Canis, Martin

[["dc.bibliographiccitation.firstpage","437"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Tumor Biology"],["dc.bibliographiccitation.lastpage","443"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Lechner, Axel"],["dc.contributor.author","Mack, Brigitte"],["dc.contributor.author","Zengel, Pamela"],["dc.contributor.author","Laubender, Ruediger Paul"],["dc.contributor.author","Koehler, Udo"],["dc.contributor.author","Heissmeyer, Vigo"],["dc.contributor.author","Gires, Olivier"],["dc.date.accessioned","2018-11-07T09:28:43Z"],["dc.date.available","2018-11-07T09:28:43Z"],["dc.date.issued","2013"],["dc.description.abstract","The pentaspan protein CD133 (Prominin-1) is part of the signature of tumour-initiating cells for various cancer entities. The aim of the present study was to investigate the impact of ectopic CD133 expression on tumourigenic properties of otherwise CD133-negative, non-tumourigenic cells in vitro and in vivo. CD133 was stably transfected into human embryonic kidney 293 (HEK293) which was then sorted for the expression of CD133. The effects of CD133 on cell proliferation were assessed upon standard cell counting of sorted cells at various time points. Severe combined immunodeficient (SCID) mice (n = 30) were injected with HEK293 CD133(high) and CD133(low) transfectants (5 x 10(3), 1 x 10(5), or 5 x 10(6) cells per injection). The expression of CD133, Ki67, CD44s, CD44v6, and EpCAM was analysed upon immunohistochemical staining of cryosections with specific antibodies. In vitro, ectopic expression of CD133 did influence neither cell proliferation nor cell cycle distribution of otherwise CD133-negative HEK293 cells. However, CD133(high) cells generated tumours in vivo in SCID mice with at least 1,000-fold increased frequency compared to CD133(low) cells. Tumour load was also significantly increased in CD133(high) cells as compared to those tumours formed by high numbers of CD133(low) cells. Immunohistochemistry stainings disclosed no changes in Ki67, CD44s, CD44v6, or EpCAM once tumours were formed by either cell type. CD133 induces tumour-initiating properties in HEK293 cells in vivo and is potentially involved in the regulation of tumourigenicity. Future research will aim at the elucidation of molecular mechanisms of CD133-induced tumourigenicity."],["dc.identifier.doi","10.1007/s13277-012-0568-z"],["dc.identifier.isi","000313875400051"],["dc.identifier.pmid","23150174"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8892"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30845"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1010-4283"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","CD133 induces tumour-initiating properties in HEK293 cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","154272"],["dc.bibliographiccitation.journal","BioMed Research International"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Bertlich, Mattis"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Dietzel, Steffen"],["dc.contributor.author","Canis, Martin"],["dc.date.accessioned","2018-11-07T10:03:20Z"],["dc.date.available","2018-11-07T10:03:20Z"],["dc.date.issued","2015"],["dc.description.abstract","Impairment of cochlear blood flow has been discussed as factor in the pathophysiology of various inner ear disorders. However, the microscopic study of cochlear microcirculation is limited due to small scale and anatomical constraints. Here, two-photon fluorescence microscopy is applied to visualize cochlear microvessels. Guinea pigs were injected with Fluorescein isothiocyanateor Texas red-dextrane as plasma marker. Intravital microscopy was performed in four animals and explanted cochleae from four animals were studied. The vascular architecture of the cochlea was visualized up to a depth of 90.0 +/- 22.7 mu m. Imaging yielded a mean contrast-to-noise ratio (CNR) of 3.3 +/- 1.7. Mean diameter in vivo was 16.5 +/- 6.0 mu m for arterioles and 8.0 +/- 2.4 mu m for capillaries. In explanted cochleae, the diameter of radiating arterioles and capillaries was measured with 12.2 +/- 1.6 mu m and 6.6 +/- 1.0 mu m, respectively. The difference between capillaries and arterioles was statistically significant in both experimental setups (P < 0.001 and P = 0.022, two-way ANOVA). Measured vessel diameters in vivo and ex vivo were in agreement with published data. We conclude that two-photon fluorescence microscopy allows the investigation of cochlear microvessels and is potentially a valuable tool for inner ear research."],["dc.description.sponsorship","Open Access Publikationsfonds 2015"],["dc.identifier.doi","10.1155/2015/154272"],["dc.identifier.isi","000353163300001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11857"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38437"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hindawi