Barrantes-Freer, Alonso

[["dc.bibliographiccitation.firstpage","112958"],["dc.bibliographiccitation.journal","Experimental Neurology"],["dc.bibliographiccitation.volume","320"],["dc.contributor.author","Huppke, Peter"],["dc.contributor.author","Wegener, Eike"],["dc.contributor.author","Gilley, Jonathan"],["dc.contributor.author","Angeletti, Carlo"],["dc.contributor.author","Kurth, Ingo"],["dc.contributor.author","Drenth, Joost P.H."],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Thiele, Holger"],["dc.contributor.author","Nürnberg, Peter"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Orsomando, Giuseppe"],["dc.contributor.author","Coleman, Michael P."],["dc.date.accessioned","2020-12-10T14:24:01Z"],["dc.date.available","2020-12-10T14:24:01Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.expneurol.2019.112958"],["dc.identifier.issn","0014-4886"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72107"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","848"],["dc.bibliographiccitation.journal","Multiple Sclerosis Journal"],["dc.bibliographiccitation.lastpage","849"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Bahn, Erik"],["dc.contributor.author","Paap, Franziska"],["dc.contributor.author","Mueller, F."],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Nessler, S."],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2018-11-07T10:08:50Z"],["dc.date.available","2018-11-07T10:08:50Z"],["dc.date.issued","2016"],["dc.identifier.isi","000383267203281"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39546"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.publisher.place","London"],["dc.relation.eventlocation","London, ENGLAND"],["dc.relation.issn","1477-0970"],["dc.relation.issn","1352-4585"],["dc.title","Histopathological characteristics of cavitary multiple sclerosis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1381"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Physiological Reviews"],["dc.bibliographiccitation.lastpage","1431"],["dc.bibliographiccitation.volume","99"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Timmler, Sebastian"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Simons, Mikael"],["dc.date.accessioned","2020-12-10T18:37:40Z"],["dc.date.available","2020-12-10T18:37:40Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1152/physrev.00031.2018"],["dc.identifier.eissn","1522-1210"],["dc.identifier.issn","0031-9333"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16423"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77059"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Myelin in the Central Nervous System: Structure, Function, and Pathology"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","85"],["dc.bibliographiccitation.journal","Neuroscience & Biobehavioral Reviews"],["dc.bibliographiccitation.lastpage","98"],["dc.bibliographiccitation.volume","89"],["dc.contributor.author","Parmar, Katrin"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Rocca, Maria A."],["dc.contributor.author","Langdon, Dawn"],["dc.contributor.author","D'Angelo, Egidio"],["dc.contributor.author","D’Souza, Marcus"],["dc.contributor.author","Burggraaff, Jessica"],["dc.contributor.author","Wegner, Christiane"],["dc.contributor.author","Sastre-Garriga, Jaume"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Dorn, Jonas"],["dc.contributor.author","Uitdehaag, Bernard M.J."],["dc.contributor.author","Montalban, Xavier"],["dc.contributor.author","Wuerfel, Jens"],["dc.contributor.author","Enzinger, Christian"],["dc.contributor.author","Rovira, Alex"],["dc.contributor.author","Tintore, Mar"],["dc.contributor.author","Filippi, Massimo"],["dc.contributor.author","Kappos, Ludwig"],["dc.contributor.author","Sprenger, Till"],["dc.date.accessioned","2020-12-10T15:20:25Z"],["dc.date.available","2020-12-10T15:20:25Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.neubiorev.2018.02.012"],["dc.identifier.issn","0149-7634"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72663"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The role of the cerebellum in multiple sclerosis—150 years after Charcot"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","737"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Brain Pathology"],["dc.bibliographiccitation.lastpage","747"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Albert, Monika"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Lohrberg, Melanie"],["dc.contributor.author","Antel, Jack P."],["dc.contributor.author","Prineas, John W."],["dc.contributor.author","Palkovits, Miklós"],["dc.contributor.author","Wolff, Joachim R."],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2022-03-01T11:47:07Z"],["dc.date.available","2022-03-01T11:47:07Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1111/bpa.12450"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103917"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","1015-6305"],["dc.title","Synaptic pathology in the cerebellar