Behr, Rüdiger

[["dc.bibliographiccitation.firstpage","3207"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Wahab, Fazal"],["dc.contributor.author","Rodriguez Polo, Ignacio"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2022-10-06T13:26:50Z"],["dc.date.available","2022-10-06T13:26:50Z"],["dc.date.issued","2021"],["dc.description.abstract","The epigenetic mechanisms controlling germ cell development and differentiation are still not well understood. Sirtuin-1 (SIRT1) is a nicotinamide adenosine dinucleotide (NAD)-dependent histone deacetylase and belongs to the sirtuin family of deacetylases. It catalyzes the removal of acetyl groups from a number of protein substrates. Some studies reported a role of SIRT1 in the central and peripheral regulation of reproduction in various non-primate species. However, testicular SIRT1 expression and its possible role in the testis have not been analyzed in primates. Here, we document expression of SIRT1 in testes of different primates and some non-primate species. SIRT1 is expressed mainly in the cells of seminiferous tubules, particularly in germ cells. The majority of SIRT1-positive germ cells were in the meiotic and postmeiotic phase of differentiation. However, SIRT1 expression was also observed in selected premeiotic germ cells, i.e., spermatogonia. SIRT1 co-localized in spermatogonia with irisin, an endocrine factor specifically expressed in primate spermatogonia. In marmoset testicular explant cultures, SIRT1 transcript levels are upregulated by the addition of irisin as compared to untreated controls explants. Rhesus macaques are seasonal breeders with high testicular activity in winter and low testicular activity in summer. Of note, SIRT1 mRNA and SIRT1 protein expression are changed between nonbreeding (low spermatogenesis) and breeding (high spermatogenesis) season. Our data suggest that SIRT1 is a relevant factor for the regulation of spermatogenesis in primates. Further mechanistic studies are required to better understand the role of SIRT1 during spermatogenesis."],["dc.identifier.doi","10.3390/ijms22063207"],["dc.identifier.pii","ijms22063207"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115177"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1422-0067"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","SIRT1 Expression and Regulation in the Primate Testis"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","175"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Endocrinology"],["dc.bibliographiccitation.lastpage","187"],["dc.bibliographiccitation.volume","241"],["dc.contributor.author","Wahab, Fazal"],["dc.contributor.author","Khan, Ikram Ullah"],["dc.contributor.author","Polo, Ignacio Rodriguez"],["dc.contributor.author","Zubair, Hira"],["dc.contributor.author","Drummer, Charis"],["dc.contributor.author","Shahab, Muhammad"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2022-10-06T13:26:25Z"],["dc.date.available","2022-10-06T13:26:25Z"],["dc.date.issued","2019"],["dc.description.abstract","Irisin, encoded by the\n FNDC5\n gene, is a recently discovered endocrine factor mainly secreted as a myokine and adipokine. However, irisin/\n FNDC5\n expression has also been reported in different other organs including components of the reproductive axis. Yet, there is the scarcity of data on\n FNDC5\n /irisin expression, regulation and its reproductive effects, particularly in primates. Here, we report the expression of\n FNDC5\n /irisin, along with\n PGC1A\n (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) and\n ERRA\n (estrogen-related receptor alpha), in components of the reproductive axis of marmoset monkeys. Hypothalamic\n FNDC5\n and\n ERRA\n transcript levels are developmentally regulated in both male and female. We further uncovered sex-specific differences in\n FNDC5\n ,\n ERRA\n and\n PGC1A\n expression in muscle and the reproductive axis. Moreover, irisin and ERRα co-localize in the marmoset hypothalamus. Additionally, in the arcuate nucleus of rhesus monkeys, the number of irisin+ cells was significantly increased in short-term fasted monkeys as compared to\n ad libitum\n -fed monkeys. More importantly, we observed putative interaction of irisin-immunoreactive fibers and few GnRH\n -\n immunoreactive cell bodies in the mediobasal hypothalamus of the rhesus monkeys. Functionally, we noted a stimulatory effect of irisin on GnRH synthesis and release in mouse hypothalamic neuronal GT1-7 cells. In summary, our findings show that\n FNDC5\n and irisin are developmentally, metabolic-status dependently and sex-specifically expressed in the primate hypothalamic–pituitary–gonadal axis and exert a stimulatory effect on GnRH expression and release in mouse hypothalamic cells. Further studies are required to confirm the reproductive effects of irisin\n in vivo\n and to illuminate the mechanisms of its regulation."],["dc.identifier.doi","10.1530/JOE-18-0574"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115084"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1479-6805"],["dc.relation.issn","0022-0795"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Irisin in the primate hypothalamus and its effect on GnRH in vitro"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","21"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Reviews Urology"],["dc.bibliographiccitation.lastpage","32"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Wahab, Fazal"],["dc.contributor.author","Atika, Bibi"],["dc.contributor.author","Shahab, Muhammad"],["dc.contributor.author","Behr, Ruediger"],["dc.date.accessioned","2018-11-07T10:21:36Z"],["dc.date.available","2018-11-07T10:21:36Z"],["dc.date.issued","2016"],["dc.description.abstract","Kisspeptin is a peptide hormone, which signals via the G-protein-coupled kisspeptin receptor (KISS1R). Kisspeptin-KISS1R signalling has been implicated in various physiological and pathophysiological processes in the urogenital system, including critical roles in ovarian function as a key player in the regulation of oocyte development. Kisspeptin also has roles in several different functions of the male reproductive tract, such as spermatogenesis and sperm capacitation, and is also thought to be involved in kidney physiology-studies in preclinical animal models have reported that expression of kisspeptin and/or KISS1R is altered in chronically impaired kidneys. The wider importance of kisspeptin action in the urogenital tract has been highlighted by the finding that it suppresses metastasis of urogenital carcinomas; besides