarding their roles in oxalate transport in the respective organs and male-prevalent urolithiasis, as well as the role of sex hormones in the expression of these transporters at the level of mRNA and protein, still remain to be answered."],["dc.identifier.doi","10.2478/10004-1254-64-2013-2428"],["dc.identifier.isi","000330046300016"],["dc.identifier.pmid","24384768"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28015"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Inst Medical Research & Occupational Health"],["dc.relation.issn","1848-6312"],["dc.relation.issn","0004-1254"],["dc.title","OXALATE: FROM THE ENVIRONMENT TO KIDNEY STONES"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]