Bock, Hans-Christoph

[["dc.bibliographiccitation.firstpage","613"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Child's Nervous System"],["dc.bibliographiccitation.lastpage","619"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Thomale, Ulrich-Wilhelm"],["dc.contributor.author","Cinalli, Giuseppe"],["dc.contributor.author","Kulkarni, Abhaya V."],["dc.contributor.author","Al-Hakim, Sara"],["dc.contributor.author","Roth, Jonathan"],["dc.contributor.author","Schaumann, Andreas"],["dc.contributor.author","Bührer, Christoph"],["dc.contributor.author","Cavalheiro, Sergio"],["dc.contributor.author","Sgouros, Spyros"],["dc.contributor.author","Constantini, Shlomi"],["dc.contributor.author","Bock, Hans Christoph"],["dc.date.accessioned","2020-12-10T14:10:20Z"],["dc.date.available","2020-12-10T14:10:20Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00381-019-04077-4"],["dc.identifier.eissn","1433-0350"],["dc.identifier.issn","0256-7040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70731"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","TROPHY registry study design: a prospective, international multicenter study for the surgical treatment of posthemorrhagic hydrocephalus in neonates"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","833"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Child's Nervous System"],["dc.bibliographiccitation.lastpage","841"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Bock, Hans C."],["dc.contributor.author","Dreha-Kulaczewski, Steffi F."],["dc.contributor.author","Alaid, Awad"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Ludwig, Hans C."],["dc.date.accessioned","2020-12-10T14:10:20Z"],["dc.date.available","2020-12-10T14:10:20Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00381-019-04119-x"],["dc.identifier.eissn","1433-0350"],["dc.identifier.issn","0256-7040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70732"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Upward movement of cerebrospinal fluid in obstructive hydrocephalus—revision of an old concept"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","96"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neuro-Oncology"],["dc.bibliographiccitation.lastpage","104"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Ringel, Florian"],["dc.contributor.author","Pape, Haiko"],["dc.contributor.author","Sabel, Michael"],["dc.contributor.author","Krex, Dietmar"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Misch, Martin"],["dc.contributor.author","Weyerbrock, Astrid"],["dc.contributor.author","Westermaier, Thomas"],["dc.contributor.author","Senft, Christian"],["dc.contributor.author","Schucht, Philippe"],["dc.contributor.author","Meyer, Bernhard"],["dc.contributor.author","Simon, Matthias"],["dc.date.accessioned","2018-11-07T10:20:56Z"],["dc.date.available","2018-11-07T10:20:56Z"],["dc.date.issued","2016"],["dc.description.abstract","While standards for the treatment of newly diagnosed glioblastomas exist, therapeutic regimens for tumor recurrence remain mostly individualized. The role of a surgical resection of recurrent glioblastomas remains largely unclear at present. This study aimed to assess the effect of repeated resection of recurrent glioblastomas on patient survival. In a multicenter retrospective-design study, patients with primary glioblastomas undergoing repeat resections for recurrent tumors were evaluated for factors affecting survival. Age, Karnofsky performance status (KPS), extent of resection (EOR), tumor location, and complications were assessed. Five hundred and three patients (initially diagnosed between 2006 and 2010) undergoing resections for recurrent glioblastoma at 20 institutions were included in the study. The patients' median overall survival after initial diagnosis was 25.0 months and 11.9 months after first re-resection. The following parameters were found to influence survival significantly after first re-resection: preoperative and postoperative KPS, EOR of first re-resection, and chemotherapy after first re-resection. The rate of permanent new deficits after first re-resection was 8%. The present study supports the view that surgical resections of recurrent glioblastomas may help to prolong patient survival at an acceptable complication rate."],["dc.identifier.doi","10.1093/neuonc/nov145"],["dc.identifier.isi","000371232900013"],["dc.identifier.pmid","26243790"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41983"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1523-5866"],["dc.relation.issn","1522-8517"],["dc.title","Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Child's Nervous System"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","von