Salditt, Tim

[["dc.bibliographiccitation.artnumber","268101"],["dc.bibliographiccitation.issue","26"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","111"],["dc.contributor.author","Khakhulin, D."],["dc.contributor.author","Wulff, M."],["dc.contributor.author","Reusch, Tobias"],["dc.contributor.author","Mai, Dong-Du"],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2020-11-05T15:05:25Z"],["dc.date.available","2020-11-05T15:05:25Z"],["dc.date.issued","2013"],["dc.description.abstract","We study the nonequilibrium shape fluctuations in fluorescence labeled phospholipid multibilayers composed of the model lipid DOPC and the well-known lipid dye Texas red, driven out of equilibrium by short laser pulses. The temporal evolution of the lipid bilayer undulations after excitation was recorded by time resolved x-ray diffraction. Already at moderate peak intensities (P-p <= 10(5) W/cm(2)), pulsed laser illumination leads to significant changes of the undulation modes in a well-defined lateral wavelength band. The observed phenomena evolve on nano-to microsecond time scales after optical excitation, and can be described in terms of a modulation instability in the lipid multilamellar stack."],["dc.identifier.doi","10.1103/PhysRevLett.111.268101"],["dc.identifier.gro","3142229"],["dc.identifier.isi","000331934500020"],["dc.identifier.pmid","24483815"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10030"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/68467"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-352.6"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1079-7114"],["dc.relation.issn","0031-9007"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0/"],["dc.subject.gro","x-ray scattering"],["dc.subject.gro","membrane biophysics"],["dc.title","Nonequilibrium Collective Dynamics in Photoexcited Lipid Multilayers by Time Resolved Diffuse X-Ray Scattering"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","43"],["dc.bibliographiccitation.lastpage","86"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Komorowski, Karlo"],["dc.contributor.author","Frank, Kilian"],["dc.contributor.editor","Nieh, Mu-Ping"],["dc.contributor.editor","Heberle, Frederick A."],["dc.contributor.editor","Katsaras, John"],["dc.date.accessioned","2020-03-03T08:14:53Z"],["dc.date.available","2020-03-03T08:14:53Z"],["dc.date.issued","2019"],["dc.description.abstract","In this chapter, we describe X-ray diffraction analysis of lipid model membranes, including fundamentals of experiment and analysis. We start with solid-supported single bilayers and monolayers, then discuss solid-supported multilamellar stacks, and finally vesicles in solution. For oriented membranes, we discuss specular and nonspecular reflectivity, as well as grazing incidence diffraction, and for vesicles we discuss small-angle X-ray scattering. In each case, illustrative examples of current applications are given. The chapter closes with an outlook on free electron laser sources and new opportunities for research on lipid model membranes and biomembranes."],["dc.identifier.doi","10.1515/9783110544657-002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63066"],["dc.language.iso","en"],["dc.publisher","De Gruyter"],["dc.publisher.place","Berlin, Boston"],["dc.relation.eisbn","978-3-11-054465-7"],["dc.relation.ispartof","Characterization of Biological Membranes: Structure and Dynamics"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray scattering"],["dc.subject.gro","membrane biophysics"],["dc.title","X-ray structure analysis of lipid membrane systems: solid-supported bilayers, bilayer stacks, and vesicles"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1576"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Biophysical Journal"],["dc.bibliographiccitation.lastpage","1584"],["dc.bibliographiccitation.volume","85"],["dc.contributor.author","Spaar, Alexander"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2017-09-07T11:44:15Z"],["dc.date.available","2017-09-07T11:44:15Z"],["dc.date.issued","2003"],["dc.description.abstract","We present a study of the short range ordering of hydrocarbon chains in phospholipid bilayers. The x-ray peak associated with the hydrocarbon chains has been probed by means of reciprocal space mappings. Using 20 keV undulator radiation and samples of negligible mosaicity ( orientational disorder), the intensity distribution is probed as a function of two coordinates, the momentum transfer parallel and perpendicular to the bilayer, over a wide range and at high resolution. Structural results are obtained concerning the distribution of tilted segments, the correlation length and the radial distribution function of the quasi two-dimensional liquid structure. A comparison is made with published molecular dynamics data ( H. Heller, M. Schaefer, and K. Schulten. 1993. J. Phys. Chem. 97: 8343 - 8360) by direct Fourier transformation of the atomic coordinates. The exact prefactor in the relationship between interchain distance and peak position is derived."],["dc.identifier.doi","10.1016/S0006-3495(03)74589-5"],["dc.identifier.gro","3144064"],["dc.identifier.isi","000185009900021"],["dc.identifier.pmid","12944274"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1647"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0006-3495"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray scattering"],["dc.subject.gro","membrane biophysics"],["dc.title","Short range order of hydrocarbon chains in fluid phospholipid bilayers studied by x-ray diffraction from highly oriented membranes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","118102"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","113"],["dc.contributor.author","Reusch, Tobias"],["dc.contributor.author","Schuelein, Florian J. R."],["dc.contributor.author","Nicolas, Jan-David"],["dc.contributor.author","Osterhoff, Markus"],["dc.contributor.author","Beerlink, André"],["dc.contributor.author","Krenner, Hubert