Publishing Corp"],["dc.relation.issn","2314-6141"],["dc.relation.issn","2314-6133"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Two-Photon Microscopy Allows Imaging and Characterization of Cochlear Microvasculature In Vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e74991"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Moeller, Winfried"],["dc.contributor.author","Schuschnig, Uwe"],["dc.contributor.author","Celik, Guelnaz"],["dc.contributor.author","Muenzing, Wolfgang"],["dc.contributor.author","Bartenstein, Peter"],["dc.contributor.author","Haeussinger, Karl"],["dc.contributor.author","Kreyling, Wolfgang G."],["dc.contributor.author","Knoch, Martin"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Becker, Sven"],["dc.date.accessioned","2018-11-07T09:19:56Z"],["dc.date.available","2018-11-07T09:19:56Z"],["dc.date.issued","2013"],["dc.description.abstract","Objectives: Chronic rhinosinusitis (CRS) is a common chronic disease of the upper airways and has considerable impact on quality of life. Topical delivery of drugs to the paranasal sinuses is challenging, therefore the rate of surgery is high. This study investigates the delivery efficiency of a pulsating aerosol in comparison to a nasal pump spray to the sinuses and the nose in healthy volunteers and in CRS patients before and after sinus surgery. Methods: Tc-99m-DTPA pulsating aerosols were applied in eleven CRSsNP patients without nasal polyps before and after sinus surgery. In addition, pulsating aerosols were studied in comparison to nasal pump sprays in eleven healthy volunteers. Total nasal and frontal, maxillary and sphenoidal sinus aerosol deposition and lung penetration were assessed by anterior and lateral planar gamma camera imaging. Results: In healthy volunteers nasal pump sprays resulted in 100% nasal, non-significant sinus and lung deposition, while pulsating aerosols resulted 61.3+/-8.6% nasal deposition and 38.7% exit the other nostril. 9.7+/-2.0 % of the nasal dose penetrated into maxillary and sphenoidal sinuses. In CRS patients, total nasal deposition was 56.7+/-13.3% and 46.7+/-12.7% before and after sinus surgery, respectively (p<0.01). Accordingly, maxillary and sphenoidal sinus deposition was 4.8+/-2.2% and 8.2+/-3.8% of the nasal dose (p<0.01). Neither in healthy volunteers nor in CRS patients there was significant dose in the frontal sinuses. Conclusion: In contrast to nasal pump sprays, pulsating aerosols can deliver significant doses into posterior nasal spaces and paranasal sinuses, providing alternative therapy options before and after sinus surgery. Patients with chronic lung diseases based on clearance dysfunction may also benefit from pulsating aerosols, since these diseases also manifest in the upper airways."],["dc.description.sponsorship","Pari GmbH, Starnberg, Germany; Bavarian Research foundation [AZ-914-10]"],["dc.identifier.doi","10.1371/journal.pone.0074991"],["dc.identifier.isi","000326734500130"],["dc.identifier.pmid","24040372"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9292"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28759"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Topical Drug Delivery in Chronic Rhinosinusitis Patients before and after Sinus Surgery Using Pulsating Aerosols"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0141827"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Welz, Christian"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Becker, Sven"],["dc.contributor.author","Baumeister, Philipp"],["dc.contributor.author","Shimizu, Tetsuji"],["dc.contributor.author","Morfill, Gregor E."],["dc.contributor.author","Harreus, Uli"],["dc.contributor.author","Zimmermann, Julia L."],["dc.date.accessioned","2018-11-07T09:48:49Z"],["dc.date.available","2018-11-07T09:48:49Z"],["dc.date.issued","2015"],["dc.description.abstract","Head and neck squamous cell cancer (HNSCC) is the 7th most common cancer worldwide. Despite the development of new therapeutic agents such as monoclonal antibodies, prognosis did not change for the last decades. Cold atmospheric plasma (CAP) presents the most promising new technology in cancer treatment. In this study the efficacy of a surface micro discharging (SMD) plasma device against two head and neck cancer cell lines was proved. Effects on the cell viability, DNA fragmentation and apoptosis induction were evaluated with the MTT assay, alkaline microgel electrophoresis (comet assay) and Annexin-V/PI staining. MTT assay revealed that the CAP treatment markedly decreases the cell viability for all tested treatment times (30, 60, 90, 120 and 180 s). IC 50 was reached within maximal 120 seconds of CAP treatment. Comet assay analysis showed a dose dependent high DNA fragmentation being one of the key players in anti-cancer activity of CAP. Annexin-V/PI staining revealed induction of apoptosis