Burckhardt, Birgitta-Christina

[["dc.bibliographiccitation.firstpage","447"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Croatian medical journal"],["dc.bibliographiccitation.lastpage","459"],["dc.bibliographiccitation.volume","56"],["dc.contributor.author","Breljak, Davorka"],["dc.contributor.author","Brzica, Hrvoje"],["dc.contributor.author","Vrhovac, Ivana"],["dc.contributor.author","Micek, Vedran"],["dc.contributor.author","Karaica, Dean"],["dc.contributor.author","Ljubojević, Marija"],["dc.contributor.author","Sekovanić, Ankica"],["dc.contributor.author","Jurasović, Jasna"],["dc.contributor.author","Rašić, Dubravka"],["dc.contributor.author","Peraica, Maja"],["dc.contributor.author","Lovrić, Mila"],["dc.contributor.author","Schnedler, Nina"],["dc.contributor.author","Henjakovic, Maja"],["dc.contributor.author","Wegner, Waja"],["dc.contributor.author","Burckhardt, Gerhard"],["dc.contributor.author","Burckhardt, Birgitta C."],["dc.contributor.author","Sabolić, Ivan˝"],["dc.date.accessioned","2019-07-10T08:11:57Z"],["dc.date.available","2019-07-10T08:11:57Z"],["dc.date.issued","2015-10-31"],["dc.description.abstract","Aim To investigate whether the sex-dependent expression of hepatic and renal oxalate transporter sat-1 (Slc26a1) changes in a rat model of ethylene glycol (EG)-induced hyperoxaluria. METHODS: Rats were given tap water (12 males and 12 females; controls) or EG (12 males and 12 females; 0.75% v/v in tap water) for one month. Oxaluric state was confirmed by biochemical parameters in blood plasma, urine, and tissues. Expression of sat-1 and rate-limiting enzymes of oxalate synthesis, alcohol dehydrogenase 1 (Adh1) and hydroxy-acid oxidase 1 (Hao1), was determined by immunocytochemistry (protein) and/or real time reverse transcription polymerase chain reaction (mRNA). RESULTS: EG-treated males had significantly higher (in μmol/L; mean±standard deviation) plasma (59.7±27.2 vs 12.9±4.1, P<0.001) and urine (3716±1726 vs 241±204, P<0.001) oxalate levels, and more abundant oxalate crystaluria than controls, while the liver and kidney sat-1 protein and mRNA expression did not differ significantly between these groups. EG-treated females, in comparison with controls had significantly higher (in μmol/L) serum oxalate levels (18.8±2.9 vs 11.6±4.9, P<0.001), unchanged urine oxalate levels, low oxalate crystaluria, and significantly higher expression (in relative fluorescence units) of the liver (1.59±0.61 vs 0.56±0.39, P=0.006) and kidney (1.77±0.42 vs 0.69±0.27, P<0.001) sat-1 protein, but not mRNA. The mRNA expression of Adh1 was female-dominant and that of Hao1 male-dominant, but both were unaffected by EG treatment. CONCLUSIONS: An increased expression of hepatic and renal oxalate transporting protein sat-1 in EG-treated female rats could protect from hyperoxaluria and oxalate urolithiasis."],["dc.identifier.pmid","26526882"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12681"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60827"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1332-8166"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.title","In female rats, ethylene glycol treatment elevates protein expression of hepatic and renal oxalate transporter sat-1 (Slc26a1) without inducing hyperoxaluria."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","286"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Arhiv za Higijenu Rada i Toksikologiju"],["dc.bibliographiccitation.lastpage","303"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Karaica, Dean"],["dc.contributor.author","Breljak, Davorka"],["dc.contributor.author","Lončar, Jovica"],["dc.contributor.author","Lovrić, Mila"],["dc.contributor.author","Micek, Vedran"],["dc.contributor.author","Vrhovac Madunić, Ivana"],["dc.contributor.author","Brzica, Hrvoje"],["dc.contributor.author","Herak-Kramberger, Carol M."],["dc.contributor.author","Dupor, Jana Ivković"],["dc.contributor.author","Ljubojević, Marija"],["dc.contributor.author","Smital, Tvrtko"],["dc.contributor.author","Vogrinc, Željka"],["dc.contributor.author","Burckhardt, Gerhard"],["dc.contributor.author","Burckhardt, Birgitta C."],["dc.contributor.author","Sabolić, Ivan"],["dc.date.accessioned","2020-12-10T18:43:50Z"],["dc.date.available","2020-12-10T18:43:50Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.2478/aiht-2018-69-3157"],["dc.identifier.eissn","0004-1254"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78239"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Sex-independent expression of chloride/formate exchanger Cfex (Slc26a6) in rat pancreas, small intestine, and liver, and male-dominant expression in