Schneider, Anja

[["dc.bibliographiccitation.artnumber","945709"],["dc.bibliographiccitation.journal","Frontiers in Psychology"],["dc.bibliographiccitation.volume","13"],["dc.contributor.affiliation","Böttcher, Adriana; 1German Center for Neurodegenerative Diseases, Dresden, Germany"],["dc.contributor.affiliation","Zarucha, Alexis; 1German Center for Neurodegenerative Diseases, Dresden, Germany"],["dc.contributor.affiliation","Köbe, Theresa; 1German Center for Neurodegenerative Diseases, Dresden, Germany"],["dc.contributor.affiliation","Gaubert, Malo; 1German Center for Neurodegenerative Diseases, Dresden, Germany"],["dc.contributor.affiliation","Höppner, Angela; 1German Center for Neurodegenerative Diseases, Dresden, Germany"],["dc.contributor.affiliation","Altenstein, Slawek; 3German Center for Neurodegenerative Diseases, Berlin, Germany"],["dc.contributor.affiliation","Bartels, Claudia; 5Department of Psychiatry and Psychotherapy, University Medical Center, University of Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Buerger, Katharina; 6Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany"],["dc.contributor.affiliation","Dechent, Peter; 8MR-Research in Neurology and Psychiatry, Georg-August-University Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Dobisch, Laura; 9German Center for Neurodegenerative Diseases, Magdeburg, Germany"],["dc.contributor.affiliation","Ewers, Michael; 7German Center for Neurodegenerative Diseases, Munich, Germany"],["dc.contributor.affiliation","Fliessbach, Klaus; 11German Center for Neurodegenerative Diseases, Bonn, Germany"],["dc.contributor.affiliation","Freiesleben, Silka Dawn; 4Department of Psychiatry, Charité – Universitätsmedizin Berlin, Berlin, Germany"],["dc.contributor.affiliation","Frommann, Ingo; 11German Center for Neurodegenerative Diseases, Bonn, Germany"],["dc.contributor.affiliation","Haynes, John Dylan; 13Bernstein Center for Computational Neuroscience, Charité – Universitätsmedizin, Berlin, Germany"],["dc.contributor.affiliation","Janowitz, Daniel; 6Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany"],["dc.contributor.affiliation","Kilimann, Ingo; 14German Center for Neurodegenerative Diseases, Rostock, Germany"],["dc.contributor.affiliation","Kleineidam, Luca; 11German Center for Neurodegenerative Diseases, Bonn, Germany"],["dc.contributor.affiliation","Laske, Christoph; 16German Center for Neurodegenerative Diseases, Tübingen, Germany"],["dc.contributor.affiliation","Maier, Franziska; 18Department of Psychiatry, Faculty of Medicine, University of Cologne, Cologne, Germany"],["dc.contributor.affiliation","Metzger, Coraline; 9German Center for Neurodegenerative Diseases, Magdeburg, Germany"],["dc.contributor.affiliation","Munk, Matthias H. J.; 16German Center for Neurodegenerative Diseases, Tübingen, Germany"],["dc.contributor.affiliation","Perneczky, Robert; 7German Center for Neurodegenerative Diseases, Munich, Germany"],["dc.contributor.affiliation","Peters, Oliver; 3German Center for Neurodegenerative Diseases, Berlin, Germany"],["dc.contributor.affiliation","Priller, Josef; 3German Center for Neurodegenerative Diseases, Berlin, Germany"],["dc.contributor.affiliation","Rauchmann, Boris-Stephan; 23Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany"],["dc.contributor.affiliation","Roy, Nina; 11German Center for Neurodegenerative Diseases, Bonn, Germany"],["dc.contributor.affiliation","Scheffler, Klaus; 25Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany"],["dc.contributor.affiliation","Schneider, Anja; 11German Center for Neurodegenerative Diseases, Bonn, Germany"],["dc.contributor.affiliation","Spottke, Annika; 11German Center for Neurodegenerative Diseases, Bonn, Germany"],["dc.contributor.affiliation","Teipel, Stefan J.; 14German Center for Neurodegenerative Diseases, Rostock, Germany"],["dc.contributor.affiliation","Wiltfang, Jens; 5Department of Psychiatry and Psychotherapy, University Medical Center, University of Göttingen, Göttingen, Germany"],["dc.contributor.affiliation","Wolfsgruber, Steffen; 11German Center for Neurodegenerative Diseases, Bonn, Germany"],["dc.contributor.affiliation","Yakupov, Renat; 9German Center for Neurodegenerative Diseases, Magdeburg, Germany"],["dc.contributor.affiliation","Düzel, Emrah; 9German Center for Neurodegenerative Diseases, Magdeburg, Germany"],["dc.contributor.affiliation","Jessen, Frank; 11German Center for Neurodegenerative Diseases, Bonn, Germany"],["dc.contributor.affiliation","Röske, Sandra; 11German Center for