J."],["dc.contributor.author","Mueller, M."],["dc.contributor.author","Wixforth, Achim"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2020-11-05T15:05:24Z"],["dc.date.available","2020-11-05T15:05:24Z"],["dc.date.issued","2014"],["dc.description.abstract","We use standing surface acoustic waves to induce coherent phonons in model lipid multilayers deposited on a piezoelectric surface. Probing the structure by phase-controlled stroboscopic x-ray pulses we find that the internal lipid bilayer electron density profile oscillates in response to the externally driven motion of the lipid film. The structural response to the well-controlled motion is a strong indication that bilayer structure and membrane fluctuations are intrinsically coupled, even though these structural changes are averaged out in equilibrium and time integrating measurements. Here the effects are revealed by a timing scheme with temporal resolution on the picosecond scale in combination with the sub-nm spatial resolution, enabled by high brilliance synchrotron x-ray reflectivity."],["dc.identifier.doi","10.1103/PhysRevLett.113.118102"],["dc.identifier.gro","3142054"],["dc.identifier.isi","000345970800012"],["dc.identifier.pmid","25260008"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11552"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/68462"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-352.6"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1079-7114"],["dc.relation.issn","0031-9007"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0/"],["dc.subject.gro","x-ray scattering"],["dc.subject.gro","membrane biophysics"],["dc.title","Collective Lipid Bilayer Dynamics Excited by Surface Acoustic Waves"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","061908"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Physical Review E"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Rheinstädter, Maikel C."],["dc.contributor.author","Seydel, Tilo"],["dc.contributor.author","Demmel, F."],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2017-09-07T11:54:26Z"],["dc.date.available","2017-09-07T11:54:26Z"],["dc.date.issued","2005"],["dc.description.abstract","We report a high energy-resolution neutron backscattering study to investigate slow motions on nanosecond time scales in highly oriented solid supported phospholipid bilayers of the model system DMPC-d54 (deuterated 1,2-dimyristoyl-sn-glycero-3-phoshatidylcholine), hydrated with heavy water. This technique allows to discriminate the onset of mobility at different length scales for the different molecular components, as, e. g., the lipid acyl-chains and the hydration water in between the membrane stacks, respectively, and provides a benchmark test regarding the feasibility of neutron backscattering investigations on these sample systems. We discuss freezing of the lipid acyl-chains, as observed by this technique, and observe a second freezing transition which we attribute to the hydration water."],["dc.identifier.doi","10.1103/PhysRevE.71.061908"],["dc.identifier.gro","3143841"],["dc.identifier.isi","000230274500058"],["dc.identifier.pmid","16089766"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1399"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1539-3755"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","membrane biophysics"],["dc.title","Molecular motions in lipid bilayers studied by the neutron backscattering technique"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","283"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","The European Physical Journal E - Soft Matter"],["dc.bibliographiccitation.lastpage","290"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Constantin, Doru"],["dc.contributor.author","Mennicke, U."],["dc.contributor.author","Li, C"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2017-09-07T11:44:13Z"],["dc.date.available","2017-09-07T11:44:13Z"],["dc.date.issued","2003"],["dc.description.abstract","We present a theoretical description of the thermal fluctuations in a solid-supported stack of lipid bilayers, for the case of vanishing surface tension gamma= 0 and in the framework of continuous smectic elasticity. The model is successfully used to model the reflectivity profile of a thin (16 bilayers) DMPC sample under applied osmotic pressure and the diffuse scattering from a thick (800 bilayers) stack. We compare our model to previously existing theories."],["dc.identifier.doi","10.1140/epje/i2003-10063-1"],["dc.identifier.gro","3144053"],["dc.identifier.isi","000186890500009"],["dc.identifier.pmid","15007664"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1635"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1292-8941"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","membrane biophysics"],["dc.title","Solid-supported lipid multilayers: Structure factor and fluctuations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","769"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Molecular Biology"],["dc.bibliographiccitation.lastpage","779"],["dc.bibliographiccitation.volume","341"],["dc.contributor.author","Arbely, E"],["dc.contributor.author","Khattari, Ziad"],["dc.contributor.author","Brotons, Guillaume"],["dc.contributor.author","Akkawi, M"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Arkin, I. T."],["dc.date.accessioned","2017-09-07T11:43:16Z"],["dc.date.available","2017-09-07T11:43:16Z"],["dc.date.issued","2004"],["dc.description.abstract","The agent responsible for the recent severe acute respiratory syndrome (SARS) outbreak is a previously unidentified coronavirus. While there is a wealth of epidemiological studies, little if any molecular characterization of SARS coronavirus (SCoV) proteins has been carried out. Here we describe the molecular characterization of SCoV E protein, a