Al Ghazal, Philipp

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Brehmer, Franziska"],["dc.contributor.author","Baltzer, Anne"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T09:53:40Z"],["dc.date.available","2018-11-07T09:53:40Z"],["dc.date.issued","2015"],["dc.format.extent","41"],["dc.identifier.isi","000360219800091"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36374"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Complete Remission of cutaneous Melanoma Metastases with Combination Therapy of Ipilimumab and Diphenylcyclopropenone (DPCP)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","158"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Melanoma Research"],["dc.bibliographiccitation.lastpage","164"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Gutzmer, Ralf"],["dc.contributor.author","Satzger, Imke"],["dc.contributor.author","Starz, Hans"],["dc.contributor.author","Bader, Christina"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Kapp, Alexander"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T09:42:15Z"],["dc.date.available","2018-11-07T09:42:15Z"],["dc.date.issued","2014"],["dc.description.abstract","Head or neck location of primary cutaneous melanomas has been described as an adverse prognostic factor, but this has to be reassessed after the introduction of sentinel lymph node (SLN) excision (SLNE). Descriptive statistics, Kaplan-Meier estimates and Cox proportional hazard models were used to study retrospectively a population of 2302 consecutive melanoma patients from three German melanoma centres undergoing SLNE. Approximately 10% of the patients (N=237) had a primary melanoma located at the head or neck (HNM). In both the SLN-positive and SLN-negative subpopulation, patients with HNM were significantly older, more frequently men and had thicker primaries compared with patients with tumours in other locations. The proportion of positive SLNs was lower in HNM compared with other locations of the primary (20 vs. 26%, P=0.048). The false-negative rate was higher in HNM (17.5 vs. 8.4%, P=0.05). In patients with HNM, the SLN status was a significant factor for recurrence-free survival but not for overall survival. SLN-negative HNM patients had a significantly worse overall survival than the SLN negatives with primaries at other sites, whereas the prognosis of the SLN-positive patients was similar in both groups. The prevalence of lymph node metastases after SLNE is lower in patients with HNM compared with other melanoma locations. As a result, the prognostic information provided by the SLN for HNM seems less important. Decision making for SLNE in HNM should be carefully balanced considering the potential morbidity of the procedure."],["dc.identifier.doi","10.1097/CMR.0000000000000042"],["dc.identifier.isi","000332601400009"],["dc.identifier.pmid","24346168"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33915"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1473-5636"],["dc.relation.issn","0960-8931"],["dc.title","Lower prevalence of lymphatic metastasis and poorer survival of the sentinel node-negative patients limit the prognostic value of sentinel node biopsy for head or neck melanomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1137"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Der Onkologe"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Lippert, Undine"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Emmert, Steffen"],["dc.date.accessioned","2018-11-07T09:48:32Z"],["dc.date.available","2018-11-07T09:48:32Z"],["dc.date.issued","2015"],["dc.description.abstract","Despite the rarity of extracutaneous melanomas they represent a tumor entity with a very high mortality due to delayed diagnosis. This review article presents the various biological and diagnostic characteristics of extracutaneous melanomas with special emphasis on mucosal melanoma and provides an overview of new pharmacological approaches urgently needed due to the lack of efficacious standard therapies. A systematic literature search was conducted by using the English terms extracutaneous melanoma, mucosal melanoma, uveal melanoma, leptomeningeal melanoma and c-KIT in the Medline database between 1982 and 2014. Extracutaneous melanomas comprise approximately 1.4-5 % of all melanomas and are a rare tumor entity. They develop from de-differentiated dendritic melanocytes in the mucus membranes of the gastrointestinal tract, genitourinary tract and respiratory system, in the back of the eyes or the meninges. As they are difficult to detect, extracutaneous melanomas are often already associated with an advanced disease progression at the time of first diagnosis. The class of c-KIT inhibitors has proven to be a new effective targeted therapy for extracutaneous melanomas harboring the appropriate mutational status. Because of the rarity of this tumor entity prospective, randomized control trials are lacking. Therapeutic approaches should, therefore, always be individualized taking into account the special requirements in each case."],["dc.identifier.doi","10.1007/s00761-014-2884-y"],["dc.identifier.isi","000365723700004"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35328"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1433-0415"],["dc.relation.issn","0947-8965"],["dc.title","Extracutaneous melanoma with special emphasis on mucosal melanoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Bremmer, S."],["dc.contributor.author","Amschler, Katharina"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Olbricht, N."],["dc.contributor.author","Schon, M."],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Thoms, Kai Martin"],["dc.date.accessioned","2018-11-07T10:08:54Z"],["dc.date.available","2018-11-07T10:08:54Z"],["dc.date.issued","2016"],["dc.format.extent","40"],["dc.identifier.isi","000383669600091"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39560"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Remission of metastatic Melanomas under Checkpoint Inhibition does not protect against the bright Skin Cancer"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","850"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","852"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Baltzer, Anne"],["dc.contributor.author","Brehmer, Franziska"],["dc.contributor.author","Forkel, Susann"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T10:10:40Z"],["dc.date.available","2018-11-07T10:10:40Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1111/ddg.13090"],["dc.identifier.isi","000385272200015"],["dc.identifier.pmid","27509434"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39900"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Percutaneous ultrasound-guided drainage of needle aspiration-refractory seromas following lymph node excision"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]