Neef, Nicole E.

[["dc.bibliographiccitation.firstpage","945"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","954"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Jung, Kristina"],["dc.contributor.author","Rothkegel, Holger"],["dc.contributor.author","Pollok, Bettina"],["dc.contributor.author","von Gudenberg, Alexander Wolff"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2018-11-07T08:53:01Z"],["dc.date.available","2018-11-07T08:53:01Z"],["dc.date.issued","2011"],["dc.description.abstract","Introduction: In adults who do not stutter (AWNS), the control of hand movement timing is assumed to be lateralized to the left dorsolateral premotor cortex (PMd). In adults who stutter (AWS), the network of speech motor control is abnormally shifted to the right hemisphere. Motor impairments in AWS are not restricted to speech, but extend to non-speech orofacial and finger movements. We here investigated the lateralization of finger movement timing control in AWS. Methods: We explored PMd function in 14 right-handed AWS and 15 age matched AWNS. In separate sessions, they received subthreshold repetitive transcranial magnetic stimulation (rTMS) for 20 min at 1 Hz over the left or right PMd, respectively. Pre- and post-stimulation participants were instructed to synchronize their index finger taps of either hand with an isochronous sequence of clicks presented binaurally via earphones. Synchronization accuracy was measured to quantify the effect of the PMd stimulation. Results: In AWNS inhibition of left PMd affected synchronization accuracy of the left hand. Conversely, in AWS TMS over the right PMd increased the asynchrony of the left hand. Conclusions: The present data indicate an altered functional connectivity in AWS in which the right PMd seems to be important for the control of timed non-speech movements. Moreover, the laterality-shift suggests a compensatory role of the right PMd to successfully perform paced finger tapping. (C) 2010 Elsevier Srl. All rights reserved."],["dc.identifier.doi","10.1016/j.cortex.2010.06.007"],["dc.identifier.isi","000293155300005"],["dc.identifier.pmid","20822768"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22305"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Masson"],["dc.relation.issn","0010-9452"],["dc.title","Right-shift for non-speech motor processing in adults who stutter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","I"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Cortex"],["dc.bibliographiccitation.lastpage","II"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Jung, Kristina"],["dc.contributor.author","Rothkegel, Holger"],["dc.contributor.author","Pollok, Bettina"],["dc.contributor.author","von Gudenberg, Alexander Wolff"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Sommer, Martin"],["dc.date.accessioned","2018-11-07T08:50:12Z"],["dc.date.available","2018-11-07T08:50:12Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1016/j.cortex.2011.08.009"],["dc.identifier.isi","000296930600023"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21644"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Masson"],["dc.relation.issn","0010-9452"],["dc.title","Right-shift for non-speech motor processing in adults who stutter (vol 47, pg 945, 2011)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","276"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Speech Language and Hearing Research"],["dc.bibliographiccitation.lastpage","289"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Neef, Nicole E."],["dc.contributor.author","Sommer, Martin"],["dc.contributor.author","Neef, Andreas"],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","von Gudenberg, Alexander Wolff"],["dc.contributor.author","Jung, Kristina"],["dc.contributor.author","Wuestenberg, Torsten"],["dc.date.accessioned","2018-11-07T09:13:41Z"],["dc.date.available","2018-11-07T09:13:41Z"],["dc.date.issued","2012"],["dc.description.abstract","Purpose: In individuals who stutter (IWS), speech fluency can be enhanced by altered auditory feedback, although it has adverse effects in control speakers. This indicates abnormalities in the auditory feedback loop in stuttering. Current motor control theories on stuttering propose an impaired processing of internal forward models that might be related to a blurred auditory-to-motor translation. Although speech sound perception is an essential skill to form internal models, perceptual acuity has not been studied in IWS so far. The authors tested the stability of phoneme percepts by analyzing participants' ability to identify voiced and voiceless stop consonants. Method: Two syllable continua were generated by systematic modification of the voice onset time. The authors determined speech perceptual acuity by means of discriminatory power in 25 IWS and 24 matched control participants by determining the phoneme boundaries and by quantifying the interval of voice onset times for which phonemes were perceived ambiguously. Results: In IWS, discriminatory performance was weaker and less stable over time when compared with control participants. In addition, phoneme boundaries were located at longer voice onset times in IWS. Conclusion: Persistent developmental stuttering is associated with less reliable phonological percepts, supporting current theories regarding the sensory-motor interaction in human speech."],["dc.identifier.doi","10.1044/1092-4388(2011/10-0224)"],["dc.identifier.isi","000301117200021"],["dc.identifier.pmid","22337496"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27229"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Speech-language-hearing Assoc"],["dc.relation.issn","1092-4388"],["dc.title","Reduced Speech Perceptual Acuity for Stop Consonants in Individuals Who Stutter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1802"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Neurophysiology"],["dc.bibliographiccitation.lastpage","1811"],["dc.bibliographiccitation.volume","122"],["dc.contributor.author","Neef, N. E."],["dc.contributor.author","Paulus, Walter J."],["dc.contributor.author","Neef, A."],["dc.contributor.author","von Gudenberg, Alexander Wolff"],["dc.contributor.author","Sommer, M."],["dc.date.accessioned","2018-11-07T08:52:57Z"],["dc.date.available","2018-11-07T08:52:57Z"],["dc.date.issued","2011"],["dc.description.abstract","Objective: We aimed at detecting neurophysiological changes, in the primary motor tongue representation in adults with persistent stuttering. Methods: Using transcranial magnetic stimulation in 12 patients and 14 controls, we examined motor threshold, motor-evoked potential (MEP) input-output curve, short-term intracortical inhibition (SICI) and intracortical facilitation (ICF), based on eight trials per conditioning-test interval. Results: In controls inhibition of the MEP-amplitude at short inter-stimulus intervals (ISI) and facilitation of the MEP-amplitude at long ISIs was evident. Patients showed an inhibition at ISI 3 ms and weaker nonsignificant inhibition at ISI 2 ms; this delay of inhibitory activity was especially prominent in the right hemisphere. Facilitation was reduced at ISI 10 and 15 ms in patients. Furthermore, MEP input-output curve was steeper in patients. Motor thresholds did not differ between groups. Conclusions: In persistent stuttering intracortical excitability of the primary motor tongue representation is altered with a deviant time course for inhibitory activity in the right hemisphere and reduced paired-pulse facilitation. Significance: These results specify changes in intracortical networks possibly mediated by altered GABAergic regulations in persistent stuttering. Thus, a better understanding of pathomechanisms and a potential role in understanding pharmacological treatment responses emerge by using transcranial magnetic stimulation. (C) 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.clinph.2011.02.003"],["dc.identifier.isi","000293267800016"],["dc.identifier.pmid","21377925"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22288"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","1388-2457"],["dc.title","Reduced intracortical inhibition and facilitation in the primary motor tongue representation of adults who stutter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]