Barrantes-Freer, Alonso

[["dc.bibliographiccitation.firstpage","112958"],["dc.bibliographiccitation.journal","Experimental Neurology"],["dc.bibliographiccitation.volume","320"],["dc.contributor.author","Huppke, Peter"],["dc.contributor.author","Wegener, Eike"],["dc.contributor.author","Gilley, Jonathan"],["dc.contributor.author","Angeletti, Carlo"],["dc.contributor.author","Kurth, Ingo"],["dc.contributor.author","Drenth, Joost P.H."],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Thiele, Holger"],["dc.contributor.author","Nürnberg, Peter"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Orsomando, Giuseppe"],["dc.contributor.author","Coleman, Michael P."],["dc.date.accessioned","2020-12-10T14:24:01Z"],["dc.date.available","2020-12-10T14:24:01Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.expneurol.2019.112958"],["dc.identifier.issn","0014-4886"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72107"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4359"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Cancer Research"],["dc.bibliographiccitation.lastpage","4371"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Schwartz, H."],["dc.contributor.author","Blacher, E."],["dc.contributor.author","Amer, M."],["dc.contributor.author","Livneh, N."],["dc.contributor.author","Abramovitz, L."],["dc.contributor.author","Klein, A."],["dc.contributor.author","Ben-Shushan, D."],["dc.contributor.author","Soffer, S."],["dc.contributor.author","Blazquez, R."],["dc.contributor.author","Barrantes-Freer, A."],["dc.contributor.author","Mu ller, M."],["dc.contributor.author","Mu ller-Decker, K."],["dc.contributor.author","Stein, R."],["dc.contributor.author","Tsarfaty, G."],["dc.contributor.author","Satchi-Fainaro, R."],["dc.contributor.author","Umansky, V."],["dc.contributor.author","Pukrop, T."],["dc.contributor.author","Erez, N."],["dc.date.accessioned","2020-12-10T18:37:43Z"],["dc.date.available","2020-12-10T18:37:43Z"],["dc.date.issued","2016"],["dc.description.abstract","Malignant melanoma is the deadliest of skin cancers. Melanoma frequently metastasizes to the brain, resulting in dismal survival. Nevertheless, mechanisms that govern early metastatic growth and the interactions of disseminated metastatic cells with the brain microenvironment are largely unknown. To study the hallmarks of brain metastatic niche formation, we established a transplantable model of spontaneous melanoma brain metastasis in immunocompetent mice and developed molecular tools for quantitative detection of brain micrometastases. Here we demonstrate that micrometastases are associated with instigation of astrogliosis, neuroinflammation, and hyperpermeability of the blood-brain barrier. Furthermore, we show a functional role for astrocytes in facilitating initial growth of melanoma cells. Our findings suggest that astrogliosis, physiologically instigated as a brain tissue damage response, is hijacked by tumor cells to support metastatic growth. Studying spontaneous melanoma brain metastasis in a clinically relevant setting is the key to developing therapeutic approaches that may prevent brain metastatic relapse. (C) 2016 AACR."],["dc.identifier.doi","10.1158/0008-5472.CAN-16-0485"],["dc.identifier.eissn","1538-7445"],["dc.identifier.isi","000382295300008"],["dc.identifier.issn","0008-5472"],["dc.identifier.pmid","27261506"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77077"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Cancer Research"],["dc.relation.issn","1538-7445"],["dc.relation.issn","0008-5472"],["dc.title","Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Journal of Neurosurgery"],["dc.bibliographiccitation.lastpage","6"],["dc.contributor.author","Bettag, Christoph"],["dc.contributor.author","Hussein, Abdelhalim"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Abboud, Tammam"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.date.accessioned","2022-06-01T09:39:47Z"],["dc.date.available","2022-06-01T09:39:47Z"],["dc.date.issued","2022"],["dc.description.abstract","OBJECTIVE Fluorescence-guided resection of cerebral metastases has been proposed as an approach to visualize residual tumor tissue and maximize the extent of resection. Critics have argued that tumor cells at the resection margins might be overlooked under microscopic visualization because of technical limitations. Therefore, an endoscope, which is capable of inducing fluorescence, has been applied with the aim of improving exposure of fluorescent tumor tissue. In this retrospective analysis, authors assessed the utility of endoscope assistance in 5-aminolevulinic acid (5-ALA) fluorescence–guided resection of brain metastases. METHODS Between June 2013 and December 2016, a standard 20-mg/kg dose of 5-ALA was administered 4 hours prior to surgery in 26 patients with suspected single brain metastases. After standard neuronavigated microsurgical tumor resection, a microscope capable of inducing fluorescence was used to examine tumor margins. The authors classified the remaining fluorescence into 3 grades (0 = none, 1 = weak, and 2 = strong). Endoscopic assistance was employed if no or only weak fluorescence was visualized at the resection margins under the microscope. Endoscopically identified fluorescent tissue at the margins was resected and evaluated separately via histological examination to prove or disprove tumor infiltration. RESULTS Under the