Malzahn, Dörthe

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Biological Psychiatry"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Kaestner, Anne"],["dc.contributor.author","Malzahn, Doerthe"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2018-11-07T09:11:08Z"],["dc.date.available","2018-11-07T09:11:08Z"],["dc.date.issued","2012"],["dc.format.extent","87S"],["dc.identifier.isi","000302466000276"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26656"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","67th Annual Meeting of the Society-of-Biological-Psychiatry"],["dc.relation.eventlocation","Philadelphia, PA"],["dc.relation.issn","0006-3223"],["dc.title","Introducing ORNI, the 'Odor Recognition, Naming and Interpretation Test', a Simple and Specific Measure of Sensory-Cognitive-Emotional Processing in Schizophrenia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","5523"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The Journal of Immunology"],["dc.bibliographiccitation.lastpage","5533"],["dc.bibliographiccitation.volume","179"],["dc.contributor.author","Elsner, Leslie"],["dc.contributor.author","Muppala, Vijayakumar"],["dc.contributor.author","Gehrmann, Mathias"],["dc.contributor.author","Lozano, Jingky"],["dc.contributor.author","Malzahn, Dörthe"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","Zientkowska, Marta"],["dc.contributor.author","Herrmann, Thomas"],["dc.contributor.author","Walter, Lutz"],["dc.contributor.author","Dressel, Ralf"],["dc.date.accessioned","2022-06-08T07:57:36Z"],["dc.date.available","2022-06-08T07:57:36Z"],["dc.date.issued","2007"],["dc.description.abstract","The stress-inducible heat shock protein (HSP) 70 is known to function as an endogenous danger signal that can increase the immunogenicity of tumors and induce CTL responses. We show in this study that HSP70 also activates mouse NK cells that recognize stress-inducible NKG2D ligands on tumor cells. Tumor size and the rate of metastases derived from HSP70-overexpressing human melanoma cells were found to be reduced in T and B cell-deficient SCID mice, but not in SCID/beige mice that lack additionally functional NK cells. In the SCID mice with HSP70-overexpressing tumors, NK cells were activated so that they killed ex vivo tumor cells that expressed NKG2D ligands. In the tumors, the MHC class I chain-related (MIC) A and B molecules were found to be expressed. Interestingly, a counter selection was observed against the expression of MICA/B in HSP70-overexpressing tumors compared with control tumors in SCID, but not in SCID/beige mice, suggesting a functional relevance of MICA/B expression. The melanoma cells were found to release exosomes. HSP70-positive exosomes from the HSP70-overexpressing cells, in contrast to HSP70-negative exosomes from the control cells, were able to activate mouse NK cells in vitro to kill YAC-1 cells, which express NKG2D ligands constitutively, or the human melanoma cells, in which MICA/B expression was induced. Thus, HSP70 and inducible NKG2D ligands synergistically promote the activation of mouse NK cells resulting in a reduced tumor growth and suppression of metastatic disease."],["dc.identifier.doi","10.4049/jimmunol.179.8.5523"],["dc.identifier.isi","000250099400061"],["dc.identifier.pmid","17911639"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110150"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.eissn","1550-6606"],["dc.relation.issn","0022-1767"],["dc.title","The Heat Shock Protein HSP70 Promotes Mouse NK Cell Activity against Tumors That Express Inducible NKG2D Ligands"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","487"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.lastpage","488"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Malzahn, D."],["dc.contributor.author","Neumann, A."],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Wichmann, Heinz-Erich"],["dc.contributor.author","Bickeboeller, Heike"],["dc.date.accessioned","2018-11-07T11:00:59Z"],["dc.date.available","2018-11-07T11:00:59Z"],["dc.date.issued","2007"],["dc.identifier.isi","000247603700139"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51053"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.publisher.place","Hoboken"],["dc.relation.conference","15th Annual Meeting of the International-Genetic-Epidemiology-Society"],["dc.relation.eventlocation","St Petersburg, FL"],["dc.title","A non-parametric approach to detect gene-gene and gene-time interaction for longitudinal data in cohort