Rublack, Jennifer

[["dc.bibliographiccitation.firstpage","302"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal Of Clinical Periodontology"],["dc.bibliographiccitation.lastpage","310"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Rublack, Jennifer"],["dc.contributor.author","Foerster, Anne"],["dc.contributor.author","Schwenzer, Bernd"],["dc.contributor.author","Reichert, Judith"],["dc.contributor.author","Scharnweber, Dieter"],["dc.date.accessioned","2018-11-07T10:00:17Z"],["dc.date.available","2018-11-07T10:00:17Z"],["dc.date.issued","2015"],["dc.description.abstract","Aims: To test the immobilization of vascular endothelial growth factor (VEGF(165)) on the surface of titanium implants using DNA oligonucleotide (ODN) anchor strands for the ability to enhance periimplant bone formation. Materials and Methods: DNA oligonucleotides were anchored to the surface of sandblasted acid-etched (SAE) titanium screw implants and were hybridized with complementary strands of ODN conjugated to rhVEGF(165). The implants were tested against blank SAE implants and SAE implants with nano-anchored ODN. The implants were inserted into the tibiae of 36 Sprague-Dawley rats. Primary outcome parameters were bone-implant contact (BIC), amount of new bone formation and periimplant bone density (BD). density after 1, 4 and 13 weeks. Unit of analysis has been the individual implant. Results: Implants with rhVEGF165 hybridized to ODN anchor strands exhibited significantly increased average BIC after 1 month compared to blank implants and implants with anchored ODN strands. Conclusions: It is concluded that rhVEGF(165)immobilized on the surface of titanium implants through nano-anchored oligonucleotide strands can accelerate BIC of sandblasted and etched titanium implants to a certain extent. The radius of effect of the growth factor appears to be limited to tissue immediately adjacent to the implant surface."],["dc.identifier.doi","10.1111/jcpe.12370"],["dc.identifier.isi","000351303600011"],["dc.identifier.pmid","25640057"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37772"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1600-051X"],["dc.relation.issn","0303-6979"],["dc.title","Functionalization of titanium implants using a modular system for binding and release of VEGF enhances bone-implant contact in a rodent model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e175"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The International Journal of Oral and Maxillofacial Implants"],["dc.bibliographiccitation.lastpage","e182"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Böhrnsen, Florian"],["dc.contributor.author","Rublack, Jennifer"],["dc.contributor.author","Aeckerle, Nelia"],["dc.contributor.author","Foerster, Anne"],["dc.contributor.author","Schwenzer, Bernd"],["dc.contributor.author","Reichert, Judith"],["dc.contributor.author","Scharnweber, Dieter"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-06-26T06:41:11Z"],["dc.date.available","2018-06-26T06:41:11Z"],["dc.date.issued","2017"],["dc.description.abstract","Previous in vitro studies have shown that DNA oligonucleotides (ODN) can be successfully used as anchor strands for the binding and retarded release of biologically active recombinant human bone morphogenetic protein 2 (rhBMP-2). The aim of the present study was to test the hypothesis that rhBMP-2 bound to the surface of titanium implants through hybridization with nano-anchored ODN strands is biologically active and can enhance the induction of osteogenic markers in peri-implant bone in vivo."],["dc.fs.pkfprnr","87299"],["dc.identifier.doi","10.11607/jomi.5256"],["dc.identifier.fs","626953"],["dc.identifier.pmid","28212453"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15146"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1942-4434"],["dc.title","Bone Morphogenetic Protein-2 Hybridized with Nano-Anchored Oligonucleotides on Titanium Implants Enhances Osteogenic Differentiation In Vivo"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","28"],["dc.bibliographiccitation.journal","European Cells and Materials"],["dc.bibliographiccitation.lastpage","40"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Schliephake, H"],["dc.contributor.author","Rublack, J"],["dc.contributor.author","Aeckerle, N"],["dc.contributor.author","Förster, A"],["dc.contributor.author","Schwenzer, B"],["dc.contributor.author","Reichert, J"],["dc.contributor.author","Scharnweber, D"],["dc.contributor.authorgroup","Dept. of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str 40, 37075 Göttingen, Germany"],["dc.date.accessioned","2021-06-01T10:48:38Z"],["dc.date.available","2021-06-01T10:48:38Z"],["dc.date.issued","2015"],["dc.description.abstract","The aim of the present study was to test the hypothesis that immobilisation of bone morphogenic proteins on the surface of titanium implants through nano-anchored oligonucleotides can enhance peri-implant bone formation. Non-coding 60-mer DNA oligonucleotides (ODN) were anchored to the surface of custom made sandblasted acid etched (SAE) titanium screw implants through anodic polarisation, gamma-sterilised with a standard dose of 25 kGy, and were hybridised with complementary 30-mer strands of DNA oligonucleotides conjugated to rhBMP2. Blank SAE implants, SAE implants with nano-anchored ODN and SAE implants with nano-anchored ODN and non-conjugated rhBMP2 served as controls. The implants were inserted into the tibiae of 36 Sprague Dawley rats. Perforations at the head and the tip of the implants allowed for bone ingrowth. Bone ingrowth into perforations and bone implant contact (BIC) as well as bone density (BD) at a distance of 200 mu m from the implant surface were assessed after 1, 4 and 13 weeks. Implants with nano-anchored ODN strands hybridised with conjugated rhBMP2 exhibited enhanced bone ingrowth into the perforations and increased BIC after 1 week as well as increased BIC after 4 weeks compared to controls. No difference was seen after 13 weeks. Bone density around the outer implant surface did not differ significantly at any of the intervals. It is concluded that rhBMP2 immobilised on the surface of titanium implants through nano-anchored oligonucleotide strands can enhance bone implant contact. The conditions of sterilisation tested allowed for handling under clinically relevant conditions."],["dc.identifier.doi","10.22203/eCM.v030a03"],["dc.identifier.isi","000366141600003"],["dc.identifier.pmid","26214288"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86005"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ao Research Institute Davos-ari"],["dc.relation.issn","1473-2262"],["dc.title","In vivo effect of immobilisation of bone morphogenic protein 2 on titanium implants through nano-anchored oligonucleotides"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]