Rothenberger, Aribert

[["dc.bibliographiccitation.firstpage","914"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Child Psychology and Psychiatry"],["dc.bibliographiccitation.lastpage","923"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Albrecht, Björn"],["dc.contributor.author","Brandeis, Daniel"],["dc.contributor.author","Uebel-von Sandersleben, Henrik"],["dc.contributor.author","Valko, Lilian"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Xu, X."],["dc.contributor.author","Drechsler, Renate"],["dc.contributor.author","Heise, Alexander"],["dc.contributor.author","Kuntsi, Jonna"],["dc.contributor.author","Mueller, Ueli C."],["dc.contributor.author","Asherson, Philip"],["dc.contributor.author","Steinhausen, Hans-Christoph"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Banaschewski, Tobias"],["dc.date.accessioned","2018-11-07T09:37:19Z"],["dc.date.available","2018-11-07T09:37:19Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: Difficulties with performance and brain activity related to attentional orienting (Cue-P3), cognitive or response preparation (Cue-CNV) and inhibitory response control (Nogo-P3) during tasks tapping executive functions are familial in ADHD and may represent endophenotypes. The aim of this study was to clarify the impact of dopamine receptor D4 (DRD4) and dopamine transporter (DAT1) gene polymorphisms on these processes in ADHD and control children. Methods: Behavioural and electrophysiological parameters from cued continuous performance tests with low and high attentional load were assessed in boys with ADHD combined type (N = 94) and controls without family history of ADHD (N = 31). Both groups were split for the presence of at least one DRD4 7-repeat allele and the DAT1 10-6 haplotype. Results: Children with ADHD showed diminished performance and lower Cue-P3, CNV and Nogo-P3 amplitudes. Children with DRD4 7R showed similar performance problems and lower Cue-P3 and CNV, but Nogo-P3 was not reduced. Children with the DAT1 10-6 haplotype had no difficulties with performance or Cue-P3 and CNV, but contrary to expectations increased Nogo-P3. There were no Genotype by ADHD interactions. Conclusions: This study detected specific effects of DRD4 7R on performance and brain activity related to attentional orienting and response preparation, while DAT1 10-6 was associated with elevated brain activity related to inhibitory response control, which potentially compensates increased impulsivity. As these genotype effects were additive to the impact of ADHD, the current results indicate that DRD4 and DAT1 polymorphisms are functionally relevant risk factors for ADHD and presumably other disorders sharing these endophenotypes."],["dc.identifier.doi","10.1111/jcpp.12212"],["dc.identifier.isi","000339384700009"],["dc.identifier.pmid","24521003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32815"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1469-7610"],["dc.relation.issn","0021-9630"],["dc.title","Genetics of preparation and response control in ADHD: the role of DRD4 and DAT1"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","990"],["dc.bibliographiccitation.journal","Frontiers in human neuroscience"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Albrecht, Björn"],["dc.contributor.author","Lütcke, Henry"],["dc.contributor.author","Auer, Tibor"],["dc.contributor.author","Dewiputri, Wan Ilma"],["dc.contributor.author","Schweizer, Renate"],["dc.contributor.author","Moll, Gunther"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Rothenberger, Aribert"],["dc.date.accessioned","2019-07-09T11:40:54Z"],["dc.date.available","2019-07-09T11:40:54Z"],["dc.date.issued","2014"],["dc.description.abstract","To elucidate basic mechanisms underlying neurofeedback we investigated neural mechanisms of training of slow cortical potentials (SCPs) by considering EEG- and fMRI. Additionally, we analyzed the feasibility of a double-blind, placebo-controlled design in NF research based on regulation performance during treatment sessions and self-assessment of the participants. Twenty healthy adults participated in 16 sessions of SCPs training: 9 participants received regular SCP training, 11 participants received sham feedback. At three time points (pre, intermediate, post) fMRI and EEG/ERP-measurements were conducted during a continuous performance test (CPT). Performance-data during the sessions (regulation performance) in the treatment group and the placebo group were analyzed. Analysis of EEG-activity revealed in the SCP group a strong enhancement of the CNV (electrode Cz) at the intermediate assessment, followed by a decrease back to baseline at the post-treatment assessment. In contrast, in the placebo group a continuous but smaller increase of the CNV could be obtained from pre to post assessment. The increase of the CNV in the SCP group at intermediate testing was superior to the enhancement in the placebo group. The changes of the CNV were accompanied by a continuous improvement in the test performance of the CPT from pre to intermediate to post assessment comparable in both groups. The change of the CNV in the SCP group