Feltgen, Nicolas

[["dc.bibliographiccitation.firstpage","3097"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","FEBS letters"],["dc.bibliographiccitation.lastpage","3102"],["dc.bibliographiccitation.volume","582"],["dc.contributor.author","Stahl, A."],["dc.contributor.author","Paschek, L."],["dc.contributor.author","Martin, G."],["dc.contributor.author","Gross, N. J."],["dc.contributor.author","Feltgen, N."],["dc.contributor.author","Hansen, L. L."],["dc.contributor.author","Agostini, H. T."],["dc.date.accessioned","2019-07-09T11:52:59Z"],["dc.date.available","2019-07-09T11:52:59Z"],["dc.date.issued","2008"],["dc.description.abstract","Anti-VEGF treatment has become accepted first-line treatment for choroidal neovascularisation (CNV) in age-related macular degeneration. However, VEGF-inhibition does not always lead to sustained CNV-reduction. In this study, the effect of rapamycin was superior to VEGF-inhibition in a co-culture assay of endothelial cells (ECs) and retinal pigment epithelium (RPE). Rapamycin reduced EC sprouting in groups that did not respond to anti-VEGF treatment. Rapamycin did not induce EC apoptosis, but reduced both VEGF-production in RPE and the responsiveness of ECs to stimulation. Rapamycin might therefore be a therapeutic option for CNV patients that do not respond sufficiently to the established anti-VEGF treatments."],["dc.identifier.doi","10.1016/j.febslet.2008.08.005"],["dc.identifier.pmid","18703055"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6261"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60313"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","0014-5793"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.subject.mesh","Angiogenesis Inhibitors"],["dc.subject.mesh","Apoptosis"],["dc.subject.mesh","Cells, Cultured"],["dc.subject.mesh","Choroidal Neovascularization"],["dc.subject.mesh","Coculture Techniques"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Pigment Epithelium of Eye"],["dc.subject.mesh","Sirolimus"],["dc.subject.mesh","Vascular Endothelial Growth Factor A"],["dc.title","Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]