Philipp, Gottberg"],["dc.contributor.author","Ludwig, Hans Christoph"],["dc.date.accessioned","2021-07-05T15:00:52Z"],["dc.date.available","2021-07-05T15:00:52Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Objective Shunt treatment for hydrocephalus in children should aim for sustainable flexibility in regard to optional, perspective pressure level adjustment during advancing physical and mental development. Gravitation-assisted shunt valves are designed to prevent hydrostatic over-drainage frequently observed in the long course of shunt-treated hydrocephalus. We prospectively studied and analyzed the implication, safety, and feasibility for an adjustable gravitational unit combined with a fixed differential-pressure (DP) valve for neonates and infants primary shunted within the first 12 months of life. Methods Clinical course of hydrocephalic neonates and infants who received initial VP-shunt insertion in the early post-natal phase were monitored prospectively on the basis of our digital institutional Hydrocephalus & Shunt Registry. All patients were equipped with a fixed DP valve combined with a programmable gravitational unit activated in upright body position. Patients with a minimum shunt follow-up of 24 months were considered for further statistical analysis regarding hydrocephalus etiology, surgical setting, pre- and post-operative ventricular enlargement, head circumference, valve pressure setting, implication for the adjustment option of the gravitational unit, type and number of shunt complications, and revision-free shunt and valve survival. Results Seventy-eight pediatric patients received primary VP-shunt insertion at a mean age of 10 weeks with age gestationally corrected for preterm neonates. Hydrocephalus was related to perinatal IVH (64%), CNS malformation (11%), spina bifida (9%), congenital aqueductal stenosis (9%), and idiopathic (4%) or post-infectious etiology (3%). Fifty-two patients (70%) presented with history of prematurity (gestational age 23–36 weeks). Regular follow-up carried out for a mean period of 63 months demonstrated that ventricular enlargement decreased significantly after applied treatment and excessive head growth could be counteracted effectively. At least one pressure level adjustment was performed in 31% of all patients after 12 months, in 42% after 24 months, and in 64% at the time of last clinical follow-up since initial shunt insertion. Pressure level adjustments were successful in cases of clinical or radiographic signs of under- or over-drainage for individual patients of various ages during entire clinical course. Mean pressure setting for upright position was 24.1 cm H 2 O at the time of initial shunt insertion and increased to 26.4 cmH 2 O at the time of last clinical follow-up. Revision-free shunt-survival rates after 12 and 24 months were 79% and 70% and valve-survival rates 91% and 90%, respectively. Conclusion The combination of a fixed DP valve with an adjustable gravitational unit utilized as first-line shunt regimen was feasible and safe in a highly vulnerable subgroup of hydrocephalic infants. The adjustment option for the gravitational unit showed frequent and increasing implication over time and was beneficial even during the very early developmental stage of limited autonomous mobility. To our knowledge this is the first ever reported long-term investigation of an age-consistent pediatric patient collective primary shunted with an adjustable gravitational valve system."],["dc.description.abstract","Abstract Objective Shunt treatment for hydrocephalus in children should aim for sustainable flexibility in regard to optional, perspective pressure level adjustment during advancing physical and mental development. Gravitation-assisted shunt valves are designed to prevent hydrostatic over-drainage frequently observed in the long course of shunt-treated hydrocephalus. We prospectively studied and analyzed the implication, safety, and feasibility for an adjustable gravitational unit combined with a fixed differential-pressure (DP) valve for neonates and infants primary shunted within the first 12 months of life. Methods Clinical course of hydrocephalic neonates and infants who received initial VP-shunt insertion in the early post-natal phase were monitored prospectively on the basis of our digital institutional Hydrocephalus & Shunt Registry. All patients were equipped with a fixed DP valve combined with a programmable gravitational unit activated in upright body position. Patients with a minimum shunt follow-up of 24 months were considered for further statistical analysis regarding hydrocephalus etiology, surgical setting, pre- and post-operative ventricular enlargement, head