Emmert, Steffen

[["dc.bibliographiccitation.firstpage","1085"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Carcinogenesis"],["dc.bibliographiccitation.lastpage","1090"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Blankenburg, S."],["dc.contributor.author","Konig, I. R."],["dc.contributor.author","Moessner, R."],["dc.contributor.author","Laspe, Petra"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Khan, Sajjad"],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Berking, Carola"],["dc.contributor.author","Volkenandt, Matthias"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Kraemer, Kenneth H."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T10:29:15Z"],["dc.date.available","2018-11-07T10:29:15Z"],["dc.date.issued","2005"],["dc.description.abstract","Individuals with the rare DNA repair deficiency syndrome xeroderma pigmentosum (XP) are sensitive to the sun and exhibit a 1000-fold increased risk for developing skin cancers, including cutaneous melanoma. Inherited polymorphisms of XP genes may contribute to subtle variations in DNA repair capacity and genetic susceptibility to melanoma. We investigated the role of three polymorphic alleles of the DNA repair gene XPC in a hospital-based case-control study of 294 Caucasian patients from Germany who had cutaneous melanoma and 375 healthy cancer-free sex-matched Caucasian control subjects from the same area. We confirmed that the XPC intron 9 PAT+, intron 11 -6A, and the exon 15 2920C polymorphisms are in a linkage disequilibrium. Only 1.6% of the 669 donors genotyped were discordant for these three polymorphisms. The allele frequencies (cases: controls) were for intron 9 PAT+ 41.7%:36.9%, for intron 11 -6A 41.8%:37.0% and for exon 15 2920C 41.3%:37.3%. Using multivariate logistic regression analyses to control for age, skin type and number of nevi, the three polymorphisms were significantly associated with increased risks of melanoma: OR 1.87 (95% CI: 1.10-3.19; P = 0.022), OR 1.83 (95% CI: 1.07-3.11; P = 0.026), and OR 1.82 (95% CI: 1.07-3.08; P = 0.026), respectively. Exploratory multivariate analyses of distinct subgroups revealed that these polymorphisms were associated with increased risks for the development of multiple primary melanomas (n = 28). The results of our case-control study support the hypothesis that the intron 9 PAT+, intron 11 -6A and exon 15 2920C haplotype may contribute to the risk of developing cutaneous melanoma by increasing the rate of an alternatively spliced XPC mRNA isoform that skips exon 12 and leads to reduced DNA repair. Our results should be validated in independent samples in order to guard against false positive findings."],["dc.description.sponsorship","Intramural NIH HHS [Z01 BC004517-31]"],["dc.identifier.doi","10.1093/carcin/bgi055"],["dc.identifier.isi","000229700100008"],["dc.identifier.pmid","15731165"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43601"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0143-3334"],["dc.title","Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","220"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.lastpage","221"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Kaune, Kjell Matthias"],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Steidl, Christian"],["dc.contributor.author","Ressel, A."],["dc.contributor.author","Baesecke, Joerg"],["dc.contributor.author","Glass, Bertram"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T10:12:10Z"],["dc.date.available","2018-11-07T10:12:10Z"],["dc.date.issued","2006"],["dc.identifier.isi","000235370600115"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40180"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.publisher.place","Oxford"],["dc.relation.conference","33rd Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF)"],["dc.relation.eventlocation","Aachen, GERMANY"],["dc.relation.issn","0906-6705"],["dc.title","Sweet-like bullous skin infiltrations in a chronic myeloic leucemia patient treated with tyrosine kinase inhibitors"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","299"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Melanoma Research"],["dc.bibliographiccitation.lastpage","302"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T10:38:43Z"],["dc.date.available","2018-11-07T10:38:43Z"],["dc.date.issued","2003"],["dc.description.abstract","The anti-melanoma activity of vindesine as a single or polychemotherapeutic agent has been reported previously in adjuvant and first-line melanoma treatment. In this study, we investigated the usefulness of vindesine monotherapy as salvage therapy in stage IV melanoma patients after failure of other chemotherapies. Thirteen patients with progressive disease were treated with 3 mg/m(2) vindesine every 2 weeks (median age, 61 years). Previous systemic treatment consisted of polychemotherapy or combined chemo-immunotherapy. All 13 patients suffered from visceral metastases (three lung, one liver, one adrenal gland and eight multiple visceral metastases). A median of three vindesine treatments was administered. Despite the various pretreatments, the toxicity of vindesine was mild. In all 13 patients, vindesine treatment