Eberle, Manfred

[["dc.bibliographiccitation.artnumber","e1000688"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS Genetics"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Averdam, Anne"],["dc.contributor.author","Petersen, Beatrix"],["dc.contributor.author","Rosner, Cornelia"],["dc.contributor.author","Neff, Jennifer"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Eberle, Manfred"],["dc.contributor.author","Aujard, Fabienne"],["dc.contributor.author","Münch, Claudia"],["dc.contributor.author","Schempp, Werner"],["dc.contributor.author","Carrington, Mary"],["dc.contributor.author","Shiina, Takashi"],["dc.contributor.author","Inoko, Hidetoshi"],["dc.contributor.author","Knaust, Florian"],["dc.contributor.author","Coggill, Penny"],["dc.contributor.author","Sehra, Harminder"],["dc.contributor.author","Beck, Stephan"],["dc.contributor.author","Abi-Rached, Laurent"],["dc.contributor.author","Reinhardt, Richard"],["dc.contributor.author","Walter, Lutz"],["dc.date.accessioned","2019-07-09T11:54:06Z"],["dc.date.available","2019-07-09T11:54:06Z"],["dc.date.issued","2009-11-16"],["dc.description.abstract","There are two main classes of natural killer (NK) cell receptors in mammals, the killer cell immunoglobulin-like receptors (KIR) and the structurally unrelated killer cell lectin-like receptors (KLR). While KIR represent the most diverse group of NK receptors in all primates studied to date, including humans, apes, and Old and New World monkeys, KLR represent the functional equivalent in rodents. Here, we report a first digression from this rule in lemurs, where the KLR (CD94/NKG2) rather than KIR constitute the most diverse group of NK cell receptors. We demonstrate that natural selection contributed to such diversification in lemurs and particularly targeted KLR residues interacting with the peptide presented by MHC class I ligands. We further show that lemurs lack a strict ortholog or functional equivalent of MHC-E, the ligands of nonpolymorphic KLR in ‘‘higher’’ primates. Our data support the existence of a hitherto unknown system of polymorphic and diverse NK cell receptors in primates and of combinatorial diversity as a novel mechanism to increase NK cell receptor repertoire."],["dc.format.extent","15"],["dc.identifier.doi","10.1371/journal.pgen.1000688"],["dc.identifier.pmid","19834558"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8447"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60571"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1553-7404"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","A Novel System of Polymorphic and Diverse NK Cell Receptors in Primates"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","20140830"],["dc.bibliographiccitation.issue","1791"],["dc.bibliographiccitation.journal","Proceedings of the Royal Society B: Biological Sciences"],["dc.bibliographiccitation.volume","281"],["dc.contributor.author","Hämäläinen, Anni"],["dc.contributor.author","Dammhahn, Melanie"],["dc.contributor.author","Aujard, Fabienne"],["dc.contributor.author","Eberle, Manfred"],["dc.contributor.author","Hardy, Isabelle"],["dc.contributor.author","Kappeler, Peter"],["dc.contributor.author","Perret, Martine"],["dc.contributor.author","Schliehe-Diecks, Susanne"],["dc.contributor.author","Kraus, Cornelia"],["dc.date.accessioned","2017-09-07T11:48:24Z"],["dc.date.available","2017-09-07T11:48:24Z"],["dc.date.issued","2014"],["dc.description.abstract","Classic theories of ageing consider extrinsic mortality (EM) a major factor in shaping longevity and ageing, yet most studies of functional ageing focus on species with low EM. This bias may cause overestimation of the influence of senescent declines in performance over condition-dependent mortality on demographic processes across taxa. To simultaneously investigate the roles of functional senescence (FS) and intrinsic, extrinsic and condition-dependent mortality in a species with a high predation risk in nature, we compared age trajectories of body mass (BM) in wild and captive grey mouse lemurs (Microcebus murinus) using longitudinal data (853 individuals followed through adulthood). We found evidence of non-random mortality in both settings. In captivity, the oldest animals showed senescence in their ability to regain lost BM, whereas no evidence of FS was found in the wild. Overall, captive animals lived longer, but a reversed sex bias in lifespan was observed between wild and captive populations. We suggest that even moderately condition-dependent EM may lead to negligible FS in the wild. While high EM may act to reduce the average lifespan, this evolutionary process may be counteracted by the increased fitness of the long-lived, high-quality individuals."],["dc.identifier.doi","10.1098/rspb.2014.0830"],["dc.identifier.gro","3150801"],["dc.identifier.pmid","25100693"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7593"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0962-8452"],["dc.subject","body mass; condition-dependent mortality; functional senescence; life-history evolution; lifespan; sex difference"],["dc.title","Senescence or selective disappearance? Age trajectories of body mass in wild and captive populations of a small-bodied primate"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]