Seif, Amir Hosseini Ali

[["dc.bibliographiccitation.firstpage","4331"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Hettler, Madelaine"],["dc.contributor.author","Kitz, Julia"],["dc.contributor.author","Seif Amir Hosseini, Ali"],["dc.contributor.author","Guhlich, Manuel"],["dc.contributor.author","Panahi, Babak"],["dc.contributor.author","Ernst, Jennifer"],["dc.contributor.author","Conradi, Lena-Christin"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Jakob, Jens"],["dc.date.accessioned","2022-10-04T10:21:39Z"],["dc.date.available","2022-10-04T10:21:39Z"],["dc.date.issued","2022"],["dc.description.abstract","Histological subtype and grading are cornerstones of treatment decisions in soft tissue sarcoma (STS). Due to intratumoral heterogeneity, pretreatment grading assessment is frequently unreliable and may be improved through functional imaging. In this pilot study, 12 patients with histologically confirmed STS were included. Preoperative functional magnetic resonance imaging was fused with a computed tomography scan of the resected specimen after collecting core needle biopsies and placing radiopaque markers at distinct tumor sites. The Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) grading criteria of the biopsies and apparent diffusion coefficients (ADCs) of the biopsy sites were correlated. Concordance in grading between the specimen and at least one biopsy was achieved in 9 of 11 cases (81.8%). In 7 of 12 cases, fusion imaging was feasible without relevant contour deviation. Functional analysis revealed a tendency for high-grade regions (Grade 2/3 (G2/G3)) (median (range) ± standard deviation: 1.13 (0.78–1.70) ± 0.23 × 10−3 mm2/s) to have lower ADC values than low-grade regions (G1; 1.43 (0.64–2.03) ± 0.46 × 10−3 mm2/s). In addition, FNCLCC scoring of multiple tumor biopsies proved intratumoral heterogeneity as expected. The ADC appears to correlate with the FNCLCC grading criteria. Further studies are needed to determine whether functional imaging may supplement histopathological grading."],["dc.identifier.doi","10.3390/cancers14174331"],["dc.identifier.pii","cancers14174331"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114467"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","2072-6694"],["dc.title","Comparing Apparent Diffusion Coefficient and FNCLCC Grading to Improve Pretreatment Grading of Soft Tissue Sarcoma—A Translational Feasibility Study on Fusion Imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","175628482110511"],["dc.bibliographiccitation.journal","Therapeutic Advances in Gastroenterology"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Azizian, Azadeh"],["dc.contributor.author","König, Alexander"],["dc.contributor.author","Hartmann, Amelie"],["dc.contributor.author","Schuppert, Frank"],["dc.contributor.author","Seif Amir Hosseini, Ali"],["dc.contributor.author","Kitz, Julia"],["dc.contributor.author","Ghadimi, Michael"],["dc.date.accessioned","2022-01-11T14:08:01Z"],["dc.date.available","2022-01-11T14:08:01Z"],["dc.date.issued","2021"],["dc.description.abstract","VIPoma, a neuroendocrine tumour mostly occurring in the human pancreas and producing high levels of vasoactive intestinal peptide, is a rare disease that presents with a wide spectrum of symptoms, including intense diarrhoea, hypokalaemia, and cardiac complications, with life-threatening consequences. In most cases, metastatic lesions are present at VIPoma diagnosis. Treatment options include symptomatic therapy, chemotherapy, radiation and surgery. Due to its low incidence, there are no evidence-based therapy recommendations to date. Here, we present a case of a 39-year-old woman with severe symptoms due to VIPoma of the pancreas with diffuse hepatic metastasis, who underwent simultaneous resection of the primary tumour, extensive liver resection and radiofrequency ablation. The patient was released in good health and was recurrence-free during 12 months surveillance. According to the existing literature and our own experience, surgical procedures appear to be the most promising therapy option for cases with diffuse hepatic metastasis, offering patients relief from their symptoms and (chemo)therapy-free time."],["dc.identifier.doi","10.1177/17562848211051132"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97916"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.issn","1756-2848"],["dc.rights","CC BY-NC 4.0"],["dc.title","Surgical treatment of metastatic VIPoma: a case report"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","469"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Digestion"],["dc.bibliographiccitation.lastpage","479"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Jung, Carlo Felix Maria"],["dc.contributor.author","Müller-Dornieden, Annegret"],["dc.contributor.author","Gaedcke, Jochen"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Gromski, Mark A."],["dc.contributor.author","Biggemann, Lorenz"],["dc.contributor.author","Seif Amir Hosseini, Ali"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Wedi, Edris"],["dc.date.accessioned","2021-06-01T09:42:09Z"],["dc.date.available","2021-06-01T09:42:09Z"],["dc.date.issued","2020"],["dc.description.abstract","Introduction: Management of esophageal anastomotic leaks (AL) and esophageal perforations (EP) remains difficult and often requires an interdisciplinary treatment modality. For primary endoscopic management, self-expanding metallic stent (SEMS) placement is often considered first-line therapy. Recently, endoscopic vacuum therapy (EVT) has emerged as an alternative or adjunct for management of these conditions. So far, data for EVT in the upper gastrointestinal-tract is restricted to single centre, non-randomized trials. No studies on optimal negative pressure application during EVT exist. The aim of our study is to describe our centre’s experience with low negative pressure (LNP) EVT for these indications over the past 5-years. Patients and Methods: Between January 2014 and December 2018, 30 patients were endoscopically treated for AL (n = 23) or EP (n = 7). All patients were primarily treated with EVT and LNP between –20 and –50 mm Hg. Additional endoscopic treatment was added when EVT failed. Procedural and peri-procedural data, as well as clinical outcomes including morbidity and mortality, were analysed. Results: Clinical successful endoscopic treatment of EP and AL was achieved in 83.3% (n = 25/30), with 73.3% success using EVT alone (n = 22/30). Mean treatment duration until leak closure was 16.1 days (range 2–58 days). Additional treatment modalities for complete leak resolution was necessary in 10% (n = 3/30), including SEMS placement and fibrin glue injection. Mean hospital stay for patients with EP was shorter with 33.7 days compared to AL with 54.4 days (p = 0.08). Estimated preoperative 10-year overall survival (Charlson comorbidity score) was 39.4% in patients with AL and 59.9% in patients with EP (p = 0.26). A mean of 5.1 EVT changes (range 1–12) was needed in EP and 3.6 changes (range 1–13) in AL to achieve complete closure, switch to other treatment modality, or reach endoscopic failure (p = 0.38). Conclusion: LNP EVT enables effective minimally – invasive endoluminal leak closure from anastomotic esophageal leaks and EP in high-morbid patients. In this study, EVT was combined with other endoscopic treatment options such as SEMS placement or fibrin glue injection in order to achieve leak or perforation closure in the vast majority of patients (83.3%). Low aspiration pressures led to slower but still sufficient clinical results."],["dc.identifier.doi","10.1159/000506101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85161"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1421-9867"],["dc.relation.issn","0012-2823"],["dc.title","Impact of Endoscopic Vacuum Therapy with Low Negative Pressure for Esophageal Perforations and Postoperative Anastomotic Esophageal Leaks"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]