is interpreted as an indicator of neural plasticity and efficiency while an increase of the CNV in the placebo group might reflect learning and improved timing due to the frequent task repetition. In the fMRI analysis evidence was obtained for neuronal plasticity. After regular SCP neurofeedback activation in the posterior parietal cortex decreased from the pre- to the intermediate measurement and increased again in the post measurement, inversely following the U-shaped increase and decrease of the tCNV EEG amplitude in the SCP-trained group. Furthermore, we found a localized increase of activity in the anterior cingulate cortex (ACC). Analyses of the estimation of treatment assignment by the participants indicate feasibility of blinding. Participants could not assess treatment assignment confidently. Participants of the SCP-group improved regulation capability during treatment sessions (in contrast to the participants of the placebo-group), although regulation capability appeared to be instable, presumably due to diminished confidence in the training (SCP- or sham-training). Our results indicate that SCP training in healthy adults might lead to functional changes in neuronal circuits serving cognitive preparation even after a limited number of sessions."],["dc.format.extent","13"],["dc.identifier.doi","10.3389/fnhum.2014.00990"],["dc.identifier.fs","607730"],["dc.identifier.pmid","25566020"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11462"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58291"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1662-5161"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Neurofeedback of slow cortical potentials: neural mechanisms and feasibility of a placebo-controlled design in healthy adults."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","53"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Biological Psychology"],["dc.bibliographiccitation.lastpage","62"],["dc.bibliographiccitation.volume","77"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Yordanova, Juliana"],["dc.contributor.author","Koiev, V."],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Albrecht, B."],["dc.contributor.author","Rothenberger, A."],["dc.date.accessioned","2018-11-07T11:19:34Z"],["dc.date.available","2018-11-07T11:19:34Z"],["dc.date.issued","2008"],["dc.description.abstract","Aim: To investigate (1) whether and how local stimulus context variation may modify behavioural and preparatory motor processes in children, and (2) if these effects differ between healthy children and children with attention-deficit/hyperactivity disorder (ADHD) aged 9-12 years. Methods: Behavioural parameters and contingent negative variation (CNV) at conical motor electrodes were recorded during a cued continuous performance task (AX-CPT) in three stimulus context conditions (Go, NoGo, neutral). Stimulus context was varied on the basis of stimulus types preceding the cue letter A. Results: In all children, responses were slowed in both the NoGo- and Go-conditions relative to the neutral condition. Stimulus context affected preparatory motor processes in both groups but differentially. ADHD children showed smaller CNV potentials and a functionally irrelevant over-activation of the ipsilateral motor area. Conclusions: Local stimulus context may modify behavioural and preparatory motor processes in children. In ADHD, local context variations may disrupt behaviour due to inefficient regulation of supervisory higher control systems. (C) 2007 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.biopsycho.2007.09.003"],["dc.identifier.isi","000252766400008"],["dc.identifier.pmid","17964058"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55312"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0301-0511"],["dc.title","Stimulus context and motor preparation in attention-deficit/hyperactivity disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","149"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","International Journal of Psychophysiology"],["dc.bibliographiccitation.lastpage","157"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Holl, Birgit"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Schlamp, Dieter"],["dc.contributor.author","Kratz, Oliver"],["dc.contributor.author","Studer, Petra"],["dc.contributor.author","Wangler, Susanne"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Heinrich, Hartmut"],["dc.date.accessioned","2018-11-07T11:22:46Z"],["dc.date.available","2018-11-07T11:22:46Z"],["dc.date.issued","2009"],["dc.description.abstract","In a randomized controlled trial, neurofeedback (NF) training was found to be superior to a computerised attention skills training concerning the reduction of ADHD symptomatology (Gevensleben et al., 2009). The aims of this investigation were to assess the impact of different NF protocols (theta/beta training and training of slow cortical potentials, SCPs) on the resting EEG and the association between distinct EEG measures and behavioral improvements. In 72 (of initially 102) children with ADHD, aged 8-12, EEG changes after either a NF training (n = 46) or the control training (n = 26) could be studied. The combined NF training consisted of one block of theta/beta training and one block of SCP training, each block comprising 18 units of 50 minutes (balanced order). Spontaneous EEG was recorded in a two-minute resting condition before the start of the training, between the two training blocks and after the end of the training. Activity in the different EEG frequency bands was analyzed. In contrast to the control condition, the combined NF training was accompanied by a reduction of theta activity. Protocol-specific EEG changes (theta/beta training: decrease of posterior-midline theta activity; SCP training: increase of central-midline alpha activity) were associated with improvements in the German ADHD rating scale. Related EEG-based predictors were obtained. Thus, differential EEG patterns for theta/beta and SCP training provide further evidence that distinct neuronal mechanisms may contribute to similar behavioral improvements in children with ADHD. (C) 2009 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","German Research Foundation [HE 4536/2, MO 726/2, RO 698/4]"],["dc.identifier.doi","10.1016/j.ijpsycho.2009.08.005"],["dc.identifier.isi","000271783100010"],["dc.identifier.pmid","19712709"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56049"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0167-8760"],["dc.title","Distinct EEG effects related to neurofeedback training in children with ADHD: A randomized controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","447"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Expert Review of Neurotherapeutics"],["dc.bibliographiccitation.lastpage","460"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Heinrich, Hartmut"],["dc.date.accessioned","2018-11-07T09:11:34Z"],["dc.date.available","2018-11-07T09:11:34Z"],["dc.date.issued","2012"],["dc.description.abstract","Neurofeedback (NF), a type of neurobehavioral training, has gained increasing attention in recent years, especially concerning the treatment of children with ADHD. Promising results have emerged from recent randomized controlled studies, and thus, NF is on its way to becoming a valuable addition to the multimodal treatment of ADHD. In this review, we summarize the randomized controlled trials in children with ADHD that have been published within the last 5 years and discuss issues such as the efficacy and specificity of effects, treatment fidelity and problems inherent in placebo-controlled trials of NF. Directions for future NF research are outlined, which should further address specificity and help to determine moderators and mediators to optimize and individualize NF training. Furthermore, we describe methodological (tomographic NF) and technical ('tele-NF') developments that may also contribute to further improvements in treatment outcome."],["dc.description.sponsorship","German Research Foundation [HE 4536/2, MO 726/2, RO 698/4]"],["dc.identifier.doi","10.1586/ERN.12.22"],["dc.identifier.isi","000302982600013"],["dc.identifier.pmid","22449216"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26752"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Expert Reviews"],["dc.relation.issn","1473-7175"],["dc.title","Neurofeedback in children with ADHD: validation and challenges"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","381"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Developmental Science"],["dc.bibliographiccitation.lastpage","391"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Rothenberger, A."],["dc.date.accessioned","2018-11-07T10:12:38Z"],["dc.date.available","2018-11-07T10:12:38Z"],["dc.date.issued","2002"],["dc.description.abstract","Normal development and dysfunctions of motor system excitability can be investigated in vivo by means of single- and paired-pulse transcranial magnetic stimulation (TMS). While different TMS-parameters show different developmental time courses between 8 and 16 years of age, distinct dysfunctional patterns of motor system excitability can be demonstrated in child psychiatric disorders with hypermotoric behavior; in tic disorder a shortened cortical silent period can be stated providing evidence for deficient inhibitory mechanisms within the sensorimotor loop, probably primarily at the level of the basal ganglia. In attention deficit hyperactivity disorder (ADHD), a decreased intracortical inhibition indicates deficient inhibitory mechanisms within the motor cortex (but enhancement of intracortical inhibition after oral intake of 10 mg methylphenidate). In children with comorbid ADHD and tic disorder, the findings of a reduced intracortical inhibition as well as a shortened cortical silent period provide evidence for additive effects at the level of motor system excitability. Thus, TMS allows us to obtain substantial insight into both the normal development and the neurobiological basis of hypermotoric syndromes in child psychiatry."],["dc.identifier.doi","10.1111/1467-7687.00377"],["dc.identifier.isi","000177220500014"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40276"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publ Ltd"],["dc.relation.issn","1363-755X"],["dc.title","Transcranial magnetic stimulation in child psychiatry: disturbed motor system excitability in hypermotoric syndromes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","602"],["dc.bibliographiccitation.journal","Frontiers in Human Neuroscience"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Arns, Martijn"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Ros, Tomas"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Strehl, Ute"],["dc.date.accessioned","2018-11-07T09:49:59Z"],["dc.date.available","2018-11-07T09:49:59Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.3389/fnhum.2015.00602"],["dc.identifier.isi","000366491200001"],["dc.identifier.pmid","26578942"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12794"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35616"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1662-5161"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Editorial: Neurofeedback in ADHD"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","editorial_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","780"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Child Psychology and Psychiatry"],["dc.bibliographiccitation.lastpage","789"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Gevensleben, Holger"],["dc.contributor.author","Holl, Birgit"],["dc.contributor.author","Albrecht, Bjoern"],["dc.contributor.author","Vogel, Claudia"],["dc.contributor.author","Schlamp, Dieter"],["dc.contributor.author","Kratz, Oliver"],["dc.contributor.author","Studer, Petra"],["dc.contributor.author","Rothenberger, Aribert"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Heinrich, Hartmut"],["dc.date.accessioned","2018-11-07T08:28:14Z"],["dc.date.available","2018-11-07T08:28:14Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: For children with attention deficit/hyperactivity disorder (ADHD), a reduction of inattention, impulsivity and hyperactivity by neurofeedback (NF) has been reported in several studies. But so far, unspecific training effects have not been adequately controlled for and/or studies do not provide sufficient statistical power. To overcome these methodological shortcomings we evaluated the clinical efficacy of neurofeedback in children with ADHD in a multisite randomised controlled study using a computerised attention skills training as a control condition. Methods: 102 children with ADHD, aged 8 to 12 years, participated in the study. Children performed either 36 sessions of NF training or a computerised attention skills training within two blocks of about four weeks each (randomised group assignment). The combined NF treatment consisted of one block of theta/beta training and one block of slow cortical potential (SCP) training. Pre-training, intermediate and post-training assessment encompassed several behaviour rating scales (e. g., the German ADHD rating scale, FBB-HKS) completed by parents and teachers. Evaluation ('placebo') scales were applied to control for parental expectations and satisfaction with the treatment. Results: For parent and teacher ratings, improvements in the NF group were superior to those of the control group. For the parent-rated FBB-HKS total score (primary outcome measure), the effect size was .60. Comparable effects were obtained for the two NF protocols (theta/beta training, SCP training). Parental attitude towards the treatment did not differ between NF and control group. Conclusions: Superiority of the combined NF training indicates clinical efficacy of NF in children with ADHD. Future studies should further address the specificity of effects and how to optimise the benefit of NF as treatment module for ADHD."],["dc.description.sponsorship","German Research Foundation [HE 4536/2, MO 726/2, RO 698/4]"],["dc.identifier.doi","10.1111/j.1469-7610.2008.02033.x"],["dc.identifier.isi","000266980600003"],["dc.identifier.pmid","19207632"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6334"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16374"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0021-9630"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Is neurofeedback an efficacious treatment for ADHD? A randomised controlled clinical trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","940"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","955"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Yordanova, Juliana"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Kolev, Vasil"],["dc.contributor.author","Rothenberger, Aribert"],["dc.date.accessioned","2018-11-07T09:25:56Z"],["dc.date.available","2018-11-07T09:25:56Z"],["dc.date.issued","2006"],["dc.description.abstract","Objective: The question as to whether coexisting tic disorder (TD) and attention-deficit/hyperactivity disorder (ADRD) in children represent a combination of two independent pathologies, a separate nosologic entity manifested by both tics and hyperactivity or a phenotype subgroup of one of the two major clinical forms has received increasing attention. The aim of the present study was to classify the TD+ADHD comorbidity in the neurocognitive domain