Canis, Martin

[["dc.bibliographiccitation.firstpage","463"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery"],["dc.bibliographiccitation.lastpage","469"],["dc.bibliographiccitation.volume","145"],["dc.contributor.author","Arpornchayanon, Warangkana"],["dc.contributor.author","Canis, Martin"],["dc.contributor.author","Suckfuell, Markus"],["dc.contributor.author","Ihler, Fritz"],["dc.contributor.author","Olzowy, Bernhard"],["dc.contributor.author","Strieth, Sebastian"],["dc.date.accessioned","2019-07-09T11:53:48Z"],["dc.date.available","2019-07-09T11:53:48Z"],["dc.date.issued","2011-09-01"],["dc.description.abstract","OBJECTIVE: Recent findings support the crucial role of microcirculatory disturbance and ischemia for hearing impairment especially after noise-induced hearing loss (NIHL). The aim of this study was to establish an animal model for in vivo analysis of cochlear microcirculation and hearing function after a loud noise to allow precise measurements of both parameters in vivo. STUDY DESIGN: Randomized controlled trial. Setting. Animal study. Subjects and Methods. After assessment of normacusis (0 minutes) using evoked auditory brainstem responses (ABRs), noise (106-dB sound pressure level [SPL]) was applied to both ears in 6 guinea pigs for 30 minutes while unexposed animals served as controls. In vivo fluorescence microscopy of the stria vascularis capillaries was performed after surgical exposure of 1 cochlea. ABR measurements were derived from the contralateral ear. RESULTS: After noise exposure, red blood cell velocity was reduced significantly by 24.3% (120 minutes) and further decreased to 44.5% at the end of the observation (210 minutes) in contrast to stable control measurements. Vessel diameters were not affected in both groups. A gradual decrease of segmental blood flow became significant (38.1%) after 150 minutes compared with controls. Hearing thresholds shifted significantly from 20.0 ± 5.5 dB SPL (0 minutes) to 32.5 ± 4.2 dB SPL (60 minutes) only in animals exposed to loud noise. CONCLUSION: With regard to novel treatments targeting the stria vascularis in NIHL, this standardized model allows us to analyze in detail cochlear microcirculation and hearing function in vivo."],["dc.identifier.doi","10.1177/0194599811407829"],["dc.identifier.fs","586230"],["dc.identifier.pmid","21636842"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8048"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60497"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1097-6817"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Auditory Threshold"],["dc.subject.mesh","Cochlea"],["dc.subject.mesh","Disease Models, Animal"],["dc.subject.mesh","Evoked Potentials, Auditory, Brain Stem"],["dc.subject.mesh","Guinea Pigs"],["dc.subject.mesh","Hearing Loss, Noise-Induced"],["dc.subject.mesh","Loudness Perception"],["dc.subject.mesh","Male"],["dc.subject.mesh","Microcirculation"],["dc.subject.mesh","Microscopy, Fluorescence"],["dc.subject.mesh","Noise"],["dc.subject.mesh","Random Allocation"],["dc.subject.mesh","Statistics, Nonparametric"],["dc.title","Modeling the measurements of cochlear microcirculation and hearing function after loud noise."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]