Rothenberger, Aribert

[["dc.bibliographiccitation.firstpage","163"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neural Transmission"],["dc.bibliographiccitation.lastpage","175"],["dc.bibliographiccitation.volume","115"],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Chen, W."],["dc.contributor.author","Oades, Robert D."],["dc.contributor.author","Asherson, Philip"],["dc.contributor.author","Taylor, Eric A."],["dc.contributor.author","Lasky-Su, Jessica"],["dc.contributor.author","Zhou, K."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Buschgens, Cathelijne"],["dc.contributor.author","Franke, Barbara"],["dc.contributor.author","Gabriels, Isabel"],["dc.contributor.author","Manor, Iris"],["dc.contributor.author","Marco, R."],["dc.contributor.author","Mueller, Ueli C."],["dc.contributor.author","Mulligan, Aisling"],["dc.contributor.author","Psychogiou, Lamprini"],["dc.contributor.author","Rommelse, Nanda N. J."],["dc.contributor.author","Uebel, Henrik"],["dc.contributor.author","Buitelaar, J. K."],["dc.contributor.author","Ebstein, Richard P."],["dc.contributor.author","Eisenberg, Jacques"],["dc.contributor.author","Gil, Miguel Alvarino"],["dc.contributor.author","Miranda, Ana"],["dc.contributor.author","Mulas, Fernando"],["dc.contributor.author","Roeyers, Herbert"],["dc.contributor.author","Rothenberger, A."],["dc.contributor.author","Sergeant, Joseph A."],["dc.contributor.author","Sonuga-Barke, Edmund J."],["dc.contributor.author","Steinhausen, H.-C."],["dc.contributor.author","Thompson, Margaret"],["dc.contributor.author","Faraone, Steven V."],["dc.date.accessioned","2018-11-07T11:18:40Z"],["dc.date.available","2018-11-07T11:18:40Z"],["dc.date.issued","2008"],["dc.description.abstract","Common disorders of childhood and adolescence are attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD) and conduct disorder (CD). For one to two cases in three diagnosed with ADHD the disorders may be comorbid. However, whether comorbid conduct problems (CP) represents a separate disorder or a severe form of ADHD remains controversial. We investigated familial recurrence patterns of the pure or comorbid condition in families with at least two children and one definite case of DSM-IV ADHDct (combined-type) as part of the International Multicentre ADHD Genetics Study (IMAGE). Using case diagnoses (PACS, parental account) and symptom ratings (Parent/Teacher Strengths and Difficulties [SDQ], and Conners Questionnaires [CPTRS]) we studied 1009 cases (241 with ADHDonly and 768 with ADHD + CP), and their 1591 siblings. CP was defined as >= 4 on the SDQ conduct-subscale, and T >= 65, on Conners' oppositional-score. Multinomial logistic regression was used to ascertain recurrence risks of the pure and comorbid conditions in the siblings as predicted by the status of the cases. There was a higher relative risk to develop ADHD + CP for siblings of cases with ADHD + CP (RRR = 4.9; 95%CI: 2.59-9.41); p < 0.001) than with ADHDonly. Rates of ADHDonly in siblings of cases with ADHD + CP were lower but significant (RRR = 2.9; 95%CI: 1.6-5.3, p < 0.001). Children with ADHD + CP scored higher on the Conners ADHDct symptom-scales than those with ADHDonly. Our finding that ADHD + CP can represent a familial distinct subtype possibly with a distinct genetic etiology is consistent with a high risk for cosegregation. Further, ADHD + CP can be a more severe disorder than ADHDonly with symptoms stable from childhood through adolescence. The findings provide partial support for the ICD-10 distinction between hyperkinetic disorder (F90.0) and hyperkinetic conduct disorder (F90.1)."],["dc.description.sponsorship","Medical Research Council; NIMH NIH HHS [R01MH062873]"],["dc.identifier.doi","10.1007/s00702-007-0837-y"],["dc.identifier.isi","000253214800003"],["dc.identifier.pmid","18200434"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55091"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.conference","39th International Danube Symposium for Neurological Science and Continuing Education/1st International Congress on ADHD, from Childhood to Adult Disease"],["dc.relation.eventlocation","Wurzburg, GERMANY"],["dc.relation.issn","1435-1463"],["dc.relation.issn","0300-9564"],["dc.title","Co-transmission of conduct problems with attention-deficit/hyperactivity disorder: familial evidence for a distinct