Soltau, Jakob

[["dc.bibliographiccitation.firstpage","7"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","American Journal of Respiratory and Critical Care Medicine"],["dc.bibliographiccitation.lastpage","16"],["dc.bibliographiccitation.volume","181"],["dc.contributor.author","Aguilar-Pimentel, J. A."],["dc.contributor.author","Alessandrini, Francesca"],["dc.contributor.author","Huster, K. M."],["dc.contributor.author","Jakob, T."],["dc.contributor.author","Schulz, H."],["dc.contributor.author","Behrendt, H."],["dc.contributor.author","Ring, J."],["dc.contributor.author","de Angelis, M. H."],["dc.contributor.author","Busch, D. H."],["dc.contributor.author","Mempel, M."],["dc.contributor.author","Ollert, M."],["dc.date.accessioned","2011-04-21T15:37:51Z"],["dc.date.accessioned","2021-10-27T13:10:49Z"],["dc.date.available","2011-04-21T15:37:51Z"],["dc.date.available","2021-10-27T13:10:49Z"],["dc.date.issued","2009"],["dc.description.abstract","Rationale: Studies in humans and rodents have indicated a causative role for CD81 T cells in IgE-mediated allergic inflammation, but their function is still controversial. Objectives: Toanalyze the role of allergen-specificCD81Tcells during the development of allergic airway inflammation in two parallel but diverging outcome models. Methods: We used H2-Kb SIINFEKL (OVA257–264) multimers to analyze induction, natural distribution, and phenotype of allergen-specificCD81 T cells in amurine C57BL/6 model of ovalbumin (OVA)-induced allergic airway inflammation using low-dose or high-dose OVA sensitization. Measurements and Main Results: The low-dose protocol was characterized by a significant induction of total and OVA-specific IgE, eosinophilic airway inflammation, IL-4 levels in bronchoalveolar lavage fluid. And significant alterations in lung function. The high dose protocol was characterizedbya significant reductionof theallergicphenotype. Using OVA257–264 H2-Kb multimers, we observed lung and airway infiltrating OVA-specific CD81 T cells showing an effector/effectormemory phenotype. The high-dose protocol caused significantly higher infiltration of allergen-specific CD81 cells to the airways and enhanced their cytotoxicity. Adoptive transferwith CD81 T cells from transgenic OT-I mice to TAP12/2 or wild-type mice showed their migration to the lungs and TAP1-dependent proliferation after OVAaerosol exposure. TAP12/2 mice defective in CD81 T cells showed exacerbated symptoms in the low-dose sensitizationmodel. Conclusions: Allergen-specific CD81 T cells seem to protect from allergic inflammation in the lungs. Their number, which is dependent on the sensitization dose, appears to be a critical predictor for the severity of the allergic phenotype."],["dc.identifier.doi","10.1164/rccm.200902-0190OC"],["dc.identifier.fs","575523"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6286"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91536"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Specific CD8 T Cells in IgE-mediated Allergy Correlate with Allergen Dose and Allergic Phenotype"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]