Gross, Julia Christina

[["dc.bibliographiccitation.firstpage","e202000855"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Life Science Alliance"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Lin, Yu-Chih"],["dc.contributor.author","Haas, Alexander"],["dc.contributor.author","Bufe, Anja"],["dc.contributor.author","Parbin, Sabnam"],["dc.contributor.author","Hennecke, Magdalena"],["dc.contributor.author","Voloshanenko, Oksana"],["dc.contributor.author","Gross, Julia"],["dc.contributor.author","Boutros, Michael"],["dc.contributor.author","Acebron, Sergio P"],["dc.contributor.author","Bastians, Holger"],["dc.date.accessioned","2021-04-14T08:29:53Z"],["dc.date.available","2021-04-14T08:29:53Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.26508/lsa.202000855"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83017"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2575-1077"],["dc.title","Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","17"],["dc.bibliographiccitation.lastpage","28"],["dc.bibliographiccitation.seriesnr","1481"],["dc.contributor.author","Glaeser, Kathrin"],["dc.contributor.author","Boutros, Michael"],["dc.contributor.author","Gross, Julia Christina"],["dc.contributor.editor","Barrett, Quinn"],["dc.contributor.editor","Lum, Lawrence"],["dc.date.accessioned","2021-06-02T10:44:25Z"],["dc.date.available","2021-06-02T10:44:25Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1007/978-1-4939-6393-5_3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87029"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Springer New York"],["dc.publisher.place","New York, NY"],["dc.relation.crisseries","Methods in Molecular Biology"],["dc.relation.eisbn","978-1-4939-6393-5"],["dc.relation.isbn","978-1-4939-6391-1"],["dc.relation.ispartof","Methods in Molecular Biology"],["dc.relation.ispartof","Wnt Signaling"],["dc.relation.ispartofseries","Methods in Molecular Biology; 1481"],["dc.title","Biochemical Methods to Analyze Wnt Protein Secretion"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","43"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Worst, Thomas Stefan"],["dc.contributor.author","Previti, Christopher"],["dc.contributor.author","Nitschke, Katja"],["dc.contributor.author","Diessl, Nicolle"],["dc.contributor.author","Gross, Julia Christina"],["dc.contributor.author","Hoffmann, Lena"],["dc.contributor.author","Frey, Lisa"],["dc.contributor.author","Thomas, Vanessa"],["dc.contributor.author","Kahlert, Christoph"],["dc.contributor.author","Bieback, Karen"],["dc.contributor.author","Torres Crigna, Adriana"],["dc.contributor.author","Fricke, Fabia"],["dc.contributor.author","Porubsky, Stefan"],["dc.contributor.author","Westhoff, Niklas"],["dc.contributor.author","von Hardenberg, Jost"],["dc.contributor.author","Nuhn, Philipp"],["dc.contributor.author","Erben, Philipp"],["dc.contributor.author","Michel, Maurice Stephan"],["dc.contributor.author","Boutros, Michael"],["dc.date.accessioned","2020-12-10T18:46:58Z"],["dc.date.available","2020-12-10T18:46:58Z"],["dc.date.issued","2020"],["dc.description.sponsorship","German Society of Urology"],["dc.identifier.doi","10.3390/cancers12010043"],["dc.identifier.eissn","2072-6694"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78598"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.publisher","MDPI"],["dc.relation.eissn","2072-6694"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","miR-10a-5p and miR-29b-3p as Extracellular Vesicle-Associated Prostate Cancer Detection Markers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1378056"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Extracellular Vesicles"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Menck, Kerstin"],["dc.contributor.author","Sönmezer, Can"],["dc.contributor.author","Worst, Thomas Stefan"],["dc.contributor.author","Schulz, Matthias"],["dc.contributor.author","Dihazi, Gry Helene"],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Erdmann, Gerrit"],["dc.contributor.author","Kling, Simon"],["dc.contributor.author","Boutros, Michael"],["dc.contributor.author","Binder, Claudia"],["dc.contributor.author","Gross, Julia Christina"],["dc.date.accessioned","2019-07-09T11:45:57Z"],["dc.date.available","2019-07-09T11:45:57Z"],["dc.date.issued","2017"],["dc.description.abstract","Extracellular vesicles (EVs) are membrane particles secreted from cells into all body fluids. Several EV populations exist differing in size and cellular origin. Using differential centrifugation EVs pelleting at 14,000 g (\"microvesicles\" (MV)) and 100,000 g (\"exosomes\") are distinguishable by protein markers. Neutral sphingomyelinase (nSMase) inhibition has been shown to inhibit exosome release from cells and has since been used to study their functional implications. How nSMases (also known as SMPD2 and SMPD3) affect the basal secretion of MVs is unclear. Here we investigated how SMPD2/3 impact both EV populations. SMPD2/3 inhibition by GW4869 or RNAi decreases secretion of exosomes, but also increases secretion of MVs from the plasma membrane. Both populations differ significantly in metabolite