Wobrock, Thomas

[["dc.bibliographiccitation.firstpage","719"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","The World Journal of Biological Psychiatry"],["dc.bibliographiccitation.lastpage","728"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Martins-De-Souza, Daniel"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Zerr, Inga"],["dc.contributor.author","Schmitt, Andrea"],["dc.contributor.author","Gawinecka, Joanna"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Turck, Christoph W."],["dc.date.accessioned","2018-11-07T08:41:14Z"],["dc.date.available","2018-11-07T08:41:14Z"],["dc.date.issued","2010"],["dc.description.abstract","Objectives. To identify proteins differentially expressed in schizophrenia patients, we collected 50 mu l cerebrospinal fluid from 17 first-episode schizophrenia patients and 10 healthy controls. Methods. Their proteins were separated by two-dimensional gel electrophoresis without using any depletion method and identified by mass spectrometry. Results. Approximately 550 spots were detected, six of which had significantly different intensities in schizophrenia compared to control specimens. We were able to validate in individual samples the upregulation of apolipoprotein E, apolipoprotein A1 and prostaglandin-H2 D-isomerase by Western blot analyses and detect the downregulation of transthyretin, TGF-beta receptor type-1 and coiled-coil domain-containing protein 3 precursor. Conclusions. These findings may help to elucidate the disease mechanisms and confirm the hypothesis of disturbed cholesterol and phospholipid metabolism in schizophrenia, and thus reveal the final role players. Moreover, a grouped protein expression analysis of apolipoprotein E, apolipoprotein A-I, and prostaglandin-H2 D-isomerase in cerebrospinal fluid from patients might be a potential diagnostic tool for schizophrenia."],["dc.identifier.doi","10.3109/15622971003758748"],["dc.identifier.isi","000280009300005"],["dc.identifier.pmid","20446881"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19420"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.relation.issn","1562-2975"],["dc.title","Different apolipoprotein E, apolipoprotein A1 and prostaglandin-H2 D-isomerase levels in cerebrospinal fluid of schizophrenia patients and healthy controls"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","397"],["dc.bibliographiccitation.journal","Schizophrenia Research"],["dc.bibliographiccitation.lastpage","407"],["dc.bibliographiccitation.volume","216"],["dc.contributor.author","Takahashi, Shun"],["dc.contributor.author","Keeser, Daniel"],["dc.contributor.author","Rauchmann, Boris-Stephan"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Keller-Varady, Katriona"],["dc.contributor.author","Maurus, Isabel"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Schmitt, Andrea"],["dc.contributor.author","Ertl-Wagner, Birgit"],["dc.contributor.author","Malchow, Berend"],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2021-04-14T08:27:38Z"],["dc.date.available","2021-04-14T08:27:38Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.schres.2019.11.004"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82355"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0920-9964"],["dc.title","Effect of aerobic exercise combined with cognitive remediation on cortical thickness and prediction of social adaptation in patients with schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","127"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Archives of Psychiatry and Clinical Neuroscience"],["dc.bibliographiccitation.lastpage","136"],["dc.bibliographiccitation.volume","265"],["dc.contributor.author","Kittel-Schneider, Sarah"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Trost, Sarah"],["dc.contributor.author","Zilles, David"],["dc.contributor.author","Wolf, C."],["dc.contributor.author","Schmitt, A."],["dc.contributor.author","Malchow, Berend"],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Backens, Martin"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Reif, A."],["dc.date.accessioned","2018-11-07T10:00:31Z"],["dc.date.available","2018-11-07T10:00:31Z"],["dc.date.issued","2015"],["dc.description.abstract","The diacylglycerol kinase eta (DGKH) gene, first identified in a genome-wide association study, is one of the few replicated risk genes of bipolar affective disorder (BD). Following initial positive studies, it not only was found to be associated with BD but also implicated in the etiology of other psychiatric disorders featuring affective symptoms, rendering DGKH a cross-disorder risk gene. However, the (patho-)physiological role of the encoded enzyme is still elusive. In the present study, we