Zappel, Hildegard Franziska

[["dc.bibliographiccitation.firstpage","945"],["dc.bibliographiccitation.journal","Journal of Pediatric Endocrinology and Metabolism"],["dc.bibliographiccitation.lastpage","948"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Roth, C."],["dc.contributor.author","Freiberg, Clemens"],["dc.contributor.author","Zappel, H."],["dc.contributor.author","Albers, N."],["dc.date.accessioned","2018-11-07T10:22:35Z"],["dc.date.available","2018-11-07T10:22:35Z"],["dc.date.issued","2002"],["dc.description.abstract","Testolactone is used to treat conditions with excessive estrogen synthesis, e.g. gonadotropin-independent precocious puberty in McCune-Albright syndrome (MAS). Unfortunately, daily treatment with testolactone requires 3 to 4 doses (10-20 tablets) and even at these doses it is sometimes ineffective. We treated a patient with MAS (cafe-au-lait spots; thelarche at age 2-(6)/(12) yr; menarche at 5-(5)/(12) yr; accelerated bone age [BA 10 yr]) with the highly selective aromatase inhibitor anastrozolle (1 mg once per day). Tamoxifen 1 mg/kg per day was added for 1 year but was discontinued when an ovarian cyst developed with markedly elevated estradiol levels. Estradiol levels returned to normal after resuming anastrozole-only treatment and accelerated BA progressed only 6 months during 21/2 years of treatment. The potent estrogen suppressive action and simple dosage regimen of anastrozole suggest it may be advantageous compared to other aromatase inhibitors such as testolactone or anti-estrogens."],["dc.identifier.isi","000177550800012"],["dc.identifier.pmid","12199354"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42304"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Freund Publishing House Ltd"],["dc.publisher.place","London"],["dc.relation.conference","Meeting on McCune-Albright Syndrome - New Insights"],["dc.relation.eventlocation","TURIN, ITALY"],["dc.relation.issn","0334-018X"],["dc.title","Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","321"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","DMW - Deutsche Medizinische Wochenschrift"],["dc.bibliographiccitation.lastpage","325"],["dc.bibliographiccitation.volume","126"],["dc.contributor.author","Roth, C."],["dc.contributor.author","Meller, J."],["dc.contributor.author","Bobrzik, S."],["dc.contributor.author","Thal, H."],["dc.contributor.author","Becker, W."],["dc.contributor.author","Kulenkampff, D."],["dc.contributor.author","Lakomek, Max"],["dc.contributor.author","Zappel, H."],["dc.date.accessioned","2018-11-07T09:16:06Z"],["dc.date.available","2018-11-07T09:16:06Z"],["dc.date.issued","2001"],["dc.description.abstract","Background: Since 1989 the use of iodized salt has been allowed in Germany, additional supplementation with iodide tablets has been recommended during pregnancy and lactation. This study was undertaken to clarify whether the iodine intake of neonates and young infants improved since then. Patients and methods: In the first part of the study the urinary iodine excretion of 52 newborns and their mothers in 1998 was compared to data of similar studies 1983 in the area of Gottingen and 1982 in the areas of Heidelberg and Rothenburg, Germany. All these are geographically low-iodine areas. In the second part the iodine supply of infants in 1998-1999 under feeding with mother's milk or formulas in 1998 and 1999 was obtained by measuring iodide concentrations in urine and milk using a high pressure liquid chromatography (HPLC) method. Results: 45% of pregnant women were without iodide supplementation in 1998. In 1998 the median urinary iodide concentration during the first week of life was 4,3 mug/dl, which was more than twice that found in 1983 (1,75 mug/dl). Infants feeded by mother's milk without maternal iodine supplentation or by semi-elementary diet had the lowest urinary iodine excretion, whereas significantly higher values were measured when feeding formulas for term or preterm infants. Conclusions: The iodine intake of newborns has markedly improved during 15 years. The WHO criterias for adequate iodine supply (TSH < 5 U/ml and urinary iodine >/ = 1 mug/dl) were only partly fulfilled in Gottingen indicating that a mild iodine deficiency still exists with the risk of iodine deficiency disorders."],["dc.identifier.doi","10.1055/s-2001-12099"],["dc.identifier.isi","000167664400001"],["dc.identifier.pmid","11305199"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27861"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0012-0472"],["dc.title","Iodine supply in newborns and infants - a comparative study of iodine intake and iodine excretion of children and their mothers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]