König, Sarah

[["dc.bibliographiccitation.firstpage","723"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Histochemistry and Cell Biology"],["dc.bibliographiccitation.lastpage","734"],["dc.bibliographiccitation.volume","126"],["dc.contributor.author","Koenig, Sarah"],["dc.contributor.author","Probst, Irmelin"],["dc.contributor.author","Becker, Heinz"],["dc.contributor.author","Krause, Petra"],["dc.date.accessioned","2018-11-07T08:53:50Z"],["dc.date.available","2018-11-07T08:53:50Z"],["dc.date.issued","2006"],["dc.description.abstract","Oval cells constitute a heterogeneous population of proliferating progenitors found in rat livers following carcinogenic treatment (2-acetylaminofluorene and 70% hepatectomy). The aim of this study was to investigate the cellular pattern of various differentiation and cell type markers in this model of liver regeneration. Immunophenotypic characterisation revealed at least two subtypes emerging from the portal field. First, a population of oval cells formed duct-like structures and expressed bile duct (CD49f) as well as hepatocytic markers (alpha-foetoprotein, CD26). Second, a population of non-ductular oval cells was detected between and distally from the ductules expressing the neural marker nestin and the haematopoietic marker Thy1. Following oval cell isolation, a subset of the nestin-positive cells was shown to co-express hepatocytic and epithelial markers (albumin, CD26, pancytokeratin) and could be clearly distinguished from anti-desmin reactive hepatic stellate cells. The gene expression profiles (RT-PCR) of isolated oval cells and oval cell liver tissue were found to be similar to foetal liver (ED14). The present results suggest that the two oval cell populations are organised in a zonal hierarchy with a marker gradient from the inner (displaying hepatocytic and biliary markers) to the outer zone (showing hepatocytic and extrahepatic progenitor markers) of the proliferating progeny clusters."],["dc.identifier.doi","10.1007/s00418-006-0204-3"],["dc.identifier.isi","242624400009"],["dc.identifier.pmid","16835754"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22524"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0948-6143"],["dc.title","Zonal hierarchy of differentiation markers and nestin expression during oval cell mediated rat liver regeneration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","29"],["dc.bibliographiccitation.lastpage","39"],["dc.bibliographiccitation.seriesnr","1213"],["dc.contributor.author","Krause, Petra"],["dc.contributor.author","Rave-Frank, Margret"],["dc.contributor.author","Christiansen, Hans"],["dc.contributor.author","Koenig, Sarah"],["dc.contributor.editor","Christ, Bruno"],["dc.contributor.editor","Oerlecke, Jana"],["dc.contributor.editor","Stock, Peggy"],["dc.date.accessioned","2021-06-02T10:44:23Z"],["dc.date.available","2021-06-02T10:44:23Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1007/978-1-4939-1453-1_3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87018"],["dc.notes.intern","DOI-Import GROB-425"],["dc.publisher","Springer New York"],["dc.publisher.place","New York, NY"],["dc.relation.crisseries","Methods in Molecular Biology"],["dc.relation.eisbn","978-1-4939-1453-1"],["dc.relation.isbn","978-1-4939-1452-4"],["dc.relation.ispartof","Methods in Molecular Biology"],["dc.relation.ispartof","Animal Models for Stem Cell Therapy"],["dc.relation.ispartofseries","Methods in Molecular Biology; 1213"],["dc.title","Preconditioning of the Liver for Efficient Repopulation by Primary Hepatocyte Transplants"],["dc.type","book_chapter"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","711"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Surgical Education"],["dc.bibliographiccitation.lastpage","719"],["dc.bibliographiccitation.volume","76"],["dc.contributor.author","Backhaus, Joy"],["dc.contributor.author","Huth, Katrin"],["dc.contributor.author","Entwistle, Andrew"],["dc.contributor.author","Homayounfar, Kia"],["dc.contributor.author","Koenig, Sarah"],["dc.date.accessioned","2020-12-10T14:25:27Z"],["dc.date.available","2020-12-10T14:25:27Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.jsurg.2018.12.001"],["dc.identifier.issn","1931-7204"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72557"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Digital