Trenkwalder, Claudia

[["dc.bibliographiccitation.firstpage","152"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Movement Disorders"],["dc.bibliographiccitation.lastpage","153"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Salminen, Aaro V."],["dc.contributor.author","Allen, Richard P."],["dc.contributor.author","Högl, Birgit"],["dc.contributor.author","Inoue, Yuichi"],["dc.contributor.author","Oertel, Wolfgang"],["dc.contributor.author","Winkelman, John W."],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Sampaio, Cristina"],["dc.contributor.author","Winkelmann, Juliane"],["dc.date.accessioned","2021-06-01T10:46:50Z"],["dc.date.available","2021-06-01T10:46:50Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/mds.27570"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85400"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1531-8257"],["dc.relation.issn","0885-3185"],["dc.title","Reply to: A note on rotigotine for restless legs syndrome after renal transplantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","78"],["dc.bibliographiccitation.journal","Sleep Medicine"],["dc.bibliographiccitation.lastpage","85"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Zieglgänsberger, Walter"],["dc.contributor.author","Ahmedzai, Sam"],["dc.contributor.author","Högl, Birgit"],["dc.date.accessioned","2018-10-10T06:53:44Z"],["dc.date.available","2018-10-10T06:53:44Z"],["dc.date.issued","2017"],["dc.description.abstract","Opioid receptor agonists are known to relieve restless legs syndrome (RLS) symptoms, including both sensory and motor events, as well as improving sleep. The mechanisms of action of opioids in RLS are still a matter of speculation. The mechanisms by which endogenous opioids contribute to the pathophysiology of this polygenetic disorder, in which there are a number of variants, including developmental factors, remains unknown. A summary of the cellular mode of action of morphine and its (partial) antagonist naloxone via α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and the involvement of dendritic spine activation is described. By targeting pain and its consequences, opioids are the first-line treatment in many diseases and conditions with both acute and chronic pain and have thus been used in both acute and chronic pain conditions over the last 40 years. Addiction, dependence, and tolerability of opioids show a wide variability interindividually, as the response to opioids is influenced by a complex combination of genetic, molecular, and phenotypic factors. Although several trials have now addressed opioid treatment in RLS, hyperalgesia as a complication of long-term opioid treatment, or opioid-opioid interaction have not received much attention so far. Therapeutic opioids may act not only on opioid receptors but also via histamine or N-methyl-d-aspartate (NMDA) receptors. In patients with RLS, one of the few studies investigating opioid bindings found that possible brain regions involved in the severity of RLS symptoms are similar to those known to be involved in chronic pain, such as the medial pain system (medial thalamus, amygdala, caudate nucleus, anterior cingulate gyrus, insular cortex, and orbitofrontal cortex). The results of this diprenorphine positron emission tomography study suggested that the more severe the RLS, the greater the release of endogenous opioids. Since 1993, when the first small controlled study was performed with oxycodone in RLS, opioids have been considered an efficacious off-label therapy in patients with severe RLS. A recent trial has proved the efficacy of a combination of prolonged release oxycodone/naloxone in patients with severe RLS as second-line therapy, with a mean dosage of 10/5 mg twice daily (mean difference of International Restless Legs Syndrome Study Group Rating Scale (IRLS) score between groups at 12 weeks: 8.15), and has now been licensed as the first opioid therapy in Europe. The current results from both short- and long-term trials and studies with opioids encourage optimism in alleviating RLS symptoms in patients with severe RLS, or possibly during or after augmentation."],["dc.fs.pkfprnr","47312"],["dc.identifier.doi","10.1016/j.sleep.2016.09.017"],["dc.identifier.fs","634111"],["dc.identifier.pmid","27964861"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15914"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1878-5506"],["dc.title","Pain, opioids, and sleep: implications for restless legs syndrome treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","744"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Brain"],["dc.bibliographiccitation.lastpage","759"],["dc.bibliographiccitation.volume","142"],["dc.contributor.author","Postuma, Ronald B."],["dc.contributor.author","Iranzo, Alex"],["dc.contributor.author","Hu, Michele"],["dc.contributor.author","Högl, Birgit"],["dc.contributor.author","Boeve, Bradley F."],["dc.contributor.author","Manni, Raffaele"],["dc.contributor.author","Oertel, Wolfgang H."],["dc.contributor.author","Arnulf, Isabelle"],["dc.contributor.author","Ferini-Strambi, Luigi"],["dc.contributor.author","Puligheddu, Monica"],["dc.contributor.author","Antelmi, Elena"],["dc.contributor.author","Cochen De