Feltgen, Nicolas

[["dc.bibliographiccitation.firstpage","1207"],["dc.bibliographiccitation.journal","Clinical Ophthalmology"],["dc.bibliographiccitation.lastpage","1213"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Storch, Marcus Werner"],["dc.contributor.author","Zinser, Greta"],["dc.contributor.author","Lauermann, Peer"],["dc.contributor.author","Khattab, Mohammed Haitham"],["dc.contributor.author","Nguyen-Höhl, Anna"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Gollisch, Katja"],["dc.contributor.author","Callizo, Josep"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","Feltgen, Nicolas"],["dc.date.accessioned","2022-05-02T08:09:30Z"],["dc.date.available","2022-05-02T08:09:30Z"],["dc.date.issued","2022"],["dc.description.abstract","Purpose: To correlate functional and morphological parameters with foveal avascular zone’s (FAZ) size in diabetic patients with mild to moderate stage nonproliferative diabetic retinopathy. Methods: Monocentric and prospective study of a consecutive case series of diabetic patients. Medical history, best corrected visual acuity (BCVA), best corrected high/low contrast visual acuity (BChcVA/BClcVA), mean sensitivity (MS) and mean defect (MD) in central visual field testing, and FAZ size in fluorescein-angiography (FAG) were recorded. Macular thickness (central point thickness CPT, central subfield thickness CST) and volume measurements (central subfield volume CSV, total macular volume) were taken from SD-OCT (6x6mm ETDRS-grid). Groups were categorised as presenting FAZ sizes smaller (G1) or larger (G2) than 0.35mm2 . Smallest (Q1) and largest quartiles (Q3) were also compared. Results: Thirty-six of 40 patients were included. MS differed significantly between G1 (n = 6) and G2 (n = 30), and BChcVA/BClcVA as well as TMV correlated significantly with FAZ size in correlation analysis. Mean HbA1c tended to be lower in G1 than G2. Patients in G1 were slightly older than in G2. Treatment period with insulin was shorter in G1/Q1 than in G2/Q3. CPT and TMV were lower in G1/Q1 than in G2/Q3. Our analysis of the FAZ in terms of patient age, HbA1c, disease duration and insulin therapy duration revealed no significance. That lack of significance also applies to BCVA, MS, MD, CPT, CST and CSV. Conclusion: As significantly associated, contrast sensitivity, central visual field parameters and potentially retinal thickness or volume seem to be suitable to detect early macular ischaemia. However, we failed to establish any correlation between FAZ and BCVA"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.2147/OPTH.S358467"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107396"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-561"],["dc.relation.eissn","1177-5483"],["dc.rights","CC BY-NC 3.0"],["dc.title","Influence of the Size of the Foveal Avascular Zone on Functional and Morphological Parameters in Patients with Early-Stage Diabetic Retinopathy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","100031"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Ophthalmology Science"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Bemme, Sebastian"],["dc.contributor.author","Heins, Amelie"],["dc.contributor.author","Lauermann, Peer"],["dc.contributor.author","Storch, Marcus Werner"],["dc.contributor.author","Khattab, Mohammed Haitham"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","van Oterendorp, Christian"],["dc.date.accessioned","2022-05-13T06:27:45Z"],["dc.date.available","2022-05-13T06:27:45Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1016/j.xops.2021.100031"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107850"],["dc.language.iso","en"],["dc.relation.issn","2666-9145"],["dc.rights","CC BY-NC-ND 4.0"],["dc.title","Reliability of Subjective Assessment of Spectral-Domain OCT Pathologic Features by Multiple Raters in Retinal Vein Occlusion"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0241005"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Lauermann, Peer"],["dc.contributor.author","Gebest, Julia"],["dc.contributor.author","Pfeiffer, Sebastian"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","Bemme, Sebastian"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","van Oterendorp, Christian"],["dc.contributor.editor","Grzybowski, Andrzej"],["dc.date.accessioned","2021-04-14T08:31:16Z"],["dc.date.available","2021-04-14T08:31:16Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1371/journal.pone.0241005"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17683"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83535"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Influence