Seitz, Tina

[["dc.bibliographiccitation.artnumber","56"],["dc.bibliographiccitation.journal","Genome Medicine"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Seitz, Tina"],["dc.contributor.author","Stalmann, Robert"],["dc.contributor.author","Dalila, Nawar"],["dc.contributor.author","Chen, Jiayin"],["dc.contributor.author","Pojar, Sherin"],["dc.contributor.author","Pereira, Joao N. dos Santos"],["dc.contributor.author","Kraetzner, Ralph"],["dc.contributor.author","Brockmoeller, Juergen"],["dc.contributor.author","Tzvetkov, Mladen Vassilev"],["dc.date.accessioned","2018-11-07T09:55:48Z"],["dc.date.available","2018-11-07T09:55:48Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: The organic cation transporter OCT1 (SLC22A1) mediates the uptake of vitamin B1, cationic drugs, and xenobiotics into hepatocytes. Nine percent of Caucasians lack or have very low OCT1 activity due to loss-of-function polymorphisms in OCT1 gene. Here we analyzed the global genetic variability in OCT1 to estimate the therapeutic relevance of OCT1 polymorphisms in populations beyond Caucasians and to identify evolutionary patterns of the common loss of OCT1 activity in humans. Methods: We applied massively parallel sequencing to screen for coding polymorphisms in 1,079 unrelated individuals from 53 populations worldwide. The obtained data was combined with the existing 1000 Genomes data comprising an additional 1,092 individuals from 14 populations. The identified OCT1 variants were characterized in vitro regarding their cellular localization and their ability to transport 10 known OCT1 substrates. Both the population genetics data and transport data were used in tandem to generate a world map of loss of OCT1 activity. Results: We identified 16 amino acid substitutions potentially causing loss of OCT1 function and analyzed them together with five amino acid substitutions that were not expected to affect OCT1 function. The variants constituted 16 major alleles and 14 sub-alleles. Six major alleles showed improper subcellular localization leading to substrate-wide loss in activity. Five major alleles showed correct subcellular localization, but substrate-specific loss of activity. Striking differences were observed in the frequency of loss of OCT1 activity worldwide. While most East Asian and Oceanian individuals had completely functional OCT1, 80 % of native South American Indians lacked functional OCT1 alleles. In East Asia and Oceania the average nucleotide diversity of the loss-of-function variants was much lower than that of the variants that do not affect OCT1 function (ratio of 0.03) and was significantly lower than the theoretically expected heterozygosity (Tajima's D=-1.64, P < 0.01). Conclusions: Comprehensive genetic analyses showed strong global variations in the frequency of loss of OCT1 activity with selection pressure for maintaining OCT1 activity in East Asia and Oceania. These results not only enable pharmacogenetically-based optimization of drug treatment worldwide, but may help elucidate the functional role of human OCT1."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2015"],["dc.identifier.doi","10.1186/s13073-015-0172-0"],["dc.identifier.isi","000357566500001"],["dc.identifier.pmid","26157489"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13466"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36829"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1756-994X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","A51"],["dc.bibliographiccitation.journal","Astronomy and Astrophysics"],["dc.bibliographiccitation.volume","518"],["dc.contributor.author","Fouqué, P."],["dc.contributor.author","Heyrovský, D."],["dc.contributor.author","Dong, S."],["dc.contributor.author","Gould, A."],["dc.contributor.author","Udalski, A."],["dc.contributor.author","Albrow, M. D."],["dc.contributor.author","Batista, V."],["dc.contributor.author","Beaulieu, J.-P."],["dc.contributor.author","Bennett, D. P."],["dc.contributor.author","Bond, I. A."],["dc.contributor.author","Seitz, S."],["dc.date.accessioned","2019-07-09T11:54:47Z"],["dc.date.available","2019-07-09T11:54:47Z"],["dc.date.issued","2010-09-02"],["dc.description.abstract","Context. Not only is gravitational microlensing a successful tool for discovering distant exoplanets, but it also enables characterization of the lens and source stars involved in the lensing event. Aims. In high-magnification events, the lens caustic may cross over the source disk, which allows determination of the angular size of the source and measurement of its limb darkening. Methods. When such extended-source effects appear close to maximum magnification, the resulting light curve differs from the characteristic Paczyński point-source curve. The exact shape of the light curve close to the peak depends on the limb darkening of the source. Dense photometric coverage permits measurement of the respective limb-darkening coefficients. Results. In the case of the microlensing event OGLE 2008-BLG-290, the K giant source star reached a peak magnification at about 100. Thirteen different telescopes have covered this event in eight different photometric bands. Subsequent light-curve analysis yielded measurements of linear limb-darkening coefficients of the source in six photometric bands. The best-measured coefficients lead to an estimate of the source effective temperature of about 4700 K. However, the photometric estimate from colour-magnitude diagrams favours a cooler temperature of 4200 ± 100 K. Conclusions. Because the limb-darkening measurements, at least in the CTIO/SMARTS2 - and -bands, are among the most accurate obtained, the above disagreement needs to be