Brunner, Edgar

[["dc.bibliographiccitation.firstpage","3727"],["dc.bibliographiccitation.issue","1743"],["dc.bibliographiccitation.journal","Proceedings of The Royal Society B Biological Sciences"],["dc.bibliographiccitation.lastpage","3735"],["dc.bibliographiccitation.volume","279"],["dc.contributor.author","Benhaiem, Sarah"],["dc.contributor.author","Hofer, Heribert"],["dc.contributor.author","Kramer-Schadt, Stephanie"],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","East, Marion L."],["dc.date.accessioned","2018-11-07T09:05:46Z"],["dc.date.available","2018-11-07T09:05:46Z"],["dc.date.issued","2012"],["dc.description.abstract","Within-brood or -litter dominance provides fitness-related benefits if dominant siblings selfishly skew access to food provided by parents in their favour. Models of facultative siblicide assume that dominants exert complete control over their subordinate sibling's access to food and that control is maintained, irrespective of the subordinate's hunger level. By contrast, a recent functional hypothesis suggests that subordinates should contest access to food when the cost of not doing so is high. Here, we show that within spotted hyena (Crocuta crocuta) twin litters, dominants most effectively skew access to maternal milk in their favour when their aggression prompts a highly submissive response. When hungry, subordinates were less submissive in response to aggression, thereby decreasing lost suckling time and increasing suckling time lost by dominants. In a species where adult females socially dominate adult males, juvenile females were more often dominant than males in mixed-sex litters, and subordinate sisters used more effective counter-tactics against dominant brothers than subordinate brothers against dominant sisters. Our results provide, to our knowledge, the first evidence in a mammal that dominant offspring in twin litters do not exert complete control over their sibling's access to resources (milk), and that sibling dominance relationships are influenced by sibling sex and training effects."],["dc.description.sponsorship","TAWIRI; IZW"],["dc.identifier.doi","10.1098/rspb.2012.0925"],["dc.identifier.isi","000307780400013"],["dc.identifier.pmid","22719032"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10619"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25403"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc"],["dc.relation.issn","0962-8452"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Sibling rivalry: training effects, emergence of dominance and incomplete control"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2111"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Molecular Ecology"],["dc.bibliographiccitation.lastpage","2130"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Nikolin, Veljko M."],["dc.contributor.author","Olarte-Castillo, Ximena A."],["dc.contributor.author","Osterrieder, Nikolaus"],["dc.contributor.author","Hofer, Heribert"],["dc.contributor.author","Dubovi, Edward"],["dc.contributor.author","Mazzoni, Camila J."],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","Goller, Katja V."],["dc.contributor.author","Fyumagwa, Robert D."],["dc.contributor.author","Moehlman, Patricia D."],["dc.contributor.author","Thierer, Dagmar"],["dc.contributor.author","East, Marion L."],["dc.date.accessioned","2018-11-07T10:25:30Z"],["dc.date.available","2018-11-07T10:25:30Z"],["dc.date.issued","2017"],["dc.description.abstract","Was the 1993/1994 fatal canine distemper virus (CDV) epidemic in lions and spotted hyaenas in the Serengeti ecosystem caused by the recent spillover of a virulent domestic dog strain or one well adapted to these noncanids? We examine this question using sequence data from 13 Serengeti' strains including five complete genomes obtained between 1993 and 2011. Phylogenetic and haplotype network analyses reveal that strains from noncanids during the epidemic were more closely related to each other than to those from domestic or wild canids. All noncanid Serengeti' strains during the epidemic encoded: (1) one novel substitution G134S in the CDV-V protein; and (2) therare amino acid combination 519I/549H at two sites under positive selection in the region of the CDV-H protein that binds to SLAM (CD 150) host cell receptors. Worldwide, only a few noncanid strains in the America II lineage encode CDV-H 519I/549H. All canid Serengeti' strains during the epidemic coded CDV-V 134G, and CDV-H 519R/549Y, or 519R/549H. A functional assay of cell entry revealed the highest performance by CDV-H proteins encoding 519I/549H in cells expressing lion SLAM receptors, and the highest performance by proteins encoding 519R/549Y, typical of dog strains worldwide, in cells expressing dog SLAM receptors. Our findings are consistent with an epidemic in lions and hyaenas caused by CDV variants better adapted to noncanids than canids, but not with the recent spillover of a dog strain. Our study reveals a greater complexity of CDV molecular epidemiology in multihost environments than previously thought."],["dc.identifier.doi","10.1111/mec.13902"],["dc.identifier.isi","000399639200031"],["dc.identifier.pmid","27928865"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42867"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Wiley"],["dc.relation.issn","1365-294X"],["dc.relation.issn","0962-1083"],["dc.title","Canine distemper virus in the Serengeti ecosystem: molecular adaptation to different carnivore species"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e50955"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Nikolin, Veljko M."],["dc.contributor.author","Osterrieder, Klaus"],["dc.contributor.author","von Messling, Veronika"],["dc.contributor.author","Hofer, Heribert"],["dc.contributor.author","Anderson, Danielle"],["dc.contributor.author","Dubovi, Edward"],["dc.contributor.author","Brunner, Edgar"],["dc.contributor.author","East, Marion L."],["dc.date.accessioned","2018-11-07T09:02:21Z"],["dc.date.available","2018-11-07T09:02:21Z"],["dc.date.issued","2012"],["dc.description.abstract","Theoretically, homogeneous environments favor the evolution of specialists whereas heterogeneous environments favor generalists. Canine distemper is a multi-host carnivore disease caused by canine distemper virus (CDV). The described cell receptor of CDV is SLAM (CD150). Attachment of CDV hemagglutinin protein (CDV-H) to this receptor facilitates fusion and virus entry in cooperation with the fusion protein (CDV-F). We investigated whether CDV strains co-evolved in the large, homogeneous domestic dog population exhibited specialist traits, and strains adapted to the heterogeneous environment of smaller populations of different carnivores exhibited generalist traits. Comparison of amino acid sequences of the SLAM binding region revealed higher similarity between sequences from Canidae species than to sequences from other carnivore families. Using an in vitro assay, we quantified syncytia formation mediated by CDV-H proteins from dog and non-dog CDV strains in cells expressing dog, lion or cat SLAM. CDV-H proteins from dog strains produced significantly higher values with cells expressing dog SLAM than with cells expressing lion or cat SLAM. CDV-H proteins from strains of non-dog species produced similar values in all three cell types, but lower values in cells expressing dog SLAM than the values obtained for CDV-H proteins from dog strains. By experimentally changing one amino acid (Y549H) in the CDV-H protein of one dog strain we decreased expression of specialist traits and increased expression of generalist traits, thereby confirming its functional importance. A virus titer assay demonstrated that dog strains produced higher titers in cells expressing dog SLAM than cells expressing SLAM of non-dog hosts, which suggested possible fitness benefits of specialization post-cell entry. We provide in vitro evidence for the expression of specialist and generalist traits by CDV strains, and fitness trade-offs across carnivore host environments caused by antagonistic pleiotropy. These findings extend knowledge on CDV molecular epidemiology of particular relevance to wild carnivores."],["dc.identifier.doi","10.1371/journal.pone.0050955"],["dc.identifier.isi","000312290800032"],["dc.identifier.pmid","23239996"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8452"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24665"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Antagonistic Pleiotropy and Fitness Trade-Offs Reveal Specialist and Generalist Traits in Strains of Canine Distemper Virus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]