Neurodegenerative Diseases, Bonn, Germany"],["dc.contributor.affiliation","Wagner, Michael; 11German Center for Neurodegenerative Diseases, Bonn, Germany"],["dc.contributor.affiliation","Kempermann, Gerd; 1German Center for Neurodegenerative Diseases, Dresden, Germany"],["dc.contributor.affiliation","Wirth, Miranka; 1German Center for Neurodegenerative Diseases, Dresden, Germany"],["dc.contributor.author","Böttcher, Adriana"],["dc.contributor.author","Zarucha, Alexis"],["dc.contributor.author","Köbe, Theresa"],["dc.contributor.author","Gaubert, Malo"],["dc.contributor.author","Höppner, Angela"],["dc.contributor.author","Altenstein, Slawek"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Dobisch, Laura"],["dc.contributor.author","Wirth, Miranka"],["dc.contributor.author","Ewers, Michael"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Freiesleben, Silka Dawn"],["dc.contributor.author","Frommann, Ingo"],["dc.contributor.author","Haynes, John Dylan"],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Kleineidam, Luca"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Maier, Franziska"],["dc.contributor.author","Metzger, Coraline"],["dc.contributor.author","Munk, Matthias H. J."],["dc.contributor.author","Perneczky, Robert"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Rauchmann, Boris-Stephan"],["dc.contributor.author","Roy, Nina"],["dc.contributor.author","Scheffler, Klaus"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Teipel, Stefan J."],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Wolfsgruber, Steffen"],["dc.contributor.author","Yakupov, Renat"],["dc.contributor.author","Düzel, Emrah"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Röske, Sandra"],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Kempermann, Gerd"],["dc.date.accessioned","2022-10-04T10:21:56Z"],["dc.date.available","2022-10-04T10:21:56Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:14:36Z"],["dc.description.abstract","Regular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer’s disease. This cross-sectional study investigated the association and interplay between musical instrument playing during life, multi-domain cognitive abilities and brain morphology in older adults (OA) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Participants reporting having played a musical instrument across three life periods (\r\n n\r\n = 70) were compared to controls without a history of musical instrument playing (\r\n n\r\n = 70), well-matched for reserve proxies of education, intelligence, socioeconomic status and physical activity. Participants with musical activity outperformed controls in global cognition, working memory, executive functions, language, and visuospatial abilities, with no effects seen for learning and memory. The musically active group had greater gray matter volume in the somatosensory area, but did not differ from controls in higher-order frontal, temporal, or hippocampal volumes. However, the association between gray matter volume in distributed frontal-to-temporal regions and cognitive abilities was enhanced in participants with musical activity compared to controls. We show that playing a musical instrument during life relates to better late-life cognitive abilities and greater brain capacities in OA. Musical activity may serve as a multimodal enrichment strategy that could help preserve cognitive and brain health in late life. Longitudinal and interventional studies are needed to support this notion."],["dc.identifier.doi","10.3389/fpsyg.2022.945709"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114545"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1664-1078"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","102495"],["dc.bibliographiccitation.journal","NeuroImage: Clinical"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Herdick, Meret"],["dc.contributor.author","Dyrba, Martin"],["dc.contributor.author","Fritz, Hans-Christian J."],["dc.contributor.author","Altenstein, Slawek"],["dc.contributor.author","Ballarini, Tommaso"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Can Cetindag, Arda"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Dobisch, Laura"],["dc.contributor.author","Duezel, Emrah"],["dc.contributor.author","Ertl-Wagner, Birgit"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Dawn Freiesleben, Silka"],["dc.contributor.author","Frommann, Ingo"],["dc.contributor.author","Glanz, Wenzel"],["dc.contributor.author","Dylan Haynes, John"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Metzger, Coraline