disorder"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","97"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie"],["dc.bibliographiccitation.lastpage","107"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Coghill, David"],["dc.contributor.author","Santosh, Parmala"],["dc.contributor.author","Zuddas, Alessandro"],["dc.contributor.author","Asherson, Philip"],["dc.contributor.author","Buitelaar, J. K."],["dc.contributor.author","Danckaerta, Marina"],["dc.contributor.author","Doepfner, Manfred"],["dc.contributor.author","Faraone, Steven V."],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Sergeant, Joseph"],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Sonuga-Barke, Edmund J.-S."],["dc.contributor.author","Taylor, Eric A."],["dc.date.accessioned","2018-11-07T11:18:09Z"],["dc.date.available","2018-11-07T11:18:09Z"],["dc.date.issued","2008"],["dc.description.abstract","A panel of experts from several European countries has accomplished a systematic review of published and unpublished data on the use of long-acting medications in ADHD and hyperkinetic disorders, on the basis of which practical recommendations for the application of these medications have been developed. The current article outlines results of this analysis, comparing the effect sizes and numbers-needed to-treat for extended-release stimulant preparations and atomoxetine (ATX). It is concluded (1) that long-acting preparations should be licensed and used. (2) However, they should not completely replace short-acting medications, in view of costs as well as the greater flexibility of dosing. Individual choices of therapy are necessary. (3) Both ATX and retarded-release stimulants should be available."],["dc.identifier.doi","10.1024/1422-4917.36.2.97"],["dc.identifier.isi","000254746300003"],["dc.identifier.pmid","18622939"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54972"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Verlag Hans Huber"],["dc.relation.issn","1422-4917"],["dc.title","Long-acting medications for the treatment of hyperkinetic disorders - A systematic review and European treatment guidelines. Part 2: A quantitative evaluation of long-acting medications"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","94"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","American Journal of Medical Genetics Part B Neuropsychiatric Genetics"],["dc.bibliographiccitation.lastpage","99"],["dc.bibliographiccitation.volume","147B"],["dc.contributor.author","Brookes, Keeley-Joanne"],["dc.contributor.author","Neale, B."],["dc.contributor.author","Xu, X."],["dc.contributor.author","Thapar, Anita"],["dc.contributor.author","Gil, Miguel Alvarino"],["dc.contributor.author","Langley, K."],["dc.contributor.author","Hawi, Ziarah"],["dc.contributor.author","Mill, J."],["dc.contributor.author","Taylor, Eric A."],["dc.contributor.author","Franke, Barbara"],["dc.contributor.author","Chen, W."],["dc.contributor.author","Ebstein, R."],["dc.contributor.author","Buitelaar, J. K."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Sonuga-Barke, Edmund J."],["dc.contributor.author","Eisenberg, Jacques"],["dc.contributor.author","Manor, Iris"],["dc.contributor.author","Miranda, Ana"],["dc.contributor.author","Oades, Robert D."],["dc.contributor.author","Roeyers, Herbert"],["dc.contributor.author","Rothenberger, A."],["dc.contributor.author","Sergeant, Joseph A."],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Faraone, Steven V."],["dc.contributor.author","Asherson, Philip"],["dc.date.accessioned","2018-11-07T11:19:11Z"],["dc.date.available","2018-11-07T11:19:11Z"],["dc.date.issued","2008"],["dc.description.abstract","Season of birth (SOB) has been associated with attention deficit hyperactivity disorder (ADHD) in two existing studies. One further study reported an interaction between SOB and genotypes of the dopamine D4 receptor (DRD4) gene. It is important that these findings are further investigated to confirm or refute the findings. In this study, we investigated the SOB association with ADHD in four independent samples collected for molecular genetic studies of ADHD and found a small but significant increase in summer births compared to a large population control dataset. We also observed a significant association with the 7-repeat allele of the DRD4 gene variable number tandem repeat polymorphism in exon three with probands born