kidneys"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","F227"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY"],["dc.bibliographiccitation.lastpage","F238"],["dc.bibliographiccitation.volume","311"],["dc.contributor.author","Breljak, Davorka"],["dc.contributor.author","Ljubojevic, Marija"],["dc.contributor.author","Hagos, Yohannes"],["dc.contributor.author","Micek, Vedran"],["dc.contributor.author","Eror, Daniela Balen"],["dc.contributor.author","Madunic, Ivana Vrhovac"],["dc.contributor.author","Brzica, Hrvoje"],["dc.contributor.author","Karaica, Dean"],["dc.contributor.author","Radovic, Nikola"],["dc.contributor.author","Kraus, Ognjen"],["dc.contributor.author","Anzai, Naohiko"],["dc.contributor.author","Koepsell, Hermann"],["dc.contributor.author","Burckhardt, Gerhard"],["dc.contributor.author","Burckhardt, Birgitta-Christina"],["dc.contributor.author","Sabolic, Ivan"],["dc.date.accessioned","2018-11-07T10:11:58Z"],["dc.date.available","2018-11-07T10:11:58Z"],["dc.date.issued","2016"],["dc.description.abstract","The initial step in renal secretion of organic anions (OAs) is mediated by transporters in the basolateral membrane (BLM). Contributors to this process are primary active Na+-K+-ATPase (EC 3.6.3.9), secondary active Na+-dicarboxylate cotransporter 3 (NaDC3/SLC13A3), and tertiary active OA transporters (OATs) OAT1/SLC22A6, OAT2/SLC22A7, and OAT3/SLC22A8. In human kidneys, we analyzed the localization of these transporters by immunochemical methods in tissue cryosections and isolated membranes. The specificity of antibodies was validated with human embryonic kidney-293 cells stably transfected with functional OATs. Na+-K+-ATPase was immunolocalized to the BLM along the entire human nephron. NaDC3-related immunostaining was detected in the BLM of proximal tubules and in the BLM and/or luminal membrane of principal cells in connecting segments and collecting ducts. The thin and thick ascending limbs, macula densa, and distal tubules exhibited no reactivity with the anti-NaDC3 antibody. OAT1-OAT3-related immunostaining in human kidneys was detected only in the BLM of cortical proximal tubules; all three OATs were stained more intensely in S1/S2 segments compared with S3 segment in medullary rays, whereas the S3 segment in the outer stripe remained unstained. Expression of NaDC3, OAT1, OAT2, and OAT3 proteins exhibited considerable interindividual variability in both male and female kidneys, and sex differences in their expression could not be detected. Our experiments provide a side-by-side comparison of basolateral transporters cooperating in renal OA secretion in the human kidney."],["dc.identifier.doi","10.1152/ajprenal.00113.2016"],["dc.identifier.isi","000380826900029"],["dc.identifier.pmid","27053689"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40147"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physiological Soc"],["dc.relation.issn","1522-1466"],["dc.relation.issn","1931-857X"],["dc.title","Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1381"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Pflügers Archiv - European Journal of Physiology"],["dc.bibliographiccitation.lastpage","1392"],["dc.bibliographiccitation.volume","457"],["dc.contributor.author","Brzica, Hrvoje"],["dc.contributor.author","Breljak, Davorka"],["dc.contributor.author","Krick, Wolfgang"],["dc.contributor.author","Lovric, Mila"],["dc.contributor.author","Burckhardt, Gerhard"],["dc.contributor.author","Burckhardt, Birgitta-Christina"],["dc.contributor.author","Sabolic, Ivan"],["dc.date.accessioned","2018-11-07T08:31:22Z"],["dc.date.available","2018-11-07T08:31:22Z"],["dc.date.issued","2009"],["dc.description.abstract","The sulfate anion transporter (sat-1, Slc26a1) has been cloned from rat liver, functionally characterized, and localized to the sinusoidal membrane in hepatocytes and basolateral membrane (BLM) in proximal tubules (PT). Here, we confirm previously described localization of sat-1 protein in rat liver and kidneys and report on gender differences (GD) in its expression by immunochemical, transport, and excretion studies in rats. The similar to 85-kDa sat-1 protein was localized to the sinusoidal membrane in hepatocytes and BLM in renal cortical PT, with the male-dominant expression. However, the real-time reverse-transcription polymerase chain reaction data indicated no GD at the level of sat-1 mRNA. In agreement with the protein data, isolated membranes from both organs exhibited the male-dominant exchange of radiolabeled sulfate for oxalate, whereas higher oxalate in plasma and 24-h urine indicated higher oxalate production and excretion in male rats. Furthermore, the expression of liver, but not renal, sat-1 protein was: unaffected by castration, upregulated by ovariectomy, and downregulated by estrogen or progesterone treatment in males. Therefore, GD (males > females) in the expression of sat-1 protein in rat liver (and, possibly, kidneys) are