and to elucidate the neurophysiological background of TD+ADHD coexistence by analyzing event-related electroencephalographic (EEG) oscillations in the theta (3-7.5 Hz) frequency band. Methods: Event-related potentials were recorded at 10 electrodes in 53 children (9-13 years old) from four groups (healthy controls, TD-only, ADHD-only, and combined TD+ADRD patients), while they performed an auditory selective attention task requiring a button press to a predefined target. Event-related theta oscillations were analyzed by means of time-frequency decomposition (wavelet analysis) in two latency ranges-early (0 - 200 ms) and late (200 - 450 ms). The effects of psychopathology factors (TD and ADHD) and task variables (attended channel and stimulus task relevance) on early (ETR) and late (LTR) theta response's were evaluated statistically. Theta response measures were further correlated with psychopathology scores and spontaneous theta EEG activity. Results: (1) The ETR was enhanced only in comorbid children and did not differ between the control, TD-only, and ADHD-only groups. (2) The LTR was larger in children with ADHD (ADHD-only and comorbid), but this effect was mediated by the spontaneous theta EEG activity. (3) The ETR was larger to attended stimuli at frontal-central electrodes contralateral to the side of attention, to the target stimulus type at frontal locations, and at the hemisphere contralateral to the side of the response. The functional reactivity and scalp distribution of ETRs were modulated by psychopathological factors. Conclusions: In the neurocognitive domain, the TD+ADHD comorbidity can be identified as a unique nosologic entity. Both the spontaneous theta activity and late event-related theta oscillations appear as neurophysiological markers of the ADHD condition. In children, the early event-related theta oscillations may be associated with representations of relevant target features in working memory. Significance: (1) A new model is proposed according to which TD+ADHD comorbidity can be classified at different levels (from neurobiological to cognitive). (2) The functional significance of stimulus-synchronized theta oscillations in children is described for the first time. (c) 2006 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2006.03.056"],["dc.identifier.isi","000239848700046"],["dc.identifier.pmid","16730196"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30180"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.title","Increased event-related theta activity as a psychophysiological marker of comorbidity in children with tics and attention-deficit/hyperactivity disorders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1280"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Clinical Neurophysiology"],["dc.bibliographiccitation.lastpage","1287"],["dc.bibliographiccitation.volume","112"],["dc.contributor.author","Heinrich, Hartmut"],["dc.contributor.author","Moll, Gunther H."],["dc.contributor.author","Dickhaus, H."],["dc.contributor.author","Kolev, V."],["dc.contributor.author","Yordanova, Juliana"],["dc.contributor.author","Rothenberger, A."],["dc.date.accessioned","2018-11-07T08:54:20Z"],["dc.date.available","2018-11-07T08:54:20Z"],["dc.date.issued","2001"],["dc.description.abstract","Objective: The aim of this event-related potential (ERP) study was to test time-on-task analysis at the level of single sweeps in a clinical trial. Since inattentiveness is one of the main symptoms of attention-deficit hyperactivity disorder (ADHD). this child psychiatric disorder was chosen as an exemplary application. Methods: Twenty-four healthy and 24 ADHD boys, aged 9-15 years, performed an auditory selective attention task fur about 5 min. ERP single trials were analyzed using wavelet networks. Time-on-task analysis was applied to omission errors, reaction time and slow ERP components (frontal negativity, parietal positivity), represented by a low-frequency wavelet component. Results: Both performance and ERP measures showed distinct temporal al dynamics. Time-on-task effects were not only linear, but also of higher order and started after less than 1 min. For ADHD children, earlier time-on-task effects, i.e. an earlier increase of omission errors and frontal negativity, resulted. Healthy children could allocate more attentional resources juring the course of the experiment. Conclusion: Time-on-task analysis at the level of single trials revealed phenomena probably reflecting ADHD children's attentional deficits. Thus, a more differentiated ERP analysis may provide a better understanding of the pathophysiological background in neuropsychiatric disorders. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S1388-2457(01)00541-7"],["dc.identifier.isi","000169789400015"],["dc.identifier.pmid","11516740"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22648"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ireland Ltd"],["dc.relation.issn","1388-2457"],["dc.title","Time-on-task analysis using wavelet networks in an event-related potential study on attention-deficit hyperactivity disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]