Langohr, Kersten

[["dc.bibliographiccitation.firstpage","520"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Neuroscience"],["dc.bibliographiccitation.lastpage","526"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Mironov, Sergej L."],["dc.contributor.author","Langohr, K."],["dc.contributor.author","Richter, Diethelm W."],["dc.date.accessioned","2018-11-07T10:21:08Z"],["dc.date.available","2018-11-07T10:21:08Z"],["dc.date.issued","2000"],["dc.description.abstract","A hyperpolarization-activated current, I-h, is often implied in pacemaker-like depolarizations during rhythmic oscillatory activity. We describe I-h in the isolated respiratory centre of immature mice (P6-P11). I-h was recorded in 15% (22/146) of all inspiratory neurons examined. The mean half-maximal I-h activation occurred at -78 mV and the reversal potential was -40 mV. I-h was inhibited by Cs+ (1-5 mm) and by organic blockers N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine (ZD 7288; 0.3-3 mu m) and N,N'-bis-(3,4-dimethylphenylethyl)-N-methylamine (YS 035, 3-30 mu m), but not by Ba2+ (0.5 mm). The organic I-h blockers did not change the inspiratory bursts recorded from the XIIth nerve and synaptic drives in inspiratory neurons. Hypoxia reversibly inhibited I-h but, in the presence of organic blockers, the hypoxic reaction remained unchanged. We conclude that although I-h channels are functional in a minority of inspiratory neurons, I-h does not contribute to respiratory rhythm generation or its modulation by hypoxia."],["dc.identifier.doi","10.1046/j.1460-9568.2000.00928.x"],["dc.identifier.isi","000085927900010"],["dc.identifier.pmid","10712631"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42035"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Science Ltd"],["dc.relation.issn","0953-816X"],["dc.title","Hyperpolarization-activated current, I-h, in inspiratory brainstem neurons and its inhibition by hypoxia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]