in the winter season, with no significant differential transmission of this allele between summer and winter seasons. Preferential transmission of the 2-repeat allele to ADHD probands occurred in those who were born during the summer season, but did not surpass significance for association, even though the difference in transmission between the two seasons was nominally significant. However, following adjustment for multiple testing of alleles none of the SOB effects remained significant. We conclude that the DRD4 7-repeat allele is associated with ADHD but there is no association or interaction with SOB for increased risk for ADHD. Our findings suggest that we can refute a possible effect of SOB for ADHD. (C) 2007 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/ajmg.b.30562"],["dc.identifier.isi","000251981400016"],["dc.identifier.pmid","17525975"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55211"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1552-485X"],["dc.relation.issn","1552-4841"],["dc.title","Differential Dopamine Receptor D4 Allele Association With ADHD Dependent of Proband Season of Birth"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","197"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Autism and Developmental Disorders"],["dc.bibliographiccitation.lastpage","209"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Mulligan, Aisling"],["dc.contributor.author","Anney, Richard J. L."],["dc.contributor.author","O'Regan, Myra"],["dc.contributor.author","Chen, Wai"],["dc.contributor.author","Butler, Louise"],["dc.contributor.author","Fitzgerald, Michael"],["dc.contributor.author","Buitelaar, J. K."],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Minderaa, Ruud"],["dc.contributor.author","Nijmeijer, Judith"],["dc.contributor.author","Hoekstra, Pieter J."],["dc.contributor.author","Oades, Robert D."],["dc.contributor.author","Roeyers, Herbert"],["dc.contributor.author","Buschgens, Cathelijne"],["dc.contributor.author","Christiansen, Hanna"],["dc.contributor.author","Franke, Barbara"],["dc.contributor.author","Gabriels, Isabel"],["dc.contributor.author","Hartman, Catharina"],["dc.contributor.author","Kuntsi, Jonna"],["dc.contributor.author","Marco, Rafaela"],["dc.contributor.author","Meidad, Sheera"],["dc.contributor.author","Mueller, Ueli C."],["dc.contributor.author","Psychogiou, Lamprini"],["dc.contributor.author","Rommelse, Nanda N. J."],["dc.contributor.author","Thompson, Margaret"],["dc.contributor.author","Uebel, Henrik"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Ebstein, Richard P."],["dc.contributor.author","Eisenberg, Jacques"],["dc.contributor.author","Manor, Iris"],["dc.contributor.author","Miranda, Ana"],["dc.contributor.author","Mulas, Fernando"],["dc.contributor.author","Sergeant, Joseph"],["dc.contributor.author","Sonuga-Barke, Edmund J."],["dc.contributor.author","Asherson, Phil"],["dc.contributor.author","Faraone, Steven V."],["dc.contributor.author","Gill, Michael"],["dc.date.accessioned","2018-11-07T08:33:06Z"],["dc.date.available","2018-11-07T08:33:06Z"],["dc.date.issued","2009"],["dc.description.abstract","It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2-4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders."],["dc.description.sponsorship","Medical Research Council [G0300189]; NIMH NIH HHS [R01MH62873]"],["dc.identifier.doi","10.1007/s10803-008-0621-3"],["dc.identifier.isi","000262566800001"],["dc.identifier.pmid","18642069"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17499"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1573-3432"],["dc.relation.issn","0162-3257"],["dc.title","Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","736"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","American Journal of Medical Genetics Part B Neuropsychiatric Genetics"],["dc.bibliographiccitation.lastpage","737"],["dc.bibliographiccitation.volume","141B"],["dc.contributor.author","Anney, Richard J. L."],["dc.contributor.author","Hawi, Ziarah"],["dc.contributor.author","Sheehan, Karen"],["dc.contributor.author","Brookes, Keeley"],["dc.contributor.author","Zhou, K."