circumference, valve pressure setting, implication for the adjustment option of the gravitational unit, type and number of shunt complications, and revision-free shunt and valve survival. Results Seventy-eight pediatric patients received primary VP-shunt insertion at a mean age of 10 weeks with age gestationally corrected for preterm neonates. Hydrocephalus was related to perinatal IVH (64%), CNS malformation (11%), spina bifida (9%), congenital aqueductal stenosis (9%), and idiopathic (4%) or post-infectious etiology (3%). Fifty-two patients (70%) presented with history of prematurity (gestational age 23–36 weeks). Regular follow-up carried out for a mean period of 63 months demonstrated that ventricular enlargement decreased significantly after applied treatment and excessive head growth could be counteracted effectively. At least one pressure level adjustment was performed in 31% of all patients after 12 months, in 42% after 24 months, and in 64% at the time of last clinical follow-up since initial shunt insertion. Pressure level adjustments were successful in cases of clinical or radiographic signs of under- or over-drainage for individual patients of various ages during entire clinical course. Mean pressure setting for upright position was 24.1 cm H 2 O at the time of initial shunt insertion and increased to 26.4 cmH 2 O at the time of last clinical follow-up. Revision-free shunt-survival rates after 12 and 24 months were 79% and 70% and valve-survival rates 91% and 90%, respectively. Conclusion The combination of a fixed DP valve with an adjustable gravitational unit utilized as first-line shunt regimen was feasible and safe in a highly vulnerable subgroup of hydrocephalic infants. The adjustment option for the gravitational unit showed frequent and increasing implication over time and was beneficial even during the very early developmental stage of limited autonomous mobility. To our knowledge this is the first ever reported long-term investigation of an age-consistent pediatric patient collective primary shunted with an adjustable gravitational valve system."],["dc.identifier.doi","10.1007/s00381-021-05250-4"],["dc.identifier.pii","5250"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87925"],["dc.language.iso","en"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.relation.eissn","1433-0350"],["dc.relation.issn","0256-7040"],["dc.title","An adjustable gravitational valve for initial VP-shunt treatment in hydrocephalic preterm neonates and infants below 1 year of age"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","226"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Folia Neuropathologica"],["dc.bibliographiccitation.lastpage","233"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Goldmann, Torben"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Strik, Herwig"],["dc.contributor.author","Bock, Hans-Christoph"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Knauth, Michael"],["dc.date.accessioned","2018-11-07T09:45:46Z"],["dc.date.available","2018-11-07T09:45:46Z"],["dc.date.issued","2014"],["dc.description.abstract","Introduction: Malignant brain tumors tend to migration and invasion of surrounding brain tissue. Histopathological studies reported malignant cells in macroscopically unsuspicious parenchyma (normal appearing white matter - NAWM) remote from the tumor localization. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is hypothesized. Material and methods: Patients' ADC and FA values from NAWM of the hemisphere contralateral to a malignant glioma were compared to age- and sex-matched normal controls. Results: Apparent diffusion coefficient levels of the entire contra lateral hemisphere revealed a significant increase and a decrease of FA levels. An even more pronounced ADC increase was found in a region mirroring the glioma location. Conclusions: In patients with previously untreated anaplastic astrocytoma or glioblastoma, an increase of the ADC and a reduction of FA were found in the brain parenchyma of the hemisphere contralateral to the tumor localization. In the absence of visible MRI abnormalities, this may be an early indicator of microstructural changes of the NAWM attributed to malignant brain tumor."],["dc.description.sponsorship","Volkswagen Stiftung [ZN1635, ZN 2193]"],["dc.identifier.doi","10.5114/fn.2014.45563"],["dc.identifier.isi","000342712000002"],["dc.identifier.pmid","25310733"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34702"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1509-572X"],["dc.relation.issn","1641-4640"],["dc.title","Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","457"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Child's Nervous