Cock, Valerie"],["dc.contributor.author","Arnaldi, Dario"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Videnovic, Aleksandar"],["dc.contributor.author","Sonka, Karel"],["dc.contributor.author","Jung, Ki-Young"],["dc.contributor.author","Kunz, Dieter"],["dc.contributor.author","Dauvilliers, Yves"],["dc.contributor.author","Provini, Federica"],["dc.contributor.author","Lewis, Simon J."],["dc.contributor.author","Buskova, Jitka"],["dc.contributor.author","Pavlova, Milena"],["dc.contributor.author","Heidbreder, Anna"],["dc.contributor.author","Montplaisir, Jacques Y."],["dc.contributor.author","Santamaria, Joan"],["dc.contributor.author","Barber, Thomas R."],["dc.contributor.author","Stefani, Ambra"],["dc.contributor.author","St.Louis, Erik K."],["dc.contributor.author","Terzaghi, Michele"],["dc.contributor.author","Janzen, Annette"],["dc.contributor.author","Leu-Semenescu, Smandra"],["dc.contributor.author","Plazzi, Guiseppe"],["dc.contributor.author","Nobili, Flavio"],["dc.contributor.author","Sixel-Doering, Friederike"],["dc.contributor.author","Dusek, Petr"],["dc.contributor.author","Bes, Frederik"],["dc.contributor.author","Cortelli, Pietro"],["dc.contributor.author","Ehgoetz Martens, Kaylena"],["dc.contributor.author","Gagnon, Jean-Francois"],["dc.contributor.author","Gaig, Carles"],["dc.contributor.author","Zucconi, Marco"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Gan-Or, Ziv"],["dc.contributor.author","Lo, Christine"],["dc.contributor.author","Rolinski, Michal"],["dc.contributor.author","Mahlknecht, Philip"],["dc.contributor.author","Holzknecht, Evi"],["dc.contributor.author","Boeve, Angel R."],["dc.contributor.author","Teigen, Luke N."],["dc.contributor.author","Toscano, Gianpaolo"],["dc.contributor.author","Mayer, Geert"],["dc.contributor.author","Morbelli, Silvia"],["dc.contributor.author","Dawson, Benjamin"],["dc.contributor.author","Pelletier, Amelie"],["dc.date.accessioned","2020-03-04T10:32:28Z"],["dc.date.accessioned","2021-10-27T13:22:09Z"],["dc.date.available","2020-03-04T10:32:28Z"],["dc.date.available","2021-10-27T13:22:09Z"],["dc.date.issued","2019"],["dc.description.abstract","Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. This provides an unprecedented opportunity to directly observe prodromal neurodegenerative states, and potentially intervene with neuroprotective therapy. For future neuroprotective trials, it is essential to accurately estimate phenoconversion rate and identify potential predictors of phenoconversion. This study assessed the neurodegenerative disease risk and predictors of neurodegeneration in a large multicentre cohort of iRBD. We combined prospective follow-up data from 24 centres of the International RBD Study Group. At baseline, patients with polysomnographically-confirmed iRBD without parkinsonism or dementia underwent sleep, motor, cognitive, autonomic and special sensory testing. Patients were then prospectively followed, during which risk of dementia and parkinsonsim were assessed. The risk of dementia and parkinsonism was estimated with Kaplan-Meier analysis. Predictors of phenoconversion were assessed with Cox proportional hazards analysis, adjusting for age, sex, and centre. Sample size estimates for disease-modifying trials were calculated using a time-to-event analysis. Overall, 1280 patients were recruited. The average age was 66.3 ± 8.4 and 82.5% were male. Average follow-up was 4.6 years (range = 1-19 years). The overall conversion rate from iRBD to an overt neurodegenerative syndrome was 6.3% per year, with 73.5% converting after 12-year follow-up. The rate of phenoconversion was significantly increased with abnormal quantitative motor testing [hazard ratio (HR) = 3.16], objective motor examination (HR = 3.03), olfactory deficit (HR = 2.62), mild cognitive impairment (HR = 1.91-2.37), erectile dysfunction (HR = 2.13), motor symptoms (HR = 2.11), an abnormal DAT scan (HR = 1.98), colour vision abnormalities (HR = 1.69), constipation (HR = 1.67), REM atonia loss (HR = 1.54), and age (HR = 1.54). There was no significant predictive value of sex, daytime somnolence, insomnia, restless legs syndrome, sleep apnoea, urinary dysfunction, orthostatic symptoms, depression, anxiety, or hyperechogenicity on substantia nigra ultrasound. Among predictive markers, only cognitive variables were different at baseline between those converting to primary dementia versus parkinsonism. Sample size estimates for definitive neuroprotective trials ranged from 142 to 366 patients per arm. This large multicentre study documents the high phenoconversion rate from iRBD to an overt neurodegenerative syndrome. Our findings provide estimates of the relative predictive value of prodromal markers, which can be used to stratify patients for neuroprotective trials."],["dc.identifier.doi","10.1093/brain/awz030"],["dc.identifier.pmid","30789229"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17196"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92072"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.eissn","1460-2156"],["dc.relation.issn","1460-2156"],["dc.relation.issn","0006-8950"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.subject.ddc","610"],["dc.title","Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

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