Trenkwalder, Claudia

[["dc.bibliographiccitation.firstpage","A371"],["dc.bibliographiccitation.journal","SLEEP"],["dc.bibliographiccitation.lastpage","A372"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Winkelmann, Juliane"],["dc.contributor.author","Prager, M."],["dc.contributor.author","Lieb, Roselind"],["dc.contributor.author","Pfister, H."],["dc.contributor.author","Spiegel, B."],["dc.contributor.author","Wittchen, Hans-Ulrich"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Strohle, A."],["dc.date.accessioned","2018-11-07T10:30:39Z"],["dc.date.available","2018-11-07T10:30:39Z"],["dc.date.issued","2002"],["dc.identifier.isi","000174927200517"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43916"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Acad Sleep Medicine"],["dc.publisher.place","Westchester"],["dc.relation.issn","0161-8105"],["dc.title","Mood and anxiety disorders in patients with restless legs syndrome"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","284"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.lastpage","285"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Weniger, Godehard"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Dornte, M."],["dc.contributor.author","Irle, Eva"],["dc.date.accessioned","2018-11-07T10:56:36Z"],["dc.date.available","2018-11-07T10:56:36Z"],["dc.date.issued","2005"],["dc.identifier.isi","000232591900260"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50054"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","24th Symposium of the Arbeitsgemeinschaft-fur-Neuropsychopharmakologie-und-Pharmakopsychiatrie (AGNP)"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","Psychiatric comorbidity and neuropsychological changes in patients with restless-legs-syndrome"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","507"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","SLEEP"],["dc.bibliographiccitation.lastpage","512"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Eisensehr, I."],["dc.contributor.author","Linke, R."],["dc.contributor.author","Tatsch, Klaus"],["dc.contributor.author","Kharraz, B."],["dc.contributor.author","Gildehaus, J. F."],["dc.contributor.author","Wetter, C. T."],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Schwarz, J."],["dc.contributor.author","Noachtar, S."],["dc.date.accessioned","2018-11-07T10:37:31Z"],["dc.date.available","2018-11-07T10:37:31Z"],["dc.date.issued","2003"],["dc.description.abstract","Objectives: Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by complex behavior during REM sleep. The etiology of this disorder is still unknown, but a recent study showed that RBD precedes symptoms of Parkinson disease (PD) by several years, and in a previous study, we found reduced striatal dopamine transporters in idiopathic clinically manifest RBD. Design: Hypothesizing that subclinical RBD shows a less severe reduction of striatal dopamine transporters than clinically manifest RBD, we studied striatal postsynaptic dopamine D2-receptors with (S)-2hydroxy-3iodo-6-methoxy-([1-ethyl-2-pyrrolidinyl]methyl) benzamide labeled with iodine 123 (IBZM) and the striatal presynaptic dopamine transporters with (N)-(3-iodopropene-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane labeled with iodine 123 (IPT) using single-photon emission computed tomography (SPECT) in the following groups: 8 patients with idiopathic subclinical RBD, 8 patients with idiopathic clinically manifest RBD, 11 controls, and 8 patients with PD stage Hoehn & Yahr 1. Results: The IPT uptake was highest in controls. There was a significant decrease in IPT uptake from controls to patients with subclinical RBD, from patients with subclinical RBD to clinically manifest RBD, and from patients with clinically manifest RBD to patients with PD (controls: right = 4.07 +/- 0.29, left = 4.07 +/- 0.30; subclinical RBD: right = 3.56 +/- 0.21, left = 3.55 +/- 0.25; clinically manifest RBD: right = 3.18 +/- 0.43, left 3.2 +/- 0.43; PD: ipsilateral to the clinically affected body side 3.25 +/- 0.35, contralateral to the clinically affected body side = 2.51 +/- 0.28). Muscle activity during REM sleep lasting persistently longer than 0.5 seconds was independently associated with reduction of striatal dopamine transporters (P=0.001). The IBZM uptake was not significantly different between the groups. Conclusions: This study suggests that there is a continuum of reduced striatal dopamine transporters involved in the pathophysiologic mechanisms causing increased muscle activity during REM sleep in patients with subclinical RBD. Key Words: presynaptic dopamine transporter, postsynaptic D2-receptor, REM sleep behavior disorder, Parkinson disease Citation: Eisensehr 1; Linke R,- Tatsch K et al. Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporters. IPT and IBZM SPECT imaging in subclinical and clinically manifest idiopathic REM sleep behavior disorder, parkinson's disease, and controls."],["dc.identifier.isi","000184546800002"],["dc.identifier.pmid","12938802"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45583"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Acad Sleep Medicine"],["dc.relation.issn","0161-8105"],["dc.title","Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporters. IPT and IBZM SPECT imaging in subclinical and clinically disorder, Parkinson's disease, and manifest idiopathic REM sleep behavior controls"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","116"],["dc.bibliographiccitation.journal","Sleep Medicine"],["dc.bibliographiccitation.lastpage","122"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Kohnen, Ralf"],["dc.contributor.author","Martinez-Martin, Pablo"],["dc.contributor.author","Benes, Heike"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Hoegl, Birgit"],["dc.contributor.author","Dunkl, Elmar"],["dc.contributor.author","Walters, Arthur S."],["dc.date.accessioned","2018-11-07T10:15:43Z"],["dc.date.available","2018-11-07T10:15:43Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: The International Restless Legs Scale (IRLS) is the most widely used of the scales rating the severity of restless legs syndrome/Willis-Ekbom disease (RLS/WED). It has been well validated and is the primary end point for most of the therapeutic and nontherapeutic studies of RLS/WED. It has excellent psychometric properties, although it does not capture the severity of RLS under a wide variety of circumstances and times of day. Moreover, the IRLS has a large placebo effect. Methods: The Restless Legs Syndrome-6 Scale (RLS-6), however, takes another potentially valuable approach. Six items are rated on a 0-10 scale from no symptoms at 0 to very severe at 10. In addition to questions on satisfaction with sleep and sleepiness, the scale rates the severity of RLS for the past week under four separate circumstances: while falling asleep, during the night, during the day while sitting or lying, and during the day when moving around. The purpose of the current study is to report the validation of the RLS-6 under baseline and therapeutic conditions. Results: The RLS-6 seems to be an acceptable, reliable, precise, valid, and responsive instrument for the assessment of RLS severity in a specific and pragmatic manner. Conclusions: At present, we view the RLS-6 not as a replacement for the IRLS but as a supplement, as each scale provides information not captured by the other. (C) 2015 The Authors. Published by Elsevier B.V."],["dc.identifier.doi","10.1016/j.sleep.2015.10.014"],["dc.identifier.isi","000378051400018"],["dc.identifier.pmid","27318235"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40871"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1878-5506"],["dc.relation.issn","1389-9457"],["dc.title","Rating of daytime and nighttime symptoms in RLS: validation of the RLS-6 scale of restless legs syndrome/Willis-Ekbom disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","919"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Neural Transmission"],["dc.bibliographiccitation.lastpage","927"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Bibl, Mirko"],["dc.contributor.author","Esselmann, Herrmann"],["dc.contributor.author","Steinacker, Petra"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Wiltfang, J."],["dc.contributor.author","Otto, Markus"],["dc.date.accessioned","2018-11-07T11:06:56Z"],["dc.date.available","2018-11-07T11:06:56Z"],["dc.date.issued","2007"],["dc.description.abstract","To evaluate variations in amyloid beta (A beta) peptide pattern in cerebrospinal fluid (CSF) in neurodegenerative disorders. A recently estabfished quantitative urea-based A beta-sodium-dodecylsulfate-polyacrylamide-gel-electrophoresis with western immunoblot (AP-SDS-PAGE/immunoblot) revealed a highly conserved A beta peptide (A beta 1-37, 1-38, 1-39, 1-40, 1-42) pattern in CSF. We asked whether the variation might be useful to further elucidate the overlap between or distinctions among neurodegenerative diseases in A beta-processing. We used the A beta-SDS-PAGE/immunoblot to investigate CSF for diseasespecific A beta peptide patterns. CSF samples from 96 patients with mainly clinically diagnosed Alzheimer's disease (n = 15), progressive supranuclear palsy (n = 20), corticobasal degeneration (n =: 12), Parkinson's disease (n = 11), multiple systems atrophy (n = 18), and dementia with Lewy-bodies (n = 20) were analysed as well a comparison group (n = 19). The A beta peptide patterns varied between tauopathies and synucleinopathies and between all diseases and the comparison group, possibly due to the influence of tau and a-synuctein on Ap-processing."],["dc.identifier.doi","10.1007/s00702-007-0629-4"],["dc.identifier.isi","000248001800007"],["dc.identifier.pmid","17318305"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52433"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0300-9564"],["dc.title","Tauopathies and synucleinopathies: Do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","396"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Neurochemistry"],["dc.bibliographiccitation.lastpage","405"],["dc.bibliographiccitation.volume","123"],["dc.contributor.author","Luk, Connie"],["dc.contributor.author","Compta, Yaroslau"],["dc.contributor.author","Magdalinou, Nadia"],["dc.contributor.author","Jose Marti, Maria"],["dc.contributor.author","Hondhamuni, Geshanthi"],["dc.contributor.author","Zetterberg, Henrik"],["dc.contributor.author","Blennow, Kaj"],["dc.contributor.author","Constantinescu, Radu"],["dc.contributor.author","Pijnenburg, Yolande"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","van Swieten, John"],["dc.contributor.author","Chiu, Wan Zheng"],["dc.contributor.author","Borroni, Barbara"],["dc.contributor.author","Camara, Ana"],["dc.contributor.author","Cheshire, Perdita"],["dc.contributor.author","Williams, David R."],["dc.contributor.author","Lees, Andrew J."],["dc.contributor.author","de Silva, Rohan"],["dc.date.accessioned","2018-11-07T09:04:11Z"],["dc.date.available","2018-11-07T09:04:11Z"],["dc.date.issued","2012"],["dc.description.abstract","Characteristic tau isoform composition of the insoluble fibrillar tau inclusions define