investigated primarily the influence of a risk haplotype on amygdala volume in patients suffering from schizophrenia or BD as well as healthy controls and four single nucleotide polymorphisms conveying risk. There was a significant association of the DGKH risk haplotype with increased amygdala volume in BD, but not in schizophrenia or healthy controls. These findings add to the notion of a role of DGKH in the pathogenesis of BD."],["dc.description.sponsorship","DFG [RTG 1253/1, RE1632/5-1]; BMBF (DZHI) [01EO1004]; IZKF [Z3-24]"],["dc.identifier.doi","10.1007/s00406-014-0513-9"],["dc.identifier.isi","000350305500005"],["dc.identifier.pmid","24958494"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37825"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1433-8491"],["dc.relation.issn","0940-1334"],["dc.title","Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","65"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Biological Psychiatry"],["dc.bibliographiccitation.lastpage","71"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Kamer, Thomas"],["dc.contributor.author","Roy, Anand"],["dc.contributor.author","Vogeley, Kai"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Wagner, Michael"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Schulze, Thomas G."],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Schild, Hans H."],["dc.contributor.author","Block, Wolfgang"],["dc.contributor.author","Traeber, Frank"],["dc.contributor.author","Tepest, Ralf"],["dc.contributor.author","Honer, William G."],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2018-11-07T11:19:33Z"],["dc.date.available","2018-11-07T11:19:33Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: The anterior limb of the internal capsule (ALIC), connecting cortical and subcortical structures, is involved in functional important circuits. To detect volumetric changes in ALIC, including the influence of genetic factors, a magnetic resonance imaging (MRI) study of families affected with schizophrenia was performed. Methods: The study sample comprised 22 family members with schizophrenia (FM-SZ), 34 family members without schizophrenia (FM-NSZ), and 43 control subjects. In addition to manual tracing of ALIC, subjects underwent proton magnetic resonance spectroscopy in the left prefrontal cortex, psychopathological rating, and neuropsychological assessment of frontal lobe function. Results: Compared with controls, a significant reduction of right ALIC volume was seen in all family members (12%-16% reduction, p <.01) and a reduction of left ALIC volume in FM-NSZ (10% reduction, p =.028) was also observed. Both groups of family members showed a bilateral reduction in maximal cross sectional area of the ALIC. FM-SZ performed significantly worse on neurocognitive measures (Subject Ordered Pointing Task [SOPT] and Wisconsin Card Sorting Test), and performance correlated negatively with the ALIC volume (SOPT, r = -.6, p =.03). Conclusions: A reduced volume of ALIC in affected families supports the hypothesis of disturbed frontothalamic connectivity in schizophrenia and demonstrates functional relevance by an association with reduced neurocognitive performance."],["dc.identifier.doi","10.1016/j.biopsych.2007.02.026"],["dc.identifier.isi","000251864000011"],["dc.identifier.pmid","17574215"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55310"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0006-3223"],["dc.title","Reduction of the internal capsule in families affected with schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","370"],["dc.bibliographiccitation.journal","Schizophrenia Research"],["dc.bibliographiccitation.lastpage","376"],["dc.bibliographiccitation.volume","208"],["dc.contributor.author","Wagner, Elias"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Kunze, Birgit"],["dc.contributor.author","Langguth, Berthold"],["dc.contributor.author","Landgrebe, Michael"],["dc.contributor.author","Eichhammer, Peter"],["dc.contributor.author","Frank, Elmar"],["dc.contributor.author","Cordes, Joachim"],["dc.contributor.author","Wölwer, Wolfgang"],["dc.contributor.author","Winterer, Georg"],["dc.contributor.author","Gaebel, Wolfgang"],["dc.contributor.author","Hajak, Göran"],["dc.contributor.author","Ohmann, Christian"],["dc.contributor.author","Verde, Pablo E."],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Ahmed, Raees"],["dc.contributor.author","Honer, William G."],["dc.contributor.author","Siskind, Dan"],["dc.contributor.author","Malchow, Berend"],["dc.contributor.author","Strube, Wolfgang"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Hasan, Alkomiet"],["dc.date.accessioned","2020-12-10T15:21:10Z"],["dc.date.available","2020-12-10T15:21:10Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.schres.2019.01.021"],["dc.identifier.issn","0920-9964"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72938"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Efficacy