Olthoff, Arno

[["dc.bibliographiccitation.artnumber","joor.13220"],["dc.bibliographiccitation.firstpage","1044"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Oral Rehabilitation"],["dc.bibliographiccitation.lastpage","1049"],["dc.bibliographiccitation.volume","48"],["dc.contributor.affiliation","Adamske, Deike; 1Department of Oral and Maxillofacial Surgery Charité – University Medical Center Berlin Berlin Germany"],["dc.contributor.affiliation","Heyduck, Adrienne; 2Phoniatrics and Pedaudiology Department of Otorhinolaryngology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Weidenmüller, Matthias; 2Phoniatrics and Pedaudiology Department of Otorhinolaryngology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Göricke, Bettina; 3Department of Neurology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.affiliation","Frank, Tobias; 3Department of Neurology University Medical Center Göttingen Göttingen Germany"],["dc.contributor.author","Adamske, Deike"],["dc.contributor.author","Heyduck, Adrienne"],["dc.contributor.author","Weidenmüller, Matthias"],["dc.contributor.author","Göricke, Bettina"],["dc.contributor.author","Frank, Tobias"],["dc.contributor.author","Olthoff, Arno"],["dc.date.accessioned","2021-08-12T07:45:24Z"],["dc.date.available","2021-08-12T07:45:24Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T11:10:06Z"],["dc.description.abstract","Abstract Background Dysphagia as a sequel and possible early sign of amyotrophic lateral sclerosis (ALS) is caused by progressive impaired bulbar motor function. Objective To evaluate bulbar motor dysfunction in patients suffering from ALS compared to a healthy reference group. Methods A clinical study and prospective group comparison was designed. Patients and healthy volunteers were examined in the outpatient clinic of our university medical center. Ten patients with ALS and 20 healthy volunteers were included. All participants underwent a flexible endoscopic evaluation of swallowing (FEES) and a manometric measurement of the maximal sub‐palatal atmospheric pressure generated by suction as well as of the prevalent pressure during swallowing. Additionally, the Sydney Swallow Questionnaire (SSQ) was completed by all participants to score the self‐rated extent of dysphagia. Results Comparing maximal suction pressures, the group of patients showed significantly lower values (p < .001). There was a significant correlation between reduced pressures and the degree of dysphagia (SSQ score) (r = −0.73). Conclusions As the oral cavity is an easily accessible compartment of the upper digestive tract, manometric measurements might serve as a simple instrument in order to detect or to monitor bulbar motor dysfunction. Oral manometry may facilitate early detection and monitoring of dysphagia in ALS. Larger studies are required to confirm our findings."],["dc.identifier.doi","10.1111/joor.13220"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88456"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","1365-2842"],["dc.relation.issn","0305-182X"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.title","Dysphagia in amyotrophic lateral sclerosis: Quantification of bulbar motor dysfunction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","493174"],["dc.bibliographiccitation.journal","Gastroenterology Research and Practice"],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Zhang, S."],["dc.contributor.author","Schweizer, Renate"],["dc.contributor.author","Frahm, Jens"],["dc.date.accessioned","2018-11-07T09:46:32Z"],["dc.date.available","2018-11-07T09:46:32Z"],["dc.date.issued","2014"],["dc.description.abstract","The aim of this study was to assess the physiology of normal swallowing using recent advances in real-time magnetic resonance imaging (MRI). Therefore ten young healthy subjects underwent real-time MRI and flexible endoscopic evaluations of swallowing (FEES) with thickened pineapple juice as oral contrast bolus. MRI movies were recorded in sagittal, coronal, and axial orientations during successive swallows at about 25 frames per second. Intermeasurement variation was analyzed and comparisons between real-time MRI and FEES were performed. Twelve distinct swallowing events could be quantified by real-time MRI (start time, end time, and duration). These included five valve functions: oro-velar opening, velo-pharyngeal closure, glottal closure, epiglottic retroflexion, and esophageal opening; three bolus transports: oro-velar transit, pharyngeal delay, pharyngeal transit; and four additional events: laryngeal ascent, laryngeal descent, vallecular, and piriform sinus filling and pharyngeal constriction. Repetitive measurements confirmed the general reliability of the MRI method with only two significant differences for the start times of the velo-pharyngeal closure (t(8) = -2.4, P <= 0.046) and laryngeal ascent (t(8) = -2.6, P <= 0.031). The duration of the velo-pharyngeal closure was significantly longer in real-time MRI compared to FEES (t(8) = -3.3, P <= 0.011). Real-time MRI emerges as a simple, robust, and reliable tool for obtaining comprehensive functional and anatomical information about the swallowing process."],["dc.identifier.doi","10.1155/2014/493174"],["dc.identifier.isi","000331937800001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11686"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34894"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Hindawi Publishing Corporation"],["dc.relation.issn","1687-630X"],["dc.relation.issn","1687-6121"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","On the Physiology of Normal Swallowing as Revealed by Magnetic Resonance Imaging in Real Time"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1019"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Archives of Oto-Rhino-Laryngology"],["dc.bibliographiccitation.lastpage","1025"],["dc.bibliographiccitation.volume","270"],["dc.contributor.author","Santander, Petra"],["dc.contributor.author","Engelke, Wilfried G. H."],["dc.contributor.author","Olthoff, Arno"],["dc.contributor.author","Voelter, Christiane"],["dc.date.accessioned","2018-11-07T09:27:42Z"],["dc.date.available","2018-11-07T09:27:42Z"],["dc.date.issued","2013"],["dc.description.abstract","Swallowing disturbances are common after neurological disease and oropharyngeal tumor resection. In this case the oral stage is often affected. So far the clinical evaluation of the oral phase is limited. Recently the role of pressure changes during oropharyngeal swallowing has been pointed out, but until now there are not enough data. Thereby 52 healthy adults aged between 20 and 45 years were examined using an oral shield (Silencos(A (R)), Bredent, Senden, Germany) connected to a digital manometer (GDUSB 1000(A (R)), Greisinger electronics, Regenstauf, Germany) able to record pressures in a range of 2,000 to -1,000 mbar at a frequency of 1 kHz. Three swallowing conditions were measured: an active bolus intake (ABI) of water, a passive bolus application of a water-bolus (PWA) and a passive application of a gel-bolus (PGA). We found negative pressures with a median value of -278.9 mbar during ABI, of -24.2 mbar during PWA and of -29.4 mbar during PGA. Significant differences in pressure amplitudes and the pressure pattern were observed depending on the kind of bolus application and its consistency. The used test presents a simple and easy to handle method to assess the oral phase of swallowing."],["dc.identifier.doi","10.1007/s00405-012-2299-6"],["dc.identifier.isi","000315443000033"],["dc.identifier.pmid","23238701"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10305"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30600"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0937-4477"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Intraoral pressure patterns during swallowing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]