Freimann, Florian Baptist

[["dc.bibliographiccitation.artnumber","e110588"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Streitberger, Kaspar-Josche"],["dc.contributor.author","Reiss-Zimmermann, Martin"],["dc.contributor.author","Freimann, Florian Baptist"],["dc.contributor.author","Bayerl, Simon"],["dc.contributor.author","Guo, Jing"],["dc.contributor.author","Arlt, Felix"],["dc.contributor.author","Wuerfel, Jens"],["dc.contributor.author","Braun, Juergen"],["dc.contributor.author","Hoffmann, Karl-Titus"],["dc.contributor.author","Sack, Ingolf"],["dc.date.accessioned","2018-11-07T09:33:28Z"],["dc.date.available","2018-11-07T09:33:28Z"],["dc.date.issued","2014"],["dc.description.abstract","Objective: To generate high-resolution maps of the viscoelastic properties of human brain parenchyma for presurgical quantitative assessment in glioblastoma (GB). Methods: Twenty-two GB patients underwent routine presurgical work-up supplemented by additional multifrequency magnetic resonance elastography. Two three-dimensional viscoelastic parameter maps, magnitude vertical bar G vertical bar, and phase angle phi of the complex shear modulus were reconstructed by inversion of full wave field data in 2-mm isotropic resolution at seven harmonic drive frequencies ranging from 30 to 60 Hz. Results: Mechanical brain maps confirmed that GB are composed of stiff and soft compartments, resulting in high intratumor heterogeneity. GB could be easily differentiated from healthy reference tissue by their reduced viscous behavior quantified by phi (0.37 +/- 0.08 vs. 0.58 +/- 0.07). vertical bar G vertical bar, which in solids more relates to the material's stiffness, was significantly reduced in GB with a mean value of 1.32 +/- 0.26 kPa compared to 1.54 +/- 0.27 kPa in healthy tissue (P = 0.001). However, some GB (5 of 22) showed increased stiffness. Conclusion: GB are generally less viscous and softer than healthy brain parenchyma. Unrelated to the morphology-based contrast of standard magnetic resonance imaging, elastography provides an entirely new neuroradiological marker and contrast related to the biomechanical properties of tumors."],["dc.description.sponsorship","German Research Foundation (DFG) [Sa901/10]"],["dc.identifier.doi","10.1371/journal.pone.0110588"],["dc.identifier.isi","000343674800060"],["dc.identifier.pmid","25338072"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11033"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31968"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","High-Resolution Mechanical Imaging of Glioblastoma by Multifrequency Magnetic Resonance Elastography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","278139"],["dc.bibliographiccitation.journal","Critical care research and practice"],["dc.bibliographiccitation.volume","2015"],["dc.contributor.author","Chopra, Sascha Santosh"],["dc.contributor.author","Wolf, Stefan"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Freimann, Florian Baptist"],["dc.date.accessioned","2019-07-09T11:41:23Z"],["dc.date.available","2019-07-09T11:41:23Z"],["dc.date.issued","2015"],["dc.description.abstract","Introduction. Intra-abdominal pressure (IAP) measurement is an indispensable tool for the diagnosis of abdominal hypertension. Different techniques have been described in the literature and applied in the clinical setting. Methods. A porcine model was created to simulate an abdominal compartment syndrome ranging from baseline IAP to 30 mmHg. Three different measurement techniques were applied, comprising telemetric piezoresistive probes at two different sites (epigastric and pelvic) for direct pressure measurement and intragastric and intravesical probes for indirect measurement. Results. The mean difference between the invasive IAP measurements using telemetric pressure probes and the IVP measurements was -0.58 mmHg. The bias between the invasive IAP measurements and the IGP measurements was 3.8 mmHg. Compared to the realistic results of the intraperitoneal and intravesical measurements, the intragastric data showed a strong tendency towards decreased values. The hydrostatic character of the IAP was eliminated at high-pressure levels. Conclusion. We conclude that intragastric pressure measurement is potentially hazardous and might lead to inaccurately low intra-abdominal pressure values. This may result in missed diagnosis of elevated abdominal pressure or even ACS. The intravesical measurements showed the most accurate values during baseline pressure and both high-pressure plateaus."],["dc.identifier.doi","10.1155/2015/278139"],["dc.identifier.pmid","26113992"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12011"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58418"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2090-1305"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Pressure Measurement Techniques for Abdominal Hypertension: Conclusions from an Experimental Model."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]