in CAP treated HNSCC cell lines but no significant dose dependency was seen. Thus, we confirmed that SMD Plasma technology is definitely a promising new approach on cancer treatment."],["dc.description.sponsorship","Friedrich-Baur-Stiftung Munich [40/13]"],["dc.identifier.doi","10.1371/journal.pone.0141827"],["dc.identifier.isi","000365251500006"],["dc.identifier.pmid","26588072"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12554"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35387"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Cold Atmospheric Plasma: A Promising Complementary Therapy for Squamous Head and Neck Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","The Laryngoscope"],["dc.bibliographiccitation.lastpage","9"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Weiss, Bernhard G."],["dc.contributor.author","Anczykowski, Mahalia Z."],["dc.contributor.author","Flach, Susanne"],["dc.contributor.author","Spiegel, Jennifer L."],["dc.contributor.author","Kitz, Julia"],["dc.contributor.author","Bertlich, Mattis"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Jakob, Mark"],["dc.contributor.author","Ihler, Friedrich"],["dc.date.accessioned","2020-01-14T09:01:11Z"],["dc.date.accessioned","2021-10-27T13:22:03Z"],["dc.date.available","2020-01-14T09:01:11Z"],["dc.date.available","2021-10-27T13:22:03Z"],["dc.date.issued","2019"],["dc.description.abstract","OBJECTIVES/HYPOTHESIS: Indication for postoperative radiotherapy in patients with locally circumscribed tumors (pT1-pT2) and a single ipsilateral lymph node metastasis (pN1) is debatable. The aim of this study was to evaluate the oncological long-term outcome of patients with pT1-pT2 pN1 squamous cell carcinoma (SCC) of the oral cavity, the oropharynx, and the hypopharynx without extracapsular spread (ECS) after a margin-negative surgical resection, who either received or did not receive postoperative (chemo)radiotherapy. STUDY DESIGN: Retrospective case series. METHODS: The oncological outcome of patients with pT1-pT2 pN1 SCC without ECS was evaluated retrospectively. All patients underwent primary tumor resection that included transoral laser microsurgery and neck dissection at an academic tertiary referral center. RESULTS: Of 65 identified patients treated between 1986 and 2015 (18 oral cavity, 30 oropharynx, 17 hypopharynx), 21 (32%) received postoperative radiotherapy, and 44 (68%) were treated by surgery alone. The group of patients receiving postoperative treatment showed a significantly superior 5-year disease-specific (94.4% vs. 73.2%, P = .029) and recurrence-free survival (85.2% vs. 43.2%, P = .002), as well as a higher local control rate (90.2% vs. 64.9%, P = .042). The overall survival was 71.4% vs. 62.6% (P = .53). The mean follow-up was 80.7 months. CONCLUSIONS: Patients with locally circumscribed carcinomas and a single ipsilateral ECS-negative lymph node metastasis seem to benefit from postoperative radiotherapy. LEVEL OF EVIDENCE: 4 Laryngoscope, 2019."],["dc.identifier.doi","10.1002/lary.28394"],["dc.identifier.eissn","1531-4995"],["dc.identifier.issn","0023-852X"],["dc.identifier.pmid","31837151"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17078"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92065"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.eissn","1531-4995"],["dc.relation.issn","1531-4995"],["dc.relation.issn","0023-852X"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.subject.ddc","610"],["dc.title","Benefit of postoperative radiotherapy for early tumors with single ipsilateral lymph node metastasis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2719"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","2727"],["dc.bibliographiccitation.volume","270"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Ihler, Friedrich"],["dc.contributor.author","Martin, Alexios"],["dc.contributor.author","Wolff, Hendrik Andreas"],["dc.contributor.author","Matthias, Christoph"],["dc.contributor.author","Steiner, Wolfgang"],["dc.date.accessioned","2018-11-07T09:20:45Z"],["dc.date.available","2018-11-07T09:20:45Z"],["dc.date.issued","2013"],["dc.description.abstract","The main objective of this study is to assess the feasibility of transoral laser microsurgery (TLM) in the treatment of T4a laryngeal cancer and to report the oncological and functional outcomes. This is a retrospective case-series study, held in a single-institute, academic tertiary referral center. Seventy-nine patients with previously untreated T4a glottic (n = 31, 39 %) or supraglottic laryngeal carcinoma (n = 48, 61 %) were included in this study. Five patients (6 %) were treated exclusively by TLM, 16 (20 %) had TLM and unilateral neck dissection, 27 (35 %) had TLM and bilateral neck dissection. Adjuvant (chemo)radiotherapy was additionally administered in 26 (33 %) cases following TLM and