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Buitelaar, J. K."],["dc.contributor.author","Ebstein, Richard P."],["dc.contributor.author","Miranda, Ana"],["dc.contributor.author","Oades, Robert D."],["dc.contributor.author","Roeyers, Herbert"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Sergeant, Joseph"],["dc.contributor.author","Sonuga-Barke, Edmund J."],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.date.accessioned","2018-11-07T09:07:16Z"],["dc.date.available","2018-11-07T09:07:16Z"],["dc.date.issued","2006"],["dc.identifier.isi","000240877700233"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25757"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","14th World Congress on Psychiatric Genetics"],["dc.relation.eventlocation","Cagliari, ITALY"],["dc.relation.issn","1552-485X"],["dc.relation.issn","1552-4841"],["dc.title","Epigenetic effects in ADHD: Parent-of-origin effects in image sample"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1159"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","ARCHIVES OF GENERAL PSYCHIATRY"],["dc.bibliographiccitation.lastpage","1167"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Kuntsi, Jonna"],["dc.contributor.author","Wood, Alexis C."],["dc.contributor.author","Rijsdijk, Fruehling"],["dc.contributor.author","Johnson, Katherine A."],["dc.contributor.author","Andreou, Penelope"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Arias-Vasquez, Alejandro"],["dc.contributor.author","Buitelaar, J. K."],["dc.contributor.author","McLoughlin, Grainne"],["dc.contributor.author","Rommelse, Nanda N. J."],["dc.contributor.author","Sergeant, Joseph A."],["dc.contributor.author","Sonuga-Barke, Edmund J."],["dc.contributor.author","Uebel, Henrik"],["dc.contributor.author","van der Meere, Jaap J."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Gill, Michael"],["dc.contributor.author","Manor, Iris"],["dc.contributor.author","Miranda, Ana"],["dc.contributor.author","Mulas, Fernando"],["dc.contributor.author","Oades, Robert D."],["dc.contributor.author","Roeyers, Herbert"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Faraone, Steven V."],["dc.contributor.author","Asherson, Philip"],["dc.date.accessioned","2018-11-07T08:37:15Z"],["dc.date.available","2018-11-07T08:37:15Z"],["dc.date.issued","2010"],["dc.description.abstract","Context: Attention-deficit/hyperactivity disorder (ADHD) is associated with widespread cognitive impairments, but it is not known whether the apparent multiple impairments share etiological roots or separate etiological pathways exist. A better understanding of the etiological pathways is important for the development of targeted interventions and for identification of suitable intermediate phenotypes for molecular genetic investigations. Objectives: To determine, by using a multivariate familial factor analysis approach, whether 1 or more familial factors underlie the slow and variable reaction times, impaired response inhibition, and choice impulsivity associated with ADHD. Design: An ADHD and control sibling-pair design. Setting: Belgium, Germany, Ireland, Israel, Spain, Switzerland, and the United Kingdom. Participants: A total of 1265 participants, aged 6 to 18 years: 464 probands with ADHD and 456 of their siblings (524 with combined-subtype ADHD), and 345 control participants. Main Outcome Measures: Performance on a 4-choice reaction time task, a go/no-go inhibition task, and a choice-delay task. Results: The final model consisted of 2 familial factors. The larger factor, reflecting 85% of the familial variance of ADHD, captured 98% to 100% of the familial influences on mean reaction time and reaction time variability. The second, smaller factor, reflecting 13% of the familial variance of ADHD, captured 62% to 82% of the familial influences on commission and omission errors on the go/no-go task. Choice impulsivity was excluded in the final model because of poor fit. Conclusions: The findings suggest the existence of 2 familial pathways to cognitive impairments in ADHD and indicate promising cognitive targets for future molecular genetic investigations. The familial distinction between the 2 cognitive impairments is consistent with recent theoretical models-a developmental model and an arousal-attention model-of 2 separable underlying processes in ADHD. Future research that tests the familial model within a developmental framework may inform developmentally sensitive interventions."],["dc.identifier.isi","000283737500012"],["dc.identifier.pmid","21041617"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18489"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Medical