Baraki, Hassina

[["dc.bibliographiccitation.firstpage","107"],["dc.bibliographiccitation.issue","02"],["dc.bibliographiccitation.journal","The Thoracic and Cardiovascular Surgeon"],["dc.bibliographiccitation.lastpage","113"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Saha, Shekhar"],["dc.contributor.author","Varghese, Sam"],["dc.contributor.author","Ahmad, Ammar Al"],["dc.contributor.author","Jebran, Ahmad Fawad"],["dc.contributor.author","Waezi, Narges"],["dc.contributor.author","Niehaus, Heidi"],["dc.contributor.author","Baraki, Hassina"],["dc.contributor.author","Kutschka, Ingo"],["dc.date.accessioned","2020-12-10T18:12:17Z"],["dc.date.available","2020-12-10T18:12:17Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1055/s-0038-1670663"],["dc.identifier.eissn","1439-1902"],["dc.identifier.issn","0171-6425"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74313"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Complex Valve Surgery in Elderly Patients: Increasingly Necessary and Surprisingly Feasible"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","850"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Tissue Engineering and Regenerative Medicine"],["dc.bibliographiccitation.lastpage","861"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Minol, Jan-Philipp"],["dc.contributor.author","Baraki, Hassina"],["dc.contributor.author","Akhyari, Payam"],["dc.contributor.author","Bagaev, Eric"],["dc.contributor.author","Suprunov, Marc"],["dc.contributor.author","Brandes, Gudrun"],["dc.contributor.author","Bara, Christoph L."],["dc.contributor.author","Hort, Waldemar"],["dc.contributor.author","Hurschler, Christof"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Haverich, Axel"],["dc.contributor.author","Hilfiker, Andres"],["dc.contributor.author","Lichtenberg, Artur"],["dc.date.accessioned","2018-11-07T09:33:10Z"],["dc.date.available","2018-11-07T09:33:10Z"],["dc.date.issued","2014"],["dc.description.abstract","Modern cardiovascular medicine aims for procedures that preferably involve biological materials and, ideally, living implants. Thereby, the regenerative capacity of the target organ may be preserved or even supported, with a potential implant growth capacity during the following time. In the current study we sought to evaluate the integrative capacity of vital and non-vital tracheal cartilage rings (TCRs) of allogenic or xenogenic origin (allo-/xeno-vTCR; allo-/xeno-nvTCR) as biomaterials under the in vivo functional load of the circulatory system. Ovine and porcine vTCRs and nvTCRs were implanted in the mitral valve (MV) position for 3 and 9 months (n=3 each), respectively, in lambs. MV function and TCR position were analysed by echocardiography. Tissue morphology (planimetry), vitality (live/dead-assay) and implant endothelialization (scanning electron microscopy) were analysed. No functional impairment or significant MV insufficiency or stenosis was observed in any group. TCR shrinkage was observed in all xeno-TCRs and allo-nvTCRs at 3 months. Only TCRs of allogenic groups at 9 months and allo-vTCRs at 3 months showed a ring area comparable to its size at implantation. Moreover, allogenic vital cartilage showed superior tissue integration, greater endothelialization, less inflammation and calcification. Interestingly, in this group viable cartilage cells were found up to 9 months after implantation. Allogenic viable cartilage may represent a well-suited living material for reconstructive cardiovascular procedures, and further studies are warranted to elucidate the benefits of this novel material, particularly as a structurally supportive component in growing recipients. Copyright (c) 2012 John Wiley & Sons, Ltd."],["dc.description.sponsorship","Braukmann-Wittenberg Foundation, Lower Saxony, Germany"],["dc.identifier.doi","10.1002/term.1585"],["dc.identifier.isi","000344335700002"],["dc.identifier.pmid","22837178"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31908"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1932-7005"],["dc.relation.issn","1932-6254"],["dc.title","Tracheal cartilage - evaluating the potential of a novel biomaterial for reconstructive cardiovascular procedures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4603"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Anticancer Research"],["dc.bibliographiccitation.lastpage","4612"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","BUENTZEL, JUDITH"],["dc.contributor.author","HEINZ, JUDITH"],["dc.contributor.author","BLECKMANN, ANNALEN"],["dc.contributor.author","BAUER, CHRISTOPH"],["dc.contributor.author","RÖVER, CHRISTIAN"],["dc.contributor.author","BOHNENBERGER, HANIBAL"],["dc.contributor.author","SAHA, SHEKHAR"],["dc.contributor.author","HINTERTHANER, MARC"],["dc.contributor.author","BARAKI, HASSINA"],["dc.contributor.author","KUTSCHKA, INGO"],["dc.contributor.author","EMMERT, ALEXANDER"],["dc.date.accessioned","2020-12-10T18:43:04Z"],["dc.date.available","2020-12-10T18:43:04Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.21873/anticanres.13640"],["dc.identifier.eissn","1791-7530"],["dc.identifier.issn","0250-7005"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78183"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Sarcopenia as Prognostic Factor in Lung Cancer Patients: A Systematic Review and Meta-analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.volume","128"],["dc.contributor.author","Kyryachenko, Sergiy"],["dc.contributor.author","Georges, Adrien"],["dc.contributor.author","Yu, Mengyao"],["dc.contributor.author","Barrandou, Takiy"],["dc.contributor.author","Guo, Lilong"],["dc.contributor.author","Bruneval, Patrick"],["dc.contributor.author","Rubio, Tony"],["dc.contributor.author","Gronwald, Judith"],["dc.contributor.author","Baraki, Hassina"],["dc.contributor.author","Bouatia-Naji, Nabila"],["dc.date.accessioned","2021-06-01T09:42:11Z"],["dc.date.available","2021-06-01T09:42:11Z"],["dc.date.issued","2021"],["dc.description.abstract","Rationale: Mitral valve prolapse (MVP) is a common valvopathy that leads to mitral insufficiency, heart failure, and sudden death. Functional genomic studies in mitral valves are needed to better characterize MVP-associated variants and target genes. Objective: