Falla, Deborah Lorraine

[["dc.bibliographiccitation.artnumber","e0186400"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Gram, Mikkel"],["dc.contributor.author","Erlenwein, Joachim"],["dc.contributor.author","Petzke, Frank"],["dc.contributor.author","Falla, Deborah"],["dc.contributor.author","Przemeck, Michael"],["dc.contributor.author","Emons, Miriam I."],["dc.contributor.author","Reuster, Michael"],["dc.contributor.author","Olesen, Søren S."],["dc.contributor.author","Drewes, Asbjørn M."],["dc.date.accessioned","2019-07-09T11:44:41Z"],["dc.date.available","2019-07-09T11:44:41Z"],["dc.date.issued","2017"],["dc.description.abstract","BACKGROUND: Experimental models have been used extensively to evaluate pain using e.g., visual analogue scales or electroencephalography (EEG). Stimulation using tonic pain has been shown to better mimic the unpleasantness of chronic pain, but has mainly been evoked by non-clinical stimuli. This study aims to, evaluate the EEG during clinical pain in patients scheduled for total hip replacement with control and resting conditions. METHODS: The hip scheduled for replacement was moved by the examiner to evoke pain for 30 seconds while recording EEG. The control condition entailed movement of the opposite hip in a similar fashion and holding it for 30 seconds. In addition, EEG was recorded during the resting condition with open eyes. The relative spectral content was calculated from the EEG as well as functional connectivity using phase-lag index for frequency bands delta (1-4Hz), theta (4-8Hz), alpha (8-12Hz) and beta (12-32Hz). A mixed model was used for statistical comparison between the three recording conditions. RESULTS: Spectral content differed between conditions in all bands. Functional connectivity differed in delta and theta frequency bands. Post-hoc analysis revealed differences between the painful and control condition in delta, theta and beta for spectral content. Pain during the hip rotation was correlated to the theta (r = -0.24 P = 0.03) and beta (r = 0.25 P = 0.02) content in the EEG. CONCLUSION: EEG differences during hip movements in the affected and unaffected hip appeared in the spectral beta and theta content. This was correlated to the reported pain perceived, pointing towards pain specific brain activity related to clinical pain."],["dc.identifier.doi","10.1371/journal.pone.0186400"],["dc.identifier.pmid","29084278"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14866"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59066"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Cats"],["dc.subject.mesh","Cerebral Cortex"],["dc.subject.mesh","Electroencephalography"],["dc.subject.mesh","Female"],["dc.subject.mesh","Guinea Pigs"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Male"],["dc.subject.mesh","Osteoarthritis, Hip"],["dc.subject.mesh","Pain"],["dc.title","The cortical responses to evoked clinical pain in patients with hip osteoarthritis."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0206514"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","PlOS ONE"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Crawford, Rebecca"],["dc.contributor.author","Gizzi, Leonardo"],["dc.contributor.author","Dieterich, Angela"],["dc.contributor.author","Ni Mhuiris, Áine"],["dc.contributor.author","Falla, Deborah"],["dc.date.accessioned","2019-07-09T11:50:17Z"],["dc.date.available","2019-07-09T11:50:17Z"],["dc.date.issued","2018"],["dc.description.abstract","The influence of age on spinal muscle activation patterns and its relation to kinematics is poorly understood. We aimed at understanding age-related changes to spine and trunk muscle activity in addition to spinal and lower limb kinematics during treadmill walking under various conditions. An observational study was conducted evaluating asymptomatic young (n = 10; 3F, 7M; 26.3±2.5yrs) and older (n = 9; 3F, 6M; 67.1±4.2yrs) adults' treadmill walking at 2km/h and 4km/h, each at 0, 1, 5, and 10% inclination. Unilateral (right side) electromyography (EMG) was recorded from deep and superficial multifidus (intramuscular) and erector spinae and abdominal obliques (surface); trunk and leg kinematics were also measured. Muscle activity was characterised by peak amplitude and duration of activity, and the time-point of peak amplitude in the gait cycle (0-100%). Peak activation in older adults was lower for the superficial multifidus (p<0.0001) and higher for the thoracolumbar (p<0.001) and lumbar erector spinae (p<0.01). The duration of activation was longer in older adults for all muscles (p<0.05) except the superficial multifidus, and longer during faster walking for all participants. The time-point of peak amplitude in the gait cycle was earlier in older participants for the external obliques (p<0.05). Walking speed appeared to influence muscle activity more than inclination. Older adults used less spine, trunk and lower limb motion, except at the ankle. Age-related differences within multifidus and between paravertebral and trunk muscles were inconsistent. Walking at 4km/h at 5-10% inclination may specifically target the lumbar paravertebral muscles."],["dc.identifier.doi","10.1371/journal.pone.0206514"],["dc.identifier.pmid","30408111"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15902"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59739"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Age-related changes in trunk muscle activity and spinal and lower limb kinematics during gait"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]