studies"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S37"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.lastpage","S43"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Chen, Han"],["dc.contributor.author","Malzahn, Doerthe"],["dc.contributor.author","Balliu, Brunilda"],["dc.contributor.author","Li, Cong"],["dc.contributor.author","Bailey, Julia N."],["dc.date.accessioned","2018-11-07T09:36:08Z"],["dc.date.available","2018-11-07T09:36:08Z"],["dc.date.issued","2014"],["dc.description.abstract","With the advance of next-generation sequencing technologies in recent years, rare genetic variant data have now become available for genetic epidemiology studies. For family samples, however, only a few statistical methods for association analysis of rare genetic variants have been developed. Rare variant approaches are of great interest, particularly for family data, because samples enriched for trait-relevant variants can be ascertained and rare variants are putatively enriched through segregation. To facilitate the evaluation of existing and new rare variant testing approaches for analyzing family data, Genetic Analysis Workshop 18 (GAW18) provided genotype and next-generation sequencing data and longitudinal blood pressure traits from extended pedigrees of Mexican American families from the San Antonio Family Study. Our GAW18 group members analyzed real and simulated phenotype data from GAW18 by using generalized linear mixed-effects models or principal components to adjust for familial correlation or by testing binary traits using a correction factor for familial effects. With one exception, approaches dealt with the extended pedigrees in their original state using information based on the kinship matrix or alternative genetic similarity measures. For simulated data our group demonstrated that the familybased kernel machine score test is superior in power to family-based single-marker or burden tests, except in a few specific scenarios. For real data three contributions identified significant associations. They substantially reduced the number of tests before performing the association analysis. We conclude from our real data analyses that further development of strategies for targeted testing or more focused screening of genetic variants is strongly desirable. (C) 2014 Wiley Periodicals, Inc."],["dc.identifier.doi","10.1002/gepi.21823"],["dc.identifier.isi","000340610500006"],["dc.identifier.pmid","25112186"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32543"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1098-2272"],["dc.relation.issn","0741-0395"],["dc.title","Testing Genetic Association With Rare and Common Variants in Family Data"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","150"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Journal of Infectious Diseases"],["dc.bibliographiccitation.lastpage","158"],["dc.bibliographiccitation.volume","215"],["dc.contributor.author","Ribes, Sandra"],["dc.contributor.author","Nessler, Stefan"],["dc.contributor.author","Heide, Ev-Christin"],["dc.contributor.author","Malzahn, Dörthe"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Nau, Roland"],["dc.date.accessioned","2018-11-07T10:28:48Z"],["dc.date.available","2018-11-07T10:28:48Z"],["dc.date.issued","2017"],["dc.description.abstract","Background. The adaptive immune system has been considered to play a minimal role in the early host response during bacterial meningitis. Methods. We investigated the progression and outcome of pneumococcal meningitis in Rag1(-/-) mice lacking functional B and T cells by assessing overall and symptom-free survival, bacteriological and histological studies, as well as flow cytometry and measurements of proinflammatory mediators. Results. The intracerebral injection of S. pneumoniae D39 induced the recruitment of B and T cells (CD4+, gamma delta and natural killer) into the brain of wild-type mice. Mice with no functional B and T cells developed clinical symptoms and succumbed to the infection earlier than the wild-type group. In the CNS, Rag1(-/-) mice showed lower levels of interleukin 1 beta, reduced microglial proliferation, and impaired granulocyte recruitment with an earlier spread of pneumococci into the bloodstream, compared with wild-type mice. Lack of B and T cells resulted in a severe impairment of bacterial clearance in blood, spleen, and liver and an exaggerated systemic inflammatory response. Conclusions. B and T cells are important effector cells delaying the spread of pneumococci from the