To establish the chromatin accessibility profiles and assess functionality of variants and narrow down target genes at MVP loci. Methods and Results: We mapped the open chromatin regions in nuclei from 11 human pathogenic and 7 nonpathogenic mitral valves by an assay for transposase-accessible chromatin with high-throughput sequencing. Open chromatin peaks were globally similar between pathogenic and nonpathogenic valves. Compared with the heart tissue and cardiac fibroblasts, we found that MV-specific assay for transposase-accessible chromatin with high-throughput sequencing peaks are enriched near genes involved in extracellular matrix organization, chondrocyte differentiation, and connective tissue development. One of the most enriched motifs in MV-specific open chromatin peaks was for the nuclear factor of activated T cells family of TFs (transcription factors) involved in valve endocardial and interstitial cell formation. We also found that MVP-associated variants were significantly enriched ( P <0.05) in mitral valve open chromatin peaks. Integration of the assay for transposase-accessible chromatin with high-throughput sequencing data with risk loci, extensive functional annotation, and gene reporter assay suggest plausible causal variants for rs2641440 at the SMG6/SRR locus and rs6723013 at the IGFBP2/IGFBP5/TNS1 locus. CRISPR-Cas9 deletion of the sequence including rs6723013 in human fibroblasts correlated with increased expression only for TNS1 . Circular chromatin conformation capture followed by high-throughput sequencing experiments provided evidence for several target genes, including SRR , HIC1 , and DPH1 at the SMG6/SRR locus and further supported TNS1 as the most likely target gene on chromosome 2. Conclusions: Here, we describe unprecedented genome-wide open chromatin profiles from human pathogenic and nonpathogenic MVs and report specific gene regulation profiles, compared with the heart. We also report in vitro functional evidence for potential causal variants and target genes at MVP risk loci involving established and new biological mechanisms. Graphic Abstract: A graphic abstract is available for this article."],["dc.identifier.doi","10.1161/CIRCRESAHA.120.317581"],["dc.identifier.pmid","33508947"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85168"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/301"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/395"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A13: Bedeutung einer gestörten zytosolischen Calciumpufferung bei der atrialen Arrhythmogenese bei Patienten mit Herzinsuffizienz (HF)"],["dc.relation.eissn","1524-4571"],["dc.relation.issn","0009-7330"],["dc.relation.workinggroup","RG Voigt (Molecular Pharmacology)"],["dc.title","Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","86"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Herz"],["dc.bibliographiccitation.lastpage","94"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Hadem, J."],["dc.contributor.author","Rossnick, R."],["dc.contributor.author","Hesse, B."],["dc.contributor.author","Herr, M."],["dc.contributor.author","Hansen, M."],["dc.contributor.author","Bergmann, A."],["dc.contributor.author","Kensah, G."],["dc.contributor.author","Maess, C."],["dc.contributor.author","Baraki, H."],["dc.contributor.author","Kümpers, P."],["dc.contributor.author","Lukasz, A."],["dc.contributor.author","Kutschka, I."],["dc.date.accessioned","2020-12-10T14:07:55Z"],["dc.date.available","2020-12-10T14:07:55Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00059-018-4708-0"],["dc.identifier.eissn","1615-6692"],["dc.identifier.issn","0340-9937"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70333"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Endotheliale Dysfunktion nach koronarer Bypass-Operation"],["dc.title.alternative","Endothelial dysfunction following coronary artery bypass grafting. Influence of patient and procedural factors"],["dc.title.subtitle","Einfluss von Patientenfaktoren und Operationstechnik"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","409"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Interactive Cardiovascular and Thoracic Surgery"],["dc.bibliographiccitation.lastpage","415"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Jebran, Ahmad-Fawad"],["dc.contributor.author","Saha, Shekhar"],["dc.contributor.author","Waezi, Narges"],["dc.contributor.author","Al-Ahmad, Ammar"],["dc.contributor.author","Niehaus, Heidi"],["dc.contributor.author","Danner, Bernhard C."],["dc.contributor.author","Baraki, Hassina"],["dc.contributor.author","Kutschka, Ingo"],["dc.date.accessioned","2020-12-10T18:19:16Z"],["dc.date.available","2020-12-10T18:19:16Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1093/icvts/ivz112"],["dc.identifier.eissn","1569-9285"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75185"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Design and training effects of a physical reality simulator for minimally invasive mitral valve surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","975"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Biomarkers in Medicine"],["dc.bibliographiccitation.lastpage","985"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Albert, Christian"],["dc.contributor.author","Albert, Annemarie"],["dc.contributor.author","Bellomo, Rinaldo"],["dc.contributor.author","Kropf, Siegfried"],["dc.contributor.author","Devarajan, Prasad"],["dc.contributor.author","Westphal, Sabine"],["dc.contributor.author","Baraki, Hassina"],["dc.contributor.author","Kutschka, Ingo"],["dc.contributor.author","Butter, Christian"],["dc.contributor.author","Haase, Michael"],["dc.contributor.author","Haase-Fielitz, Anja"],["dc.date.accessioned","2020-12-10T18:43:38Z"],["dc.date.available","2020-12-10T18:43:38Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.2217/bmm-2018-0071"],["dc.identifier.eissn","1752-0371"],["dc.identifier.issn","1752-0363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78200"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Urinary neutrophil gelatinase-associated lipocalin-guided risk assessment for major adverse kidney events after open-heart surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]