Salditt, Tim

[["dc.bibliographiccitation.firstpage","41932"],["dc.bibliographiccitation.issue","25"],["dc.bibliographiccitation.journal","Optics Express"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Soltau, Jakob"],["dc.contributor.author","Lohse, Leon Merten"],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2021-12-02T15:07:31Z"],["dc.date.available","2021-12-02T15:07:31Z"],["dc.date.issued","2021-12-01"],["dc.description.abstract","Recent progress in nanofabrication, namely of multilayer optics, and the constructionof coherent hard x-ray sources has enabled high resolution x-ray microscopy with large numericalaperture optics for small focal spot sizes. Sub-10 nm and even sub-5 nm focal spot sizes havealready been achieved using multilayer optics such as multilayer Laue lenses and multilayerzone plates. However these optics can not be described by the kinematic theory given theirextreme aspect-ratio between the depth (thickness) and the layer width. Moreover, the numericalsimulation of these optics is challenging, and the absence of an accessible numerical frameworkinhibits further progress in their design and utilization. Here, we simulate the propagation of x-raywavefields within and behind optical multilayer elements using a finite-difference propagationmethod. We show that the method offers high accuracy at reasonable computational cost. Weinvestigate how small focal spot sizes and highest diffraction efficiency of multilayer opticscan be achieved, considering volume diffraction effects such as waveguiding and Pendellösung.Finally, we show the simulation of a novel imaging scheme, allowing for a detailed study ofimage formation and the development of customized phase retrieval schemes."],["dc.identifier.doi","10.1364/OE.445300"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94973"],["dc.relation.issn","1094-4087"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.title","Finite-difference propagation for the imulation of x-ray multilayer optics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Kalbfleisch, Sebastian"],["dc.contributor.author","Neubauer, Heike"],["dc.contributor.author","Krüger, Sven P"],["dc.contributor.author","Bartels, Matthias"],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Mai, Dong-Du"],["dc.contributor.author","Giewekemeyer, Klaus"],["dc.contributor.author","Hartmann, Britta"],["dc.contributor.author","Sprung, Michael"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","McNulty, Ian"],["dc.contributor.author","Eyberger, Catherine"],["dc.contributor.author","Lai, Barry"],["dc.date.accessioned","2017-09-07T11:54:07Z"],["dc.date.available","2017-09-07T11:54:07Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1063/1.3625313"],["dc.identifier.gro","3145117"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2818"],["dc.language.iso","en"],["dc.notes.intern","Crossref Import"],["dc.notes.status","public"],["dc.publisher","AIP Publishing"],["dc.publisher.place","Melville, NY"],["dc.relation","SFB 755: Nanoscale Photonic Imaging"],["dc.relation.conference","10th International Conference on X-Ray Microscopy"],["dc.relation.eventend","2010-08-20"],["dc.relation.eventlocation","Chicago, Illinois"],["dc.relation.eventstart","2010-08-15"],["dc.relation.isbn","0-7354-0925-0"],["dc.relation.isbn","978-0-7354-0925-5"],["dc.relation.ispartof","The 10th International Conference on X-Ray Microscopy"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray optics"],["dc.subject.gro","x-ray imaging"],["dc.title","The Göttingen Holography Endstation of Beamline P10 at PETRA III∕DESY"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","203902"],["dc.bibliographiccitation.issue","20"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Hoffmann, S."],["dc.contributor.author","Vassholz, M."],["dc.contributor.author","Haber, J."],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Hilhorst, J."],["dc.contributor.orcid","0000-0002-0368-8782"],["dc.creator.author","Vassholz, Malte"],["dc.date.accessioned","2022-11-21T10:16:33Z"],["dc.date.available","2022-11-21T10:16:33Z"],["dc.date.issued","2015"],["dc.description.abstract","We study the propagation of hard x rays in single curved x-ray waveguide channels and observe waveguide effects down to surprisingly small radii of curvature R similar or equal to 10 mm and a large contour length s similar or equal to 5 mm, deflecting beams up to 30 degrees. At these high angles, about 2 orders of magnitude above the critical angle of total reflection theta(c), most radiation modes are lost by \"leaking\" into the cladding, while certain \"survivor\" modes persist. This may open up a new form of integrated x-ray optics \"on a chip,\" requiring curvatures mostly well below the extreme values studied here, e.g., to split and to delay x-ray