was stopped due to disease progression. The median survival after primary tumour diagnosis was 42 months (8-151 months), the survival after entering stage IV was 11 months (3-35 months), and the survival after starting vindesine therapy was 4 months (1-22 months). We conclude that vindesine monotherapy is ineffective in stage IV melanoma patients previously treated with other chemotherapeutic agents."],["dc.identifier.doi","10.1097/00008390-200306000-00012"],["dc.identifier.isi","000183426800012"],["dc.identifier.pmid","12777986"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45877"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0960-8931"],["dc.title","Inefficacy of vindesine monotherapy in advanced stage IV malignant melanoma patients previously treated with other chemotherapeutic agents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","342"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Der Hautarzt"],["dc.bibliographiccitation.lastpage","347"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Hanssle, H."],["dc.contributor.author","Grafe, A."],["dc.contributor.author","Domhof, S."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T10:39:45Z"],["dc.date.available","2018-11-07T10:39:45Z"],["dc.date.issued","2003"],["dc.description.abstract","Background and Objective. The objective of the study was to evaluate the use of a medical surgical zipper (Medizip(TM)) for wound closure under tension in comparison to conventional cutaneous sutures. The surgical zipper is supposed to reduce wound tension by approximating of the wound edges via epidermal traction. Patients/Methods. This prospective study included patients with a wound diameter of more than 1 cm. 45 patients were treated with the surgical zipper, 38 were randomized into a control group with conventional wound closure. Scars were assessed after 6-18 months focusing on aesthetic and functional aspects. Results. The average length of the scars in both groups was 9 cm, but after a observation time of at least 6 month, there were differences in the width of the scars. The group with the surgical zipper showed significantly thinner scars (2,74 mm versus 4,24 mm, p=0,0008). Only 17% of the Medizip(TM) patients developed unaesthetic rope ladder-like scars versus 65% in the control group. This observation was statistically significant (p<0,0001). Conclusions. Wound stabilization by approximation of the wound edges via surgical zipper results in improved scar formation in wounds with moderate tension. Using the Medizip(TM) in wounds under heavy tension is not recommended because of the possible development of to tension bullae under the zipper."],["dc.identifier.doi","10.1007/s00105-002-0460-7"],["dc.identifier.isi","000182445300006"],["dc.identifier.pmid","12669206"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46127"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0017-8470"],["dc.title","Improved scar formation after using a medical surgical zipper for wound closure under tension"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The Journal of Gene Medicine"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Baesecke, Joerg"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T10:40:35Z"],["dc.date.available","2018-11-07T10:40:35Z"],["dc.date.issued","2003"],["dc.format.extent","S17"],["dc.identifier.isi","000181972700056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46333"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Wiley & Sons Ltd"],["dc.publisher.place","Chichester"],["dc.relation.conference","2nd International Symposium on Molecular Diagnostics and Skin Gene therapy"],["dc.relation.eventlocation","DUSSELDORF, GERMANY"],["dc.relation.issn","1099-498X"],["dc.title","Effective DEAE dextran mediated transfection of primary blood lymphocytes, dendritic cells, and immature hematopoietic cells for use in functional DNA repair assays"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","123"],["dc.contributor.author","Blankenburg, S."],["dc.contributor.author","Konig, I. R."],["dc.contributor.author","Moessner, R."],["dc.contributor.author","Laspe, Petra"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Krueger, Ulrich"],["dc.contributor.author","Khan, G."],["dc.contributor.author","Westphal, G."],["dc.contributor.author","Volkenandt, Matthias"],["dc.contributor.author","Reich, Kristian"],["dc.contributor.author","Ziegler, Andreas"],["dc.contributor.author","Kraemer, Kenneth H."