Canis, Martin

[["dc.bibliographiccitation.firstpage","545"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","International Journal of Audiology"],["dc.bibliographiccitation.lastpage","552"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Arpornchayanon, Warangkana"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Settevendemie, Claudia"],["dc.contributor.author","Strieth, Sebastian"],["dc.date.accessioned","2018-11-07T09:22:09Z"],["dc.date.available","2018-11-07T09:22:09Z"],["dc.date.issued","2013"],["dc.description.abstract","Objective: Exposure to loud noise can impair cochlear microcirculation and cause noise-induced hearing loss (NIHL). TNF-alpha signaling has been shown to be activated in NIHL and to control spiral modiolar artery vasoconstriction that regulates cochlear microcirculation. It was the aim of this experimental study to analyse the effects of the TNF-alpha inhibitor etanercept on cochlear microcirculation and hearing threshold shift in NIHL in vivo. Design: After assessment of normacusis using ABR, loud noise (106 dB SPL, 30 minutes) was applied on both ears in guinea pigs. Etanercept was administered systemically after loud noise exposure while control animals received a saline solution. In vivo fluorescence microscopy of strial capillaries was performed after surgical exposure of the cochlea for microcirculatory analysis. ABR measurements were derived from the contralateral ear. Study sample: Guinea pigs (n=6, per group). Results: Compared to controls, cochlear blood flow in strial capillary segments was significantly increased in etanercept-treated animals. Additionally, hearing threshold was preserved in animals receiving the TNF-alpha inhibitor in contrast to a significant threshold raising in controls. Conclusions: TNF-alpha inhibition using etanercept improves cochlear microcirculation and protects hearing levels after loud noise exposure and appears as a promising treatment strategy for human NIHL."],["dc.identifier.doi","10.3109/14992027.2013.790564"],["dc.identifier.isi","000321693900004"],["dc.identifier.pmid","23786392"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29275"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.relation.issn","1499-2027"],["dc.title","TNF-alpha inhibition using etanercept prevents noise-induced hearing loss by improvement of cochlear blood flow in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","463"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery"],["dc.bibliographiccitation.lastpage","469"],["dc.bibliographiccitation.volume","145"],["dc.contributor.author","Arpornchayanon, Warangkana"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Suckfuell, Markus"],["dc.contributor.author","Ihler, Fritz"],["dc.contributor.author","Olzowy, Bernhard"],["dc.contributor.author","Strieth, Sebastian"],["dc.date.accessioned","2019-07-09T11:53:48Z"],["dc.date.available","2019-07-09T11:53:48Z"],["dc.date.issued","2011-09-01"],["dc.description.abstract","OBJECTIVE: Recent findings support the crucial role of microcirculatory disturbance and ischemia for hearing impairment especially after noise-induced hearing loss (NIHL). The aim of this study was to establish an animal model for in vivo analysis of cochlear microcirculation and hearing function after a loud noise to allow precise measurements of both parameters in vivo. STUDY DESIGN: Randomized controlled trial. Setting. Animal study. Subjects and Methods. After assessment of normacusis (0 minutes) using evoked auditory brainstem responses (ABRs), noise (106-dB sound pressure level [SPL]) was applied to both ears in 6 guinea pigs for 30 minutes while unexposed animals served as controls. In vivo fluorescence microscopy of the stria vascularis capillaries was performed after surgical exposure of 1 cochlea. ABR measurements were derived from the contralateral ear. RESULTS: After noise exposure, red blood cell velocity was reduced significantly by 24.3% (120 minutes) and further decreased to 44.5% at the end of the observation (210 minutes) in contrast to stable control measurements. Vessel diameters were not affected in both groups. A gradual decrease of segmental blood flow became significant (38.1%) after 150 minutes compared with controls. Hearing thresholds shifted significantly from 20.0 ± 5.5 dB SPL (0 minutes) to 32.5 ± 4.2 dB SPL (60 minutes) only in animals exposed to loud noise. CONCLUSION: With regard to novel treatments targeting the stria vascularis in NIHL, this standardized model allows us to analyze in detail cochlear microcirculation and hearing function in vivo."],["dc.identifier.doi","10.1177/0194599811407829"],["dc.identifier.fs","586230"],["dc.identifier.pmid","21636842"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8048"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60497"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1097-6817"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Auditory Threshold"],["dc.subject.mesh","Cochlea"],["dc.subject.mesh","Disease Models, Animal"],["dc.subject.mesh","Evoked Potentials, Auditory, Brain Stem"],["dc.subject.mesh","Guinea Pigs"],["dc.subject.mesh","Hearing Loss, Noise-Induced"],["dc.subject.mesh","Loudness Perception"],["dc.subject.mesh","Male"],["dc.subject.mesh","Microcirculation"],["dc.subject.mesh","Microscopy, Fluorescence"],["dc.subject.mesh","Noise"],["dc.subject.mesh","Random Allocation"],["dc.subject.mesh","Statistics, Nonparametric"],["dc.title","Modeling the measurements of cochlear microcirculation and hearing function after loud noise."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]