Neef, Nicole E.

[["dc.bibliographiccitation.artnumber","e0202634"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PLOS ONE"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Whillier, Alexander"],["dc.contributor.author","Hommel, Sina"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Wolff von Gudenberg, Alexander"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2019-07-09T11:46:08Z"],["dc.date.available","2019-07-09T11:46:08Z"],["dc.date.issued","2018"],["dc.description.abstract","OBJECTIVES: Persistent developmental stuttering is a speech fluency disorder defined by its symptoms, where the underlying neurophysiological causes remain uncertain. This study examined the underlying neurophysiological mechanisms of the speech planning process, using facilitation in the motor cortex during speech preparation as an analogue. METHODS: transcranial magnetic stimulation (TMS) pulses induced motor evoked potentials (MEPs), which were recorded from the tongue. Eighteen adults who stutter (AWS) and 17 adults who do not stutter (ANS) completed three experiments, which involved reading a German prefix+verb utterance from a screen. Each experiment involved 120 trials with three distinct levels of speech production: immediate speech, delayed speech without pacing and delayed speech with predefined pacing. TMS was applied shortly before speech onset. Trial MEPs were normalised to average non-speech MEPs. MEP amplitude, MEP facilitation ratio (amplitude: pre-speech offset) and group difference were the outcomes of interest analysed by multiple regression, as well as speech reaction time analysed by correlation. RESULTS: MEP values were 11·1%-23·4% lower in AWS than ANS (by standardised Beta), across all three experiments. MEP facilitation ratio slopes were also 4·9%-18·3% flatter in AWS than ANS across all three experiments. Reaction times for AWS were only significantly slower than for ANS in immediate speech and predefined pacing experiments. No stuttering was detected during the trials. The group difference in immediate speech was 100% and 101% greater than the other two experiments respectively. DISCUSSION: While performance of both ANS and AWS worsens under disturbed speech conditions, greater disturbance conditions affected controls worse than AWS. Future research and therapy in stuttering should focus on non-disturbed speech."],["dc.identifier.doi","10.1371/journal.pone.0202634"],["dc.identifier.pmid","30303960"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15398"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59381"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/15696 but duplicate"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Adults who stutter lack the specialised pre-speech facilitation found in non-stutterers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Human Neuroscience"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Wolff von Gudenberg, Alexander"],["dc.contributor.author","Baehr, Mathias"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2021-04-14T08:27:59Z"],["dc.date.available","2021-04-14T08:27:59Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3389/fnhum.2021.639269"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82466"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1662-5161"],["dc.rights","CC BY 4.0"],["dc.title","Enlarged Area of Mesencephalic Iron Deposits in Adults Who Stutter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Human Neuroscience"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Vreeswijk, Sarah M. E."],["dc.contributor.author","Hoang, T. N. Linh"],["dc.contributor.author","Korzeczek, Alexandra"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Wolff von Gudenberg, Alexander"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2020-12-10T18:44:33Z"],["dc.date.available","2020-12-10T18:44:33Z"],["dc.date.issued","2019"],["dc.description.abstract","Persistent developmental stuttering (PDS) disrupts speech fluency in about 1% of adults. Although many models of speech production assume an intact sensory feedback from the speech organs to the brain, very little is actually known about the integrity of their sensory representation in PDS. Here, we studied somatosensory evoked potentials (SEPs) in adults who stutter (AWS), with the aim of probing the integrity of sensory pathways. In addition, we tested the processing of dual sensory input to address a putative link between stuttering and focal dystonia. In 15 AWS (aged 15–55 years; three females) and 14 matched fluent speaking adults (ANS), we recorded SEPs at C5′ and C6′ induced by stimulating separately or simultaneously the tongue or the cheek at the corner of the mouth. We determined latencies (N13, P19, and N27) and peak-to-peak amplitudes (N13-P19, P19-N27). We divided amplitudes from simultaneous stimulation by the sum of those from separate stimulation. Amplitude ratios did not differ between groups, indicating normal processing of dual sensory input. This does not support a clinical analogy between focal dystonia and persistent stuttering. SEP latencies as a measure of transmission speed in sensory pathways were significantly shorter in stuttering subjects than in fluent speaking participants, however, this might have been related to a trend for a height difference between groups, and was not confirmed in a replication dataset. In summary, we did not find evidence for dystonia-like sensory overflow of tongue representations in AWS."],["dc.identifier.doi","10.3389/fnhum.2019.00336"],["dc.identifier.eissn","1662-5161"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16479"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78502"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","1662-5161"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","No Evidence for Dystonia-Like Sensory Overflow of Tongue Representations in Adults Who Stutter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Human Brain Mapping"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Korzeczek, Alexandra"],["dc.contributor.author","Primaßin, Annika"],["dc.contributor.author","Wolff von Gudenberg, Alexander"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Riedel, Christian Heiner"],["dc.contributor.author","Paulus, Walter"],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2022-05-02T08:02:09Z"],["dc.date.available","2022-05-02T08:02:09Z"],["dc.date.issued","2022"],["dc.description.abstract","Persistent stuttering is a prevalent neurodevelopmental speech disorder, which presents with involuntary speech blocks, sound and syllable repetitions, and sound prolongations. Affected individuals often struggle with negative feelings, elevated anxiety, and low self-esteem. Neuroimaging studies frequently link persistent stuttering with cortical alterations and dysfunctional cortico-basal ganglia-thalamocortical loops; dMRI data also point toward connectivity changes of the superior longitudinal fasciculus (SLF) and the frontal aslant tract (FAT). Both tracts are involved in speech and language functions, and the FAT also supports inhibitory control and conflict monitoring. Whether the two tracts are involved in therapy-associated improvements and how they relate to therapeutic outcomes is currently unknown. Here, we analyzed dMRI data of 22 patients who participated in a fluency-shaping program, 18 patients not participating in therapy, and 27 fluent control participants, measured 1 year apart. We used diffusion tractography to segment the SLF and FAT bilaterally and to quantify their microstructural properties before and after a fluency-shaping program. Participants learned to speak with soft articulation, pitch, and voicing during a 2-week on-site boot camp and computer-assisted biofeedback-based daily training for 1 year. Therapy had no impact on the microstructural properties of the two tracts. Yet, after therapy, stuttering severity correlated positively with left SLF fractional anisotropy, whereas relief from the social–emotional burden to stutter correlated negatively with right FAT fractional anisotropy. Thus, posttreatment, speech motor performance relates to the left dorsal stream, while the experience of the adverse impact of stuttering relates to the structure recently associated with conflict monitoring and action inhibition."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1002/hbm.25853"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107245"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-561"],["dc.relation.eissn","1097-0193"],["dc.relation.issn","1065-9471"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","http://creativecommons.org/licenses/by-nc-nd/4.0/"],["dc.title","White matter tract strength correlates with therapy outcome in persistent developmental stuttering"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]