Affinity in Medical Students Influences Learning Outcome: A Cluster Analytical Design Comparing Vodcast With Traditional Lecture"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","876"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","International Journal of Radiation Biology"],["dc.bibliographiccitation.lastpage","883"],["dc.bibliographiccitation.volume","90"],["dc.contributor.author","Serra, Maria Paola"],["dc.contributor.author","Marongiu, Fabio"],["dc.contributor.author","Sini, Marcella"],["dc.contributor.author","Marongiu, Michela"],["dc.contributor.author","Contini, Antonella"],["dc.contributor.author","Wolff, Hendrik"],["dc.contributor.author","Rave-Frank, Margret"],["dc.contributor.author","Krause, Petra"],["dc.contributor.author","Laconi, Ezio"],["dc.contributor.author","Koenig, Sarah"],["dc.date.accessioned","2018-11-07T09:34:32Z"],["dc.date.available","2018-11-07T09:34:32Z"],["dc.date.issued","2014"],["dc.description.abstract","Purpose: Exposure to radiation primes the liver for extensive replacement of the resident parenchymal cells by transplanted hepatocytes. The mechanisms underlying this repopulation remain to be clarified. In these studies, we examined the possible occurrence of cell senescence in vivo following radiationassociated preconditioning of the host liver. Materials and methods: Fischer 344 rats underwent externalbeam, computed-tomography-based partial liver irradiation. A single dose of 25 Gy was delivered to the right liver lobes (40% of liver mass). An additional group of animals received a 1/3 partial hepatectomy (removal of the left anterior lobe) four days after irradiation. Non-irradiated groups served as controls. All rats were sacrificed four weeks after the initial treatment. Results: The irradiated livers displayed several markers of cell senescence, including expression of senescence-associatedp-galactosidase (SA-I3-gal), increase in cell size, and up-regulation of cyclin-dependent kinase inhibitors (CDK-I) p16 and p21. Furthermore, quantitative reverse-transcriptase polyrnerase chain reaction (qRT-PCR) analysis revealed activation of the senescence-associated secretory phenotype (SAW), including the cytokines interleukin 6 (IL6) and le (ILla). The senescencerelated changes were more prominent in rats undergoing partial hepatectomy (PH) following irradiation (IR). Conclusions: We conclude that priming with radiation for liver repopulation results in the induction of cell senescence and the up-regulation of a senescence-associated secretory phenotype. The latter can contribute to the extensive growth of transplanted cells in this system."],["dc.identifier.doi","10.3109/09553002.2014.922714"],["dc.identifier.isi","000343001200006"],["dc.identifier.pmid","24827852"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32189"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Informa Healthcare"],["dc.relation.issn","1362-3095"],["dc.relation.issn","0955-3002"],["dc.title","Hepatocyte senescence induced by radiation and partial hepatectomy in rat liver"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","532-535"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Zentralblatt für Chirurgie"],["dc.bibliographiccitation.lastpage","535"],["dc.bibliographiccitation.volume","144"],["dc.contributor.author","Adili, Farzin"],["dc.contributor.author","Dahmen, Uta"],["dc.contributor.author","Heinemann, Markus K"],["dc.contributor.author","Kadmon, Martina"],["dc.contributor.author","Kauffels-Sprenger, Anne"],["dc.contributor.author","König, Sarah"],["dc.contributor.author","Meder, Adrian"],["dc.contributor.author","Obertacke, Udo"],["dc.contributor.author","Schwanitz von Keitz, Paul"],["dc.contributor.author","Stefanescu, Christina"],["dc.contributor.author","Sterz, Jasmina"],["dc.contributor.author","Rüsseler, Miriam"],["dc.date.accessioned","2020-04-02T14:59:09Z"],["dc.date.available","2020-04-02T14:59:09Z"],["dc.date.issued","2019-12"],["dc.description.abstract","The \"Masterplan Medizinstudium 2020\" from the German Federal Government should not be underestimated as only one among many announcement. Thus, the Surgical Working Group on Medical