microscope, weakly fluorescent tissue was seen at the margins of the resection cavity in 15/26 (57.7%) patients. In contrast, endoscopic inspection revealed strongly fluorescent tissue in 22/26 (84.6%) metastases. In 11/26 (42.3%) metastases no fluorescence at the tumor margins was detected by the microscope; however, strong fluorescence was visualized under the endoscope in 7 (63.6%) of these 11 metastases. In the 15 metastases with microscopically weak fluorescence, strong fluorescence was seen when using the endoscope. Neither microscopic nor endoscopic fluorescence was found in 4/26 (15.4%) cases. In the 26 patients, 96 histological specimens were obtained from the margins of the resection cavity. Findings from these specimens were in conjunction with the histopathological findings, allowing identification of metastatic infiltration with a sensitivity of 95.5% and a specificity of 75% using endoscope assistance. CONCLUSIONS Fluorescence-guided endoscope assistance may overcome the technical limitations of the conventional microscopic exposure of 5-ALA–fluorescent metastases and thereby increase visualization of fluorescent tumor tissue at the margins of the resection cavity with high sensitivity and acceptable specificity."],["dc.identifier.doi","10.3171/2022.3.JNS212301"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108564"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","1933-0693"],["dc.relation.issn","0022-3085"],["dc.title","Endoscope-assisted visualization of 5-aminolevulinic acid fluorescence in surgery for brain metastases"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1321"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","1324"],["dc.bibliographiccitation.volume","159"],["dc.contributor.author","Hernandez-Duran, S."],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","von der Brelie, Christian"],["dc.date.accessioned","2018-11-07T10:22:12Z"],["dc.date.available","2018-11-07T10:22:12Z"],["dc.date.issued","2017"],["dc.description.abstract","Posterior reversible encephalopathy syndrome (PRES) is thought to result from endothelial dysfunction and breakdown of the blood-brain barrier with subsequent vasogenic edema. Abrupt hypertension has been identified as one of its risk factors. We present a rare case of PRES in the anterior circulation with sudden onset of left hemiparesis and rapid neurological deterioration on the basis of hypertensive crisis. Due to refractory intracranial hypertension, the patient required emergent right decompressive craniectomy. Further investigations, including a biopsy, revealed an atypical form of PRES. This case illustrates the importance of aggressive medical and early surgical management to prevent permanent neurological deficits."],["dc.identifier.doi","10.1007/s00701-017-3197-x"],["dc.identifier.isi","000403508400022"],["dc.identifier.pmid","28516363"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42234"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0942-0940"],["dc.relation.issn","0001-6268"],["dc.title","Posterior reversible encephalopathy syndrome presenting in the anterior circulation with malignant intracranial hypertension requiring surgical decompression: a case report and literature review"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","848"],["dc.bibliographiccitation.journal","Multiple Sclerosis Journal"],["dc.bibliographiccitation.lastpage","849"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Bahn, Erik"],["dc.contributor.author","Paap, Franziska"],["dc.contributor.author","Mueller, F."],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Nessler, S."],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2018-11-07T10:08:50Z"],["dc.date.available","2018-11-07T10:08:50Z"],["dc.date.issued","2016"],["dc.identifier.isi","000383267203281"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39546"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Sage Publications Ltd"],["dc.publisher.place","London"],["dc.relation.eventlocation","London, ENGLAND"],["dc.relation.issn","1477-0970"],["dc.relation.issn","1352-4585"],["dc.title","Histopathological characteristics of cavitary multiple sclerosis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","85"],["dc.bibliographiccitation.journal","Neuroscience & Biobehavioral Reviews"],["dc.bibliographiccitation.lastpage","98"],["dc.bibliographiccitation.volume","89"],["dc.contributor.author","Parmar, Katrin"],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Rocca, Maria A."],["dc.contributor.author","Langdon, Dawn"],["dc.contributor.author","D'Angelo, Egidio"],["dc.contributor.author","D’Souza, Marcus"],["dc.contributor.author","Burggraaff, Jessica"],["dc.contributor.author","Wegner, Christiane"],["dc.contributor.author","Sastre-Garriga, Jaume"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Dorn, Jonas"],["dc.contributor.author","Uitdehaag, Bernard M.J."],["dc.contributor.author","Montalban, Xavier"],["dc.contributor.author","Wuerfel, Jens"],["dc.contributor.author","Enzinger, Christian"],["dc.contributor.author","Rovira, Alex"],["dc.contributor.author","Tintore, Mar"],["dc.contributor.author","Filippi, Massimo"],["dc.contributor.author","Kappos, Ludwig"],["dc.contributor.author","Sprenger, Till"],["dc.date.accessioned","2020-12-10T15:20:25Z"],["dc.date.available","2020-12-10T15:20:25Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.neubiorev.2018.02.012"],["dc.identifier.issn","0149-7634"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72663"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","The