neck dissection, and in 5 (6 %) cases after TLM without neck dissection. The main outcome measures included organ preservation, local control, functional outcome, overall, recurrence-free, and disease-specific survival. The median follow-up period was 49 months, 5 year organ preservation rate and local control rate were 80.0 and 67.2 %, 5 year overall, recurrence-free and disease-specific survival were 55.8, 61.9 and 71.8 %. The 5 year overall survival rates were 62.5 % in pN0 cases and 57.2 % in cases with pN-positive neck disease. With respect to survival, these results are comparable to total laryngectomy, while being superior to primary (chemo)radiotherapy. TLM results in a low morbidity, rapid recovery and good function and can be a valid option for organ preserving surgery of pT4a glottic and supraglottic cancer."],["dc.identifier.doi","10.1007/s00405-013-2382-7"],["dc.identifier.isi","000323739100020"],["dc.identifier.pmid","23408021"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10308"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28952"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0937-4477"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Organ preservation in T4a laryngeal cancer: is transoral laser microsurgery an option?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","36"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology Supplements"],["dc.bibliographiccitation.lastpage","40"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Heigl, Franz"],["dc.contributor.author","Suckfuell, Markus"],["dc.date.accessioned","2019-07-09T11:54:19Z"],["dc.date.available","2019-07-09T11:54:19Z"],["dc.date.issued","2012"],["dc.description.abstract","Fibrinogen/LDL apheresis has been proven to be effective in treatment of sudden sensorineural hearing loss (SSNH). This study is aimed to investigate if reduction of fibrinogen and serum LDL is also effective in patients with SSNH non-responding toward treatment with corticosteroids and plasmaexpanders.Remission rates of 217 patients suffering from SSHL were investigated after treatment with apheresis. All patients were non-responders after other therapies such as high doses of steroids or plasmaexpanders.Single apheresis resulted in complete or partial remissions in 61% of patients when given after other unsuccessful conducted therapies such as corticosteroids and plasmaexpanders.Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss even after unsuccessful other therapies."],["dc.identifier.doi","10.1007/s11789-012-0044-8"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8879"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60626"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Springer"],["dc.publisher.place","Berlin/Heidelberg"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Fibrinogen/LDL apheresis is a promising rescue therapy for sudden sensorineural hearing loss"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Cells"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Jakob, Mark"],["dc.contributor.author","Hambrecht, Mario"],["dc.contributor.author","Spiegel, Jennifer L."],["dc.contributor.author","Kitz, Julia"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Streckfuss-Bömeke, Katrin"],["dc.date.accessioned","2021-04-14T08:29:46Z"],["dc.date.available","2021-04-14T08:29:46Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.3390/cells10010033"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17778"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82983"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","MDPI"],["dc.relation.eissn","2073-4409"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Show Comparable Functionality to Their Autologous Origin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Trends in Hearing"],["dc.bibliographiccitation.lastpage","12"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Ihler, F."],["dc.contributor.author","Blum, J."],["dc.contributor.author","Berger, M.-U."],["dc.contributor.author","Weiss, B. G."],["dc.contributor.author","Welz, C."],["dc.contributor.author","Canis, M."],["dc.date.accessioned","2019-07-09T11:42:57Z"],["dc.date.available","2019-07-09T11:42:57Z"],["dc.date.issued","2016"],["dc.description.abstract","Semi-implantable transcutaneous bone conduction devices are treatment options for conductive and mixed hearing loss (CHL/MHL). For counseling of patients, realistic simulation of the functional result is desirable. This study compared speech recognition in noise with a semi-implantable transcutaneous bone conduction device to external stimulation with a bone conduction device fixed by a headband. Eight German-language adult patients were enrolled after a semi-implantable transcutaneous bone conduction device (Bonebridge, Med-El) was implanted and fitted. Patients received a bone conduction device for