dentate nucleus in chronic multiple sclerosis"],["dc.title.alternative","Synaptic pathology in the cerebellar dentate nucleus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Acta Neuropathologica Communications"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Christians, Arne"],["dc.contributor.author","Adel-Horowski, Antonia"],["dc.contributor.author","Banan, Rouzbeh"],["dc.contributor.author","Lehmann, Ulrich"],["dc.contributor.author","Bartels, Stephan"],["dc.contributor.author","Behling, Felix"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Stockhammer, Florian"],["dc.contributor.author","Hartmann, Christian"],["dc.date.accessioned","2020-12-10T18:41:23Z"],["dc.date.available","2020-12-10T18:41:23Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1186/s40478-019-0817-0"],["dc.identifier.eissn","2051-5960"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16626"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77568"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The prognostic role of IDH mutations in homogeneously treated patients with anaplastic astrocytomas and glioblastomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","307"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Neuropathology and Experimental Neurology"],["dc.bibliographiccitation.lastpage","324"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Kim, Ella L."],["dc.contributor.author","Bielanska, Joanna"],["dc.contributor.author","Giese, Alf"],["dc.contributor.author","Mortensen, Lena Suenke"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Pardo, Luis A."],["dc.date.accessioned","2018-11-07T09:26:43Z"],["dc.date.available","2018-11-07T09:26:43Z"],["dc.date.issued","2013"],["dc.description.abstract","Glioma-initiating cells (GICs) represent a potential important therapeutic target because they are likely to account for the frequent recurrence of malignant gliomas; however, their identity remains unsolved. Here, we characterized the cellular lineage fingerprint of GICs through a combination of electrophysiology, lineage marker expression, and differentiation assays of 5 human patient-derived primary GIC lines. Most GICs coexpressed nestin, NG2 proteoglycan, platelet-derived growth factor receptor-alpha, and glial fibrillary acidic protein. Glioma-initiating cells could be partially differentiated into astrocytic but not oligodendroglial or neural lineages. We also demonstrate that GICs have a characteristic electrophysiologic profile distinct from that of well-characterized tumor bulk cells. Together, our results suggest that GICs represent a unique type of cells reminiscent of an immature phenotype that closely resembles but is not identical to NG2 glia with respect to marker expression and functional membrane properties."],["dc.identifier.doi","10.1097/NEN.0b013e31828afdbd"],["dc.identifier.isi","000316944200004"],["dc.identifier.pmid","23481707"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30362"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0022-3069"],["dc.title","Human Glioma-Initiating Cells Show a Distinct Immature Phenotype Resembling but Not Identical to NG2 Glia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","95"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Journal of Neuroimmunology"],["dc.bibliographiccitation.volume","275"],["dc.contributor.author","Barrantes-freer, Alonso"],["dc.contributor.author","Mortensen, Lena Sünke"],["dc.contributor.author","Lohrberg, Melanie"],["dc.contributor.author","Götz, Alexander"],["dc.contributor.author","Hanisch, Uwe-karsten"],["dc.contributor.author","Pardo, Luis A."],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Stadelmann-Nessler, Christine"],["dc.date.accessioned","2022-03-01T11:45:14Z"],["dc.date.available","2022-03-01T11:45:14Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1016/j.jneuroim.2014.08.255"],["dc.identifier.pii","S0165572814004883"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103259"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0165-5728"],["dc.title","MyD88 signaling mediates the effects of the innate immune response in cerebellar short-term synaptic plasticity"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","404"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Clinical & Experimental Immunology"],["dc.bibliographiccitation.lastpage","411"],["dc.bibliographiccitation.volume","177"],["dc.contributor.author","Waschbisch, Anne"],["dc.contributor.author","Sammet, Laura"],["dc.contributor.author","Schroeder, S."],["dc.contributor.author","Lee, D.