of high-frequency repetitive transcranial magnetic stimulation in schizophrenia patients with treatment-resistant negative symptoms treated with clozapine"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","252"],["dc.bibliographiccitation.issue","1-3"],["dc.bibliographiccitation.journal","Schizophrenia Research"],["dc.bibliographiccitation.lastpage","261"],["dc.bibliographiccitation.volume","105"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Schneider, M."],["dc.contributor.author","Kadovic, D."],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Eckerd, U. K. H."],["dc.contributor.author","Retz, Wolfgang"],["dc.contributor.author","Roesler, M."],["dc.contributor.author","Falkaia, P."],["dc.date.accessioned","2018-11-07T11:10:49Z"],["dc.date.available","2018-11-07T11:10:49Z"],["dc.date.issued","2008"],["dc.description.abstract","Disturbances in cortico-cortical and cortico-subcortical circuits in schizophrenia have been described by previous neuroimaging and electrophysiological studies. Transcranial magnetic stimulation (TMS) provides a neurophysiological technique for the measurement of cortical excitability, especially of the motoneural system. Previous studies using paired-pulse TMS to investigate short-interval cortical inhibition (SICI) and intracortical facilitation (ICF), mainly involving chronic schizophrenia patients, have been inconsistent and only one study in first-episode patients has been conducted so far. We assessed SICI (interstimulus interval, ISI, 3 milliseconds, ms) and ICF (ISI 7 ms) in 29 first-episode schizophrenia patients (FE-SZ) with limited exposure to antipsychotic treatment against measures of 28 healthy controls (HC). Amplitudes of motor evoked potentials (MEPs) were measured from the left and right first dorsal interosseus muscle (FDI). The conditioning stimulus was set at 80% intensity of resting motor threshold (RMT) and the test stimulus (TS) was set at an intensity that produced an MEP amplitude of about 1 mV. For SICI conditions, FE-SZ demonstrated significantly higher MEP amplitudes from left motor cortex (right FDI) compared to HC, and for MEPs from right motor cortex (left FDI) a similar trend was observable (FE-SZ 41% vs. HC 21% of TS, p = 0.017 for left motor cortex, and FE-SZ 59% vs. HC 31% of TS, p=0.059 for right motor cortex; Mann-Whitney U-test). No significant difference in MEPs could be detected for ICF on either hemisphere. In addition, there was no difference in left and right RMT comparing patients and control subjects. Our result of a reduced SICI in a large sample of well characterized first-episode schizophrenia patients suggests that a GABAergic deficit may be involved in schizophrenic pathophysiology, already early in the disease course, supporting the intracortical dysconnectivity hypothesis. (C) 2008 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.schres.2008.06.001"],["dc.identifier.isi","000260591900028"],["dc.identifier.pmid","18625547"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53294"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0920-9964"],["dc.title","Reduced cortical inhibition in first-episode schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Menzel, Patrick"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T10:59:21Z"],["dc.date.available","2018-11-07T10:59:21Z"],["dc.date.issued","2007"],["dc.format.extent","228"],["dc.identifier.isi","000249873600120"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50681"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","25th Symposium of the Arbeitsgemeinschaft-Neuropsychopharmakologie-und-Pharmakopsychiatrie"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","5-HTTLPR polymorphism influences amygdala volume"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","182"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Schizophrenia Research"],["dc.bibliographiccitation.lastpage","191"],["dc.bibliographiccitation.volume","173"],["dc.contributor.author","Malchow, Berend"],["dc.contributor.author","Keeser, Daniel"],["dc.contributor.author","Keller, Katriona"],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Rauchmann, Boris-Stephan"],["dc.contributor.author","Kimura, Hiroshi"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Gruber, Oliver"],["dc.contributor.author","Ertl-Wagner, Birgit"],["dc.contributor.author","Honer, William G."],["dc.contributor.author","Hillmer-Vogel, Ursula"],["dc.contributor.author","Schmitt, Andrea"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Niklas, Andree"],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2018-11-07T10:13:58Z"],["dc.date.available","2018-11-07T10:13:58Z"],["dc.date.issued","2016"],["dc.description.abstract","The objective of this longitudinal magnetic resonance (MR) imaging study was to examine the effects of endurance training on hippocampal and grey matter volumes in schizophrenia patients and healthy controls. 