composition and Wnt proteins are specifically loaded onto MVs under these conditions. Taken together, our data reveal a novel regulatory function of SMPD2/3 in vesicle budding from the plasma membrane and clearly suggest that - despite the different vesicle biogenesis - the routes of vesicular export are adaptable."],["dc.identifier.doi","10.1080/20013078.2017.1378056"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15354"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59345"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2001-3078"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.subject.ddc","610"],["dc.title","Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","8759"],["dc.bibliographiccitation.issue","26"],["dc.bibliographiccitation.journal","Journal of Biological Chemistry"],["dc.bibliographiccitation.lastpage","8774"],["dc.bibliographiccitation.volume","295"],["dc.contributor.author","Wesslowski, Janine"],["dc.contributor.author","Kozielewicz, Pawel"],["dc.contributor.author","Wang, Xianxian"],["dc.contributor.author","Cui, Haijun"],["dc.contributor.author","Schihada, Hannes"],["dc.contributor.author","Kranz, Dominique"],["dc.contributor.author","Karuna M, Pradhipa"],["dc.contributor.author","Levkin, Pavel"],["dc.contributor.author","Gross, Julia Christina"],["dc.contributor.author","Boutros, Michael"],["dc.contributor.author","Schulte, Gunnar"],["dc.contributor.author","Davidson, Gary"],["dc.date.accessioned","2021-04-14T08:25:37Z"],["dc.date.available","2021-04-14T08:25:37Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1074/jbc.RA120.012892"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81688"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0021-9258"],["dc.title","eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","UNSP M117.068577"],["dc.bibliographiccitation.firstpage","998"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Molecular & Cellular Proteomics"],["dc.bibliographiccitation.lastpage","1008"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Worst, Thomas Stefan"],["dc.contributor.author","von Hardenberg, Jost"],["dc.contributor.author","Gross, Julia Christina"],["dc.contributor.author","Erben, Philipp"],["dc.contributor.author","Schnoelzer, Martina"],["dc.contributor.author","Hausser, Ingrid"],["dc.contributor.author","Bugert, Peter"],["dc.contributor.author","Michel, Maurice Stephan"],["dc.contributor.author","Boutros, Michael"],["dc.date.accessioned","2018-11-07T10:23:18Z"],["dc.date.available","2018-11-07T10:23:18Z"],["dc.date.issued","2017"],["dc.description.abstract","In prostate cancer and other malignancies sensitive and robust biomarkers are lacking or have relevant limitations. Prostate specific antigen (PSA), the only biomarker widely used in prostate cancer, is suffering from low specificity. Exosomes offer new perspectives in the discovery of blood-based biomarkers. Here we present a proof-of principle study for a proteomics-based identification pipeline, implementing existing data sources, to exemplarily identify exosome-based biomarker candidates in prostate cancer. Exosomes from malignant PC3 and benign PNT1A cells and from FBS-containing medium were isolated using sequential ultracentrifugation. Exosome and control samples were analyzed on an LTQ-Orbitrap XL mass spectrometer. Proteomic data is available via Proteom-eXchange with identifier PXD003651. We developed a scoring scheme to rank 64 proteins exclusively found in PC3 exosomes, integrating data from four public databases and published mass spectrometry data sets. Among the top candidates, we focused on the tight junction protein claudin 3. Retests under serum-free conditions using immunoblotting and immunogold labeling confirmed the presence of claudin 3 on PC3 exosomes. Claudin 3 levels were determined in the blood plasma of patients with localized (n = 58; 42 with Gleason score 6-7, 16 with Gleason score >= 8) and metastatic prostate cancer (n = 11) compared with patients with benign prostatic hyperplasia (n = 15) and healthy individuals (n = 15) using ELISA, without prior laborious exosome isolation. ANOVA showed different CLDN3 plasma levels in these groups (p = 0.004). CLDN3 levels were higher in patients with Gleason >= 8 tumors compared with patients with benign prostatic hyperplasia (p = 0.012) and Gleason 6-7 tumors (p = 0.029). In patients with localized tumors CLDN3 levels predicted a Gleason score >= 8 (AUC = 0.705; p = 0.016) and did not correlate with serum PSA. By using the described workflow claudin 3 was identified and validated as a potential blood-based biomarker in prostate cancer. Furthermore this workflow could serve as a template to be used in other cancer entities."],["dc.identifier.doi","10.1074/mcp.M117.068577"],["dc.identifier.isi","000402576600003"],["dc.identifier.pmid","28396511"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42432"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Amer Soc Biochemistry Molecular Biology Inc"],["dc.relation.issn","1535-9484"],["dc.relation.issn","1535-9476"],["dc.title","Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]