Schlumbohm, Christina

[["dc.bibliographiccitation.firstpage","452"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain Pathology"],["dc.bibliographiccitation.lastpage","464"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Stassart, Ruth Martha"],["dc.contributor.author","Helms, Gunther"],["dc.contributor.author","Garea-Rodriguez, Enrique"],["dc.contributor.author","Nessler, Stefan"],["dc.contributor.author","Hayardeny, Liat"],["dc.contributor.author","Wegner, Christiane"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Brueck, Wolfgang"],["dc.date.accessioned","2018-11-07T10:12:06Z"],["dc.date.available","2018-11-07T10:12:06Z"],["dc.date.issued","2016"],["dc.description.abstract","Multiple sclerosis (MS) is the most common cause for sustained disability in young adults, yet treatment options remain very limited. Although numerous therapeutic approaches have been effective in rodent models of experimental autoimmune encephalomyelitis (EAE), only few proved to be beneficial in patients with MS. Hence, there is a strong need for more predictive animal models. Within the past decade, EAE in the common marmoset evolved as a potent, alternative model for MS, with immunological and pathological features resembling more closely the human disease. However, an often very rapid and severe disease course hampers its implementation for systematic testing of new treatment strategies. We here developed a new focal model of EAE in the common marmoset, induced by myelin oligodendrocyte glycoprotein (MOG) immunization and stereotactic injections of proinflammatory cytokines. At the injection site of cytokines, confluent inflammatory demyelinating lesions developed that strongly resembled human MS lesions. In a proof-of-principle treatment study with the immunomodulatory compound laquinimod, we demonstrate that targeted EAE in marmosets provides a promising and valid tool for preclinical experimental treatment trials in MS research."],["dc.identifier.doi","10.1111/bpa.12292"],["dc.identifier.isi","000380034000002"],["dc.identifier.pmid","26207848"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40173"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1750-3639"],["dc.relation.issn","1015-6305"],["dc.title","A New Targeted Model of Experimental Autoimmune Encephalomyelitis in the Common Marmoset"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","290"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Medical Primatology"],["dc.bibliographiccitation.lastpage","296"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Helms, Gunther"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Garea-Rodriguez, Enrique"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2018-11-07T10:05:33Z"],["dc.date.available","2018-11-07T10:05:33Z"],["dc.date.issued","2016"],["dc.description.abstract","BackgroundThis study determined the pharmacokinetics of the contrast agent gadobutrol in marmosets by quantitative MRI to derive guidelines for neuroimaging protocols. MethodsLocal concentrations of gadobutrol were determined from consecutive gradient echo-based mapping of the relaxation rate R1 on a clinical 3T MRI scanner. Half-time of renal elimination was measured after injection of a triple dose of gadobutrol (0.3mmol/kg) into the saphenous vein. A first-order single-compartment model was fitted to the measured R1 values and verified by blood analysis. ResultsSlow injection (1.5minutes) resulted in an elimination half-time of 264minutes. After bolus injection (15seconds), elimination was much slower (62 +/- 8minutes) with 45% larger distribution volumes. Importantly, more gadobutrol entered the cerebrospinal fluid. ConclusionsSlow injection and a latency of about 20minutes are recommended to avoid extravasation. Application of a triple dose of gadobutrol compensates for the fast elimination in healthy marmosets."],["dc.description.sponsorship","Schilling Foundation; EU ERA-Net NEURON (PARKCDNF)"],["dc.identifier.doi","10.1111/jmp.12227"],["dc.identifier.isi","000387363700002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38917"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1600-0684"],["dc.relation.issn","0047-2565"],["dc.title","Pharmacokinetics of the MRI contrast agent gadobutrol in common marmoset monkeys (Callithrix jacchus)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neuroscience