D."],["dc.contributor.author","Munk, Matthias H."],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Roy, Nina"],["dc.contributor.author","Scheffler, Klaus"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Jakob Spruth, Eike"],["dc.contributor.author","Tscheuschler, Maike"],["dc.contributor.author","Vukovich, Ruth"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Teipel, Stefan"],["dc.contributor.author","Grothe, Michel J."],["dc.date.accessioned","2021-04-14T08:27:38Z"],["dc.date.available","2021-04-14T08:27:38Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.nicl.2020.102495"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82356"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","2213-1582"],["dc.title","Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer’s disease spectrum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Alzheimer's Research & Therapy"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Sannemann, Lena"],["dc.contributor.author","Schild, Ann-Katrin"],["dc.contributor.author","Altenstein, Slawek"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Cosma, Nicoleta Carmen"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Freiesleben, Silka Dawn"],["dc.contributor.author","Glanz, Wenzel"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Kobeleva, Xenia"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Metzger, Coraline D."],["dc.contributor.author","Munk, Matthias H. J."],["dc.contributor.author","Perneczky, Robert"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Polcher, Alexandra"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Rauchmann, Boris"],["dc.contributor.author","Rösch, Christina"],["dc.contributor.author","Rudolph, Janna"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Spruth, Eike Jakob"],["dc.contributor.author","Teipel, Stefan"],["dc.contributor.author","Vukovich, Ruth"],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Wolfsgruber, Steffen"],["dc.contributor.author","Duezel, Emrah"],["dc.contributor.author","Jessen, Frank"],["dc.date.accessioned","2021-04-14T08:31:19Z"],["dc.date.available","2021-04-14T08:31:19Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1186/s13195-020-00701-7"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17604"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83557"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1758-9193"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Neuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers—results from the DELCODE study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Alzheimer's Research & Therapy"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Miebach, Lisa"],["dc.contributor.author","Wolfsgruber, Steffen"],["dc.contributor.author","Polcher, Alexandra"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Menne, Felix"],["dc.contributor.author","Luther, Katja"],["dc.contributor.author","Incesoy, Enise"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Spruth, Eike"],["dc.contributor.author","Altenstein, Slawek"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Catak, Cihan"],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Perneczky, Robert"],["dc.contributor.author","Utecht, Julia"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Buchmann, Martina"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Kalbhen, Pascal"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Roy, Nina"],["dc.contributor.author","Teipel, Stefan J."],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Düzel, Emrah"],["dc.contributor.author","Dobisch, Laura"],["dc.contributor.author","Metzger, Coraline"],["dc.contributor.author","Meiberth, Dix"],["dc.contributor.author","Ramirez, Alfredo"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Wagner, Michael"],["dc.date.accessioned","2020-12-10T18:39:08Z"],["dc.date.available","2020-12-10T18:39:08Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1186/s13195-019-0515-y"],["dc.identifier.eissn","1758-9193"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16326"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77551"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","102533"],["dc.bibliographiccitation.journal","NeuroImage: Clinical"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Amaefule, Chimezie O."],["dc.contributor.author","Dyrba, Martin"],["dc.contributor.author","Wolfsgruber, Steffen"],["dc.contributor.author","Polcher, Alexandra"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Meiberth, Dix"],["dc.contributor.author","Preis, Lukas"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Incesoy, Enise