Rodnina, Marina V.

[["dc.bibliographiccitation.firstpage","317"],["dc.bibliographiccitation.lastpage","326"],["dc.contributor.author","Rodnina, Marina V."],["dc.contributor.author","Fricke, Rainer"],["dc.contributor.author","Wintermeyer, Wolfgang"],["dc.contributor.editor","Nierhaus, Knud H."],["dc.contributor.editor","Franceschi, François"],["dc.contributor.editor","Subramanian, Alap R."],["dc.contributor.editor","Erdmann, Volker A."],["dc.contributor.editor","Wittmann-Liebold, Brigitte"],["dc.date.accessioned","2017-09-07T11:54:06Z"],["dc.date.available","2017-09-07T11:54:06Z"],["dc.date.issued","1993"],["dc.description.abstract","The elongation cycle of ribosomal protein synthesis begins with the binding of the substrate, aminoacyl-tRNA, to the A site of the ribosome. The reaction is a quite complex process which involves an enzyme, elongation factor Tu (EF-Tu), and GTP. It is the complex of aminoacyl-tRNA with EF-Tu and GTP (“ternary complex”) which rapidly associates with the A site (Miller and Weissbach, 1977; Kaziro, 1978). Subsequently, the recognition of the codon takes place. The formation of the codonanticodon complex provides the signal which triggers the hydrolysis of GTP. The latter enables the dissociation of EF-Tu•GDP from the ribosome which in turn allows the aminoacyl-tRNA to accommodate in the A site such as to be positioned correctly for peptidyl transfer. There is good evidence supporting the view that the complexity of the A-site binding reaction, at least in part, is due to the necessity to optimize speed and accuracy of aminoacyl-tRNA selection by the inclusion of proofreading during the process (Thompson and Dix, 1982; Thompson and Karim, 1982; Ehrenberg and Kurland, 1984; Ruusala et al., 1984)."],["dc.identifier.doi","10.1007/978-1-4615-2407-6_30"],["dc.identifier.gro","3145106"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/2806"],["dc.language.iso","en"],["dc.notes","Printausgabe: Plenum Press, New York"],["dc.notes.intern","Crossref Import"],["dc.notes.status","final"],["dc.publisher","Springer"],["dc.publisher.place","Boston"],["dc.relation.conference","International Conference on the Translational Apparatus"],["dc.relation.eventend","1992-11-05"],["dc.relation.eventlocation","Berlin"],["dc.relation.eventstart","1992-10-31"],["dc.relation.isbn","978-1-4613-6021-6"],["dc.relation.ispartof","The Translational Apparatus. Structure, Function, Regulation, Evolution"],["dc.title","Kinetic Fluorescence Study on EF-Tu-Dependent Binding of Phe-tRNAPhe to the Ribosomal a Site"],["dc.type","conference_paper"],["dc.type.internalPublication","no"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]