of pars plana vitrectomy for macular surgery on the medium term intraocular pressure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1245"],["dc.bibliographiccitation.journal","Clinical Ophthalmology"],["dc.bibliographiccitation.lastpage","1254"],["dc.bibliographiccitation.volume","Volume 16"],["dc.contributor.author","Lauermann, Peer"],["dc.contributor.author","Klingelhöfer, Anthea"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Bahlmann, Dirk"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","Koscielny, Juergen"],["dc.contributor.author","Sucker, Christoph"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","van Oterendorp, Christian"],["dc.date.accessioned","2022-06-01T09:39:46Z"],["dc.date.available","2022-06-01T09:39:46Z"],["dc.date.issued","2022"],["dc.description.abstract","Purpose: To evaluate the influences and risk factors for severe bleeding complications during glaucoma surgery, and to investigate the\r\nrole of antiplatelet (AP) and anticoagulant (AC) agents.\r\nMethods: This prospective study enrolled patients undergoing trabeculectomy, trabeculotomy (with Trabectome® or Kahook Dual\r\nBlade®), viscocanaloplasty and Ahmed or Baerveldt implants. Bleeding severity was graded on an ordinal scale ranging from 0 to 5.\r\nImmediately after surgery and one day later, the incidence and severity of bleeding events was documented on a standardized form. A grade\r\n≥3 was defined as severe bleeding. The influence of known systemic disorders, the type of anesthesia, surgical procedure, intraoperative\r\nblood pressure, and the use of or change in AP or AC agents on intraoperative bleeding were analyzed.\r\nResults: Data from 89 eyes undergoing glaucoma procedures were included (age 71.3y ± 10.5). We observed severe intraoperative\r\nbleeding in 8 eyes (9%) and found that concomitant diseases such as the history of a deep vein thrombosis or peripheral arterial\r\nocclusive disease, and the type of surgical procedure (trabeculectomy and viscocanaloplasty) were significantly associated with severe\r\nbleeding events. By contrast, the use of AP/ AC agents had no significant influence on severe intraoperative bleeding events.\r\nConclusion: According to the results of our study cohort, glaucoma procedures entailing scleral manipulations (trabeculectomy and\r\nviscocanaloplasty) and concomitant diseases such as the history of a deep vein thrombosis or peripheral arterial occlusive disease\r\ninfluence the risk of severe intraoperative bleeding events, we detected no increased risk related to concomitant antiplatelet and/ or\r\nanticoagulant medication use."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.2147/OPTH.S361867"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108560"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","1177-5483"],["dc.rights","CC BY-NC 3.0"],["dc.title","Risk Factors for Severe Bleeding Complications in Glaucoma Surgery and the Role of Antiplatelet or Anticoagulant Agents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","28"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Translational Vision Science & Technology"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Lauermann, Peer"],["dc.contributor.author","van Oterendorp, Christian"],["dc.contributor.author","Storch, Marcus W."],["dc.contributor.author","Khattab, Mohammed H."],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","Bemme, Sebastian"],["dc.date.accessioned","2020-12-10T18:38:18Z"],["dc.date.available","2020-12-10T18:38:18Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1167/tvst.8.4.28"],["dc.identifier.issn","2164-2591"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16505"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77264"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Distance-Thresholded Intercapillary Area Analysis Versus Vessel-Based Approaches to Quantify Retinal Ischemia in OCTA"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","100884"],["dc.bibliographiccitation.journal","American Journal of Ophthalmology. Case Reports"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Lauermann, Peer"],["dc.contributor.author","Storch, Marcus"],["dc.contributor.author","Weig, Michael"],["dc.contributor.author","Tampe, Björn"],["dc.contributor.author","Winkler, Martin"],["dc.contributor.author","Hoerauf, Hans"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","Hakroush, Samy"],["dc.date.accessioned","2021-06-01T10:49:24Z"],["dc.date.available","2021-06-01T10:49:24Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.ajoc.2020.100884"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17539"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86274"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2451-9936"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","There