Völker, Uwe

[["dc.bibliographiccitation.artnumber","e96875"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Schwedhelm, Edzard"],["dc.contributor.author","Wallaschofski, Henri"],["dc.contributor.author","Atzler, Dorothee"],["dc.contributor.author","Dörr, Marcus"],["dc.contributor.author","Nauck, Matthias"],["dc.contributor.author","Volker, Uwe"],["dc.contributor.author","Kroemer, Heyo K."],["dc.contributor.author","Volzke, Henry"],["dc.contributor.author","Böger, Rainer H."],["dc.contributor.author","Friedrich, Nele"],["dc.date.accessioned","2018-08-15T06:50:42Z"],["dc.date.available","2018-08-15T06:50:42Z"],["dc.date.issued","2014"],["dc.description.abstract","BACKGROUND: L-Arginine and its dimethylated derivatives asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) have been associated with cardiovascular (CV) and all-cause mortality in populations at risk. The present study aimed to investigate the prognostic value of L-arginine and its derivatives in the general population. METHODS AND RESULTS: We evaluated 3,952 individuals (1,936 men and 2,016 women) aged 20-81 (median (IQR) 51 (37; 64) years) from the population-based Study of Health in Pomerania (SHIP). Associations of continuous [per standard deviation (SD) increase] and categorized (age- and sex-specific tertiles) serum L-arginine, ADMA, and SDMA concentrations with all-cause and cause-specific mortality were analysed. During a median (IQR) follow-up period of 10.1 (9.3; 10.8) years (38,476 person-years), 426 deaths (10.8%) were observed, including 139 CV deaths (3.5%), and 150 cancer deaths (3.8%). After multivariable adjustment, we revealed a positive association of SDMA with all-cause [hazard ratio (HR) per SD increase: 1.16, 95% confidence interval (CI): 1.07-1.25] and CV mortality [HR: 1.19, 95% CI: 1.05-1.35]. In contrast, we did not observe any association of SDMA with cancer mortality. Neither L-arginine nor ADMA were associated with all-cause or CV mortality. CONCLUSION: SDMA, but not ADMA, is an independent predictor of all-cause and CV mortality in a large population-based cohort of European ancestry."],["dc.identifier.doi","10.1371/journal.pone.0096875"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10120"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15305"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Incidence of all-cause and cardiovascular mortality predicted by symmetric dimethylarginine in the population-based study of health in pomerania"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1798"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Clinical Investigation"],["dc.bibliographiccitation.lastpage","1812"],["dc.bibliographiccitation.volume","127"],["dc.contributor.author","Wild, Philipp S."],["dc.contributor.author","Felix, Janine F."],["dc.contributor.author","Schillert, Arne"],["dc.contributor.author","Teumer, Alexander"],["dc.contributor.author","Chen, Ming-Huei"],["dc.contributor.author","Leening, Maarten J.G."],["dc.contributor.author","Völker, Uwe"],["dc.contributor.author","Großmann, Vera"],["dc.contributor.author","Brody, Jennifer A."],["dc.contributor.author","Irvin, Marguerite R."],["dc.contributor.author","Dörr, Marcus"],["dc.date.accessioned","2020-12-10T18:38:18Z"],["dc.date.available","2020-12-10T18:38:18Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1172/JCI84840"],["dc.identifier.eissn","1558-8238"],["dc.identifier.issn","0021-9738"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77267"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]