Education (CAL) of the German Association of Surgeons (DGCH) comments on the intended measures of the \"Masterplan Medizinstudium 2020\" and discusses the challenges, consequences and duties arising from the \"Masterplan Medizinstudium 2020\" for the representatives of the surgical societies and those engaged in surgical undergraduate training."],["dc.identifier.doi","10.1055/a-0869-8081"],["dc.identifier.pmid","31067573"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63568"],["dc.language.iso","other"],["dc.relation.eissn","1438-9592"],["dc.relation.issn","0044-409X"],["dc.relation.issn","1438-9592"],["dc.title","Position Paper of the Surgical Working Group for Teaching of the German Society of Surgery Regarding the \"Master Plan 2020\""],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","285"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","International Journal of Radiation Biology"],["dc.bibliographiccitation.lastpage","298"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Koenig, Sarah"],["dc.contributor.author","Krause, Petra"],["dc.contributor.author","Schmidt, Thordis-Karen"],["dc.contributor.author","Rave-Fraenk, Margret"],["dc.contributor.author","Rothe, Hilka"],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Becker, Heinz"],["dc.contributor.author","Hess, Clemens Friedrich"],["dc.contributor.author","Christiansen, Hans"],["dc.date.accessioned","2018-11-07T11:20:07Z"],["dc.date.available","2018-11-07T11:20:07Z"],["dc.date.issued","2008"],["dc.description.abstract","Purpose: Hepatocyte transplantation following liver irradiation (IR) and partial hepatectomy (PH) leads to extensive liver repopulation. We investigated the changes in the liver induced by IR explaining the loss of reproductive integrity in endogenous hepatocytes. Materials and methods: Right lobules of rat liver underwent external beam IR (25 Gy). A second group was subjected to additional 33% PH of the untreated left liver lobule. Liver specimens and controls were analyzed for DNA damage, apoptosis, proliferation and cell cycle related genes (1 hour to up to 12 weeks). Results: Double strand breaks (phosphorylated histone H2AX) induced by IR rapidly declined within hours and were no longer detectable after 4 days. No significant apoptosis was noted and steady mRNA levels (B-cell lymphoma 2-associated X protein (BAX), caspase 3 and 9) were in line with the lack of DNA fragmentation. However, gene expression of p53 and p21 in irradiated liver tissue increased. Transcripts of cyclin D1, proliferating cell nuclear antigen (PCNA), and cyclin B augmented progressively, whereas cyclin E was only affected moderately. Following PH, irradiated livers displayed persistently high protein levels of p21 and cyclin D1. However, cell divisions were infrequent, as reflected by low PCNA levels up to four weeks. Conclusion: IR leads to a major arrest in the G1/S phase and to a lesser extent in the G2/M transition of the cell cycle, resulting in reduced regenerative response following PH. The persistent block of at least four weeks may promote preferential proliferation of transplanted hepatocytes in this milieu."],["dc.identifier.doi","10.1080/09553000801953359"],["dc.identifier.isi","000254631200004"],["dc.identifier.pmid","18386194"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55458"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis Ltd"],["dc.relation.issn","1362-3095"],["dc.relation.issn","0955-3002"],["dc.title","Irradiation as preparative regimen for hepatocyte transplantation causes prolonged cell cycle block"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","220"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Nitric Oxide"],["dc.bibliographiccitation.lastpage","226"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Krause, Petra"],["dc.contributor.author","Waetzig, Esther"],["dc.contributor.author","Acil, Hasan"],["dc.contributor.author","Koenig, Sarah"],["dc.contributor.author","Unthan-Fechner, Kirsten"],["dc.contributor.author","Tsikas, Dimitrios"],["dc.contributor.author","Probst, Irmelin"],["dc.date.accessioned","2018-11-07T08:37:45Z"],["dc.date.available","2018-11-07T08:37:45Z"],["dc.date.issued","2010"],["dc.description.abstract","During liver regeneration