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T10:46:48Z"],["dc.date.available","2018-11-07T10:46:48Z"],["dc.date.issued","2004"],["dc.identifier.isi","000222483400325"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47829"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","34th Annual Meeting of the European-Society-for-Dermatological-Research"],["dc.relation.eventlocation","Vienna, AUSTRIA"],["dc.relation.issn","0022-202X"],["dc.title","Assessment of 4 xeroderma pigmentosum group C and G gene polymorphisms and risk of cutaneous malignant melanoma: A case-control study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S1"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of the American Academy of Dermatology"],["dc.bibliographiccitation.lastpage","S4"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.contributor.author","Kiessling, J."],["dc.contributor.author","Kempf, Volkhard A. J."],["dc.contributor.author","Fuchs, Tina"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T10:23:45Z"],["dc.date.available","2018-11-07T10:23:45Z"],["dc.date.issued","2006"],["dc.description.abstract","The variola virus was declared eradicated by the World Health Organization in 1980 but human infections by cowpox virus, another memher of the genus Orthopoxvirus, are still observed, mainly in European countries. We report a woman who presented with two umbilicated vesicles surrounded by an indurated erythematous edema within cat scratch injuries on her thigh. The diagnosis of an Orthopoxvirus infection was based on the visualization of characteristic virus particles by electron microscopy and the detection of the A27L gene (14-kd fusion protein gene) of the genus Orthopoxvirus by polymerase chain reaction from a lesional skin biopsy specimen. Differential diagnoses of cat scratch disease, pustula maligna, and bullous impetigo were excluded by microbiologic investigation of the biopsy specimen. Both lesions scarred after 6 weeks of a continuous local antiseptic treatment."],["dc.identifier.doi","10.1016/j.jaad.2005.09.040"],["dc.identifier.isi","000235170500001"],["dc.identifier.pmid","16427982"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42524"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby, Inc"],["dc.relation.issn","0190-9622"],["dc.title","Orthopoxvirus infection transmitted by a domestic cat"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","22"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical and Experimental Dermatology"],["dc.bibliographiccitation.lastpage","25"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Moussa, I."],["dc.contributor.author","Haas, E."],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T11:19:42Z"],["dc.date.available","2018-11-07T11:19:42Z"],["dc.date.issued","2008"],["dc.description.abstract","We describe the rare Stewart-Bluefarb syndrome in a 15-year-old boy. This syndrome presents as a congenital arteriovenous malformation of the lower leg with multiple arteriovenous shunts accompanied by the benign acroangiodermatitis of Mali (pseudo-Kaposi's sarcoma). The clinical features of this disorder and the treatment options are reviewed."],["dc.identifier.doi","10.1111/j.1365-2230.2007.02541.x"],["dc.identifier.isi","000251809700004"],["dc.identifier.pmid","17927784"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55347"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0307-6938"],["dc.title","Acroangiodermatitis Mali resulting from arteriovenous malformation: report of a case of Stewart-Bluefarb syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1166"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of the American Academy of Dermatology"],["dc.bibliographiccitation.lastpage","1169"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Kuster, W. K."],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Hanssle, H."],["dc.contributor.author","Hallermann, Christian"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Neumann, C."],["dc.date.accessioned","2018-11-07T10:34:27Z"],["dc.date.available","2018-11-07T10:34:27Z"],["dc.date.issued","2003"],["dc.description.abstract","We describe a new family with the rare genodermatosis keratosis punctata palmo-plantaris Buschke-Fischer-Brauer (keratoma disseminatum). in all, 3 family members in 3 generations were affected, a pattern consistent with autosomal dominant inheritance. Clinical symptoms started in the third decade with disseminated, small, round, hyperkeratotic papules on the palms and soles. Punctate keratoses coalesced into hyperkeratotic plaques on pressure points. Identification of additional families is necessary to permit definitive genetic classification of this genodermatosis."],["dc.identifier.doi","10.1016/S0190-9622(03)00472-9"],["dc.identifier.isi","000186784800035"],["dc.identifier.pmid","14639410"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44878"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby, Inc"],["dc.relation.issn","0190-9622"],["dc.title","A new family with the rare genodermatosis keratosis punctata palmoplantaris Buschke-Fischer-Brauer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Experimental Dermatology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Kuschal, Christiane"],["dc.contributor.author","Laspe, Petra"],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T11:04:24Z"],["dc.date.available","2018-11-07T11:04:24Z"],["dc.date.issued","2007"],["dc.format.extent","261"],["dc.identifier.isi","000244056600217"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51839"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.publisher.place","Oxford"],["dc.relation.conference","34th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung"],["dc.relation.eventlocation","Freiburg, GERMANY"],["dc.relation.issn","0906-6705"],["dc.title","Influence of cyclosporin a on DNA repair"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]