critical component of the virus responsible for virion envelope morphogenesis. We conclusively show that SCoV E protein contains an unusually short, palindromic transmembrane helical hairpin around a previously unidentified pseudo-center of symmetry, a structural feature which seems to be unique to SCoV The hairpin deforms lipid bilayers by way of increasing their curvature, providing for the first time a molecular explanation of E protein's pivotal role in viral budding. The molecular understanding of this critical component of SCoV may represent the beginning of a concerted effort aimed at inhibiting its function, and consequently, viral infectivity. (C) 2004 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.jmb.2004.06.044"],["dc.identifier.gro","3143955"],["dc.identifier.isi","000223240200010"],["dc.identifier.pmid","15288785"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1526"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","0022-2836"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","membrane biophysics"],["dc.title","A highly unusual palindromic transmembrane helical hairpin formed by SARS coronavirus E protein"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","566"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Biochimica et Biophysica Acta (BBA) - Biomembranes"],["dc.bibliographiccitation.lastpage","578"],["dc.bibliographiccitation.volume","1860"],["dc.contributor.author","Xu, Yihui"],["dc.contributor.author","Kuhlmann, Jan"],["dc.contributor.author","Brennich, Martha"],["dc.contributor.author","Komorowski, Karlo"],["dc.contributor.author","Jahn, Reinhard"],["dc.contributor.author","Steinem, Claudia"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2018-01-17T13:00:13Z"],["dc.date.available","2018-01-17T13:00:13Z"],["dc.date.issued","2018"],["dc.description.abstract","SNAREs are known as an important family of proteins mediating vesicle fusion. For various biophysical studies, they have been reconstituted into supported single bilayers via proteoliposome adsorption and rupture. In this study we extended this method to the reconstitution of SNAREs into supported multilamellar lipid membranes, i.e. oriented multibilayer stacks, as an ideal model system for X-ray structure analysis (X-ray reflectivity and diffraction). The reconstitution was implemented through a pathway of proteomicelle, proteoliposome and multibilayer. To monitor the structural evolution in each step, we used small-angle X-ray scattering for the proteomicelles and proteoliposomes, followed by X-ray reflectivity and grazing-incidence small-angle scattering for the multibilayers. Results show that SNAREs can be successfully reconstituted into supported multibilayers, with high enough orientational alignment for the application of surface sensitive X-ray characterizations. Based on this protocol, we then investigated the effect of SNAREs on the structure and phase diagram of the lipid membranes. Beyond this application, this reconstitution protocol could also be useful for X-ray analysis of many further membrane proteins."],["dc.identifier.doi","10.1016/j.bbamem.2017.10.023"],["dc.identifier.pmid","29106973"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/11697"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray scattering"],["dc.subject.gro","membrane biophysics"],["dc.title","Reconstitution of SNARE proteins into solid-supported lipid bilayer stacks and X-ray structure analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","178101"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","90"],["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Vogel, Martin"],["dc.contributor.author","Fenzl, W."],["dc.date.accessioned","2018-11-07T10:38:59Z"],["dc.date.available","2018-11-07T10:38:59Z"],["dc.date.issued","2003"],["dc.description.abstract","We have determined the positional correlation functions in aligned stacks of fully hydrated phospholipid bilayers from the thermal diffuse scattering measured by nonspecular x-ray reflectivity. While fair agreement can be obtained between experiment and linear smectic theory at length scales above 120 Angstrom, significant deviations occur at small r, which are tentatively attributed to collective protrusion modes."],["dc.identifier.doi","10.1103/PhysRevLett.90.178101"],["dc.identifier.isi","000182603800052"],["dc.identifier.pmid","12786106"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45938"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.haserratum","/handle/2/1506"],["dc.relation.issn","0031-9007"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray scattering"],["dc.subject.gro","membrane biophysics"],["dc.title","Thermal fluctuations and positional correlations in oriented lipid membranes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Salditt, Tim"],["dc.contributor.author","Plech, A."],["dc.contributor.editor","Tripathy, Surkant K."],["dc.contributor.editor","Kumar, Jayant"],["dc.contributor.editor","Nalwa, Hari Singh"],["dc.date.accessioned","2017-09-07T11:44:56Z"],["dc.date.available","2017-09-07T11:44:56Z"],["dc.date.issued","2002"],["dc.identifier.gro","3145420"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/3126"],["dc.notes.intern","lifescience"],["dc.notes.status","public"],["dc.notes.submitter","chake"],["dc.publisher","American Scientific Publishers"],["dc.publisher.place","Stevenson Ranch, Calif."],["dc.relation.isbn","1-58883-002-0"],["dc.relation.ispartof","Handbook of Polyelectrolytes and Their Applications. 1. Polyelectrolyte-based multilayers, self-assemblies and nanostructures"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.subject.gro","x-ray scattering"],["dc.subject.gro","membrane biophysics"],["dc.title","Structure of self-assembled thin films and polyelectrolyte composites studied by surface sensitive scattering techniques"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]