is no intraocular affection on a SARS-CoV-2 - Infected ocular surface"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2404"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Clinical Medicine"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Dierks, Sascha"],["dc.contributor.author","Bader, Oliver"],["dc.contributor.author","Schwanbeck, Julian"],["dc.contributor.author","Groß, Uwe"],["dc.contributor.author","Weig, Michael"],["dc.contributor.author","Mese, Kemal"],["dc.contributor.author","Lugert, Raimond"],["dc.contributor.author","Bohne, Wolfgang"],["dc.contributor.author","Hahn, Andreas"],["dc.contributor.author","Zautner, Andreas"],["dc.contributor.author","Feltgen, Nicolas"],["dc.contributor.author","Torkieh, Setare"],["dc.contributor.author","Denker, Fenja"],["dc.contributor.author","Lauermann, Peer"],["dc.contributor.author","Storch, Marcus"],["dc.contributor.author","Frickmann, Hagen"],["dc.date.accessioned","2021-07-05T15:00:47Z"],["dc.date.available","2021-07-05T15:00:47Z"],["dc.date.issued","2021"],["dc.description.abstract","This study was performed as a head-to-head comparison of the performance characteristics of (1) two SARS-CoV-2-specific rapid antigen assays with real-time PCR as gold standard as well as (2) a fully automated high-throughput transcription-mediated amplification (TMA) assay and real-time PCR in a latent class analysis-based test comparison without a gold standard with several hundred samples in a low prevalence “real world” setting. Recorded sensitivity and specificity of the NADAL and the LumiraDx antigen assays and the Hologic Aptima SARS-CoV-2 TMA assay were 0.1429 (0.0194, 0.5835), 0.7644 (0.7016, 0.8174), and 0.7157 (0, 1) as well as 0.4545 (0.2022, 0.7326), 0.9954 (0.9817, 0.9988), and 0.9997 (not estimable), respectively. Agreement kappa between the positive results of the two antigen-based assays was 0.060 (0.002, 0.167) and 0.659 (0.492, 0.825) for TMA and real-time PCR. Samples with low viral load as indicated by cycle threshold (Ct) values > 30 were generally missed by both antigen assays, while 1:10 pooling suggested higher sensitivity of TMA compared to real-time PCR. In conclusion, both sensitivity and specificity speak in favor of the use of the LumiraDx rather than the NADAL antigen assay, while TMA results are comparably as accurate as PCR, when applied in a low prevalence setting."],["dc.description.abstract","This study was performed as a head-to-head comparison of the performance characteristics of (1) two SARS-CoV-2-specific rapid antigen assays with real-time PCR as gold standard as well as (2) a fully automated high-throughput transcription-mediated amplification (TMA) assay and real-time PCR in a latent class analysis-based test comparison without a gold standard with several hundred samples in a low prevalence “real world” setting. Recorded sensitivity and specificity of the NADAL and the LumiraDx antigen assays and the Hologic Aptima SARS-CoV-2 TMA assay were 0.1429 (0.0194, 0.5835), 0.7644 (0.7016, 0.8174), and 0.7157 (0, 1) as well as 0.4545 (0.2022, 0.7326), 0.9954 (0.9817, 0.9988), and 0.9997 (not estimable), respectively. Agreement kappa between the positive results of the two antigen-based assays was 0.060 (0.002, 0.167) and 0.659 (0.492, 0.825) for TMA and real-time PCR. Samples with low viral load as indicated by cycle threshold (Ct) values > 30 were generally missed by both antigen assays, while 1:10 pooling suggested higher sensitivity of TMA compared to real-time PCR. In conclusion, both sensitivity and specificity speak in favor of the use of the LumiraDx rather than the NADAL antigen assay, while TMA results are comparably as accurate as PCR, when applied in a low prevalence setting."],["dc.identifier.doi","10.3390/jcm10112404"],["dc.identifier.pii","jcm10112404"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87903"],["dc.language.iso","en"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.publisher","MDPI"],["dc.relation.eissn","2077-0383"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Diagnosing SARS-CoV-2 with Antigen Testing, Transcription-Mediated Amplification and Real-Time PCR"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]