the possible therapeutic potential of this finding, tissue and tumour-stage-specific alterations in kisspeptin and KISS1/KISS1R expression could potentially be used as biomarkers for the diagnosis and prognosis of urogenital carcinomas."],["dc.identifier.doi","10.1038/nrurol.2015.277"],["dc.identifier.isi","000367655300004"],["dc.identifier.pmid","26620614"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42125"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1759-4820"],["dc.relation.issn","1759-4812"],["dc.title","Kisspeptin signalling in the physiology and pathophysiology of the urogenital system"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","110670"],["dc.bibliographiccitation.journal","Molecular and Cellular Endocrinology"],["dc.bibliographiccitation.volume","504"],["dc.contributor.author","Wahab, Fazal"],["dc.contributor.author","Drummer, Charis"],["dc.contributor.author","Mätz-Rensing, Kerstin"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2022-10-06T13:33:14Z"],["dc.date.available","2022-10-06T13:33:14Z"],["dc.date.issued","2020"],["dc.description.sponsorship"," http://dx.doi.org/10.13039/100005156 Alexander von Humboldt Foundation"],["dc.description.sponsorship"," http://dx.doi.org/10.13039/501100004938 German Primate Center"],["dc.identifier.doi","10.1016/j.mce.2019.110670"],["dc.identifier.pii","S0303720719303727"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115584"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0303-7207"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Irisin is expressed by undifferentiated spermatogonia and modulates gene expression in organotypic primate testis cultures"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","R780"],["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","Current Biology"],["dc.bibliographiccitation.lastpage","R782"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Wahab, Fazal"],["dc.contributor.author","Drummer, Charis"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2022-10-06T13:33:03Z"],["dc.date.available","2022-10-06T13:33:03Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1016/j.cub.2015.06.042"],["dc.identifier.pii","S0960982215007368"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115533"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0960-9822"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Marmosets"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","8447"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Molecular Neurobiology"],["dc.bibliographiccitation.lastpage","8457"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Wahab, Fazal"],["dc.contributor.author","Drummer, Charis"],["dc.contributor.author","Schlatt, Stefan"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2022-10-06T13:32:34Z"],["dc.date.available","2022-10-06T13:32:34Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1007/s12035-016-0329-x"],["dc.identifier.pii","329"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115409"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1559-1182"],["dc.relation.issn","0893-7648"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0"],["dc.title","Dynamic Regulation of Hypothalamic DMXL2, KISS1, and RFRP Expression During Postnatal Development in Non-Human Primates"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Endocrinology"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Wahab, Fazal"],["dc.contributor.author","Atika, Bibi"],["dc.contributor.author","Ullah, Farhad"],["dc.contributor.author","Shahab, Muhammad"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2020-12-10T18:44:22Z"],["dc.date.available","2020-12-10T18:44:22Z"],["dc.date.issued","2018"],["dc.description.abstract","A large body of data has established the hypothalamic kisspeptin (KP) and its receptor, KISS1R, as major players in the activation of the neuroendocrine reproductive axis at the time of puberty and maintenance of reproductive capacity in the adult. Due to its strategic location, this ligand-receptor pair acts as an integrator of cues from gonadal steroids as well as of circadian and seasonal variation-related information on the reproductive axis. Besides these cues, the activity of the hypothalamic KP signaling is very sensitive to the current metabolic status of the body. In conditions of energy imbalance, either positive or negative, a number of alterations in the hypothalamic KP signaling pathway have been documented in different mammalian models including nonhuman primates and human. Deficiency of metabolic fuels during fasting causes a marked reduction of Kiss1 gene transcript levels in the hypothalamus and, hence, decreases the output of KP-containing neurons. Food intake or exogenous supply of metabolic cues, such as leptin, reverses metabolic insufficiency-related changes in the hypothalamic KP signaling. Likewise, alterations in Kiss1 expression have also been reported in other situations of energy imbalance like diabetes and obesity. Information related to the body’s current metabolic status reaches to KP neurons both directly as well as indirectly via a complex network of other neurons. In this review article, we have provided an updated summary of the available literature on the regulation of the hypothalamic KP-Kiss1r signaling by metabolic cues. In particular, the potential mechanisms of metabolic impact on the hypothalamic KP-Kiss1r signaling, in light of available evidence, are discussed."],["dc.identifier.doi","10.3389/fendo.2018.00123"],["dc.identifier.eissn","1664-2392"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78424"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-2392"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Medical Hypotheses"],["dc.bibliographiccitation.lastpage","4"],["dc.bibliographiccitation.volume","95"],["dc.contributor.author","Wahab, Fazal"],["dc.contributor.author","Shahab, Muhammad"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2022-10-06T13:33:15Z"],["dc.date.available","2022-10-06T13:33:15Z"],["dc.date.issued","2016"],["dc.description.sponsorship"," https://doi.org/10.13039/501100004938 DPZ"],["dc.identifier.doi","10.1016/j.mehy.2016.08.003"],["dc.identifier.pii","S0306987716304571"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115588"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0306-9877"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Hypothesis: Irisin is a metabolic trigger for the activation of the neurohormonal axis governing puberty onset"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]