role of the cerebellum in multiple sclerosis—150 years after Charcot"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1037"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","1045"],["dc.bibliographiccitation.volume","161"],["dc.contributor.author","Fiss, Ingo"],["dc.contributor.author","Hussein, Abdelhalim"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Sperling, Swetlana"],["dc.contributor.author","Hernandez-Duran, Silvia"],["dc.contributor.author","Wolfert, Christina"],["dc.contributor.author","Pukrop, Tobias"],["dc.contributor.author","Ninkovic, Milena"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.date.accessioned","2020-12-10T14:10:53Z"],["dc.date.available","2020-12-10T14:10:53Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00701-019-03842-3"],["dc.identifier.eissn","0942-0940"],["dc.identifier.issn","0001-6268"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70910"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Cerebral metastases: do size, peritumoral edema, or multiplicity predict infiltration into brain parenchyma?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","737"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Brain Pathology"],["dc.bibliographiccitation.lastpage","747"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Albert, Monika"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Lohrberg, Melanie"],["dc.contributor.author","Antel, Jack P."],["dc.contributor.author","Prineas, John W."],["dc.contributor.author","Palkovits, Miklós"],["dc.contributor.author","Wolff, Joachim R."],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Stadelmann, Christine"],["dc.date.accessioned","2022-03-01T11:47:07Z"],["dc.date.available","2022-03-01T11:47:07Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1111/bpa.12450"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103917"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","1015-6305"],["dc.title","Synaptic pathology in the cerebellar dentate nucleus in chronic multiple sclerosis"],["dc.title.alternative","Synaptic pathology in the cerebellar dentate nucleus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1173"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Arthritis Care & Research"],["dc.bibliographiccitation.lastpage","1179"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Korsten, Peter"],["dc.contributor.author","Konig, Maximilian F."],["dc.contributor.author","Mueller, Georg Anton"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Sweiss, Nadera J."],["dc.contributor.author","Vasko, Radovan"],["dc.date.accessioned","2018-11-07T10:10:47Z"],["dc.date.available","2018-11-07T10:10:47Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1002/acr.22781"],["dc.identifier.isi","000383501900015"],["dc.identifier.pmid","26555558"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39927"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","2151-4658"],["dc.relation.issn","2151-464X"],["dc.title","Respiratory Distress and Nephropathy in a Young Male With Small-Joint Polyarthritis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","307"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Neuropathology and Experimental Neurology"],["dc.bibliographiccitation.lastpage","324"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Barrantes-Freer, Alonso"],["dc.contributor.author","Kim, Ella L."],["dc.contributor.author","Bielanska, Joanna"],["dc.contributor.author","Giese, Alf"],["dc.contributor.author","Mortensen, Lena Suenke"],["dc.contributor.author","Schulz-Schaeffer, Walter J."],["dc.contributor.author","Stadelmann, Christine"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Pardo, Luis A."],["dc.date.accessioned","2018-11-07T09:26:43Z"],["dc.date.available","2018-11-07T09:26:43Z"],["dc.date.issued","2013"],["dc.description.abstract","Glioma-initiating cells (GICs) represent a potential important therapeutic target because they are likely to account for the frequent recurrence of malignant gliomas; however, their identity remains unsolved. Here, we characterized the cellular lineage fingerprint of GICs through a combination of electrophysiology, lineage marker expression, and differentiation assays of 5 human patient-derived primary GIC lines. Most GICs coexpressed nestin, NG2 proteoglycan, platelet-derived growth factor receptor-alpha, and glial fibrillary acidic protein. Glioma-initiating cells could be partially differentiated into astrocytic but not oligodendroglial or neural lineages. We also demonstrate that GICs have a characteristic electrophysiologic profile distinct from that of well-characterized tumor bulk cells. Together, our results suggest that GICs represent a unique type of cells reminiscent of an immature phenotype that closely resembles but is not identical to NG2 glia with respect to marker expression and functional membrane properties."],["dc.identifier.doi","10.1097/NEN.0b013e31828afdbd"],["dc.identifier.isi","000316944200004"],["dc.identifier.pmid","23481707"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30362"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0022-3069"],["dc.title","Human Glioma-Initiating Cells Show a Distinct Immature Phenotype Resembling but Not Identical to NG2 Glia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]