Hartmann, Franziska

[["dc.bibliographiccitation.firstpage","162"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Pathobiology"],["dc.bibliographiccitation.lastpage","170"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Petrova, Darinka T."],["dc.contributor.author","Brehmer, Franziska"],["dc.contributor.author","Schultze, Frank Christian"],["dc.contributor.author","Asif, Abdul R."],["dc.contributor.author","Gross, Oliver"],["dc.contributor.author","Oellerich, Michael"],["dc.contributor.author","Brandhorst, Gunnar"],["dc.date.accessioned","2018-11-07T09:01:51Z"],["dc.date.available","2018-11-07T09:01:51Z"],["dc.date.issued","2011"],["dc.description.abstract","Aim: The aim of this study was to investigate the effect of mycophenolate mofetil (MMF) using differential kidney proteome profiling of COL4A3-deficient mice as a model of progressive renal disease. Methods: Histological evaluation of kidney sections was performed. Total protein lysate from kidneys of placebo- and MMF-treated COL4A3-deficient mice was studied for significant differences in protein abundance using 2-dimensional electrophoresis and mass spectrometry. Results: While tubulointerstitial fibrosis in COL4A3-deficient mice was inhibited by MMF, 19 proteins in the kidneys were regulated: 12 with lower (ATPO, TAGL2, CAH1, TPD52, VA0D1, SERPH, GNAL, PSB6, EF1D, OTUB1, NDUS8, and NAPSA) and 7 with higher (ACADM, ACY3, CK054, ACTB/G, ACTB, UBP5, and ACY1) spot intensity. Nine differentially expressed proteins showed interaction potential (ATPO, TPD52, PSB6, EF1D, OTUB1, NAPSA, ACTB, ACTG, and UBP5). Conclusions: The identified proteins take part in different signaling pathways. With the highest probability, the VEGF signaling pathway (TAGL2, EF1D, and ACTB) and hypoxia (CAH1, PSB6, and ACTG) were influenced by MMF in fibrotic conditions. Moreover, MMF may modulate antifibrotic and apoptotic pathways as well as epithelial-mesenchymal transition (EMT). Different signaling pathways may be influenced by MMF therapy. These results suggest an inhibitory effect of MMF on renal EMT in COL4A3-deficient mice. Further studies are necessary to validate these findings. Copyright (C) 2011 S. Karger AG, Basel"],["dc.description.sponsorship","Roche Pharma AG, Grenzach-Wyhlen, Germany"],["dc.identifier.doi","10.1159/000324597"],["dc.identifier.isi","000292410900005"],["dc.identifier.pmid","21613803"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7827"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24531"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1015-2008"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Differential Kidney Proteome Profiling in a Murine Model of Renal Fibrosis under Treatment with Mycophenolate Mofetil"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","984"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","993"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Hartmann, Franziska"],["dc.contributor.author","Lockmann, Anike"],["dc.contributor.author","Himpel, Okko"],["dc.contributor.author","Kühnle, Ingrid"],["dc.contributor.author","Hensen, Janina"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Thoms, Kai‐Martin"],["dc.date.accessioned","2021-04-14T08:22:56Z"],["dc.date.available","2021-04-14T08:22:56Z"],["dc.date.issued","2020"],["dc.description.abstract","Summary Background and aims Infantile hemangiomas can be successfully treated by both systemic propranolol and neodymium:YAG (Nd:YAG)‐dye laser combination therapy. In this retrospective study, the efficacy and safety of sequential and parallel therapy of complicated hemangiomas treated with both methods were evaluated. Patients and methods 30 children with 48 complicated hemangiomas were treated with propranolol and Nd:YAG‐dye laser combination therapy. Using photo comparison, the percentage remission rate was evaluated by three investigators on a four‐step scale (I: 0–25 %, II: 26–50 %, III: 51–75 % and IV: 76–100 %). Results Eleven children received propranolol and laser therapy in parallel (A), twelve children received laser therapy after propranolol (B) and seven children received propranolol after laser therapy (C). Due to emigration abroad, one child was lost to follow‐up. A strong improvement (IV) was observed in 23/29 (79.3 %) of all treated children (A: 90.9 %, B 75 %, C 66.7 %). The mean duration of propranolol therapy in all children was 8.6 months (A: 8.9 months, B: 8.2 months, C: 8.9 months). On average, 2.33 laser treatments were performed per hemangioma (A: 1.95, B: 3.2, C: 1.91). Serious side effects caused by propranolol and laser therapy were not observed. Conclusions Propranolol and Nd:YAG‐dye laser combination therapy can be used sequentially or in parallel safely and effectively. They complement each other in a meaningful manner."],["dc.identifier.doi","10.1111/ddg.14184"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/80739"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.title","Combination therapy of oral propranolol and combined Nd:YAG/pulsed dye laser therapy in infantile hemangiomas: a retrospective analysis of 48 treated hemangiomas in 30 children"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]