brain to the systemic circulation and shaping the immune response, thereby prolonging the survival of the host in the absence of antibiotic treatment."],["dc.identifier.doi","10.1093/infdis/jiw517"],["dc.identifier.isi","000397203500022"],["dc.identifier.pmid","27803171"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43504"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1537-6613"],["dc.relation.issn","0022-1899"],["dc.title","The Early Adaptive Immune Response in the Pathophysiological Process of Pneumococcal Meningitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S951"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Adorjan, Kristina"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Malzahn, Dörthe"],["dc.contributor.author","Sherva, Richard"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Aldinger, Fanny"],["dc.contributor.author","Kalman, Janos"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Anderson-Schmidt, Heike"],["dc.contributor.author","Pogarell, Oliver"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gelernter, Joel"],["dc.contributor.author","Schulze, Thomas"],["dc.date.accessioned","2020-12-10T14:23:55Z"],["dc.date.available","2020-12-10T14:23:55Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.euroneuro.2017.08.302"],["dc.identifier.issn","0924-977X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72073"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","POLYGENIC RISK BURDEN AND CANNABIS USE COMORBIDITY IN PATIENTS WITH SCHIZOPHRENIA AND BIPOLAR DISORDER"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","337"],["dc.bibliographiccitation.issue","2-3"],["dc.bibliographiccitation.journal","Schizophrenia Research"],["dc.bibliographiccitation.lastpage","338"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Klaus, Sabrina"],["dc.contributor.author","Begemann, Martin"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Malzahn, Doerthe"],["dc.contributor.author","Friedrichs, Heidi"],["dc.contributor.author","Ribbe, Katja"],["dc.contributor.author","El-Kordi, Ahmed"],["dc.contributor.author","Radyushkin, Konstantin A."],["dc.contributor.author","Benseler, Fritz"],["dc.contributor.author","Reim, Kerstin"],["dc.contributor.author","Riggert, Joachim"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Brose, Nils"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2018-11-07T08:44:54Z"],["dc.date.available","2018-11-07T08:44:54Z"],["dc.date.issued","2010"],["dc.identifier.isi","000276936800585"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20301"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.publisher.place","Amsterdam"],["dc.relation.eventlocation","Florence, ITALY"],["dc.relation.issn","0920-9964"],["dc.title","Complexin2 Gene Polymorphisms Modify Cognitive Performance in Schizophrenia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Annals of Human Genetics"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Viktorova, Elena"],["dc.contributor.author","Malzahn, Doerthe"],["dc.contributor.author","Balavarca, Yesilda"],["dc.contributor.author","Isernhagen, Antje"],["dc.contributor.author","von Bonin, Frederike"],["dc.contributor.author","Michael, Janne"],["dc.contributor.author","Wulf, Gerald"],["dc.contributor.author","Kube, Dieter"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Bickeboeller, Heike"],["dc.date.accessioned","2018-11-07T09:06:11Z"],["dc.date.available","2018-11-07T09:06:11Z"],["dc.date.issued","2012"],["dc.format.extent","433"],["dc.identifier.isi","000307377000064"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25495"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","European Mathematical Genetics Meeting"],["dc.relation.eventlocation","Gottingen, GERMANY"],["dc.relation.issn","0003-4800"],["dc.title","Association of MICA-129 genotype with common risks of hematopoietic stem cell transplantation (HSCT)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1217"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","European Journal of Human Genetics"],["dc.bibliographiccitation.lastpage","1224"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Malzahn, Doerthe"],["dc.contributor.author","Mueller-Nurasyid, Martina"],["dc.contributor.author","Heid, Iris M."],["dc.contributor.author","Wichmann, H-Erich"],["dc.contributor.author","Bickeboeller, Heike"],["dc.date.accessioned","2018-11-07T09:34:45Z"],["dc.date.available","2018-11-07T09:34:45Z"],["dc.date.issued","2014"],["dc.description.abstract","Among the single-nucleotide polymorphisms (SNPs) previously