Schlumbohm, Christina

[["dc.bibliographiccitation.firstpage","155"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Medical Primatology"],["dc.bibliographiccitation.lastpage","164"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Atanasova, Srebrena"],["dc.contributor.author","von Ahsen, Nicolas"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Wieland, Eberhard"],["dc.contributor.author","Oellerich, M."],["dc.contributor.author","Armstrong, Victor William"],["dc.date.accessioned","2018-11-07T09:45:57Z"],["dc.date.available","2018-11-07T09:45:57Z"],["dc.date.issued","2006"],["dc.description.abstract","Background Dysfunction of the cellular antioxidant system and accumulation of reactive oxygen species are involved in the pathophysiology of diseases such as cardiovascular disease, neurodegenerative disorders, tumors, male infertility and aging. Two gluthathione peroxidases play key roles in the cellular protection against oxidative damage. Glutathione peroxidase (GPx-1) removes cytosolic hydroperoxides while phospholipid-hydroperoxide glutathione peroxidase (GPx-4) is a unique enzyme that reduces phospholipid peroxides in membranes. Methods We cloned and sequenced the full-length cDNA for GPx-1 (GenBank: AY966403) and GPx-4 (GenBank: AY966404) from the common marmoset (Callithrix jacchus) in order to create a suitable model for studying human diseases related with oxidative stress. Results The cDNAs encode a 202 amino acid protein for GPx-1 and a 197 amino acid protein for GPx-4. Both proteins include selenocysteine (Sec, in Gpx-1 at position 48; in GPx-4 at position 73) and showed high homology (> 90%) with other mammalian GPxs. The relative levels of mRNA expression for GPx-1 and GPx-4 were determined in different marmoset tissues by quantitative real-time reverse transcriptase-polymerase chain reaction using transcription elongation factor-2 as a reference gene. GPx-1 showed increased levels of expression in the liver, heart and kidney while the highest mRNA levels for GPx-4 were detected in the testis, followed by the liver, lung, kidney and spinal cord. Conclusions These findings will be of value for studies designed to assess the role of glutathione peroxidases in non-human primate models for a variety of diseases in which increased oxidative stress has been implicated."],["dc.identifier.doi","10.1111/j.1600-0684.2006.00158.x"],["dc.identifier.isi","000237352700007"],["dc.identifier.pmid","16764674"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34757"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0047-2565"],["dc.title","Marmoset glutathione peroxidases: cDNA sequences, molecular evolution, and gene expression"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","213"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Medical Primatology"],["dc.bibliographiccitation.lastpage","218"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Abaei, A."],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Tammer, Roland"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Schlumbohm, C."],["dc.contributor.author","Fuchs, E."],["dc.date.accessioned","2017-09-07T11:45:28Z"],["dc.date.available","2017-09-07T11:45:28Z"],["dc.date.issued","2009"],["dc.description.abstract","BACKGROUND: Animal models of human brain disorders often have to rely on non-human primates because of their immunological, physiological, and cognitive similarities to humans. METHODS: Localized proton magnetic resonance spectroscopy was performed to assess cerebral metabolite profiles of male common marmoset monkeys in vivo and to determine putative alterations of adult brain metabolism in response to intrauterine hyperexposure to the synthetic glucocorticoid hormone dexamethasone. RESULTS: Excellent spectral quality allowed for absolute quantification of the concentrations of major metabolites in predominantly white matter, gray matter, and thalamus. Marmoset monkeys intrauterinely hyperexposed to dexamethasone revealed normal neurochemical profiles at adulthood. CONCLUSIONS: Prenatally applied dexamethasone does not lead to persistent metabolic alterations affecting adult brain integrity."],["dc.identifier.doi","10.1111/j.1600-0684.2009.00342.x"],["dc.identifier.gro","3150368"],["dc.identifier.pmid","19374665"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7125"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0047-2565"],["dc.subject","Brain metabolism; Callithrix jacchus; glucocorticoids; prenatal; preterm birth; proton magnetic resonance spectroscopy"],["dc.title","Intrauterine hyperexposure to dexamethasone of the common marmoset monkey revealed normal cerebral metabolite concentrations in adulthood as assessed by quantitative proton magnetic resonance spectroscopy in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Hypertension"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Amann, Kerstin"],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T11:14:45Z"],["dc.date.available","2018-11-07T11:14:45Z"],["dc.date.issued","2008"],["dc.format.extent","S154"],["dc.identifier.isi","000257197001070"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54209"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","18th Scientific Meeting of the European-Society-of-Hypertension/22nd Scientific Meeting of the International-Society-of-Hypertension"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","0263-6352"],["dc.title","The prenatal exposure of dexamethason in marmoset monkeys does not result in