Al Ghazal, Philipp

[["dc.bibliographiccitation.firstpage","595"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","EUROPEAN JOURNAL OF DERMATOLOGY"],["dc.bibliographiccitation.lastpage","601"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Erfurt-Berge, Cornelia"],["dc.contributor.author","Dissemond, Joachim"],["dc.contributor.author","Schwede, Katharina"],["dc.contributor.author","Seitz, Anna-Theresa"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Wollina, Uwe"],["dc.contributor.author","Renner, Regina"],["dc.date.accessioned","2018-11-07T09:49:08Z"],["dc.date.available","2018-11-07T09:49:08Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Necrobiosis lipoidica (NL) is a rare granulomatous disorder of unknown aetiology which can manifest in ulcerative skin lesions and is widely recognised in association with diabetes. We evaluated in total 100 patients to improve knowledge about the epidemiology and clinical course of NL. Additionally we focused on treatment options according to evidence level and expert opinion. Objectives: To examine the clinical features of patients with necrobiosis lipoidica and to give recommendations for topical and systemic treatment. Materials & Methods: This multicentre retrospective study covers data from 100 patients with the diagnosis of NL of the lower leg, treated during the period between 01/2006 and 06/2014. Data from 5 German dermatological centres with 23 men and 77 women with a median age of 52 years were evaluated. We also asked 15 dermatological experts for their opinions about ulceration, associated diseases and their preferences for treatment modalities of NL. Results: Patients' ages ranged from 15 to 95 years (median age 52 years, mean age 49.8 years). NL was significantly more common in women (77%). Ulceration of the NL was observed in 33% of cases, in particular in male patients and in patients with concomitant diabetes mellitus. Thyroidal disorders were found in 15% of all cases. Conclusion: Our data confirm that female sex, middle age and endocrine disorders like diabetes mellitus or thyroid dysfunction are characteristics of patients suffering from NL. Existing therapeutic options were very variable and - according to the opinion of our experts - only a few highly effective."],["dc.identifier.doi","10.1684/ejd.2015.2636"],["dc.identifier.isi","000370143500010"],["dc.identifier.pmid","26575980"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35447"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Libbey Eurotext Ltd"],["dc.relation.issn","1952-4013"],["dc.relation.issn","1167-1122"],["dc.title","Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1129"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","1131"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Klode, Joachim"],["dc.contributor.author","Dissemond, Joachim"],["dc.date.accessioned","2018-11-07T09:32:03Z"],["dc.date.available","2018-11-07T09:32:03Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1111/ddg.14570"],["dc.identifier.isi","000346053400065"],["dc.identifier.pmid","25482699"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31660"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Diagnostic criteria for pyoderma gangrenosum: results of a survey among dermatologic wound experts in Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1023"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","1030"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Jockenhoefer, Finja"],["dc.contributor.author","Herberger, Katharina"],["dc.contributor.author","Schaller, Joerg"],["dc.contributor.author","Hohaus, Katja Christina"],["dc.contributor.author","Stoffels-Weindorf, Maren"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Augustin, Matthias"],["dc.contributor.author","Dissemond, Joachim"],["dc.date.accessioned","2018-11-07T10:07:26Z"],["dc.date.available","2018-11-07T10:07:26Z"],["dc.date.issued","2016"],["dc.description.abstract","Introduction: Pyoderma gangrenosum (PG) is a rare neutrophilic, ulcerative skin disease of largely unknown pathophysiology. Material and methods : In this study, potentially relevant cofactors and comorbidities in patients with PG from three dermatological wound care centers in Germany were evaluated. Results: Of the 121 patients assessed, women (66.9 %) were more frequently affected than men. Patient age ranged from 18 to 96 years (mean 59.8). Wound size varied from 1-600 cm(2) (mean 65.6 cm(2)), and the pain intensity was predominantly very high (VAS 1-10, mean 7). The lower legs were most commonly (71.9 %) affected. Overall, 12 (9.9 %) patients had inflammatory bowel disease (ulcerative colitis, 5.8 %; Crohn's disease, 4.1 %), 14.1 % exhibited rheumatic comorbidities. Neoplasms were found in 20.6 % of patients, with 6.6 % classified as hematological and 14.0 % as solid neoplasms. With respect to criteria for the metabolic syndrome, obesity was found in 69.4 %, arterial hypertension