reported to be associated with body Mass index (BMI) and obesity, we focus on a common risk variant rs7566605 upstream of the insulin-induced gene 2 (INSIG2) gene and a rare protective variant rs2229616 on the melanocortin-4 receptor (MC4R) gene. INSIG2 is involved in adipogenesis and MC4R effects hormonal appetite control in response to the amount of adipose tissue. The influence of rs2229616 (MC4R) on BMI and obesity has been confirmed repeatedly and insight into the underlying mechanism provided. However, a main effect of rs7566605 (INSIG2) is under debate because of inconsistent replications of association. Interaction of rs7566605 with age may offer an explanation. SNP-age and SNP-SNP interaction models were tested on independent individuals from three population-based longitudinal cohorts, restricting the analysis to an observed age of 25-74 years. KORA S3/F3, KORA S4/F4 (Augsburg, Germany, 1994-2005, 1999-2008), and Framingham-Offspring data (Framingham, USA, 1971-2001) were analysed, with a total sample size of N=6926 in the joint analysis. The effect of interaction between rs7566605 and age on BMI and obesity status is significant and consistent across studies. This new evidence for rs7566605 (INSIG2) complements previous research. In addition, the interaction effect of rs7566605 with the MC4R variant rs2229616 on BMI was observed. This effect size was three times larger than that in a previously reported single-locus main effect of rs2229616. This leads to the conclusion that SNP-age or SNP-SNP interactions can mask genetic effects for complex diseases if left unaccounted for."],["dc.identifier.doi","10.1038/ejhg.2014.3"],["dc.identifier.isi","000342476100010"],["dc.identifier.pmid","24518831"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32241"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1476-5438"],["dc.relation.issn","1018-4813"],["dc.title","Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","237"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The World Journal of Biological Psychiatry"],["dc.bibliographiccitation.lastpage","248"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Malzahn, Doerthe"],["dc.contributor.author","Anderson-Schmidt, Heike"],["dc.contributor.author","Strohmaier, Jana"],["dc.contributor.author","Meier, Sandra"],["dc.contributor.author","Frank, Josef"],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Schulze, Thomas G."],["dc.date.accessioned","2018-11-07T09:56:47Z"],["dc.date.available","2018-11-07T09:56:47Z"],["dc.date.issued","2015"],["dc.description.abstract","Objectives. Functional outcome has recently become of interest for cross-diagnostic subphenotype approaches in psychiatric genetics. Therefore, it is crucial to know about clinical, demographic and psychosocial variables that correlate with long-term functioning. Unfortunately, there is a lack of studies that directly compare the importance of correlates for functional outcome between different disorders. Methods. Applying regression models to samples of patients with schizophrenia (SZ, n = 238), bipolar disorder (BD, n = 533) and major depressive disorder (MDD, n = 398), we compared the magnitude of association of potential correlates with functional outcome, measured by the Global Assessment of Functioning (GAF) score. Results. Shared correlates for worse functional outcome were poor premorbid functioning, insidious illness onset and poor premorbid work or social adjustment in all three disorders, and negative symptomatology in SZ and BD. Disorder-specific correlates for SZ were longer duration of illness, lower functioning during episodes and being life-time single, for BD substance abuse and suicidality, and for MDD premorbid unemployment and having a premorbid personality disorder. Conclusions. We found different patterns of correlates for long-term functioning in SZ, BD and MDD. Knowledge of these patterns may improve the quality of genetic investigations focussing on functional outcome."],["dc.identifier.doi","10.3109/15622975.2014.995221"],["dc.identifier.isi","000354811400004"],["dc.identifier.pmid","25771936"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37032"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.relation.issn","1814-1412"],["dc.relation.issn","1562-2975"],["dc.title","Functional outcome in major psychiatric disorders and associated clinical and psychosocial variables: A potential cross-diagnostic phenotype for further genetic investigations?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]