pulses."],["dc.identifier.doi","10.1103/PhysRevLett.115.203902"],["dc.identifier.gro","3141790"],["dc.identifier.isi","000364413900008"],["dc.identifier.pmid","26613440"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/117173"],["dc.identifier.url","https://publications.goettingen-research-online.de/handle/2/1101"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1079-7114"],["dc.relation.haserratum","/handle/2/98884"],["dc.relation.issn","0031-9007"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray optics and imaging"],["dc.title","X-Ray Optics on a Chip: Guiding X Rays in Curved Channels"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","19311"],["dc.bibliographiccitation.issue","16"],["dc.bibliographiccitation.journal","Optics Express"],["dc.bibliographiccitation.lastpage","19323"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Döring, Florian"],["dc.contributor.author","Robisch, Anna-Lena"],["dc.contributor.author","Eberl, Christian"],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Ruhlandt, Aike"],["dc.contributor.author","Liese, Tobias"],["dc.contributor.author","Schlenkrich, Felix"],["dc.contributor.author","Hoffmann, S."],["dc.contributor.author","Bartels, Matthias"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Krebs, Hans-Ulrich"],["dc.date.accessioned","2020-11-05T15:05:23Z"],["dc.date.available","2020-11-05T15:05:23Z"],["dc.date.issued","2013"],["dc.description.abstract","Compound optics such as lens systems can overcome the limitations concerning resolution, efficiency, or aberrations which fabrication constraints would impose on any single optical element. In this work we demonstrate unprecedented sub-5 nm point focusing of hard x-rays, based on the combination of a high gain Kirkpatrick-Baez (KB) mirror system and a high resolution W/Si multilayer zone plate (MZP) for ultra-short focal length f. The pre-focusing allows limiting the MZP radius to below 2 mu m, compatible with the required 5 nm structure width and essentially unlimited aspect ratios, provided by enabling fabrication technology based on pulsed laser deposition (PLD) and focused ion beam (FIB). (c) 2013 Optical Society of America"],["dc.identifier.doi","10.1364/OE.21.019311"],["dc.identifier.gro","3142308"],["dc.identifier.isi","000323049900072"],["dc.identifier.pmid","23938848"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/68456"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-352.6"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation","SFB 755: Nanoscale Photonic Imaging"],["dc.relation.eissn","1094-4087"],["dc.relation.issn","1094-4087"],["dc.relation.orgunit","Institut für Materialphysik"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray optics"],["dc.title","Sub-5 nm hard x-ray point focusing by a combined Kirkpatrick-Baez mirror and multilayer zone plate"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","71"],["dc.bibliographiccitation.lastpage","124"],["dc.bibliographiccitation.seriesnr","134"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.editor","Salditt, Tim"],["dc.contributor.editor","Egner, Alexander"],["dc.contributor.editor","Luke, D. Russell"],["dc.date.accessioned","2021-04-21T11:15:35Z"],["dc.date.available","2021-04-21T11:15:35Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/978-3-030-34413-9_3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84263"],["dc.relation","SFB 755: Nanoscale Photonic Imaging"],["dc.relation.crisseries","Topics in Applied Physics"],["dc.relation.doi","10.1007/978-3-030-34413-9"],["dc.relation.eisbn","978-3-030-34413-9"],["dc.relation.isbn","978-3-030-34412-2"],["dc.relation.ispartof","Nanoscale Photonic Imaging"],["dc.relation.ispartofseries","Topics in Applied Physics; 134"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.subject.gro","SFB 755"],["dc.title","X-ray Focusing and Optics"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","368"],["dc.bibliographiccitation.journal","Talanta"],["dc.bibliographiccitation.lastpage","376"],["dc.bibliographiccitation.volume","161"],["dc.contributor.author","Surowka, A.D."],["dc.contributor.author","Töpperwien, Mareike"],["dc.contributor.author","Bernhardt, Markus"],["dc.contributor.author","Nicolas, J. D."],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Adamek, D."],["dc.contributor.author","Szczerbowska-Boruchowska, M."],["dc.date.accessioned","2020-03-11T09:18:44Z"],["dc.date.available","2020-03-11T09:18:44Z"],["dc.date.issued","2016"],["dc.description.abstract","Human dopaminergic system in general, and substantia nigra (SN) neurons, in particular, are implicated in the pathologies underlying the human brain aging. The interplay between aberrations in the structural organization and elemental composition of SN neuron bodies has recently gained in importance as selected metals: Fe, Cu, Zn, Ca were found to trigger oxidative-stress-mediated aberration in their molecular assembly due to concomitant protein (alpha-synuclein, tau-protein) aggregation, gliosis and finally oxidative stress. In the present study, we demonstrate an integrated approach to the analysis of the