System"],["dc.bibliographiccitation.lastpage","464"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Kanzler, Maximilian"],["dc.contributor.author","Thomale, Ulrich-Wilhelm"],["dc.contributor.author","Ludwig, Hans Christoph"],["dc.date.accessioned","2020-12-10T14:10:20Z"],["dc.date.available","2020-12-10T14:10:20Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00381-017-3654-0"],["dc.identifier.eissn","1433-0350"],["dc.identifier.issn","0256-7040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70730"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Implementing a digital real-time Hydrocephalus and Shunt Registry to evaluate contemporary pattern of care and surgical outcome in pediatric hydrocephalus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Neuro-Oncology"],["dc.contributor.author","Bettag, Christoph"],["dc.contributor.author","Hussein, Abdelhalim"],["dc.contributor.author","Sachkova, Alexandra"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Abboud, Tammam"],["dc.date.accessioned","2021-07-05T15:00:56Z"],["dc.date.available","2021-07-05T15:00:56Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s11060-021-03792-w"],["dc.identifier.pii","3792"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87939"],["dc.language.iso","en"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.relation.eissn","1573-7373"],["dc.relation.issn","0167-594X"],["dc.title","Implantation of Carmustine wafers after resection of malignant glioma with and without opening of the ventricular system"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","233"],["dc.bibliographiccitation.issue","04"],["dc.bibliographiccitation.journal","Neuropediatrics"],["dc.bibliographiccitation.lastpage","241"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Ludwig, Hans C."],["dc.contributor.author","Bock, Hans C."],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Schiller, Stina"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dreha-Kulaczewski, Steffi"],["dc.date.accessioned","2021-08-12T07:45:08Z"],["dc.date.available","2021-08-12T07:45:08Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract New experimental and clinical findings question the historic view of hydrocephalus and its 100-year-old classification. In particular, real-time magnetic resonance imaging (MRI) evaluation of cerebrospinal fluid (CSF) flow and detailed insights into brain water regulation on the molecular scale indicate the existence of at least three main mechanisms that determine the dynamics of neurofluids: (1) inspiration is a major driving force; (2) adequate filling of brain ventricles by balanced CSF upsurge is sensed by cilia; and (3) the perivascular glial network connects the ependymal surface to the pericapillary Virchow–Robin spaces. Hitherto, these aspects have not been considered a common physiologic framework, improving knowledge and therapy for severe disorders of normal-pressure and posthemorrhagic hydrocephalus, spontaneous intracranial hypotension, and spaceflight disease."],["dc.description.abstract","Abstract New experimental and clinical findings question the historic view of hydrocephalus and its 100-year-old classification. In particular, real-time magnetic resonance imaging (MRI) evaluation of cerebrospinal fluid (CSF) flow and detailed insights into brain water regulation on the molecular scale indicate the existence of at least three main mechanisms that determine the dynamics of neurofluids: (1) inspiration is a major driving force; (2) adequate filling of brain ventricles by balanced CSF upsurge is sensed by cilia; and (3) the perivascular glial network connects the ependymal surface to the pericapillary Virchow–Robin spaces. Hitherto, these aspects have not been considered a common physiologic framework, improving knowledge and therapy for severe disorders of normal-pressure and posthemorrhagic hydrocephalus, spontaneous intracranial hypotension, and spaceflight disease."],["dc.identifier.doi","10.1055/s-0041-1731981"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88375"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","1439-1899"],["dc.relation.issn","0174-304X"],["dc.title","Hydrocephalus Revisited: New Insights into Dynamics of Neurofluids on Macro- and Microscales"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","252"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Neurosurgery"],["dc.bibliographiccitation.lastpage","262"],["dc.bibliographiccitation.volume","83"],["dc.contributor.author","Thomale, Ulrich-Wilhelm"],["dc.contributor.author","Schaumann, Andreas"],["dc.contributor.author","Stockhammer, Florian"],["dc.contributor.author","Giese, Henrik"],["dc.contributor.author","Schuster, Dhani"],["dc.contributor.author","Kästner, Stefanie"],["dc.contributor.author","Ahmadi, Sebastian