hypertension"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Neurology"],["dc.bibliographiccitation.volume","80"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Rodriguez, Enrique Garcia"],["dc.contributor.author","Stassart, Ruth"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2018-11-07T09:28:10Z"],["dc.date.available","2018-11-07T09:28:10Z"],["dc.date.issued","2013"],["dc.identifier.isi","000332068603333"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30715"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","65th Annual Meeting of the American-Academy-of-Neurology (AAN)"],["dc.relation.eventlocation","San Diego, CA"],["dc.relation.issn","1526-632X"],["dc.relation.issn","0028-3878"],["dc.title","A New Targeted Animal Model of Multiple Sclerosis in the Common Marmoset"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2873"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Diabetes"],["dc.bibliographiccitation.lastpage","2879"],["dc.bibliographiccitation.volume","58"],["dc.contributor.author","Nyirenda, Moffat J."],["dc.contributor.author","Carter, Roderick"],["dc.contributor.author","Tang, Justin I."],["dc.contributor.author","de Vries, Annick"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Hillier, Stephen G."],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Oellerich, Michael"],["dc.contributor.author","Armstrong, Victor William"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Seckl, Jonathan R."],["dc.date.accessioned","2018-11-07T11:21:24Z"],["dc.date.available","2018-11-07T11:21:24Z"],["dc.date.issued","2009"],["dc.description.abstract","OBJECTIVE-Recent studies in humans and animal models of obesity have shown increased adipose tissue activity of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which amplifies local I issue glucocorticoid concentrations. The reasons for this 11 beta-HSD1 dystegulation are unknown. Here, we tested whether 11 beta-HSD1 expression, like the metabolic syndrome, is \"programmed\" by prenatal environmental events in a nonhuman primate model, the common marmoset monkey. RESEARCH DESIGN AND METHODS-We used a \"fetal programming\" paradigm where brief antenatal exposure to glucocorticoids leads to the metabolic syndrome in the offspring. Pregnant marmosets were given the synthetic glucocorticoid dexamethasone orally for 1 week in either early or late gestation, or they were given vehicle. Tissue 11 beta-HSD1 and glucocorticoid receptor mRNA expression were examined in the offspring at 4 and 24 months of age. RESULTS-Prenatal dexamethasone administration, selectively during late gestation, resulted in early and persistent elevations in 11 beta-HSD1 mRNA expression and activity in the liver, pancreas, and subcutaneous-but not visceral-fat. The increase in 11 beta-HSD1 occurred before animals developed obesity or overt features of the metabolic syndrome. In contrast to rodents, in utero dexamethasone exposure did not alter glucocorticoid receptor expression in metabolic tissues in marmosets. CONCLUSIONS-These data suggest that long-term upregulation of 11 beta-HSD1 in metabolically active tissues may follow prenatal \"stress\" hormone exposure and indicates a novel mechanism for fetal origins of adult obesity and the metabolic syndrome. Diabetes 58:2873-2879, 2009"],["dc.description.sponsorship","European Commission [QLRT-2001-02758]; MRC"],["dc.identifier.doi","10.2337/db09-0873"],["dc.identifier.isi","000272522000021"],["dc.identifier.pmid","19720800"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55764"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Diabetes Assoc"],["dc.relation.issn","0012-1797"],["dc.title","Prenatal Programming of Metabolic Syndrome in the Common Marmoset Is Associated With Increased Expression of 11 beta-Hydroxysteroid Dehydrogenase Type 1"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","254"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Research in Veterinary Science"],["dc.bibliographiccitation.lastpage","264"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Harmeyer, J."],["dc.contributor.author","Schlumbohm, Christina"],["dc.date.accessioned","2022-10-06T13:33:23Z"],["dc.date.available","2022-10-06T13:33:23Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1016/j.rvsc.2005.10.010"],["dc.identifier.pii","S0034528805002067"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115619"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0034-5288"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Pregnancy impairs ketone body disposal in late gestating ewes: Implications for onset of pregnancy toxaemia"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","MEDIZINISCHE KLINIK"],["dc.bibliographiccitation.volume","101"],["dc.contributor.author","Bramlage, Carsten Paul"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Werner, C."],["dc.contributor.author","Mueller, Gerhard A."],["dc.contributor.author","Strutz, Frank M."],["dc.date.accessioned","2018-11-07T09:58:58Z"],["dc.date.available","2018-11-07T09:58:58Z"],["dc.date.issued","2006"],["dc.format.extent","A100"],["dc.identifier.isi","000237562000321"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37479"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.issn","0723-5003"],["dc.title","Prenatal programming of arterial hypertonia in common marmosets (EUPEAH): Study design and first