tauopathies, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and frontotemporal dementia with parkinsonism linked to chromosome 17/frontotemporal lobar degeneration-tau (FTDP-17/FTLD-tau). Exon 10 splicing mutations in the tau gene, MAPT, in familial FTDP-17 cause elevation of tau isoforms with four microtubule-binding repeat domains (4R-tau) compared to those with three repeats (3R-tau). On the basis of two well-characterised monoclonal antibodies against 3R- and 4R-tau, we developed novel, sensitive immuno-PCR assays for measuring the trace amounts of these isoforms in CSF. This was with the aim of assessing if CSF tau isoform changes reflect the pathological changes in tau isoform homeostasis in the degenerative brain and if these would be relevant for differential clinical diagnosis. Initial analysis of clinical CSF samples of PSP (n = 46), corticobasal syndrome (CBS; n = 22), AD (n = 11), Parkinson's disease with dementia (PDD; n = 16) and 35 controls revealed selective decreases of immunoreactive 4R-tau in CSF of PSP and AD patients compared with controls, and lower 4R-tau levels in AD compared with PDD. These decreases could be related to the disease-specific conformational masking of the RD4-binding epitope because of abnormal folding and/or aggregation of the 4R-tau isoforms in tauopathies or increased sequestration of the 4R-tau isoforms in brain tau pathology."],["dc.identifier.doi","10.1111/j.1471-4159.2012.07911.x"],["dc.identifier.isi","000309743600008"],["dc.identifier.pmid","22862741"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25061"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0022-3042"],["dc.title","Development and assessment of sensitive immuno-PCR assays for the quantification of cerebrospinal fluid three- and four-repeat tau isoforms in tauopathies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","SLEEP"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Garcia-Borreguero, Diego"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Kohnen, Ralf"],["dc.contributor.author","Ferini-Strambi, Luigi"],["dc.contributor.author","Schollmayer, Erwin"],["dc.date.accessioned","2018-11-07T08:35:31Z"],["dc.date.available","2018-11-07T08:35:31Z"],["dc.date.issued","2009"],["dc.format.extent","A307"],["dc.identifier.isi","000265542001289"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18087"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Acad Sleep Medicine"],["dc.publisher.place","Westchester"],["dc.relation.conference","23rd Annual Meeting of the Associated-Professional-Sleep-Societies"],["dc.relation.eventlocation","Seattle, WA"],["dc.relation.issn","0161-8105"],["dc.title","EFFECTS OF ROTIGOTINE TRANSDERMAL SYSTEM ON QUALITY OF LIFE IN IDIOPATHIC RESTLESS LEGS SYNDROME"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S393"],["dc.bibliographiccitation.journal","Movement Disorders"],["dc.bibliographiccitation.lastpage","S394"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Oertel, Wolfgang Hermann"],["dc.contributor.author","Allen, Richard P."],["dc.contributor.author","Garcia-Borreguero, Diego"],["dc.date.accessioned","2018-11-07T11:07:07Z"],["dc.date.available","2018-11-07T11:07:07Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1002/mds.21713"],["dc.identifier.isi","000251605200001"],["dc.identifier.pmid","18081163"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52480"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","0885-3185"],["dc.title","Tireless work on restless legs: Guest editors' introduction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","SLEEP"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Happe, Svenja"],["dc.contributor.author","Stiasny-Kolster, Karin"],["dc.contributor.author","Peglau, Ines"],["dc.contributor.author","Mayer, G."],["dc.contributor.author","Giani, Guido"],["dc.contributor.author","Geraedts, Max"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Dodel, R."],["dc.date.accessioned","2018-11-07T11:07:35Z"],["dc.date.available","2018-11-07T11:07:35Z"],["dc.date.issued","2007"],["dc.format.extent","A281"],["dc.identifier.isi","000246224900820"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52601"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Academy Sleep Medicine"],["dc.publisher.place","Westchester"],["dc.relation.conference","21st Annual Meeting of the Association-Professional-Sleep-Societies"],["dc.relation.eventlocation","Minneapolis, MN"],["dc.relation.issn","0161-8105"],["dc.title","Direct and indirect costs of restless legs syndrome (RLS)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","152"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Movement Disorders"],["dc.bibliographiccitation.lastpage","153"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Salminen, Aaro V."],["dc.contributor.author","Allen, Richard P."],["dc.contributor.author","Högl, Birgit"],["dc.contributor.author","Inoue, Yuichi"],["dc.contributor.author","Oertel, Wolfgang"],["dc.contributor.author","Winkelman, John W."],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Sampaio, Cristina"],["dc.contributor.author","Winkelmann, Juliane"],["dc.date.accessioned","2021-06-01T10:46:50Z"],["dc.date.available","2021-06-01T10:46:50Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1002/mds.27570"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85400"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1531-8257"],["dc.relation.issn","0885-3185"],["dc.title","Reply to: A note on rotigotine for restless legs syndrome after renal transplantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]