Assoc"],["dc.relation.issn","1538-3636"],["dc.relation.issn","0003-990X"],["dc.title","Separation of Cognitive Impairments in Attention-Deficit/Hyperactivity Disorder Into 2 Familial Factors"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1450"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","American Journal of Medical Genetics Part B Neuropsychiatric Genetics"],["dc.bibliographiccitation.lastpage","1460"],["dc.bibliographiccitation.volume","147B"],["dc.contributor.author","Chen, Wai"],["dc.contributor.author","Zhou, K."],["dc.contributor.author","Sham, Pak C."],["dc.contributor.author","Franke, Barbara"],["dc.contributor.author","Kuntsi, Jonna"],["dc.contributor.author","Campbell, Desmond"],["dc.contributor.author","Fleischman, Karin"],["dc.contributor.author","Knight, J. O."],["dc.contributor.author","Andreou, Penny"],["dc.contributor.author","Arnold, Renee"],["dc.contributor.author","Altink, Marieke"],["dc.contributor.author","Boer, Frits"],["dc.contributor.author","Boholst, Mary Jane"],["dc.contributor.author","Buschgens, Catheljjne"],["dc.contributor.author","Butler, Louise"],["dc.contributor.author","Christiansen, Hanna"],["dc.contributor.author","Fliers, Ellen A."],["dc.contributor.author","Howe-Forbes, Raoul"],["dc.contributor.author","Gabriels, Isabel"],["dc.contributor.author","Heise, Alexander"],["dc.contributor.author","Korn-Lubetzki, Isabelle"],["dc.contributor.author","Marco, Rafaela"],["dc.contributor.author","Medad, She'era"],["dc.contributor.author","Minderaa, Ruud"],["dc.contributor.author","Mueller, Ueli C."],["dc.contributor.author","Mulligan, Aisling"],["dc.contributor.author","Psychogiou, Lamprini"],["dc.contributor.author","Rommelse, Nanda N. J."],["dc.contributor.author","Sethna, Vaheshta"],["dc.contributor.author","Uebel, Henrik"],["dc.contributor.author","McGuffin, Peter"],["dc.contributor.author","Plomin, Robert"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Buitelaar, J. K."],["dc.contributor.author","Ebstein, Richard P."],["dc.contributor.author","Eisenberg, Jacques"],["dc.contributor.author","Gill, Michael"],["dc.contributor.author","Manor, Iris"],["dc.contributor.author","Miranda, Ana"],["dc.contributor.author","Mulas, Fernando"],["dc.contributor.author","Oades, Robert D."],["dc.contributor.author","Roeyers, Herbert"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Sergeant, Joseph"],["dc.contributor.author","Sonuga-Barke, Edmund J."],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Taylor, Eric A."],["dc.contributor.author","Thompson, Margaret"],["dc.contributor.author","Faraone, Steven V."],["dc.contributor.author","Asherson, Philip"],["dc.date.accessioned","2018-11-07T11:08:09Z"],["dc.date.available","2018-11-07T11:08:09Z"],["dc.date.issued","2008"],["dc.description.abstract","Attention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments. Molecular genetic studies have been successful in identifying genetic variants associated with ADHD, particularly with DSM-IV inattentive and combined subtypes. Quantitative trait locus (QTL) approaches to linkage and association mapping have yet to be widely used in ADHD research, although twin studies investigating individual differences suggest that genetic liability for ADHD is continuously distributed throughout the population, underscoring the applicability of quantitative dimensional approaches. To investigate the appropriateness: of QTL approaches, we tested the familial association between 894 probands with a research diagnosis of DSM-IV ADHD combined type and continuous trait measures among 1,135 of their siblings unselected for phenotype. The sibling recurrence rate for ADHD combined subtype was 12.7%, yielding a sibling recurrence risk ratio (lambda(sib)) of 9.0. Estimated sibling correlations around 0.2-0.3 are similar to those estimated from the analysis of fraternal twins in population twin samples. We further show that there are no threshold effects on the sibling risk for ADHD among the ADHD probands; and that both affected and unaffected siblings contributed to the association with ADRD trait scores. In conclusion, these data confirm the main requirement for QTL mapping of ADHD by demonstrating that narrowly defined DSM-IV combined type probands show familial association with dimensional ADHD symptom scores amongst their siblings. (c) 2008 