in 57.9 %, and diabetes mellitus in 33.9 % of patients. Conclusions: The present data analysis confirms the association of PG with metabolic syndrome and neoplasms. In the future, these aspects should be included in the targeted diagnostic workup of patients with PG and subsequently treated in a timely fashion."],["dc.identifier.doi","10.1111/ddg.12791"],["dc.identifier.isi","000388277100007"],["dc.identifier.pmid","27767262"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39279"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Tricenter analysis of cofactors and comorbidity in patients with pyoderma gangrenosum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","951"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","International Wound Journal"],["dc.bibliographiccitation.lastpage","956"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Jockenhoefer, Finja"],["dc.contributor.author","Klode, Joachim"],["dc.contributor.author","Kroeger, Knut"],["dc.contributor.author","Roesch, Alexander"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Dissemond, Joachim"],["dc.date.accessioned","2018-11-07T10:07:26Z"],["dc.date.available","2018-11-07T10:07:26Z"],["dc.date.issued","2016"],["dc.description.abstract","Pyoderma gangrenosum (PG) is a rarely diagnosed non-infectious neutrophil ulcerative dermatosis with only limited knowledge on the underlying auto-inflammatory process. To unravel common cofactors and comorbidities in patients with PG we analysed Diagnosis Related Groups (DRG) cases of all inpatients diagnosed with PG in German hospitals in 2012. We received data of 1227 inpatient cases having PG as primary diagnosis and 985 inpatient cases with PG as secondary diagnosis. The ratio of women to men was 2: 1, and the most often registered age was 75-79 years. Common comorbidities were arterial hypertension (50.3%), non-insulin-dependent diabetes mellitus (25.1%) and dysfunction of lipid metabolism (10.8%). In sum, 94.8% of the patients suffered from aspects of metabolic syndrome. Other comorbidities were Crohn's disease (4.5%), ulcerative colitis (4.2%), chronic polyarthritis (5.2%), monoclonal gammopathy or myelodysplastic syndrome (2.5%), leukaemia (1.1%) and lymphoma (0.4%). DRG data do not reflect individual patients, but rather patient cases. We described the worldwide largest PG population and confirmed a wide range of potentially relevant and partly not yet described cofactors and comorbidities such as metabolic syndrome."],["dc.identifier.doi","10.1111/iwj.12463"],["dc.identifier.isi","000387667600106"],["dc.identifier.pmid","26250591"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39278"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1742-481X"],["dc.relation.issn","1742-4801"],["dc.title","Patients with pyoderma gangrenosum - analyses of the German DRG data from 2012"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","317"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","325"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Dissemond, Joachim"],["dc.date.accessioned","2018-11-07T09:59:07Z"],["dc.date.available","2018-11-07T09:59:07Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: There are currently no therapeutic guidelines with respect to pyoderma gangrenosum (PG). Material and methods: In order to systematically record currently practiced therapeutic options for PG, a questionnaire was developed and sent to experts at various German dermatology departments. Results: Overall, 50 fully completed questionnaires were returned to us. On average, the diagnosis of PG is made 15 times per year. Of these patients, 11.1 % receive only - topical therapy; 22.7 %, exclusively systemic therapy; and 66.2 %, both topical and systemic immunomodulatory therapy. Topically, the experts most commonly use class III (78 %) and class IV corticosteroids (88 %). All experts (100 %) reported the frequent use of systemic corticosteroids in the therapy of PG patients. Cyclosporine is used in 74 %, TNF-alpha inhibitors in 24 %, and azathioprine or mycophenolate mofetil each in 20 % of patients. Systemic agents such as dapsone (16 %), intravenous immunoglobulins (14 %), methotrexate (6 %), cyclophosphamide (4 %), tacrolimus (4 %), and rituximab (2 %), however, are given less frequently. Conclusions: Worldwide, no uniformly accepted standard is available for the treatment of patients with PG. In our survey among experts, treatment regimens currently used in Germany, and based on expert clinical experience, have now been recorded, analyzed, and benchmarked for the first time."],["dc.identifier.doi","10.1111/ddg.12585"],["dc.identifier.isi","000352200900006"],["dc.identifier.pmid","25761564"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37516"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Therapy of pyoderma gangrenosum in Germany: results of a survey among wound experts"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]