understood. A solution is proposed, which may apply to previous events where such a discrepancy also appeared."],["dc.identifier.doi","10.1051/0004-6361/201014053"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9689"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60724"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1432-0746"],["dc.relation.orgunit","Fakultät für Physik"],["dc.title","OGLE 2008–BLG–290: an accurate measurement of the limb darkening of a galactic bulge K Giant spatially resolved by microlensing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","101"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Astronomy and Astrophysics"],["dc.bibliographiccitation.lastpage","121"],["dc.bibliographiccitation.volume","448"],["dc.contributor.author","Gabasch, A."],["dc.contributor.author","Hopp, U."],["dc.contributor.author","Feulner, G."],["dc.contributor.author","Bender, R."],["dc.contributor.author","Seitz, S."],["dc.contributor.author","Saglia, R. P."],["dc.contributor.author","Snigula, J."],["dc.contributor.author","Drory, N."],["dc.contributor.author","Appenzeller, I."],["dc.contributor.author","Heidt, J."],["dc.contributor.author","Mehlert, D."],["dc.contributor.author","Noll, S."],["dc.contributor.author","Böhm, A."],["dc.contributor.author","Jäger, K."],["dc.contributor.author","Ziegler, B."],["dc.date.accessioned","2019-07-09T11:54:57Z"],["dc.date.available","2019-07-09T11:54:57Z"],["dc.date.issued","2006-03-02"],["dc.description.abstract","We present the redshift evolution of the restframe galaxy luminosity function (LF) in the red r , i , and z bands, as derived from the FORS Deep Field (FDF), thus extending our earlier results to longer wavelengths. Using the deep and homogeneous I-band selected dataset of the FDF, we were able to follow the red LFs over the redshift range 0.5 < z < 3.5. The results are based on photometric redshifts for 5558 galaxies derived from the photometry in 9 filters and achieving an accuracy of Δz/(zspec + 1) ≤ 0.03 with only ∼1% outliers. A comparison with results from the literature shows the reliability of the derived LFs. Because of the depth of the FDF, we can give relatively tight constraints on the faint-end slope α of the LF; the faint-end of the red LFs does not show a large redshift evolution and is compatible within 1σ to 2σ with a constant slope over the redshift range 0.5 <∼ z <∼ 2.0. Moreover, the slopes in r , i , and z are very similar to a best-fitting value of α = −1.33 ± 0.03 for the combined bands. There is a clear trend of α to steepen with increasing wavelength: αUV&u = −1.07 ± 0.04 → αg &B = −1.25 ± 0.03 → αr &i &z = −1.33 ± 0.03. We subdivided our galaxy sample into four SED types and determined the contribution of a typical SED type to the overall LF. We show that the wavelength dependence of the LF slope can be explained by the relative contribution of different SED-type LFs to the overall LF, as different SED types dominate the LF in the blue and red bands. Furthermore we also derived and analyzed the luminosity density evolution of the different SED types up to z ∼ 2. We investigated the evolution of M∗ and φ∗ by means of the redshift parametrization M∗(z) = M∗ 0 + a ln (1 + z) and φ∗(z) = φ∗ 0(1 + z)b. Based on the FDF data, we found only a mild brightening of M∗ (ar ∼ −0.8, and ai ,z ∼ −0.4) and a decreasing φ∗ (br ,i ,z ∼ −0.6) with increasing redshift. Therefore, from z ∼ 0.5 to z ∼ 3 the characteristic luminosity increases by ∼0.8, ∼0.4, and ∼0.4 mag in the r , i , and z bands, respectively. Simultaneously the characteristic density decreases by about 40% in all analyzed wavebands. A comparison of the LFs with semianalytical galaxy formation models by Kauffmann et al. (1999) shows a similar result to the blue bands: the semi-analytical models predict LFs that describe the data at low redshift very well, but show growing disagreement with increasing redshifts."],["dc.identifier.doi","10.1051/0004-6361:20053986"],["dc.identifier.fs","45030"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9888"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60763"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1432-0746"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goedoc.uni-goettingen.de/licenses"],["dc.title","The evolution of the luminosity functions in the FORS deep field from low to high redshift. II. The red bands"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0189521"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Meyer, Marleen Julia"],["dc.contributor.author","Seitz, Tina"],["dc.contributor.author","Brockmöller, Jürgen"],["dc.contributor.author","Tzvetkov, Mladen Vassilev"],["dc.date.accessioned","2019-03-07T13:32:00Z"],["dc.date.available","2019-03-07T13:32:00Z"],["dc.date.issued","2017"],["dc.description.abstract","Ranitidine (Zantac®) is a H2-receptor antagonist commonly used for the treatment of acid-related gastrointestinal diseases. Ranitidine was reported to be a substrate of the organic cation transporters OCT1 and OCT2. The hepatic transporter OCT1 is highly genetically variable. Twelve major alleles confer partial or complete loss of OCT1 activity. The effects of these polymorphisms are highly substrate-specific and therefore difficult to predict. The renal transporter OCT2 has a common polymorphism, Ala270Ser, which was reported to affect OCT2 activity."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.identifier.doi","10.1371/journal.pone.0189521"],["dc.identifier.pmid","29236753"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15028"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57665"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]