in vivo carbon monoxide (CO) and nitric oxide (NO) are supposed to play a significant role. We raise the question whether CO and NO are involved in the growth process of cultured hepatocytes. Rat hepatocytes were stimulated into proliferation, growth being estimated by DNA content, mRNA by quantitative RT-PCR, and inducible NO synthase (iNOS) activity by GC-MS. Dexamethasone proved obligatory for fast proliferation. It suppressed the spontaneous rise of iNOS-mRNA in cultures devoid of glucocorticoids, but did not counteract the rise in mRNA in actively dividing cultures. Expression of iNOS-mRNA and cell growth were further enhanced by LiCl (10 mM). NOS activity was completely suppressed by the iNOS-specific inhibitors N-(3-(aminomethyl)benzyl) acetamidine (1400 W,100 mu M) and L-N(6)-(1-iminoethyl)lysine (L-NIL, 500 mu M), however, without a decrease in hepatocyte growth. Proliferation was attenuated only by very high concentrations (>0.5 mM) of N-nitro-L-arginine methyl ester NAME) and asymmetric dimethylarginine (ADMA). Various NO donors (at 100 mu M) did not stimulate cell growth. The furoxan CAS 1609 stimulated growth, decreased iNOS-mRNA expression and transiently increased haem oxygenase-1 (HO-1)-mRNA without releasing considerable amounts of NO. 1H-[1,2,4]Oxadiazolo[4,3,-alpha]quinoxalin-1-one (ODQ) attenuated the action of CAS 1609. Proliferation was stimulated by Co-protoporphyrin and tricarbonyldichlororuthenium(II) dimer (CORM-2). We conclude that CAS 1609 triggers hepatocyte mitosis most likely via direct, NO-independent induction of HO-1 expression, pointing to CO as a growth-promoting signal in the proliferation cascade in cultured hepatocytes. (C) 2010 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.niox.2010.06.007"],["dc.identifier.isi","000281659600010"],["dc.identifier.pmid","20619352"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18610"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1089-8603"],["dc.title","Role of carbon monoxide and nitric oxide in adult rat hepatocytes proliferating in vitro: Effects of CAS 1609"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","144"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Hepatology"],["dc.bibliographiccitation.lastpage","159"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Nussler, A."],["dc.contributor.author","Konig, Sarah"],["dc.contributor.author","Ott, M."],["dc.contributor.author","Sokal, E."],["dc.contributor.author","Christ, B."],["dc.contributor.author","Thasler, W."],["dc.contributor.author","Brulport, M."],["dc.contributor.author","Gabelein, G."],["dc.contributor.author","Schormann, W."],["dc.contributor.author","Schulze, M."],["dc.contributor.author","Ellis, E."],["dc.contributor.author","Kraemer, M."],["dc.contributor.author","Nocken, F."],["dc.contributor.author","Fleig, W."],["dc.contributor.author","Manns, M."],["dc.contributor.author","Strom, S. C."],["dc.contributor.author","Hengstler, Jan G."],["dc.date.accessioned","2018-11-07T09:36:53Z"],["dc.date.available","2018-11-07T09:36:53Z"],["dc.date.issued","2006"],["dc.description.abstract","In recent years the interest in liver cell therapy has been increasing continuously, since the demand for whole liver transplantations in human beings far outweighs the supply. From the clinical point of view, transplantation of hepatocytes or hepatocyte-like cells may represent an alternative to orthotopic liver transplants in acute liver failure, for the correction of genetic disorders resulting in metabolically deficient states, and for late stage liver disease such as cirrhosis. Although the concept of cell therapy for various diseases of the liver is widely accepted, the practical approach in humans often remains difficult. An international expert panel critically discussed the recent published data on clinical and experimental hepatocyte transplantation and the possible role of stem cells in liver tissue repair. This paper aims to summarise the present status of cell based therapies for liver diseases and to identify areas of future preclinical and clinical research. (c) 2006 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.jhep.2006.04.002"],["dc.identifier.isi","000238782200016"],["dc.identifier.pmid","16730092"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32713"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0168-8278"],["dc.title","Present