external stimulation (Baha BP110, Cochlear) fixed by a headband for comparison. The main outcome measure was speech recognition in noise (Oldenburg Sentence Test). Pure-tone audiometry was performed and subjective benefit was assessed using the Glasgow Benefit Inventory and Abbreviated Profile of Hearing Aid Benefit questionnaires. Unaided, patients showed a mean signal-to-noise ratio threshold of 4.6 4.2 dB S/N for speech recognition. The aided results were 3.3 7.2 dB S/N by external bone conduction stimulation and 1.2 4.0 dB S/N by the semi-implantable bone conduction device. The difference between the two devices was not statistically significant, while the difference was significant between unaided and aided situation for both devices. Both questionnaires for subjective benefit favored the semiimplantable device over external stimulation. We conclude that it is possible to simulate the result of speech recognition in noise with a semi-implantable transcutaneous bone conduction device by external stimulation. This should be part of preoperative counseling of patients with CHL/MHL before implantation of a bone conduction device."],["dc.identifier.doi","10.1177/2331216516669330"],["dc.identifier.pmid","27698259"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58795"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2331-2165"],["dc.rights","CC BY-NC 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/3.0"],["dc.title","The Prediction of Speech Recognition in Noise With a Semi-Implantable Bone Conduction Hearing System by External Bone Conduction Stimulation With Headband: A Prospective Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","463"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery"],["dc.bibliographiccitation.lastpage","469"],["dc.bibliographiccitation.volume","145"],["dc.contributor.author","Arpornchayanon, Warangkana"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Suckfuell, Markus"],["dc.contributor.author","Ihler, Fritz"],["dc.contributor.author","Olzowy, Bernhard"],["dc.contributor.author","Strieth, Sebastian"],["dc.date.accessioned","2019-07-09T11:53:48Z"],["dc.date.available","2019-07-09T11:53:48Z"],["dc.date.issued","2011-09-01"],["dc.description.abstract","OBJECTIVE: Recent findings support the crucial role of microcirculatory disturbance and ischemia for hearing impairment especially after noise-induced hearing loss (NIHL). The aim of this study was to establish an animal model for in vivo analysis of cochlear microcirculation and hearing function after a loud noise to allow precise measurements of both parameters in vivo. STUDY DESIGN: Randomized controlled trial. Setting. Animal study. Subjects and Methods. After assessment of normacusis (0 minutes) using evoked auditory brainstem responses (ABRs), noise (106-dB sound pressure level [SPL]) was applied to both ears in 6 guinea pigs for 30 minutes while unexposed animals served as controls. In vivo fluorescence microscopy of the stria vascularis capillaries was performed after surgical exposure of 1 cochlea. ABR measurements were derived from the contralateral ear. RESULTS: After noise exposure, red blood cell velocity was reduced significantly by 24.3% (120 minutes) and further decreased to 44.5% at the end of the observation (210 minutes) in contrast to stable control measurements. Vessel diameters were not affected in both groups. A gradual decrease of segmental blood flow became significant (38.1%) after 150 minutes compared with controls. Hearing thresholds shifted significantly from 20.0 ± 5.5 dB SPL (0 minutes) to 32.5 ± 4.2 dB SPL (60 minutes) only in animals exposed to loud noise. CONCLUSION: With regard to novel treatments targeting the stria vascularis in NIHL, this standardized model allows us to analyze in detail cochlear microcirculation and hearing function in vivo."],["dc.identifier.doi","10.1177/0194599811407829"],["dc.identifier.fs","586230"],["dc.identifier.pmid","21636842"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8048"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60497"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1097-6817"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Auditory Threshold"],["dc.subject.mesh","Cochlea"],["dc.subject.mesh","Disease Models, Animal"],["dc.subject.mesh","Evoked Potentials, Auditory, Brain Stem"],["dc.subject.mesh","Guinea Pigs"],["dc.subject.mesh","Hearing Loss, Noise-Induced"],["dc.subject.mesh","Loudness Perception"],["dc.subject.mesh","Male"],["dc.subject.mesh","Microcirculation"],["dc.subject.mesh","Microscopy, Fluorescence"],["dc.subject.mesh","Noise"],["dc.subject.mesh","Random Allocation"],["dc.subject.mesh","Statistics, Nonparametric"],["dc.title","Modeling the measurements of cochlear microcirculation and hearing function after loud noise."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]