-H."],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Linker, Ralf Andreas"],["dc.date.accessioned","2018-11-07T09:37:13Z"],["dc.date.available","2018-11-07T09:37:13Z"],["dc.date.issued","2014"],["dc.description.abstract","T cells with a CD4(+) CD8(+) double-positive (DP) phenotype are present in small numbers in the peripheral blood of healthy humans and may have anti-viral capacities. Here we investigate numbers and function of DP T cells in patients with relapsing-remitting multiple sclerosis (MS), either treatment-naive or under therapy with natalizumab. Flow cytometry analysis revealed that frequencies of circulating DP T cells in treatment-naive and natalizumab-treated MS patients are comparable to healthy controls. These cells have a memory phenotype with cytotoxic potential, express high levels of CD49d and are similarly functional in treatment-naive as well as natalizumab-treated MS patients. DP T cells were enriched in the cerebrospinal fluid, but do not invade acutely inflamed MS lesions. In conclusion, DP T cells are functional in MS and may play a role in the immune surveillance of the central nervous system, but do not display functional impairment under natalizumab therapy."],["dc.description.sponsorship","Biogen Idec GmbH; Else Kroner-Fresenius Stiftung [2011_A123]"],["dc.identifier.doi","10.1111/cei.12345"],["dc.identifier.isi","000339480700004"],["dc.identifier.pmid","24730443"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32788"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2249"],["dc.relation.issn","0009-9104"],["dc.title","Analysis of CD4(+)CD8(+) double-positive T cells in blood, cerebrospinal fluid and multiple sclerosis lesions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","55"],["dc.bibliographiccitation.journal","Diagnostic Pathology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Behling, Felix"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Skardelly, Marco"],["dc.contributor.author","Nieser, Maike"],["dc.contributor.author","Christians, Arne"],["dc.contributor.author","Stockhammer, Florian"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Tatagiba, Marcos"],["dc.contributor.author","Hartmann, Christian"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Schittenhelm, Jens"],["dc.date.accessioned","2018-11-07T10:12:37Z"],["dc.date.available","2018-11-07T10:12:37Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Treatment options for oncological diseases have been enhanced by the advent of targeted therapies. The point mutation of the BRAF gene at codon 600 (BRAF V600E) is found in several tumor entities and can be approached with selective inhibitory antibodies. The BRAF inhibitor vemurafenib has demonstrated clinical efficacy in patients with BRAF V600E-mutant melanoma brain metastases and in other cancer diseases. Therefore the BRAF V600E mutation is a highly interesting oncological target in brain tumors. Methods: This study assesses the BRAF V600E mutation status in 969 intracranial neoplasms using a tissue microarray method and immunohistochemical staining with the mutation-specific VE-1 antibody, followed by sequencing of positively stained cases. Results: Out of 784 primary brain tumors seven cases with a BRAF V600E mutation were detected (7/784, 1 %). Six of these cases were neuroepithelial tumors (6/667, 1 %) encompassing 2 astrocytomas WHO grade II (2/42, 5 %), 1 gliosarcoma WHO grade IV (1/75, 1 %) and 3 glioblastomas WHO grade IV (3/312, 1 %). Interestingly, all three mutant glioblastomas showed epithelioid histopathological features. Patients with V600E mutated astrocytic tumors were significantly younger (mean age 15.3 years) than wildtype cases (58.2 years). Among three rhabdoid meningiomas, one case was mutated (1/3) while all other grade I-III meningiomas (1/116, 1 %) and all fifty vestibular schwannomas analyzed were of wildtype status. The vast majority of the BRAF V600E mutations were found in cerebral metastases of malignant melanomas and carcinomas (29/135, 22 %), with false-positive staining found in four breast cancer cases and two non-small-cell lung carcinoma (NSCLC) samples. Conclusions: Our data suggest routine screening for BRAF V600E mutations for glioblastomas WHO grade IV below the age of 30, especially in glioblastomas with epithelioid features and in all rhabdoid meningiomas WHO grade III. For colorectal carcinoma, thyroid cancer, malignant melanoma and gliomas BRAF V600E immunostaining is sufficient for screening purposes. We also recommend routine immunohistochemical staining followed by sequencing validation in rare CNS metastases or metastases of unknown primary. Immunohistochemical analysis using mutation-specific antibodies on tissue microarrays is a feasible, time-and cost-efficient approach to high-throughput screening for specific mutations in large tumor series but sequencing validation is necessary in unexpected cases."],["dc.identifier.doi","10.1186/s13000-016-0506-2"],["dc.identifier.isi","000379298900001"],["dc.identifier.pmid","27350555"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13365"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40275"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1746-1596"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Frequency of BRAF V600E mutations in 969 central nervous system neoplasms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]