status and perspectives of cell-based therapies for liver diseases"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","413"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Züchtungskunde"],["dc.bibliographiccitation.lastpage","425"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Simianer, Henner"],["dc.contributor.author","Konig, Sarah"],["dc.date.accessioned","2018-11-07T09:54:57Z"],["dc.date.available","2018-11-07T09:54:57Z"],["dc.date.issued","2002"],["dc.description.abstract","Animal health is important both from the perspective of animal welfare and food quality. Also, healthy animals are a prerequisite for economically successful animal production. Health problems can be classified in infectious diseases, genetic disorders and functional diseases. In each case, different approaches are required for genetic improvement. Breeding for disease resistance is not trivial, due to the low heritability of the respective traits, unfavourable genetic correlations to important production traits, and problems to organise a population-wide recording system efficiently. Experimental studies have shown, that breeding for immune capacity based on quantitative immunological parameters is possible. Traditionally, the Scandinavian countries run efficient recording schemes for health traits and give those traits a high weight in their breeding goals. For mastitis in dairy cattle it is shown, that these activities result in a positive genetic trend for this trait relative to the trend in Germany. Marker-assisted selection against genetic defects in pigs is shown to be potentially very efficient. Compared to selection based on frequencies of defects in a boar's progeny, a marker-based pre selection of young boars is shown to lead to a significant increase in genetic progress. In conclusion, the type of recorded health traits, quality of recording and the relative weight of health traits in the breeding goal are seen as the most critical factors affecting efficiency of selection. New technologies and selection strategies have the potential to speed up the genetic trend towards more healthy animals."],["dc.identifier.isi","000179825800002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36645"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Eugen Ulmer Gmbh Co"],["dc.publisher.place","Stuttgart 70"],["dc.relation.conference","Annual Meeting of the Deutschen-Gesellschaft-fur-Zuchtungskunde e V"],["dc.relation.eventlocation","COBBELSDORF, GERMANY"],["dc.relation.issn","0044-5401"],["dc.title","Breeding for disease resistance - is it successful?"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Zentralblatt für Chirurgie"],["dc.contributor.author","König, Sarah"],["dc.contributor.author","Datta, Rabi Raj"],["dc.contributor.author","Flemming, Sven"],["dc.contributor.author","Kauffels-Sprenger, Anne"],["dc.contributor.author","Rüsseler, Miriam"],["dc.contributor.author","Sterz, Jasmina"],["dc.date.accessioned","2021-06-01T09:41:48Z"],["dc.date.available","2021-06-01T09:41:48Z"],["dc.date.issued","2021"],["dc.description.abstract","Zusammenfassung Die Gestaltung und Umsetzung von Online-Lehre werden schon seit Langem in der chirurgischen Ausbildung für das Medizinstudium diskutiert. Sie gewinnt im Zuge der fortschreitenden Digitalisierung und nicht zuletzt aufgrund des aktuellen Pandemiegeschehens eine besondere Bedeutung. Immer drängender stellen sich Fragen zu den Möglichkeiten und Grenzen der Online-Lehre, was sich aktuell unter dem Entwicklungsdruck bereits bewährt hat, und wie zukunftsträchtige Konzepte gestaltbar sind. Dieser Artikel adressiert die Rahmenbedingungen und die verschiedenen Online-Lehrformate in der Chirurgie und zeigt das Spannungsfeld zwischen technischer Machbarkeit, Umsetzungserfahrungen und didaktischer Zielerreichung auf."],["dc.identifier.doi","10.1055/a-1398-5737"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85044"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1438-9592"],["dc.relation.issn","0044-409X"],["dc.title","Online-Lehre in der Chirurgie"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]