20 chronic schizophrenia patients and 21 age- and gender-matched healthy controls underwent 3months of endurance training (30 min, 3 times per week). 19 additionally recruited schizophrenia patients played table soccer (\"foosball\" in the USA) over the same period. MR imaging with 3D-volumetric T1-weighted sequences was performed on a 3 T MR scanner at baseline, after 6 weeks and after the 3-month intervention and 3 additional training-free months. In addition to voxel-based morphometry (VBM), we performed manual and automatic delineation of the hippocampus and its substructures. Endurance capacity and psychopathological symptoms were measured as secondary endpoints. No significant increases in the volumes of the hippocampus or hippocampal substructures were observed in schizophrenia patients or healthy controls. However, VBM analyses displayed an increased volume of the left superior, middle and inferior anterior temporal gyri compared to baseline in schizophrenia patients after the endurance training, whereas patients playing table soccer showed increased volumes in the motor and anterior cingulate cortices. After the additional training-free period, the differences were no longer present. While endurance capacity improved in exercising patients and healthy controls, psychopathological symptoms did not significantly change. The subtle changes in the left temporal cortex indicate an impact of exercise on brain volumes in schizophrenia. Subsequent studies in larger cohorts are warranted to address the question of response variability of endurance training. (C) 2015 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","Dorothea Schlozer Programme at the Georg-August-Universitat Gottingen"],["dc.identifier.doi","10.1016/j.schres.2015.01.005"],["dc.identifier.isi","000375847400010"],["dc.identifier.pmid","25623601"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40533"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1573-2509"],["dc.relation.issn","0920-9964"],["dc.title","Effects of endurance training on brain structures in chronic schizophrenia patients and healthy controls"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Scherk, Harald"],["dc.contributor.author","Menzel, Patrick"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Usher, Juliana"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Reith, W."],["dc.contributor.author","Falkai, Peter Gaston"],["dc.contributor.author","Gruber, Oliver"],["dc.date.accessioned","2018-11-07T10:57:22Z"],["dc.date.available","2018-11-07T10:57:22Z"],["dc.date.issued","2007"],["dc.format.extent","276"],["dc.identifier.isi","000253318800700"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50229"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0028-2804"],["dc.title","The 5HTTLPR Genotype influences the size of Amygdala"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","515"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Brain Imaging and Behavior"],["dc.bibliographiccitation.lastpage","526"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Rauchmann, Boris-Stephan"],["dc.contributor.author","Ghaseminejad, Farhad"],["dc.contributor.author","Keeser, Daniel"],["dc.contributor.author","Keller-Varady, Katriona"],["dc.contributor.author","Schneider-Axmann, Thomas"],["dc.contributor.author","Takahashi, Shun"],["dc.contributor.author","Karali, Temmuz"],["dc.contributor.author","Helms, Gunther"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Maurus, Isabel"],["dc.contributor.author","Hasan, Alkomiet"],["dc.contributor.author","Wobrock, Thomas"],["dc.contributor.author","Ertl-Wagner, Birgit"],["dc.contributor.author","Schmitt, Andrea"],["dc.contributor.author","Malchow, Berend"],["dc.contributor.author","Falkai, Peter"],["dc.date.accessioned","2020-12-10T14:14:03Z"],["dc.date.available","2020-12-10T14:14:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s11682-019-00198-1"],["dc.identifier.eissn","1931-7565"],["dc.identifier.issn","1931-7557"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71309"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The impact of endurance training and table soccer on brain metabolites in schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]