Wiley-Liss, Inc."],["dc.description.sponsorship","NIMH [R01MH062873]"],["dc.identifier.doi","10.1002/ajmg.b.30672"],["dc.identifier.isi","000261415800018"],["dc.identifier.pmid","18189238"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52716"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1552-485X"],["dc.relation.issn","1552-4841"],["dc.title","DSM-IV Combined Type ADHD Shows Familial Association With Sibling Trait Scores: A Sampling Strategy For QTL Linkage"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","78"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Genetics"],["dc.bibliographiccitation.lastpage","U113"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Elia, Josephine"],["dc.contributor.author","Glessner, Joseph T."],["dc.contributor.author","Wang, K."],["dc.contributor.author","Takahashi, Nagahide"],["dc.contributor.author","Shtir, Corina J."],["dc.contributor.author","Hadley, Dexter"],["dc.contributor.author","Sleiman, Patrick M. A."],["dc.contributor.author","Zhang, Haitao"],["dc.contributor.author","Kim, Cecilia E."],["dc.contributor.author","Robison, Reid"],["dc.contributor.author","Lyon, Gholson J."],["dc.contributor.author","Flory, James H."],["dc.contributor.author","Bradfield, Jonathan P."],["dc.contributor.author","Imielinski, Marcin"],["dc.contributor.author","Hou, Cuiping"],["dc.contributor.author","Frackelton, Edward C."],["dc.contributor.author","Chiavacci, Rosetta M."],["dc.contributor.author","Sakurai, Takeshi"],["dc.contributor.author","Rabin, Cara"],["dc.contributor.author","Middleton, Frank A."],["dc.contributor.author","Thomas, Kelly A."],["dc.contributor.author","Garris, Maria"],["dc.contributor.author","Mentch, Frank"],["dc.contributor.author","Freitag, Christine M."],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Todorov, Alexandre A."],["dc.contributor.author","Reif, Andreas"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Franke, Barbara"],["dc.contributor.author","Mick, Eric O."],["dc.contributor.author","Roeyers, Herbert"],["dc.contributor.author","Buitelaar, J. K."],["dc.contributor.author","Lesch, Klaus-Peter"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Ebstein, Richard P."],["dc.contributor.author","Mulas, Fernando"],["dc.contributor.author","Oades, Robert D."],["dc.contributor.author","Sergeant, Joseph"],["dc.contributor.author","Sonuga-Barke, Edmund J."],["dc.contributor.author","Renner, Tobias J."],["dc.contributor.author","Romanos, Marcel"],["dc.contributor.author","Romanos, Jasmin"],["dc.contributor.author","Warnke, Andreas"],["dc.contributor.author","Walitza, Susanne"],["dc.contributor.author","Meyer, Jobst"],["dc.contributor.author","Palmason, Haukur"],["dc.contributor.author","Seitz, Christiane"],["dc.contributor.author","Loo, Sandra K."],["dc.contributor.author","Smalley, Susan L."],["dc.contributor.author","Biederman, Joseph"],["dc.contributor.author","Kent, Lindsey"],["dc.contributor.author","Asherson, Philip"],["dc.contributor.author","Anney, Richard J. L."],["dc.contributor.author","Gaynor, J. William"],["dc.contributor.author","Shaw, Philip"],["dc.contributor.author","Devoto, Marcella"],["dc.contributor.author","White, Peter S."],["dc.contributor.author","Grant, Struan F. A."],["dc.contributor.author","Buxbaum, Joseph D."],["dc.contributor.author","Rapoport, Judith L."],["dc.contributor.author","Williams, Nigel M."],["dc.contributor.author","Nelson, Stanley F."],["dc.contributor.author","Faraone, Steven V."],["dc.contributor.author","Hakonarson, Hakon"],["dc.date.accessioned","2018-11-07T09:16:19Z"],["dc.date.available","2018-11-07T09:16:19Z"],["dc.date.issued","2012"],["dc.description.abstract","Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) study on 1,013 cases with ADHD and 4,105 healthy children of European ancestry using 550,000 SNPs. We evaluated statistically significant findings in multiple independent cohorts, with a total of 2,493 cases with ADHD and 9,222 controls of European ancestry, using matched platforms. CNVs affecting metabotropic glutamate receptor genes were enriched across all cohorts (P = 2.1 x 10(-9)). We saw GRM5 (encoding glutamate receptor, metabotropic 5) deletions in ten cases and one control (P = 1.36 x 10(-6)). We saw GRM7 deletions in six cases, and we saw GRM8 deletions in eight cases and no controls. GRM1 was duplicated in eight cases. We experimentally validated the observed variants using