caused by the female sex-hormone-driven inhibition at the posttranscriptional level. The male-dominant abundance of sat-1 protein in liver may conform to elevated uptake of sulfate and extrusion of oxalate, causing higher plasma oxalate in males. Oxalate is then excreted by the kidneys via the basolateral sat-1 (males > females) and the apical CFEX (Slc26a6; GD unknown) in PT and eliminated in the urine (males > females), where it may contribute to the male-prevailing development of oxalate urolithiasis."],["dc.identifier.doi","10.1007/s00424-008-0611-5"],["dc.identifier.isi","000264184300015"],["dc.identifier.pmid","19002488"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3531"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17108"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0031-6768"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The liver and kidney expression of sulfate anion transporter sat-1 in rats exhibits male-dominant gender differences"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","609"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY"],["dc.bibliographiccitation.lastpage","630"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Brzica, Hrvoje"],["dc.contributor.author","Breljak, Davorka"],["dc.contributor.author","Burckhardt, Birgitta-Christina"],["dc.contributor.author","Burckhardt, Gerhard"],["dc.contributor.author","Sabolic, Ivan"],["dc.date.accessioned","2018-11-07T09:16:48Z"],["dc.date.available","2018-11-07T09:16:48Z"],["dc.date.issued","2013"],["dc.description.abstract","Oxalate urolithiasis (nephrolithiasis) is the most frequent type of kidney stone disease. Epidemiological research has shown that urolithiasis is approximately twice as common in men as in women, but the underlying mechanism of this sex-related prevalence is unclear. Oxalate in the organism partially originate from food (exogenous oxalate) and largely as a metabolic end-product from numerous precursors generated mainly in the liver (endogenous oxalate). Oxalate concentrations in plasma and urine can be modified by various foodstuffs, which can interact in positively or negatively by affecting oxalate absorption, excretion, and/or its metabolic pathways. Oxalate is mostly removed from blood by kidneys and partially via bile and intestinal excretion. In the kidneys, after reaching certain conditions, such as high tubular concentration and damaged integrity of the tubule epithelium, oxalate can precipitate and initiate the formation of stones. Recent studies have indicated the importance of the SoLute Carrier 26 (SLC26) family of membrane transporters for handling oxalate. Two members of this family [Sulfate Anion Transporter 1 (SAT-1; SLC26A1) and Chloride/Formate EXchanger (CFEX; SLC26A6)] may contribute to oxalate transport in the intestine, liver, and kidneys. Malfunction or absence of SAT-1 or CFEX has been associated with hyperoxaluria and urolithiasis. However, numerous questions regarding their roles in oxalate transport in the respective organs and male-prevalent urolithiasis, as well as the role of sex hormones in the expression of these transporters at the level of mRNA and protein, still remain to be answered."],["dc.identifier.doi","10.2478/10004-1254-64-2013-2428"],["dc.identifier.isi","000330046300016"],["dc.identifier.pmid","24384768"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28015"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Inst Medical Research & Occupational Health"],["dc.relation.issn","1848-6312"],["dc.relation.issn","0004-1254"],["dc.title","OXALATE: FROM THE ENVIRONMENT TO KIDNEY STONES"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","16332"],["dc.bibliographiccitation.issue","24"],["dc.bibliographiccitation.journal","Journal of Biological Chemistry"],["dc.bibliographiccitation.lastpage","16341"],["dc.bibliographiccitation.volume","283"],["dc.contributor.author","Bahn, Andrew"],["dc.contributor.author","Hagos, Yohannes"],["dc.contributor.author","Reuter, Stefan"],["dc.contributor.author","Balen, Daniela"],["dc.contributor.author","Brzica, Hrvoje"],["dc.contributor.author","Krick, Wolfgang"],["dc.contributor.author","Burckhardt, Birgitta C."],["dc.contributor.author","Sabolić, Ivan"],["dc.contributor.author","Burckhardt, Gerhard"],["dc.date.accessioned","2021-06-01T10:51:08Z"],["dc.date.available","2021-06-01T10:51:08Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1074/jbc.M800737200"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6066"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86903"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","0021-9258"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Identification of a New Urate and High Affinity Nicotinate Transporter, hOAT10 (SLC22A13)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]