A."],["dc.contributor.author","Polemikos, Manolis"],["dc.contributor.author","Bock, Hans-Christoph"],["dc.contributor.author","Gölz, Leonie"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","Hermann, Elvis"],["dc.contributor.author","Schuhmann, Martin"],["dc.contributor.author","Beez, Thomas"],["dc.contributor.author","Fritsch, Michael"],["dc.contributor.author","Orakcioglu, Berk"],["dc.contributor.author","Vajkoczy, Peter"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Bohner, Georg"],["dc.date.accessioned","2018-10-10T07:14:06Z"],["dc.date.available","2018-10-10T07:14:06Z"],["dc.date.issued","2018-08-01"],["dc.description.abstract","Freehand ventricular catheter placement may represent limited accuracy for the surgeon's intent to achieve primary optimal catheter position.To investigate the accuracy of a ventricular catheter guide assisted by a simple mobile health application (mhealth app) in a multicenter, randomized, controlled, simple blinded study (GAVCA study). In total, 139 eligible patients were enrolled in 9 centers. Catheter placement was evaluated by 3 different components: number of ventricular cannulation attempts, a grading scale, and the anatomical position of the catheter tip. The primary endpoint was the rate of primary cannulation of grade I catheter position in the ipsilateral ventricle. The secondary endpoints were rate of intraventricular position of the catheter's perforations, early ventricular catheter failure, and complications. The primary endpoint was reached in 70% of the guided group vs 56.5% (freehand group; odds ratio 1.79, 95% confidence interval 0.89-3.61). The primary successful puncture rate was 100% vs 91.3% (P = .012). Catheter perforations were located completely inside the ventricle in 81.4% (guided group) and 65.2% (freehand group; odds ratio 2.34, 95% confidence interval 1.07-5.1). No differences occurred in early ventricular catheter failure, complication rate, duration of surgery, or hospital stay. The guided ventricular catheter application proved to be a safe and simple method. The primary endpoint revealed a nonsignificant improvement of optimal catheter placement among the groups. Long-term follow-up is necessary in order to evaluate differences in catheter survival among shunted patients."],["dc.fs.pkfprnr","44523"],["dc.identifier.doi","10.1093/neuros/nyx420"],["dc.identifier.fs","633504"],["dc.identifier.pmid","28973670"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15918"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1524-4040"],["dc.title","GAVCA Study: Randomized, Multicenter Trial to Evaluate the Quality of Ventricular Catheter Placement with a Mobile Health Assisted Guidance Technique"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","199"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","CENTRAL EUROPEAN NEUROSURGERY"],["dc.bibliographiccitation.lastpage","206"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Giese, A."],["dc.contributor.author","Bock, Hans-Christoph"],["dc.contributor.author","Kantelhardt, Sven Rainer"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T08:37:23Z"],["dc.date.available","2018-11-07T08:37:23Z"],["dc.date.issued","2010"],["dc.description.abstract","Implantation of BCNU wafers (Gliadel (R)) into the resection cavity has demonstrated a survival benefit for patients with newly diagnosed malignant gliomas. The follow-up of two phase III trails has further shown that the number of long-term survivors was significantly increased by BCNU wafer treatment. BCNU wafer implantation may be integrated into current multimodal first line strategies. In the setting of recurrent disease BCNU wafer implantation has also shown a survival benefit and now extends the treatment options in a patient population that typically has undergone extensive pretreatment. An analysis of the literature has helped to clearly identify the risks associated with topic BCNU treatment. Here we summarize the incidence and time course of adverse events associated with local chemotherapy and propose solutions. The growing body of experience with BCNU wafer implantation may serve as a basis to develop adequate risk management strategies with regard to patient selection, surgical techniques, and follow-up schedules."],["dc.identifier.doi","10.1055/s-0029-1242775"],["dc.identifier.isi","000284355500007"],["dc.identifier.pmid","20063259"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18516"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0044-4251"],["dc.title","Risk Management in the Treatment of Malignant Gliomas with BCNU Wafer Implants"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]