quantitative RT-PCR. A gene network analysis showed that genes interacting with the genes in the GRM family are enriched for CNVs in similar to 10% of the cases (P = 4.38 x 10(-10)) after correction for occurrence in the controls. We identified rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts."],["dc.identifier.doi","10.1038/ng.1013"],["dc.identifier.isi","000298664000018"],["dc.identifier.pmid","22138692"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27912"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1546-1718"],["dc.relation.issn","1061-4036"],["dc.title","Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","81"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie"],["dc.bibliographiccitation.lastpage","95"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Coghill, David"],["dc.contributor.author","Santosh, Paramala"],["dc.contributor.author","Zuddas, Alessandro"],["dc.contributor.author","Asherson, Philip"],["dc.contributor.author","Buitelaar, J. K."],["dc.contributor.author","Danckerts, Marina"],["dc.contributor.author","Doefner, Manfred"],["dc.contributor.author","Faraone, Steven V."],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Sergeant, Joseph"],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Sonuga-Barke, Edmund J."],["dc.contributor.author","Taylor, Eric A."],["dc.date.accessioned","2018-11-07T11:18:09Z"],["dc.date.available","2018-11-07T11:18:09Z"],["dc.date.issued","2008"],["dc.description.abstract","A panel of experts from several European countries has accomplished a systematic review of published and unpublished data on the use of long-acting medications in ADHD and hyperkinetic disorder. Based on this analysis detailed recommendations about the use of these drugs in practice have been developed: (1) Long-acting preparations should be licensed and used; (2) They should not completely replace short-acting drugs (which will be the initial treatment for many children in view of cost and the greater flexibility of dosing). Individual clinical choices are necessary. (3) Both ATX and extended-release stimulants should be available. In addition, detailed recommendations will be made with regard to the criteria to be applied in choosing a preparation for the individual patient."],["dc.identifier.doi","10.1024/1422-4917.36.2.81"],["dc.identifier.isi","000254746300002"],["dc.identifier.pmid","18622938"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54971"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Verlag Hans Huber"],["dc.relation.issn","1422-4917"],["dc.title","Long-acting medications for the treatment of hyperkinetic disorders - A systematic review and European treatment guideline. Part 1: Overview and recommendations"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","American Journal of Medical Genetics Part B Neuropsychiatric Genetics"],["dc.bibliographiccitation.volume","141B"],["dc.contributor.author","Ben Neale, Ben Neale"],["dc.contributor.author","Asherson, Philip"],["dc.contributor.author","Purcell, Shaun M."],["dc.contributor.author","Brookes, Keeley"],["dc.contributor.author","Zhou, K."],["dc.contributor.author","Chen, Wai"],["dc.contributor.author","Buitelaar, J. K."],["dc.contributor.author","Ebstein, Richard S."],["dc.contributor.author","Gill, Michael"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Manor, Iris"],["dc.contributor.author","Miranda, Ana"],["dc.contributor.author","Oades, Bob"],["dc.contributor.author","Roeyers, Herbert"],["dc.contributor.author","Rothenberger, Ari"],["dc.contributor.author","Sergeant, J. O."],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Sonuga-Barke, Edmund J."],["dc.contributor.author","Sham, Pak C."],["dc.contributor.author","Faraone, Steve"],["dc.date.accessioned","2018-11-07T09:07:14Z"],["dc.date.available","2018-11-07T09:07:14Z"],["dc.date.issued","2006"],["dc.format.extent","719"],["dc.identifier.isi","000240877700153"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25746"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","14th World Congress on Psychiatric Genetics"],["dc.relation.eventlocation","Cagliari, ITALY"],["dc.relation.issn","1552-485X"],["dc.relation.issn","1552-4841"],["dc.title","An examination of population differences in the image sample across 47 autosomal genes implicated in psychiatric disorders"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]