structural organization, assembly, and metals' accumulation in two distinct areas of SN: in the neuromelanin neurons and neuropil. By using the highly brilliant source of PETRA III and the Kirkpatrick-Baez nano-focus, large area histological brain slices are scanned at the sub-neuronal resolution, taking advantage of continuous motor movement and reduced acquisition time. Elemental analysis with synchrotron radiation based X-ray Fluorescence (SRXRF) is combined with X-ray Phase Contrast Imaging (XPCI) to correct for inherent aberrations in the samples' density and thickness, often referred to as the mass thickness effect. Based on the raw SRXRF spectra, we observed the accumulation of P, S, Cl, K, Ca, Fe, Cu and Zn predominantly in the SN neurons. However, upon the mass thickness correction, the distributions of Cl became significantly more uniform. Simultaneously with the fluorescence signal, the Small Angle X-ray Scattering (SAXS) is recorded by a pixel detector positioned in the far-field, enabling fast online computation of the darkfield and differential phase contrast (DPC). The data has demonstrated the SN neurons and neuropil produces excellent contrast which is due to their different mass density and scattering strength, indicative of differences in local structure and assembly therein. In all, the results show that combined SRXRF-XPCI-SAXS experiments can robustly serve as a unique tool for understanding the interplay between the chemical composition and structural organization that may drive the biochemical age-related processes occurring in the human dopaminergic system."],["dc.identifier.doi","10.1016/j.talanta.2016.08.023"],["dc.identifier.gro","3142481"],["dc.identifier.pmid","27769419"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63294"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.eissn","1873-3573"],["dc.relation.issn","0039-9140"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray imaging"],["dc.title","Combined in-situ imaging of structural organization and elemental composition of substantia nigra neurons in the elderly"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Döring, Florian"],["dc.contributor.author","Eberl, Christian"],["dc.contributor.author","Wilke, Robin N."],["dc.contributor.author","Wallentin, Jesper"],["dc.contributor.author","Krebs, Hans-Ulrich"],["dc.contributor.author","Sprung, Michael"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2017-09-07T11:54:07Z"],["dc.date.available","2017-09-07T11:54:07Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1117/12.2187799"],["dc.identifier.gro","3145110"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2810"],["dc.notes.intern","Crossref Import"],["dc.notes.status","public"],["dc.publisher","SPIE"],["dc.publisher.place","Bellingham, Wash."],["dc.relation","SFB 755: Nanoscale Photonic Imaging"],["dc.relation.conference","X-ray nanoimaging: instruments and methods"],["dc.relation.eventend","2015-08-13"],["dc.relation.eventlocation","San Diego, Calif."],["dc.relation.eventstart","2015-08-12"],["dc.relation.isbn","978-1-62841-758-6"],["dc.relation.ispartof","X-ray nanoimaging: instruments and methods II: 12 - 13 August 2015, San Diego, California, United States"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray optics"],["dc.subject.gro","x-ray imaging"],["dc.title","Progress on multi-order hard x-ray imaging with multilayer zone plates"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Kalbfleisch, Sebastian"],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Giewekemeyer, Klaus"],["dc.contributor.author","Neubauer, Heike"],["dc.contributor.author","Krüger, Sven P"],["dc.contributor.author","Hartmann, Britta"],["dc.contributor.author","Bartels, Matthias"],["dc.contributor.author","Sprung, Michael"],["dc.contributor.author","Leupold, O."],["dc.contributor.author","Siewert, F."],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Garrett, R."],["dc.contributor.author","Gentle, I."],["dc.contributor.author","Nugent, K."],["dc.contributor.author","Wilkins, S."],["dc.date.accessioned","2017-09-07T11:54:07Z"],["dc.date.available","2017-09-07T11:54:07Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1063/1.3463233"],["dc.identifier.gro","3145119"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2820"],["dc.language.iso","en"],["dc.notes.intern","Crossref Import"],["dc.notes.status","public"],["dc.publisher","AIP Publishing"],["dc.publisher.place","Melville, NY"],["dc.relation","SFB 755: Nanoscale Photonic Imaging"],["dc.relation.conference","10th International Conference on Synchrotron Radiation Instrumentation"],["dc.relation.eventend","2009-10-02"],["dc.relation.eventlocation","Melbourne, Australia"],["dc.relation.eventstart","2009-09-27"],["dc.relation.isbn","978-0-7354-0782-4"],["dc.relation.ispartof","SRI 2009: the 10th International Conference on Synchrotron Radiation Instrumentation"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray optics"],["dc.subject.gro","x-ray imaging"],["dc.title","The holography endstation of beamline P10 at PETRA III"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Eckermann, Marina"],["dc.contributor.author","Frohn, Jasper"],["dc.contributor.author","Reichardt, Marius"],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Sprung, Michael"],["dc.contributor.author","Westermeier, Fabian"],["dc.contributor.author","Tzankov, Alexandar"],["dc.contributor.author","Werlein, Christopher"],["dc.contributor.author","Kuehnel, Mark"],["dc.contributor.author","Jonigk, Danny"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2020-06-26T11:04:13Z"],["dc.date.available","2020-06-26T11:04:13Z"],["dc.date.issued","2020"],["dc.description.abstract","We present a new approach of three-dimensional (3d) virtual histology and patho-histology based on multi-scale phase contrast x-ray tomography, and use this to investigate the parenchymal-architecture of unstained lung tissue from patients who succumbed to Covid-19. Based on this first proof-of-concept study, we can propose multi-scale phase contrast x-ray tomography as a novel tool to unravel the patho-physiology of Covid-19, extending conventional histology by a third dimension and allowing for a full quantification of tissue remodeling.By combining parallel and cone beam geometry, autopsy samples with a cross section of 4mm are scanned and reconstructed at a resolution and image quality which allows for the segmentation of individual cells. Using the zoom capability of the cone beam geometry, regions-of-interest are reconstructed with a minimum voxel size of 160nm. We exemplify the capability of this approach by 3d visualisation of the diffuse alveolar damage with its prominent hyaline membrane formation, by mapping the 3d distribution and density of lymphocytes infiltrating the tissue, and by providing histograms of characteristic distances from tissue interior to the closest air compartment."],["dc.identifier.doi","10.1101/2020.06.21.20134882"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66752"],["dc.language.iso","en"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.subject.gro","x-ray imaging"],["dc.subject.gro","biomedical tomography"],["dc.subject.gro","other"],["dc.title","3d Virtual Patho-Histology of Lung Tissue from Covid-19 Patients based on Phase Contrast X-ray Tomography"],["dc.type","preprint"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","884802"],["dc.bibliographiccitation.volume","8848"],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Bartels, Matthias"],["dc.contributor.author","Döring, Florian"],["dc.contributor.author","Eberl, Christian"],["dc.contributor.author","Hoinkes, Thomas"],["dc.contributor.author","Hoffmann-Urlaub, Sarah"],["dc.contributor.author","Liese, Tobias"],["dc.contributor.author","Radisch, Volker"],["dc.contributor.author","Rauschenbeutel, Arno"],["dc.contributor.author","Robisch, Anna Lena"],["dc.contributor.author","Ruhlandt, Aike"],["dc.contributor.author","Schlenkrich, Felix"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Krebs, Hans Ulrich"],["dc.contributor.editor","Goto, Shunji"],["dc.contributor.editor","Morawe, Christian"],["dc.contributor.editor","Khounsary, Ali"],["dc.date.accessioned","2020-02-24T13:39:51Z"],["dc.date.available","2020-02-24T13:39:51Z"],["dc.date.issued","2013"],["dc.description.abstract","We present experiments carried out using a combined hard x-ray focusing set-up preserving the benefits of a large-aperture Kirckpatrick-Baez (KB) mirror system and a small focal length multilayer zone plane (MZP). The high gain KB mirrors produce a pre-focus of 400 nm × 200 nm; in their defocus, two MZP lenses of diameter of 1.6 μm and 3.7 μm have been placed, with focal lengths of 50 μm and 250 μm respectively. The lenses have been produced using pulsed laser deposition (PLD) and focused ion beam (FIB). Forward simulations including error models based on measured deviations, auto-correlation analysis and three-plane phase reconstruction support two-dimensional focus sizes of 4.3 nm × 4.7 nm (7:9 keV, W/Si)1 and 4.3 nm ×5.9 nm (13:8 keV, W/ZrO2), respectively."],["dc.identifier.doi","10.1117/12.2025389"],["dc.identifier.gro","3145113"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2814"],["dc.language.iso","en"],["dc.notes.intern","Crossref Import"],["dc.notes.status","final"],["dc.relation.conference","SPIE"],["dc.relation.crisseries","Proceedings of SPIE"],["dc.relation.eventend","2013-08-28"],["dc.relation.eventlocation","San Diego"],["dc.relation.eventstart","2013"],["dc.relation.isbn","978-0-8194-9698-0"],["dc.relation.ispartof","Advances in X-ray/EUV optics and components VIII"],["dc.relation.ispartofseries","Proceedings of SPIE; 8848"],["dc.relation.issn","0277-786X"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray optics"],["dc.title","Two-dimensional sub-5-nm hard x-ray focusing with MZP"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]