Methods"],["dc.bibliographiccitation.volume","222"],["dc.contributor.author","Garea-Rodriguez, Enrique"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Czeh, Boldizsar"],["dc.contributor.author","Koenig, Jessica"],["dc.contributor.author","Helms, Gunther"],["dc.contributor.author","Heckmann, Cornelia"],["dc.contributor.author","Meller, Birgit"],["dc.contributor.author","Meller, Johannes"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2018-11-07T09:44:54Z"],["dc.date.available","2018-11-07T09:44:54Z"],["dc.date.issued","2014"],["dc.format.extent","260"],["dc.identifier.doi","10.1016/j.jneumeth.2013.10.023"],["dc.identifier.isi","000331672000031"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34496"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1872-678X"],["dc.relation.issn","0165-0270"],["dc.title","Visualizing dopamine transporter integrity with iodine-123-FP-CIT SPECT in combination with high resolution MRI in the brain of the common marmoset monkey (vol 210, pg 195, 2013)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","121"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neuroscience Methods"],["dc.bibliographiccitation.lastpage","131"],["dc.bibliographiccitation.volume","215"],["dc.contributor.author","Helms, Gunther"],["dc.contributor.author","Garea-Rodriguez, Enrique"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","König, Jessica"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2017-09-07T11:43:43Z"],["dc.date.available","2017-09-07T11:43:43Z"],["dc.date.issued","2013"],["dc.description.abstract","Purpose was to adapt structural and quantitative magnetic resonance imaging (MRI) from humans to common marmoset monkeys on a clinical 3T scanner and to demonstrate the value for translational research.Three-dimensional T1- and T2-weighted MRI and gradient echo-based multi-parameter mapping was performed on nine adult animals using a wrist coil. Structural MRI was applied in a model of targeted experimental autoimmune encephalomyelitis (EAE). Magnetization transfer (MT) and T1 parameter maps were used to depict axon-rich cortical areas. After intraveneous triple dose of gadobutrol, the excretion half-time was determined from consecutive measurements of R1 = 1/T1. Diffusion tensor imaging (DTI) was performed at 1 mm resolution.At 0.4 mm resolution, total measurement time (30 min) was compatible with injection anesthesia, permitting rapid screening and frequent follow-up. Structural MRI depicted the EAE lesion in white matter. Quantitative values of T1, MT, and R2 in marmoset brain were comparable to humans, except for smaller R2 indicating lower iron content in basal ganglia. The middle temporal V5 area and the cortical layer IV could be identified, but were considerably better delineated when averaging two images at 0.33 mm resolution (70 min). A similar distribution volume (23%), but a shorter excretion half time than in humans (30 min) was observed. DTI was feasible only in larger structures, such as major axonal tracts.High-resolution MRI of common marmosets proved feasible using clinical MRI hardware. A rapid 3D examination protocol was established for screening under injection anesthesia, thus avoiding the adverse effects of inhalation anesthesia."],["dc.identifier.doi","10.1016/j.jneumeth.2013.02.011"],["dc.identifier.gro","3151620"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/8433"],["dc.language.iso","en"],["dc.notes.status","public"],["dc.notes.submitter","chake"],["dc.relation.issn","0165-0270"],["dc.title","Structural and quantitative neuroimaging of the common marmoset monkey using a clinical MRI system"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Multiple Sclerosis Journal"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Garea-Rodriguez, Enrique"],["dc.contributor.author","Hayardeny, Liat"],["dc.contributor.author","Wegner, C."],["dc.contributor.author","Stassart, Ruth Martha"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Fuchs, E."],["dc.date.accessioned","2018-11-07T09:18:50Z"],["dc.date.available","2018-11-07T09:18:50Z"],["dc.date.issued","2013"],["dc.format.extent","139"],["dc.identifier.isi","000328751401132"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28493"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.publisher.place","London"],["dc.relation.conference","29th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis / 18th Annual Conference of Rehabilitation in MS"],["dc.relation.eventlocation","Copenhagen, DENMARK"],["dc.relation.issn","1477-0970"],["dc.relation.issn","1352-4585"],["dc.title","A new, targetted animal model of multiple sclerosis in the common marmoset"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]