results"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","113"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.lastpage","123"],["dc.bibliographiccitation.volume","235"],["dc.contributor.author","Hoffmann, Kerstin"],["dc.contributor.author","Coolen, Alex"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Meerlo, Peter"],["dc.contributor.author","Fuchs, Eberhard"],["dc.date.accessioned","2018-11-07T09:03:09Z"],["dc.date.available","2018-11-07T09:03:09Z"],["dc.date.issued","2012"],["dc.description.abstract","Initial studies in the day active marmoset monkey (Callithrix jacchus) indicate that the sleep-wake cycle of these non-human primates resembles that of humans and therefore conceivably represent an appropriate model for human sleep. The methods currently employed for sleep studies in marmosets are limited. The objective of this study was to employ and validate the use of specific remote monitoring system technologies that enable accurate long-term recordings of sleep-wake rhythms and the closely related rhythms of core body temperature (CBT) and locomotor activity in unrestrained group-housed marmosets. Additionally, a pilot sleep deprivation (SD) study was performed to test the recording systems in an applied experimental setup. Our results show that marmosets typically exhibit a monophasic sleep pattern with cyclical alternations between NREM and REM sleep. CBT displays a pronounced daily rhythm and locomotor activity is primarily restricted to the light phase. SD caused an immediate increase in NREM sleep time and EEG slow-wave activity as well as a delayed REM sleep rebound that did not fully compensate for REM sleep that had been lost during SD. In conclusion, the combination of two innovative technical approaches allows for simultaneous measurements of CBT, sleep cycles and activity in multiple subjects. The employment of these systems represents a significant refinement in terms of animal welfare and will enable many future applications and longitudinal studies of circadian rhythms in marmosets. (C) 2012 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.bbr.2012.07.033"],["dc.identifier.isi","000309801400002"],["dc.identifier.pmid","22850608"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11319"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24842"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0166-4328"],["dc.rights","CC BY-NC-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/3.0"],["dc.title","Remote long-term registrations of sleep-wake rhythms, core body temperature and activity in marmoset monkeys"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","452"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Brain Pathology"],["dc.bibliographiccitation.lastpage","464"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Stassart, Ruth Martha"],["dc.contributor.author","Helms, Gunther"],["dc.contributor.author","Garea-Rodriguez, Enrique"],["dc.contributor.author","Nessler, Stefan"],["dc.contributor.author","Hayardeny, Liat"],["dc.contributor.author","Wegner, Christiane"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Brueck, Wolfgang"],["dc.date.accessioned","2018-11-07T10:12:06Z"],["dc.date.available","2018-11-07T10:12:06Z"],["dc.date.issued","2016"],["dc.description.abstract","Multiple sclerosis (MS) is the most common cause for sustained disability in young adults, yet treatment options remain very limited. Although numerous therapeutic approaches have been effective in rodent models of experimental autoimmune encephalomyelitis (EAE), only few proved to be beneficial in patients with MS. Hence, there is a strong need for more predictive animal models. Within the past decade, EAE in the common marmoset evolved as a potent, alternative model for MS, with immunological and pathological features resembling more closely the human disease. However, an often very rapid and severe disease course hampers its implementation for systematic testing of new treatment strategies. We here developed a new focal model of EAE in the common marmoset, induced by myelin oligodendrocyte glycoprotein (MOG) immunization and stereotactic injections of proinflammatory cytokines. At the injection site of cytokines, confluent inflammatory demyelinating lesions developed that strongly resembled human MS lesions. In a proof-of-principle treatment study with the immunomodulatory compound laquinimod, we demonstrate that targeted EAE in marmosets provides a promising and valid tool for preclinical experimental treatment trials in MS research."],["dc.identifier.doi","10.1111/bpa.12292"],["dc.identifier.isi","000380034000002"],["dc.identifier.pmid","26207848"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40173"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1750-3639"],["dc.relation.issn","1015-6305"],["dc.title","A New Targeted Model of Experimental Autoimmune Encephalomyelitis in the Common Marmoset"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Osteoporosis International"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Seidlova-Wuttke, Dana"],["dc.contributor.author","Schlumbohm, Christina"],["dc.contributor.author","Wuttke, Wolfgang"],["dc.date.accessioned","2018-11-07T09:55:30Z"],["dc.date.available","2018-11-07T09:55:30Z"],["dc.date.issued","2006"],["dc.format.extent","S329"],["dc.identifier.isi","000245980600643"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36757"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Artington"],["dc.relation.conference","7th International Symposium on Osteoporosis"],["dc.relation.eventlocation","Washington, DC"],["dc.relation.issn","0937-941X"],["dc.title","Post-castrational development of osteoporosis in the common marmoset (callithrix jacchus)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]