I."],["dc.contributor.author","Spruth, Eike J."],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Altenstein, Slawek"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Bürger, Katharina"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Munk, Matthias"],["dc.contributor.author","Rudolph, Janna"],["dc.contributor.author","Glanz, Wenzel"],["dc.contributor.author","Dobisch, Laura"],["dc.contributor.author","Haynes, John D."],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Ertl-Wagner, Birgit"],["dc.contributor.author","Scheffler, Klaus"],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Düzel, Emrah"],["dc.contributor.author","Metzger, Coraline D."],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Teipel, Stefan J."],["dc.date.accessioned","2021-04-14T08:30:25Z"],["dc.date.available","2021-04-14T08:30:25Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.nicl.2020.102533"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83229"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","2213-1582"],["dc.title","Association between composite scores of domain-specific cognitive functions and regional patterns of atrophy and functional connectivity in the Alzheimer’s disease spectrum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","191"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Alzheimer's Research & Therapy"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Dyrba, Martin"],["dc.contributor.author","Hanzig, Moritz"],["dc.contributor.author","Altenstein, Slawek"],["dc.contributor.author","Bader, Sebastian"],["dc.contributor.author","Ballarini, Tommaso"],["dc.contributor.author","Brosseron, Frederic"],["dc.contributor.author","Buerger, Katharina"],["dc.contributor.author","Cantré, Daniel"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Dobisch, Laura"],["dc.contributor.author","Düzel, Emrah"],["dc.contributor.author","Ewers, Michael"],["dc.contributor.author","Fliessbach, Klaus"],["dc.contributor.author","Glanz, Wenzel"],["dc.contributor.author","Haynes, John-Dylan"],["dc.contributor.author","Heneka, Michael T."],["dc.contributor.author","Janowitz, Daniel"],["dc.contributor.author","Keles, Deniz B."],["dc.contributor.author","Kilimann, Ingo"],["dc.contributor.author","Laske, Christoph"],["dc.contributor.author","Maier, Franziska"],["dc.contributor.author","Metzger, Coraline D."],["dc.contributor.author","Munk, Matthias H."],["dc.contributor.author","Perneczky, Robert"],["dc.contributor.author","Peters, Oliver"],["dc.contributor.author","Preis, Lukas"],["dc.contributor.author","Priller, Josef"],["dc.contributor.author","Rauchmann, Boris"],["dc.contributor.author","Roy, Nina"],["dc.contributor.author","Scheffler, Klaus"],["dc.contributor.author","Schneider, Anja"],["dc.contributor.author","Schott, Björn H."],["dc.contributor.author","Spottke, Annika"],["dc.contributor.author","Spruth, Eike J."],["dc.contributor.author","Weber, Marc-André"],["dc.contributor.author","Ertl-Wagner, Birgit"],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Jessen, Frank"],["dc.contributor.author","Teipel, Stefan J."],["dc.contributor.authorgroup","for the ADNI, AIBL, DELCODE study groups"],["dc.date.accessioned","2021-12-01T09:23:04Z"],["dc.date.accessioned","2022-08-18T12:39:17Z"],["dc.date.available","2021-12-01T09:23:04Z"],["dc.date.available","2022-08-18T12:39:17Z"],["dc.date.issued","2021-11-23"],["dc.date.updated","2022-07-29T12:17:50Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy also rely more on discriminative brain regions predefined by prior knowledge.\r\n \r\n \r\n Methods\r\n We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection.\r\n \r\n \r\n Results\r\n Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001).\r\n \r\n \r\n Conclusion\r\n The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia."],["dc.identifier.citation","Alzheimer's Research & Therapy. 2021 Nov 23;13(1):191"],["dc.identifier.doi","10.1186/s13195-021-00924-2"],["dc.identifier.pii","924"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94551"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112968"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1758-9193"],["dc.rights.holder","The Author(s)"],["dc.subject","Alzheimer’s disease"],["dc.subject","Deep learning"],["dc.subject","Convolutional neural network"],["dc.subject","MRI"],["dc.subject","Layer-wise relevance propagation"],["dc.title","Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]