Olthoff, Arno

[["dc.bibliographiccitation.firstpage","1045"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Annals of Otology Rhinology & Laryngology"],["dc.bibliographiccitation.lastpage","1050"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Rohrbach, S."],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Giefer, B."],["dc.contributor.author","Gotz, W."],["dc.date.accessioned","2018-11-07T11:25:23Z"],["dc.date.available","2018-11-07T11:25:23Z"],["dc.date.issued","2001"],["dc.description.abstract","Nasal hypersecretion is predominantly caused by overaction of nasal glands, which are mainly under cholinergic control. In this work, we investigated the influence of botulinum toxin A (BTA) on the nasal mucosal tissue of the maxillary sinus turbinates of guinea pigs (n = 10) that were painlessly sacrificed 10 days (short-term group) or 3 months (long-term group) after local treatment with 20 units of BTA (Botox) or 0.2 mL of 0.9% sodium chloride (control). Histologic investigation of the nasal mucosal tissue of the BTA-treated animals (short-term group) showed degeneration of glands and ducts and apoptotic nuclei on TUNEL staining of these structures. The control animals revealed normal glandular tissue and no apoptosis. The animals of the long-term group showed almost normal glandular tissue and only a few apoptotic nuclei, In conclusion, BTA induces temporary apoptosis in the nasal glandular compartment of guinea pigs."],["dc.identifier.isi","000172151800010"],["dc.identifier.pmid","11713916"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56607"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Annals Publ Co"],["dc.relation.issn","0003-4894"],["dc.title","Botulinum toxin type a induces apoptosis in nasal glands of guinea pigs"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","330"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES"],["dc.bibliographiccitation.lastpage","334"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Rohrbach, S."],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Laskawi, Rainer"],["dc.contributor.author","Gotz, W."],["dc.date.accessioned","2018-11-07T10:08:13Z"],["dc.date.available","2018-11-07T10:08:13Z"],["dc.date.issued","2002"],["dc.description.abstract","The influence of botulinum toxin type A (BTA) on cellular mechanisms has not been studied in much detail. Since nitric oxide (NO) is of increasing interest as a neuromodulator in the innervation of the nose, its localization was examined in the nasal mucosa of guinea pigs treated with BTA or saline. Neuronal nitric oxide synthase-immunoreactivity (nNOS-IR) was found around vessels and nasal glands. Immunoreactivity was seen in the respiratory epithelium, in the periost and the osteocytes of the turbinate bone. A distinct interindividual difference in the strength of nNOS-IR was obvious among the animals, but there was no difference in the strength of immunoreactivity between the animals treated with BTA or saline. NO might therefore contribute to the regulation of vascular tone, glandular function, respiratory epithelial cell function and bone metabolism. BTA does not seem to influence the processes regulated and modulated by NO. This may represent a benefit for the application of BTA. Copyright (C) 2002 S. Karger AG, Basel."],["dc.identifier.doi","10.1159/000066087"],["dc.identifier.isi","000179464000007"],["dc.identifier.pmid","12417774"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39430"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0301-1569"],["dc.title","Neuronal nitric oxide synthase-immunoreactivity"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","180"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES"],["dc.bibliographiccitation.lastpage","185"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Rohrbach, S."],["dc.contributor.author","Faber, M."],["dc.contributor.author","Gotz, W."],["dc.contributor.author","Laskawi, Rainer"],["dc.date.accessioned","2018-11-07T10:30:24Z"],["dc.date.available","2018-11-07T10:30:24Z"],["dc.date.issued","2002"],["dc.description.abstract","The localization of neuronal nitric oxide synthase (nNOS) in the mucosa of the inferior and middle turbinates of 30 patients with and without allergic rhinitis was examined by immunohistochemical methods. Staining of paraffin sections from allergic and nonallergic patients revealed nNOS immuncreactivity, (nNOS-IR) in the muscular layer of vessels, in the basal portion of submucosal glands and in the periost and the osteocytes of the turbinate bones. In contrast to earlier investigations, nNOS-IR was also seen in the nasal respiratory epithelium of allergic and nonallergic patients. The immunostaining of sections of submucosal glands from allergic patients was stronger than that of sections from patients with idiopathic rhinitis or patients with no nasal obstruction. The present result - nNOS-IR around glands is elevated in patients with allergic rhinitis - could indicate that this enzyme is involved in the pathogenesis and symptornatology of allergic rhinitis. Copyright (C) 2002 S. Karger AG, Basel."],["dc.identifier.doi","10.1159/000058022"],["dc.identifier.isi","000176049500003"],["dc.identifier.pmid","12037384"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43859"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0301-1569"],["dc.title","Neuronal nitric oxide synthase immunoreactivity in the nasal mucosa of patients with idiopathic and allergic rhinitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]